Staff Software Engineer Jobs in Colorado
Staff Software Engineer jobs in Colorado are among the most active in the country, concentrated in aerospace and defense, enterprise software, fintech, and cloud infrastructure across the Front Range. Denver, Boulder, and Colorado Springs anchor the majority of hiring, with established employers like Lockheed Martin, Oracle, and Palantir Technologies maintaining significant engineering teams in the state. The most in-demand specialties are distributed systems, platform engineering, and backend architecture at scale. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 46+ Staff Software Engineer jobs
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 46 Staff Software Engineer Jobs in Colorado
Find roles in Colorado that match your experience and apply in just a few clicks.
Find Staff Software Engineer JobsStaff Software Engineer Jobs by City in Colorado
Where Colorado roles are concentrated, by current openings.
Staff Software Engineer Job Market in Colorado
A snapshot from current Colorado openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Aerospace & Defense
- Technology & Software
What Colorado Employers Look For
The qualifications that appear most often in staff software engineer jobs across Colorado.
- Bachelor's or master's degree in computer science, software engineering, or a related technical field
- Eight or more years of professional software engineering experience with demonstrated technical leadership
- Deep expertise in at least one major backend language such as Java, Go, Python, or C++
- Proven experience designing and operating distributed systems or large-scale cloud infrastructure
- Ability to mentor engineers, lead cross-team design reviews, and drive architectural decisions
- Experience with cloud platforms such as AWS, Google Cloud, or Azure in production environments
Staff Software Engineer Jobs in Colorado: Frequently Asked Questions
How do you become a staff software engineer in Colorado?
Reaching the staff software engineer level in Colorado typically requires a bachelor's degree in computer science or a closely related field followed by several years of progressively senior engineering work. Colorado does not issue a state license for software engineers, so the path is built on demonstrated technical scope: owning system architecture, driving cross-team projects, and mentoring engineers. Many Colorado employers expect candidates at this level to have a portfolio of shipped infrastructure or platform work they can speak to in detail.
How much do staff software engineers make in Colorado?
Staff software engineers in Colorado earn a median of about $138,390 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $96,480 for the lowest 10% to over $213,010 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire staff software engineers in Colorado?
Colorado staff software engineer roles are posted by Lockheed Martin, CesiumAstro, and SciTec and others right now, based on current listings on Migrate Mate as of November 2026. Colorado's mix of defense contractors, enterprise software companies, and high-growth tech firms means openings appear across a wider range of industries than in most states.
Which Colorado cities have the most staff software engineer jobs?
Denver, Littleton, and Westminster have the most staff software engineer openings in Colorado. Denver drives volume through its dense concentration of fintech, cloud, and enterprise software companies, Boulder's research and startup ecosystem pulls demand for platform and infrastructure roles, and Colorado Springs is anchored by defense and aerospace contractors with large engineering headcounts.
Are there remote staff software engineer jobs in Colorado?
Yes, and more than most fields. About 53% of staff software engineer openings tied to Colorado are remote or hybrid as of November 2026, reflecting how readily this work can be done distributed. Platform, backend infrastructure, and architecture roles are the most likely to be fully remote, while positions tied to classified defense programs or on-site hardware systems tend to require a physical presence.
How can I get hired as a staff software engineer in Colorado with little or no experience?
The most realistic path is starting as a software engineer I or II and building toward staff-level scope over time. In Colorado, Lockheed Martin, Oracle, and several Boulder-based scale-ups run structured new-grad and associate engineering programs that funnel into senior and staff tracks. Moving laterally from a site reliability engineering, platform, or technical lead role is also a recognized path. A strong open-source portfolio or demonstrated ownership of a production system that serves real users carries more weight in Colorado hiring than a credential alone.
Where can I find and apply to staff software engineer jobs in Colorado?
You can find and apply to staff software engineer jobs in Colorado on Migrate Mate, which lists current openings across the state. Search the roles available, find the ones that match your background and target location, and apply directly. No account creation is required to see the listings.
See All 46 Staff Software Engineer Jobs in Colorado
Find roles in Colorado that match your experience and apply in just a few clicks.
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