Office Manager Jobs in San Francisco, CA
Office Manager jobs in San Francisco are in strong demand, concentrated in the Financial District, SoMa, and Mission Bay across technology, professional services, healthcare, and finance. Employers hiring right now include Genentech, City and County of San Francisco, and Hyatt. Find a role that fits below and apply directly.
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The Position
The Program Operations Compliance Manager will play a critical role on the HCO team at Genentech. This role is responsible for operational elements and compliance guidance and reviews for external funding requests (e.g., grants, exhibits, sponsorships, corporate memberships), Advisory Boards, fair market value (FMV), and other areas of business need as assigned, including ensuring adherence to and oversight of applicable Genentech processes and guidelines. The role requires an individual with strong subject matter expertise on state and federal laws on interactions with healthcare professionals, a strong operational mindset to redesign workflows, eliminate bottlenecks, and actively implement cutting-edge technologies—including AI and automation—and ability to develop an in-depth understanding of Genentech’s policies, requirements, processes, and procedures.
The Opportunity
- Serve as a business owner for Funding Operations and/or Advisory Board Operations systems; navigation within these systems and compliance review of funding requests may be up to 80% of the role for an extended period.
- Perform compliance review and approval and appropriately process external funding requests based on relevant Genentech processes, guidelines, and SOPs.
- Broadly understand relevant healthcare fraud and abuse regulations and maintain ability to adapt to changes, both active and pending, that will impact or influence the work of Genentech.
- Ensure consistency with and adherence to Genentech standards, laws, regulations, and policies that govern the conduct of the Genentech activities in the remit of this role.
- Lead operational governance across Program Operations’ areas of accountability, providing ongoing guidance to internal stakeholders.
- Provide customer service and guidance to external organizations regarding the grant application process and pending grant requests.
- Drive co-ownership of operational elements and compliance with cross-functional internal stakeholders for the processes in Program Operations’ areas of accountability.
- Working with the end-user in mind, drive modernization of operational processes by evaluating current workflows, designing streamlined alternatives, and partnering with technology teams to successfully implement tools, including automation and AI solutions.
- Actively pursue continuous professional growth and the development of new skills through formal education, hands-on experience, or other acceptable means, utilizing Genentech's provided resources for education and professional development.
- Comply with all laws, regulations, policies and procedures that govern the conduct of Genentech activities.
- Supporting other duties and projects in functional areas such as operations, monitoring, auditing, investigations, policy, training, iHCP, FMV and transparency, as needed.
Competencies/Skills
- Impeccable ethics. Demonstrates, or has proven abilities to demonstrate, Roche Values and Leadership Commitments.
- Adept at identifying operational friction and leveraging modern technology—including automation and AI—to redesign workflows, eliminate bottlenecks, and drive organizational efficiency.
- Strong verbal and written business communication skills: highly adept at synthesizing and summarizing complex and/or voluminous content into clear, concise and actionable communications, including balancing use of AI tools and human confirmation.
- Works well within teams.
- Effectively identifies, develops and implements scalable/sustainable process and other continuous improvements to achieve organizational efficiencies and increase effectiveness.
- Experience building and cultivating relationships with key partners and stakeholders across organizational levels.
- Thinks “outside of the box” for solutions. Applies creative problem-solving and develops appropriate business solutions to effectively address compliance risk.
- Brings strong operational expertise and program management skills to HCO, with a proven ability to prioritize multiple tasks, projects, and goals. Demonstrates complete, end-to-end ownership of initiatives to ensure the timely, on-target, and within-budget delivery of outcomes, while continually identifying and implementing process improvements.
- Demonstrates ability to gain a deep understanding of business operations, including proven ability to connect operational changes to the broader organizational strategy and anticipate downstream impacts. Consistently leverages strong organizational navigation skills to guide complex initiatives to successful completion.
- Demonstrates ability to identify appropriate resources. Exercises good judgment in terms of when to leverage internal resources, including approved artificial intelligence tools.
- Can effectively drive discussions and decisions toward desired end-results.
Who You Are
- Bachelor's Degree (life sciences, law, public policy, marketing, business, education, finance/accounting or related discipline preferred).
- 3 or more years of work experience gained in the pharmaceutical, biotechnology, management consulting, or other regulated industry.
- Healthcare Compliance Certification (before or w/in 6 months of start date).
- Familiarity with funding related preventative and detective controls in the pharmaceutical industry (preferred).
- Experience serving as an advisor on or developer of key operational practices, processes, or procedures (preferred).
- Must demonstrate in-depth knowledge of the bio/pharma industry (compliance, legal, medical affairs, sales, and product marketing).
- Must demonstrate in-depth knowledge of the legal and regulatory environment, as it relates to healthcare compliance in the bio/pharma industry (includes anti-kickback statutes, healthcare fraud & abuse, off-label promotion, PhRMA Code, etc.).
- Experience in compliance disciplines (privacy, healthcare auditing and monitoring, transparency) a plus.
LOCATION
This position is based on-site in South San Francisco. A remote option is not available.
Relocation benefits are not available for this position.
COMPENSATION
- The expected salary range for this position based on the primary location of California is $111,790 to $207,610. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
See All 35 Office Manager Jobs in San Francisco
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Find Office Manager JobsOffice Manager Job Market in San Francisco
Who's Hiring
- Genentech4

- City and County of San Francisco3

- Hyatt2

- Pulley2P
- Highgate2

Top Industries Hiring
- Medical Devices4
- Government & Public Sector4
- Hospitality & Tourism2
- Staffing & Recruiting2
- Technology & Software2
Office Manager Jobs in San Francisco: Frequently Asked Questions
How do I get a office manager job in San Francisco?
The strongest path is targeting San Francisco's dominant sectors: technology companies in SoMa and Mission Bay, financial services firms in the Financial District, and life sciences operations in Mission Bay and the surrounding biotech corridor. Candidates who stand out combine hands-on facilities and vendor management experience with comfort in fast-moving environments. Familiarity with cloud-based office platforms and experience supporting distributed teams also gives applicants a clear edge with San Francisco employers.
Which companies hire office managers in San Francisco?
Employers hiring office managers in San Francisco right now include Genentech, City and County of San Francisco, and Hyatt, based on current listings on Migrate Mate as of June 2026. San Francisco's market skews heavily toward technology firms and professional services companies, many of which operate multi-floor or multi-site offices that require experienced operational support.
Are there remote office manager jobs in San Francisco?
Yes, though office manager roles are more on-site than remote by nature, since the work typically involves facilities oversight, vendor coordination, and in-person staff support. About 0% of office manager openings tied to San Francisco are remote or hybrid as of June 2026. The portions most commonly done remotely in San Francisco include administrative coordination, budget tracking, and scheduling for technology and professional services employers.
How can I get a office manager job in San Francisco with little or no experience?
The most realistic entry path in San Francisco is starting as an administrative coordinator or office coordinator at a startup or mid-size technology company in SoMa or the Financial District, where lean teams often promote quickly. Smaller venture-backed firms and professional services offices in the city regularly hire candidates with strong organizational skills and a willingness to take on cross-functional tasks. Building comfort with tools like Google Workspace, Slack, and Asana is practical preparation specific to what San Francisco employers expect.
Which industries hire the most office managers in San Francisco?
San Francisco office manager roles concentrate in Medical Devices, Government & Public Sector, and Hospitality & Tourism, based on current listings on Migrate Mate as of June 2026. Those sectors dominate because San Francisco's economy is built around technology headquarters, financial services operations, and a growing life sciences presence, all of which require sustained operational and administrative support at scale.
Related Jobs in California
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