Staff Software Engineer Jobs in Pennsylvania
Staff Software Engineer jobs in Pennsylvania are in strong demand, with significant hiring concentrated in financial technology, defense and government contracting, healthcare IT, and enterprise software across a range from senior individual contributors to principal-level engineers. Philadelphia and Pittsburgh lead hiring volume, with a growing cluster in the Lehigh Valley, and employers with a lasting presence include Comcast, Lockheed Martin, and UPMC. The most sought-after specializations in Pennsylvania right now are distributed systems, cloud infrastructure, and full-stack platform engineering. Find a role that fits below and apply directly.
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OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 18 Staff Software Engineer Jobs in Pennsylvania
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Where Pennsylvania roles are concentrated, by current openings.
Staff Software Engineer Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Science & Research
- Retail
What Pennsylvania Employers Look For
The qualifications that appear most often in staff software engineer jobs across Pennsylvania.
- Bachelor's or master's degree in computer science, software engineering, or a related technical field
- Seven or more years of professional software engineering experience with demonstrated technical leadership
- Proficiency in at least one primary language such as Java, Python, Go, or C++
- Experience designing and operating large-scale distributed systems or cloud-native architectures
- Ability to mentor engineers, lead code reviews, and drive cross-team technical decisions
- Familiarity with agile development practices, CI/CD pipelines, and DevOps tooling
Staff Software Engineer Jobs in Pennsylvania: Frequently Asked Questions
How do you become a staff software engineer in Pennsylvania?
Software engineering is not state-licensed in Pennsylvania, so there is no state board exam or registration required. The typical path runs through a computer science or engineering degree, followed by several years of progressively senior engineering roles. Pennsylvania employers, particularly in Philadelphia's fintech corridor and Pittsburgh's robotics and AI ecosystem, weight demonstrated systems-design experience and evidence of technical leadership over specific certifications when promoting or hiring at the staff level.
How much do staff software engineers make in Pennsylvania?
Staff software engineers in Pennsylvania earn a median of about $126,550 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $77,750 for the lowest 10% to over $178,080 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire staff software engineers in Pennsylvania?
Employers hiring staff software engineers in Pennsylvania right now include Stack AV, Ghost Robotics, and Zoll Medical Corporation, based on current listings on Migrate Mate as of November 2026. Pennsylvania's concentration of defense contractors, major health systems, and large media and telecom companies means staff-level roles appear across a wider range of industries than in purely startup-driven markets.
Which Pennsylvania cities have the most staff software engineer jobs?
Pittsburgh, Pennsylvania, and Philadelphia account for the most staff software engineer openings in Pennsylvania. Philadelphia dominates by volume because of its dense fintech, healthcare IT, and media-tech employer base, while Pittsburgh draws heavily from Carnegie Mellon's research ecosystem and a growing autonomous systems and AI sector that has brought anchor employers and spinouts to the region.
Are there remote staff software engineer jobs in Pennsylvania?
Yes, and more than most fields. About 85% of staff software engineer openings tied to Pennsylvania are remote or hybrid as of November 2026, reflecting how broadly distributed software development work has become for desk-based engineering roles. Platform engineering, backend infrastructure, and developer-tooling positions tend to carry the highest share of fully remote arrangements among Pennsylvania postings.
How can I get hired as a staff software engineer in Pennsylvania with little or no experience?
The most realistic path for candidates without staff-level experience is to enter through a senior software engineer role at a large Pennsylvania employer and build toward staff through demonstrated scope and leadership. UPMC, Comcast, and Lockheed Martin all run structured new-graduate and associate engineer programs in Pennsylvania that feed a pipeline into senior and staff tracks. Candidates who develop a strong portfolio of systems-design work, contribute to open-source projects at scale, or complete an advanced degree in Pittsburgh or Philadelphia research programs tend to move through that pipeline faster.
Where can I find and apply to staff software engineer jobs in Pennsylvania?
You can find and apply to staff software engineer jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings. Find the roles that fit your experience and apply directly to the ones that match.
See All 18 Staff Software Engineer Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
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