Registered Nurse Jobs in Mississippi
Registered Nurse jobs in Mississippi draw consistent demand across hospital systems, long-term care facilities, and community health centers, with openings at every level from new graduate to experienced charge nurse. Jackson, Gulfport, and Hattiesburg generate the largest share of postings, anchored by established employers such as Baptist Health Systems, Memorial Hospital at Gulfport, and Forrest Health. Critical care, med-surg, and labor and delivery are the specialties seeing the steadiest call for nurses statewide. Scan the live roles below and apply to whichever ones fit.
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Expand Access. Support Families. Elevate After-Hours Care.
We are seeking a dedicated Afterhours RN Care Manager to provide high-quality, compassionate hospice care outside standard business hours. This role ensures seamless coverage, continuity of care, and strong clinical management for patients and families during nights, weekends, and on-call hours.
About the Role
The Afterhours Care Manager RN is responsible for assessing and coordinating patient and family needs during after-hours shifts and maintaining primary clinical oversight for assigned patients. This includes routine visits, admissions, death visits, urgent after-hours calls, and any visit assigned per the patient’s plan of care. This role serves as an active member of the Interdisciplinary Group (IDG) to ensure coordination between physicians, families, and the hospice team. Clinical administrative responsibilities, workflow auditing, and survey readiness support are also part of this role.
Essential Functions
- Ensure appropriate delivery of hospice services to eligible patients and families.
- Provide direct in-person patient care during on-call, weekend, and after-hours shifts, including assessments, admissions, routine visits, death visits, and live discharges.
- Conduct initial and ongoing assessments of physical, emotional, psychosocial, and spiritual needs.
- Support the IDG process through chart reviews, plan of care updates, and interdisciplinary communication.
- Develop and revise the Hospice Plan of Care in collaboration with physicians and IDG members.
- Educate patients and families on disease progression, symptom management, medications, and hospice philosophy.
- Communicate significant changes in patient condition promptly to hospice and attending physicians.
- Maintain accurate, timely clinical documentation including assessments, care plans, and notes.
- Assist with rescheduled, missed, or reassigned visit requests based on triage direction.
- Participate in calendar and scheduling modifications, including service codes and clinician assignments.
- Support administrative and compliance activities including workflow audits, survey readiness tasks, and documentation collection.
- Assist with TPE reviews, QAPI efforts, and regulatory compliance.
- Ensure infection control standards and universal precautions are consistently followed.
- Provide leadership and guidance to field staff; conduct supervisory visits when appropriate.
- Participate in required meetings, after-hours updates, and trainings.
- Maintain proficiency in pain and symptom management for hospice and end-of-life care.
- Promote the organization’s core values and maintain a culture of compassion, professionalism, and teamwork.
- Perform other duties as assigned.
Education and Experience
- Current RN license in the state of employment
- Graduate of an accredited nursing program
- Minimum one year of RN experience in acute care, oncology, long-term care, hospice, or home health
- Must meet any state-specific requirements
Licenses and Certifications
- Active RN license
- CPR certification (in-person)
- Valid driver’s license, reliable transportation, and current auto insurance
Skills and Competencies
- Strong knowledge of hospice principles, Medicare/Medicaid regulations, and best practices
- Ability to conduct thorough patient assessments and develop individualized care plans
- Effective communication with patients, families, physicians, and interdisciplinary team members
- Strong time-management and prioritization skills in a fast-changing environment
- Proficiency with EMR systems (HomeCare HomeBase preferred), Microsoft Office, and mobile technologies
- Ability to maintain confidentiality, demonstrate integrity, and support quality outcomes
- Leadership skills to support and guide field staff
- Ability to manage administrative, documentation, and compliance responsibilities accurately
Personal Traits
- Sensitivity to end-of-life needs and the emotional realities families face
- Flexibility to shift tasks and respond to urgent needs
- Professionalism, maturity, teamwork, and resilience under pressure
- Ability to communicate effectively with individuals from diverse background
See All 41 Registered Nurse Jobs in Mississippi
Find roles in Mississippi that match your experience and apply in just a few clicks.
Find Registered Nurse JobsRegistered Nurse Jobs by City in Mississippi
Where Mississippi roles are concentrated, by current openings.
Registered Nurse Job Market in Mississippi
A snapshot from current Mississippi openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Healthcare & Medical Services
What Mississippi Employers Look For
The qualifications that appear most often in registered nurse jobs across Mississippi.
- Active registered nurse license issued or recognized by the Mississippi Board of Nursing
- Associate or Bachelor of Science in Nursing degree from an accredited program
- Current BLS certification required before the first day of patient care
- Minimum one to two years of clinical experience for most non-entry-level positions
- ACLS or PALS certification required for critical care, emergency, and procedural roles
- Strong electronic health record proficiency, commonly with Epic or Meditech platforms
Registered Nurse Jobs in Mississippi: Frequently Asked Questions
How do you become a registered nurse in Mississippi?
You become a registered nurse in Mississippi by completing an accredited associate or bachelor's degree nursing program, then passing the NCLEX-RN exam and applying for licensure through the Mississippi Board of Nursing. The Board issues your initial RN license and handles renewals. Mississippi participates in the Nurse Licensure Compact, so nurses already licensed in another compact state can work in Mississippi without obtaining a separate state license.
How much do registered nurses make in Mississippi?
Registered nurses in Mississippi earn a median of about $77,090 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $60,610 for the lowest 10% to over $100,350 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire registered nurses in Mississippi?
Employers hiring registered nurses in Mississippi right now include Diversicare Healthcare Services, National Louis University, and Baptist Memorial Health Care, based on current listings on Migrate Mate as of August 2026. Large integrated health systems and federally qualified community health centers across the state tend to post the most consistent volume of RN openings year-round.
Which Mississippi cities have the most registered nurse jobs?
Keesler AFB, Tupelo, and Jackson have the most registered nurse openings in Mississippi. Jackson leads because it is home to the state's largest hospital systems and the University of Mississippi Medical Center, while Gulfport and Hattiesburg anchor significant regional medical campuses that serve surrounding rural communities and draw RN demand well beyond their city limits.
Are there remote registered nurse jobs in Mississippi?
Yes, but they're rare. Registered nursing is a hands-on clinical role, so fully remote positions make up a small fraction of total openings. About 17% of registered nurse openings tied to Mississippi are remote or hybrid as of August 2026, and those positions are concentrated in telephonic triage, utilization review, and case management functions rather than direct bedside care.
How can I get hired as a registered nurse in Mississippi with little or no experience?
The most realistic entry path is a new-graduate residency program, and Mississippi's larger health systems run structured ones: Baptist Health Systems and the University of Mississippi Medical Center in Jackson both offer new-grad cohorts that rotate through clinical units and provide mentored onboarding. Applying to med-surg or long-term care positions is a practical alternative when residency cohorts are full. Holding an active Mississippi Board of Nursing license and a current BLS card before you apply removes the most common barriers hiring managers cite for entry-level candidates.
Where can I find and apply to registered nurse jobs in Mississippi?
You can find and apply to registered nurse jobs in Mississippi on Migrate Mate, which lists current Mississippi openings updated regularly. Search the listings, identify the roles that match your specialty and experience level, and apply directly to the ones that fit.
See All 41 Registered Nurse Jobs in Mississippi
Find roles in Mississippi that match your experience and apply in just a few clicks.
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