Medical Director Jobs in Massachusetts
Medical Director jobs in Massachusetts are in strong demand, concentrated in academic medicine, managed care, biotechnology, and hospital administration, with openings for physicians early in their leadership careers through seasoned executives overseeing large clinical programs. Boston, Worcester, and Springfield anchor most of the hiring, where institutions like Mass General Brigham, UMass Memorial Health, and Blue Cross Blue Shield of Massachusetts consistently recruit medical directors. The most sought-after subspecialties include utilization management, population health, and oncology leadership. Find a role that fits below and apply directly.
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The Global Development Medical Director is an important part of the Clinical Project Team (CPT), and Global Study Team (GST) working collaboratively and cross functionally (in a matrix environment) with other CPT, GST and GPT members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Global Development Medical Director and counterpart Global Development Scientist work collaboratively in the clinical aspects underpinning a product!
Accountabilities include clinical support for the development and implementation of late phase AstraZeneca sponsored clinical program strategies, including providing clinical input into design & implementation of clinical trial(s), their delivery, clinical data review, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to (s)NDA/(s)BLA). The Global Development Medical Director plays a critical role in the medical monitoring of a clinical study ensuring safety to patients. They share responsibility with Clinical Operations team members in the planning, execution and closure of clinical study.
The Global Development Medical Director is responsible for the ensuring the risk-benefit of a clinical study, ensuring that all clinical studies operate to the highest ethical and safety standards and in compliance FDA, EMEA, ICH and GCP guidelines as well as SOPs regarding safety.
The Global Development Medical Director may also provide expert input or lead functional process improvement initiatives and provide expert contributions to cross asset, cross tumor working groups or cross Therapy Areas, depending on the level of experience.
As a key member of the clinical team, this position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of collaborators both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws and adhere to Good Clinical Practice and regulatory requirements.
Depending upon experience level, the role will mentor the development of less experienced members of the clinical team.
Responsibilities/Accountabilities
- Responsible for evaluating the risk-benefit of a clinical study. Ensure all clinical studies follow rigorous ethical and safety principles. They must follow FDA, EMEA, ICH, and GCP guidelines, as well as SOPs related to safety.
- Work with clinical product teams (CPT) to develop the study concept document, protocol, and related documents.
- Develop relationships with appropriate consultants and key external experts (KEE), study sites, and utilize these relationships to obtain feedback on protocol design, as well as study training, study execution, and interpretation of study results, and inform recruitment strategies.
- Responsible for the relevance and accuracy of clinical science underpinning clinical study based on detailed scientific review and consultation.
- Accountable for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans (including, but not limited to, the ICF, CRF, TFL Shells, and Safety Reports).
- Supports or leads interactions with global medical affairs, marketing companies, commercial, and regulatory functions in collaboration with GCH/GCPL to ensure cross functional input into protocols.
- Contributes to technical review of protocols with governance bodies such as DRC and PRC.
- Support Health authority interactions as needed.
- Contribute to the development of Medical Oversight Plan (MOP), study level safety reviews, and study-level medical monitoring activities
- Core member of the GST representing Clinical Development.
- Clinical input into Feasibility Questionnaires and consulted on country and site selection
- Assure oversight of collected data, monitoring safety and efficacy within a study.
- Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests
- Proactively engage with MSLs to build strong partnerships with SMMs and KEEs to provide robust feasibility assessments and streamline study execution.
- Contribute to development and delivery of investigator and monitor training and the review and interpretation of clinical data (HLRs) and the development of content needed for governance committee interactions seeking Go/No Go decisions.
- Support the development of clinical components of regulatory submission documents for instances where marketing approval is warranted.
- Development and delivery of the clinical study report
- Work cross functionally in the preparation of launch & branding materials and publications.
- Where appropriate, serve as a mentor of less experienced staff.
Technical Skills
- Drug Development/Clinical Development Planning: Demonstrates the ability to undertake the planning, and timely organization of components of the clinical development plan and work with other functions to achieve successful study initiation and execution.
- Ability to drive/contribute to protocol design, writing and implementation to meet GCP, ICH and all AZ quality standards.
- Demonstrates solid understanding of methodology in the design, conduct, review and interpretation, and presentation of clinical research.
- Can conduct literature reviews to inform protocols, and author background sections on the disease or current medical therapy.
- To provide clinical input into options for the study design and development of the statistical analysis plan.
- To effectively organizes content and rationales in assigned sections of clinical reports or regulatory/EC/IRB documents
- (i.e. CTA, briefing book, BLA/NDA)
- Ability to prepare and present clinical data and/or selected training sessions to internal/external groups.
- Ability to contribute to clinical reports and integrated summary reports.
- Emerging communication & presentation skills including the ability to clearly communicate scientific concepts/data to leadership committees (e.g LSPC, DRC, PRC) or external groups (e.g Investigator Meetings, IDMCs, Conferences
- Presentations)
- Emerging leadership skills with the ability to influence others and drive consensus building
Requirements
- MD./Ph.D. degree or equivalent with industry or academic experience in drug development
- Possesses detailed knowledge of Good Clinical Practice (GCP) and other regulations governing clinical research.
- Possesses general knowledge of 1) medical monitoring 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.
- Ability to grow and maintain a high level of expertise in oncology therapeutic area.
Preferred
- Strong preference for individuals with clinical training in oncology
The annual base pay for this position ranges from $249,827.20 - $374,740.80 . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
When we put unexpected teams in the same room, we ignite ambitious thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our outstanding and ambitious world.
Why AstraZeneca:
Here, courage, curiosity, and collaboration fuel a relentless focus on transforming cancer outcomes, powered by a pipeline that fuses innovative science with advanced technology. You will work in an environment where unexpected teams come together to spark bold ideas, backed by meaningful investment and a clear path from discovery to impact. We value kindness alongside ambition, and we empower leaders at every level to ask sharp questions, take smart risks, and turn data into decisions that help patients sooner.
Date Posted
25-Aug-2026Closing Date
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
The Global Development Medical Director is an important part of the Clinical Project Team (CPT), and Global Study Team (GST) working collaboratively and cross functionally (in a matrix environment) with other CPT, GST and GPT members, Site Management & Monitoring (SMM), field-based liaisons, and site personnel. The Global Development Medical Director and counterpart Global Development Scientist work collaboratively in the clinical aspects underpinning a product!
Accountabilities include clinical support for the development and implementation of late phase AstraZeneca sponsored clinical program strategies, including providing clinical input into design & implementation of clinical trial(s), their delivery, clinical data review, interpretation of results, reporting successfully on time, and activities required for worldwide registration of the product (i.e. clinical input to (s)NDA/(s)BLA). The Global Development Medical Director plays a critical role in the medical monitoring of a clinical study ensuring safety to patients. They share responsibility with Clinical Operations team members in the planning, execution and closure of clinical study.
The Global Development Medical Director is responsible for the ensuring the risk-benefit of a clinical study, ensuring that all clinical studies operate to the highest ethical and safety standards and in compliance FDA, EMEA, ICH and GCP guidelines as well as SOPs regarding safety.
The Global Development Medical Director may also provide expert input or lead functional process improvement initiatives and provide expert contributions to cross asset, cross tumor working groups or cross Therapy Areas, depending on the level of experience.
As a key member of the clinical team, this position demands strong collaborative communication skills, including the ability to engage with and influence a diverse range of collaborators both within and external to AstraZeneca. The individual will operate according to the highest ethical standards in compliance with internal SOPs, local regulations, laws and adhere to Good Clinical Practice and regulatory requirements.
Depending upon experience level, the role will mentor the development of less experienced members of the clinical team.
Responsibilities/Accountabilities
- Responsible for evaluating the risk-benefit of a clinical study. Ensure all clinical studies follow rigorous ethical and safety principles. They must follow FDA, EMEA, ICH, and GCP guidelines, as well as SOPs related to safety.
- Work with clinical product teams (CPT) to develop the study concept document, protocol, and related documents.
- Develop relationships with appropriate consultants and key external experts (KEE), study sites, and utilize these relationships to obtain feedback on protocol design, as well as study training, study execution, and interpretation of study results, and inform recruitment strategies.
- Responsible for the relevance and accuracy of clinical science underpinning clinical study based on detailed scientific review and consultation.
- Accountable for the clinical and scientific leadership and integrity of protocols and/or components of clinical plans (including, but not limited to, the ICF, CRF, TFL Shells, and Safety Reports).
- Supports or leads interactions with global medical affairs, marketing companies, commercial, and regulatory functions in collaboration with GCH/GCPL to ensure cross functional input into protocols.
- Contributes to technical review of protocols with governance bodies such as DRC and PRC.
- Support Health authority interactions as needed.
- Contribute to the development of Medical Oversight Plan (MOP), study level safety reviews, and study-level medical monitoring activities
- Core member of the GST representing Clinical Development.
- Clinical input into Feasibility Questionnaires and consulted on country and site selection
- Assure oversight of collected data, monitoring safety and efficacy within a study.
- Responsible for timely responses to investigational study sites for local ICF changes, protocol & EC/IRB questions/requests
- Proactively engage with MSLs to build strong partnerships with SMMs and KEEs to provide robust feasibility assessments and streamline study execution.
- Contribute to development and delivery of investigator and monitor training and the review and interpretation of clinical data (HLRs) and the development of content needed for governance committee interactions seeking Go/No Go decisions.
- Support the development of clinical components of regulatory submission documents for instances where marketing approval is warranted.
- Development and delivery of the clinical study report
- Work cross functionally in the preparation of launch & branding materials and publications.
- Where appropriate, serve as a mentor of less experienced staff.
Technical Skills
- Drug Development/Clinical Development Planning: Demonstrates the ability to undertake the planning, and timely organization of components of the clinical development plan and work with other functions to achieve successful study initiation and execution.
- Ability to drive/contribute to protocol design, writing and implementation to meet GCP, ICH and all AZ quality standards.
- Demonstrates solid understanding of methodology in the design, conduct, review and interpretation, and presentation of clinical research.
- Can conduct literature reviews to inform protocols, and author background sections on the disease or current medical therapy.
- To provide clinical input into options for the study design and development of the statistical analysis plan.
- To effectively organizes content and rationales in assigned sections of clinical reports or regulatory/EC/IRB documents
- (i.e. CTA, briefing book, BLA/NDA)
- Ability to prepare and present clinical data and/or selected training sessions to internal/external groups.
- Ability to contribute to clinical reports and integrated summary reports.
- Emerging communication & presentation skills including the ability to clearly communicate scientific concepts/data to leadership committees (e.g LSPC, DRC, PRC) or external groups (e.g Investigator Meetings, IDMCs, Conferences
- Presentations)
- Emerging leadership skills with the ability to influence others and drive consensus building
Requirements
- MD./Ph.D. degree or equivalent with industry or academic experience in drug development
- Possesses detailed knowledge of Good Clinical Practice (GCP) and other regulations governing clinical research.
- Possesses general knowledge of 1) medical monitoring 2) Regulatory approval process in relevant countries; 3) pharmaceutical industry/R&D operations; 4) marketing and commercial fundamentals.
- Ability to grow and maintain a high level of expertise in oncology therapeutic area.
Preferred
- Strong preference for individuals with clinical training in oncology
The annual base pay for this position ranges from $249,827.20 - $374,740.80 . Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans.
When we put unexpected teams in the same room, we ignite ambitious thinking with the power to encourage life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility.
Join us in our outstanding and ambitious world.
Why AstraZeneca:
Here, courage, curiosity, and collaboration fuel a relentless focus on transforming cancer outcomes, powered by a pipeline that fuses innovative science with advanced technology. You will work in an environment where unexpected teams come together to spark bold ideas, backed by meaningful investment and a clear path from discovery to impact. We value kindness alongside ambition, and we empower leaders at every level to ask sharp questions, take smart risks, and turn data into decisions that help patients sooner.
Date Posted
25-Aug-2026Closing Date
Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.
See All 172+ Medical Director Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Medical Director JobsMedical Director Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Medical Director Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
- Takeda Pharmaceuticals11
- Merck KGaA9
- Biogen6
- Alkermes6
- Boston Medical Center6
Top Industries Hiring
- Biotechnology & Pharmaceuticals22
- Healthcare & Medical Services20
- Government & Public Sector2
- Education1
- Insurance1
What Massachusetts Employers Look For
The qualifications that appear most often in medical director jobs across Massachusetts.
- Active Massachusetts medical license issued by the Board of Registration in Medicine
- MD or DO degree from an accredited medical school with board certification in a relevant specialty
- Minimum five years of clinical practice experience prior to taking a leadership role
- Demonstrated experience managing clinical quality, utilization review, or population health programs
- Strong background in healthcare compliance, regulatory standards, and accreditation requirements
- Proven ability to lead interdisciplinary clinical teams and collaborate with hospital or health plan executives
Medical Director Jobs in Massachusetts: Frequently Asked Questions
How do you become a medical director in Massachusetts?
Becoming a medical director in Massachusetts requires an active license from the Massachusetts Board of Registration in Medicine, which licenses MDs and DOs practicing in the state. Candidates typically hold a medical degree, complete residency training, achieve board certification in a clinical specialty, and accumulate several years of clinical experience before transitioning into a leadership or administrative role. Many Massachusetts employers also expect a graduate degree in health administration, business, or public health for senior medical director positions.
Which companies hire medical directors in Massachusetts?
Employers hiring medical directors in Massachusetts right now include Takeda Pharmaceuticals, Merck KGaA, and Biogen, based on current listings on Migrate Mate as of August 2026. Massachusetts's concentration of academic medical centers, regional health systems, and health insurance headquarters means medical director roles appear across a uniquely broad range of clinical and administrative settings.
Which Massachusetts cities have the most medical director jobs?
Boston, Cambridge, and Waltham have the most medical director openings in Massachusetts. Boston drives the largest share of postings because of its dense cluster of academic medical centers, teaching hospitals, and health plan headquarters, while Worcester and other metros generate consistent demand through large regional health systems and community hospital networks anchored by employers like UMass Memorial Health.
Are there remote medical director jobs in Massachusetts?
Yes, but they're less common than in purely desk-based fields, since many medical director roles involve on-site clinical oversight, committee leadership, and direct provider engagement. About 73% of medical director openings tied to Massachusetts are remote or hybrid as of August 2026, reflecting the role's mixed nature. Utilization management, insurance medical director positions, and population health roles are the most likely to offer fully remote or hybrid arrangements.
How can I get hired as a medical director in Massachusetts with little or no experience?
The most realistic entry path is moving into a physician leadership role, such as associate medical director, medical director of quality, or department chief, while still maintaining clinical duties. Large Massachusetts systems like Mass General Brigham and Boston Medical Center run physician leadership development programs that prepare clinicians for administrative roles. Earning a certificate or master's in healthcare management and volunteering for quality improvement committees or utilization review panels builds the administrative record Massachusetts employers look for in first-time directors.
Where can I find and apply to medical director jobs in Massachusetts?
You can find and apply to medical director jobs in Massachusetts on Migrate Mate, which lists current openings from Massachusetts employers. Search the listings for roles that match your specialty, experience level, and preferred location, then apply directly to the ones that fit.
See All 172+ Medical Director Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Medical Director Jobs