Technical Lead Jobs in Pennsylvania
Technical Lead jobs in Pennsylvania are in strong demand, with consistent openings concentrated in software engineering, cloud infrastructure, cybersecurity, and enterprise systems integration at every level from senior software engineer stepping into leadership through principal technical lead. Philadelphia, Pittsburgh, and the Harrisburg corridor are the largest hiring metros for the role, with established employers like Comcast, Lockheed Martin, and Highmark Health carrying a steady volume of openings year-round. The most sought-after specializations are platform engineering, DevOps leadership, and full-stack architecture tied to regulated industries including healthcare, defense, and financial services. Find a role that fits below and apply directly.
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When you are a part of the team at Thermo Fisher, you’ll do important work, like helping customers in finding cures for cancer, protecting the environment, or making sure our food is safe. Your work will have real-world impact, and you’ll be supported in achieving your career goals.
How will you make an impact?
Thermo Fisher is seeking a colleague who is passionate about customer experience, is technically savvy, and has a passion for the digitization and digitalization of science and laboratories. The vision of Digital Science Solutions is to make it easy for our scientific customers to generate value from their research, development, and manufacturing lab operations.
Reporting into the regional Services Manager, the Technical Lead, working closely with Solutions Architects, Consultants, Project Managers, and other Services colleagues, is responsible for successfully owning the technical delivery of our products and solutions in both, pre- and post-sales, customer engagements.
Essential Duties and Responsibilities:
Strategic:
- Trusted advisor to our customers, account managers, services leaders, project managers, and delivery teams.
- Maintain and assume accountability for a culture of high customer service.
- Effectively contribute to the digitization & digitalization of our customers through successful technical delivery.
- Share knowledge, mentor, and guide technical personnel to improve and strengthen team capabilities.
- Engage with support, product management, and engineering as needed to get product technical issues addressed.
Operational:
- Take technical ownership of customer-facing project delivery, and lead solutions design, architecture, configuration and implementation work for our products and solutions to meet customer needs.
- Effectively partner with Solutions Architects, Consultants, and Project Managers to plan and track project delivery, allocate and oversee technical work to resources, and deliver high-quality work on-time, on-budget.
- Be the primary technical point of contact for the customer, including to lead scoping, design, and other workshops.
- Engage in pre- and post-sales project activities and contribute effectively to reviewing customer requirements, authoring RFP responses, requirements trace matrices, functional & technical specification documents, testing & validation plans, installation & user documentation, and other relevant technical project deliverables.
- Contribute to improving processes, ensuring compliance, and driving improvements.
- Travel, as needed, for internal and customer meetings.
Culture:
- In line with the 4I values of Integrity, Intensity, Innovation, and Involvement, that form the foundation of the Thermo Fisher culture and ways of working, this role will bring intensity, innovation, and a high degree of involvement to designing, proposing, and delivering on Digital Science products and solutions.
Business Partnership:
- Contribute effectively to creating and sustaining a culture of delivering excellent customer experience, embracing continuous learning, leading with digital innovation, analytical thinking, and managing complexity.
Knowledge, Skills, and Abilities
- Experience in all aspects of enterprise laboratory informatics technical solutions design and implementation for ELN, LIMS, SDMS, CDS, instrument and systems integration, amongst others.
- Experience with relational databases – Oracle, SQL Server, Postgres – and programming – C#, VGL.
- Experience with cloud services and infrastructure highly desirable.
- Demonstrated experience working in a matrix environment, across internal and external resources and regions.
- Understanding of SDLC, Quality and IT processes in the context of delivering and supporting validated systems.
- Strong communication and interpersonal skills, integrity, and credibility.
- Results focused, with a demonstrated track record of getting things done.
- Attention to detail and a concern for quality.
- Excellent analytical and problem-solving capabilities.
- Collaborative, initiates and facilitates communications and relevant information sharing, and works with different functions to achieve the best outcomes.
- Flexibility in work schedule to accommodate communications with global team.
- Able to innovate and bring ideas forward and advance issues and risks in a positive way.
Minimum Education and Experience Requirements
- Bachelor’s or master's degree in IT, IS, Engineering, Life Sciences, or equivalent.
- At least 3-5 years of relevant experience in enterprise software technical implementation projects, preferably in professional services with a life & laboratory science software product/ technology services company.
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Each one of our over 100,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier,
cleaner, and safer.
Apply today http://jobs.thermofisher.com.
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
See All 42 Technical Lead Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
Find Technical Lead JobsTechnical Lead Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Technical Lead Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring



Top Industries Hiring
- Technology & Software
- Consulting & Professional Services
- Energy
- Human Resources
What Pennsylvania Employers Look For
The qualifications that appear most often in technical lead jobs across Pennsylvania.
- Bachelor's degree in computer science, software engineering, or a directly related technical field
- Five or more years of hands-on software development experience in production environments
- Demonstrated experience leading and mentoring a team of engineers through full delivery cycles
- Proficiency in one or more primary languages such as Java, Python, Go, or C# plus cloud platforms
- Experience driving architectural decisions, code reviews, and technical standards across a team
- Strong written and verbal communication skills for cross-functional collaboration with product and business stakeholders
Technical Lead Jobs in Pennsylvania: Frequently Asked Questions
How do you become a technical lead in Pennsylvania?
Becoming a technical lead in Pennsylvania follows a practitioner-to-leadership path rather than a state-licensing process, as the role carries no Pennsylvania-issued license or registration. Most employers expect a bachelor's degree in computer science, software engineering, or a related discipline, followed by several years of hands-on engineering work. Demonstrating ownership of a project, mentoring junior engineers, and contributing to architectural decisions are the concrete steps that move a senior engineer into a technical lead role at Pennsylvania employers across Philadelphia, Pittsburgh, and Harrisburg.
Which companies hire technical leads in Pennsylvania?
Employers hiring technical leads in Pennsylvania right now include RETTEW, Jazz Pharmaceuticals, and NTT DATA, based on current listings on Migrate Mate as of September 2026. Pennsylvania's concentration of healthcare systems, defense contractors, and financial services firms means demand stays broad across both product companies and large enterprise IT organizations throughout the state.
Which Pennsylvania cities have the most technical lead jobs?
Philadelphia, Pittsburgh, and Pennsylvania have the most technical lead openings in Pennsylvania. Philadelphia leads because of its dense cluster of health systems, financial institutions, and technology companies, while Pittsburgh's strength in robotics, AI research, and advanced manufacturing drives significant demand, and the Harrisburg area adds volume through state government IT modernization and defense-sector contractors operating near the capital.
Are there remote technical lead jobs in Pennsylvania?
Yes, and more than most fields. Technical lead work is predominantly desk-based and collaboration-tool-driven, which makes remote and hybrid arrangements common in this role. About 74% of technical lead openings tied to Pennsylvania are remote or hybrid as of September 2026, reflecting employer flexibility that has become standard across the software and platform engineering segments where Pennsylvania technical leads are most active. Architecture reviews, code reviews, and team standups translate well to distributed environments.
How can I get hired as a technical lead in Pennsylvania with little or no experience?
The most realistic entry path is moving from a senior individual-contributor role into a team lead or tech lead designation within the same employer. Large Pennsylvania health systems such as Penn Medicine and UPMC, defense contractors including Lockheed Martin and Leidos, and technology firms based in Philadelphia and Pittsburgh regularly promote from within through internal mobility programs. Building a portfolio of system design work, taking on code review responsibilities, and completing a cloud or architecture certification gives candidates the edge hiring managers look for when deciding between an experienced senior engineer and a first-time technical lead.
Where can I find and apply to technical lead jobs in Pennsylvania?
You can find and apply to technical lead jobs in Pennsylvania on Migrate Mate, which lists current openings tied to Pennsylvania employers and locations. Find roles that fit your experience and specialization and apply directly to the ones that match.
See All 42 Technical Lead Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
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