Regulatory Affairs Manager Jobs in Pennsylvania
Regulatory Affairs Manager jobs in Pennsylvania are among the most active in the country, concentrated in pharmaceutical manufacturing, medical devices, and life sciences across a state with one of the deepest industry clusters on the East Coast, with openings from associate-level managers through senior directors. Philadelphia, Pittsburgh, and the Greater Delaware Valley suburbs drive the majority of hiring, with established employers like Johnson & Johnson, Merck, and West Pharmaceutical Services maintaining deep regulatory staffing needs in the region. The most in-demand specialties are FDA submissions, combination products, and post-market surveillance for drug and device approvals. Find a role that fits below and apply directly.
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Description
Penn Medicine is dedicated to our tripartite mission of providing the highest level of care to patients, conducting innovative research, and educating future leaders in the field of medicine. Working for this leading academic medical center means collaboration with top clinical, technical and business professionals across all disciplines.Today at Penn Medicine, someone will make a breakthrough. Someone will heal a heart, deliver hopeful news, and give comfort and reassurance. Our employees shape our future each day. Are you living your life's work?
- Entity: Corporate
- Department: Government Relations
- Location: Remote
- Hours: 8hr days
Summary:
The Senior Director, State Government Relations and Regulatory Affairs, in Penn Medicine's Department of Government and Community Relations is the health system's lead strategist and representative for all state-level legislative and regulatory matters. This role shapes and advances the organization's policy agenda with the Governor's Office, state agencies, the legislature, and key external partners. The Senior Director provides high-level counsel to executive leaders, anticipates emerging policy trends, and positions the health system as a key voice in state health policy, financing, and public health strategy. Reporting to the AVP of Government & Community Relations, the Director manages the Associate Director of Government Relations and coordinates state advocacy across all entities, departments, faculty and staff to facilitate communication with elected and appointed government officials. This position requires a moderate amount of travel (e.g. Harrisburg, PA and Trenton, NJ.)
Responsibilities:
- Leads the execution of the health system’s state advocacy agenda in both Pennsylvania and New Jersey. Oversee the development and implementation of Penn Medicine’s advocacy agenda. Establishes new relationships and strengthens existing relationships with state government officials and key staff in Harrisburg, PA and Trenton, NJ and their respective district offices.
- Responsible for coordinating regulatory stakeholders and experts on regulatory responses as it relates to government agencies.
- Communicates with internal and external constituencies by drafting reports and updates as necessary, including reports for the Penn Medicine Board of Trustees. This role will lead and manage the Government Relations weekly newsletter process, as well as internal and external updates from the department. Will draft advocacy correspondence on behalf of senior leadership outlining Penn Medicine’s position on current policy matters, and will brief senior leadership as necessary. Responsible for executive level coordination of state government relations with entity CEOs.
- Participates in meetings for industry associations and outside organizations focused on state government relations and health care policy, including but not limited to the Hospital & Healthsystem Association of Pennsylvania, the New Jersey Hospital Association and various chambers of commerce.
- Leads strategic initiatives and short- and long-term planning activities in collaboration with AVP and VP, including special projects and is the lead on projects as assigned.
- Direct and manage the Associate Director of Government and Community Relations to ensure alignment and coordination across entities.
- Leads and provides direction to a team of public affairs consultants who support the development and execution of Penn Medicine’s state advocacy agenda.
- Ensures compliance with lobbying disclosure and reporting requirements as applicable. Maintains ethical standards of conduct at all times.
Education or Equivalent Experience:
- Bachelor of Arts or Science Political Science/Public Administration or related fields (Required)
- 10+ years Extensive experience in the public sector and/or government relations positions. Knowledge of the legislative process, health care industry and health policy required. Position requires extensive knowledge of hospital issues such as Medicare and Medicaid reimbursement, hospital financing, and regulatory issues. (Required)
Live Your Life's Work
We are an Equal Opportunity employer. Candidates are considered for employment without regard to race, ethnicity, color, sex, sexual orientation, gender identity, religion, national origin, ancestry, age, disability, marital status, familial status, genetic information, domestic or sexual violence victim status, citizenship status, military status, status as a protected veteran or any other status protected by applicable law.
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Find JobsRegulatory Affairs Manager Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Regulatory Affairs Manager Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Medical Devices
- Chemicals & Materials
- Healthcare & Medical Services
- Consulting & Professional Services
What Pennsylvania Employers Look For
The qualifications that appear most often in regulatory affairs manager jobs across Pennsylvania.
- Bachelor's degree in life sciences, pharmacy, chemistry, or a closely related scientific field
- Minimum three to five years of regulatory affairs experience in pharmaceutical or medical device industries
- Demonstrated experience with FDA submissions including INDs, NDAs, PMAs, or 510(k)s
- Working knowledge of FDA regulations, ICH guidelines, and relevant CFR parts
- Experience with electronic submission systems such as eCTD and regulatory tracking software
- RAC certification from the Regulatory Affairs Professionals Society preferred by many Pennsylvania employers
Regulatory Affairs Manager Jobs in Pennsylvania: Frequently Asked Questions
How do you become a regulatory affairs manager in Pennsylvania?
Most regulatory affairs managers in Pennsylvania start with a bachelor's degree in a life sciences discipline and several years in a regulatory, quality, or scientific role within pharma or medical devices. Pennsylvania does not issue a state-specific regulatory affairs license, but employers in the region consistently prioritize the Regulatory Affairs Certification credential issued by the Regulatory Affairs Professionals Society. Building experience in FDA submissions at one of Pennsylvania's many contract research organizations or pharmaceutical manufacturers is the most direct path.
How much do regulatory affairs managers make in Pennsylvania?
Regulatory affairs managers in Pennsylvania earn a median of about $85,580 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $49,910 for the lowest 10% to over $130,990 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire regulatory affairs managers in Pennsylvania?
Employers hiring regulatory affairs managers in Pennsylvania right now include West Pharmaceutical Services, Globus Medical, and GSK, based on current listings on Migrate Mate as of September 2026. Pennsylvania's dense concentration of pharmaceutical headquarters and medical device manufacturers in the Philadelphia suburbs and Pittsburgh corridor makes it one of the most consistent states for regulatory hiring year-round.
Which Pennsylvania cities have the most regulatory affairs manager jobs?
Exton, Philadelphia, and Pittsburgh post the most regulatory affairs manager openings in Pennsylvania. Philadelphia and its surrounding Delaware Valley suburbs anchor the market because of the high density of pharmaceutical headquarters, biotech firms, and contract manufacturers in that corridor, while Pittsburgh draws openings from its growing life sciences and hospital system sector.
Are there remote regulatory affairs manager jobs in Pennsylvania?
Yes, and more than most fields. About 75% of regulatory affairs manager openings tied to Pennsylvania are remote or hybrid as of September 2026, reflecting the desk-based and document-driven nature of much of the work. Regulatory writing, submission management, and post-market surveillance roles are the most consistently offered in remote or hybrid formats, while positions requiring hands-on lab or manufacturing oversight tend to remain on-site.
How can I get hired as a regulatory affairs manager in Pennsylvania with little or no experience?
The most realistic entry path is moving laterally from a quality assurance, clinical research, or scientific affairs role at a Pennsylvania pharma or device company, where regulatory exposure is built on the job. Large employers in the Greater Philadelphia area and Pittsburgh regularly hire associate regulatory affairs specialists as entry points for candidates with a relevant science degree and some quality or clinical background. Pursuing RAC certification early and targeting contract research organizations in suburban Philadelphia, which frequently take on candidates transitioning from adjacent roles, gives applicants a measurable edge.
Where can I find and apply to regulatory affairs manager jobs in Pennsylvania?
You can find and apply to regulatory affairs manager jobs in Pennsylvania on Migrate Mate, which lists current openings across the state. Find roles that fit your background and apply directly to the employers posting them.
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