Nurse Practitioner Jobs in Buffalo, NY

Nurse Practitioner jobs in Buffalo, New York are in strong demand, concentrated in the Medical Campus district, Downtown, and the Elmwood Village corridor, across hospital systems, federally qualified health centers, and specialty clinics. Employers hiring right now include Kaleida Health, Catholic Health System, and Roswell Park Comprehensive Cancer Center. Scan the live roles below and apply to whichever ones fit.

Find Nurse Practitioner Jobs

Overview

Open roles38
Top employerKaleida Health
Work type92% On-site
Top credentialMaster's degree in nursing
Companies hiring25

Showing 5 of 38+ Nurse Practitioner jobs

CHE Behavioral Health Services
Psychiatric Mental Health Nurse Practitioner (PMHNP)
We won't show you this job again
CHE Behavioral Health Services
New 1m ago
Psychiatric Mental Health Nurse Practitioner (PMHNP)
CHE Behavioral Health Services
Buffalo, New York
Healthcare Administration
Nursing
Patient Services & Wellbeing
Master's degree in nursing
501-1,000

Have you applied for this role?

Catholic Health System
Advanced Practice Provider Neuroscience
We won't show you this job again
Catholic Health System
New 1m ago
Advanced Practice Provider Neuroscience
Catholic Health System
Buffalo, New York
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

Have you applied for this role?

Spectrum Health and Human Services
Nurse Practitioner
We won't show you this job again
Spectrum Health and Human Services
New 1m ago
Nurse Practitioner
Spectrum Health and Human Services
Buffalo, New York
Allied Health
Healthcare Administration
Nursing
201-500

Have you applied for this role?

Optum
Nurse Practitioner or Physician Assistant, HouseCalls- Erie, Wyoming Counties
We won't show you this job again
Optum
New 1m ago
Nurse Practitioner or Physician Assistant, HouseCalls- Erie, Wyoming Counties
Optum
Buffalo, New York
Healthcare Administration
Nursing
Patient Services & Wellbeing
$125k - $175k/yr
On-Site
10,000+

Have you applied for this role?

First Docs
Inpatient internal medicine Nurse Practitioner
We won't show you this job again
First Docs
New 1m ago
Inpatient internal medicine Nurse Practitioner
First Docs
Buffalo, New York
Healthcare Administration
Patient Services & Wellbeing
Physicians
On-Site
Master's degree in nursing
51-200

Have you applied for this role?

See All 38 Nurse Practitioner Jobs in Buffalo

Find roles in Buffalo that match your experience and apply in just a few clicks.

Find Nurse Practitioner Jobs

Nurse Practitioner Job Market in Buffalo

Who's Hiring

  • Kaleida Health
    Kaleida Health5
  • Catholic Health System
    Catholic Health System5
  • Roswell Park Comprehensive Cancer Center
    Roswell Park Comprehensive Cancer Center3
  • Two Chairs
    Two Chairs2
  • Jewish Family Service
    Jewish Family Service2

Top Industries Hiring

  • Healthcare & Medical Services14
  • Non-Profit & Social Services5
  • Consulting & Professional Services3

Nurse Practitioner Jobs in Buffalo: Frequently Asked Questions

How do I get a nurse practitioner job in Buffalo?

Buffalo's strongest hiring comes from its large hospital systems on the Medical Campus, community health centers serving the East and West Side neighborhoods, and growing urgent care networks. Candidates with primary care, psychiatric, or acute care experience tend to move fastest in this market. Tailoring your application to Buffalo's high-need populations, including underserved urban communities and aging residents in surrounding Erie County, gives you a concrete edge over generalist applicants.

Which companies hire nurse practitioners in Buffalo?

Employers hiring nurse practitioners in Buffalo right now include Kaleida Health, Catholic Health System, and Roswell Park Comprehensive Cancer Center, based on current listings on Migrate Mate as of July 2026. Buffalo's hiring is anchored by large academic medical centers, regional health systems, and a network of federally qualified community health centers spread across the city's neighborhoods.

Are there remote nurse practitioner jobs in Buffalo?

Yes, though remote work is limited for nurse practitioners given the hands-on clinical nature of most roles. About 8% of nurse practitioner openings tied to Buffalo are remote or hybrid as of July 2026, with most of those positions concentrated in telepsychiatry, care management, and utilization review functions that don't require direct patient contact.

How can I get a nurse practitioner job in Buffalo with little or no experience?

The most realistic entry path in Buffalo is through residency or fellowship programs offered by the Medical Campus health systems, which are structured for new NP graduates transitioning from RN roles. Community health centers on the East and West Side frequently hire new graduates for primary care positions, valuing candidates with prior RN experience in Buffalo's safety-net settings. Acute care float pool and per-diem positions at regional hospitals are also practical starting points that build local credentials quickly.

Which industries hire the most nurse practitioners in Buffalo?

The sectors hiring the most nurse practitioners in Buffalo are Healthcare & Medical Services, Non-Profit & Social Services, and Consulting & Professional Services, based on current listings on Migrate Mate as of July 2026. Buffalo's concentration of academic medical institutions, VA facilities serving Western New York veterans, and community health infrastructure across its urban neighborhoods drives sustained demand across those sectors.

See All 38 Nurse Practitioner Jobs in Buffalo

Find roles in Buffalo that match your experience and apply in just a few clicks.

Find Nurse Practitioner Jobs