Manufacturing Supervisor Visa Sponsorship Jobs in California
California is one of the most active states for manufacturing supervisor visa sponsorship, with major employers in aerospace, semiconductors, food production, and medical devices. Companies like Northrop Grumman, Intel, and Abbott operate large facilities across Los Angeles, San Jose, Fresno, and San Diego, regularly hiring internationally for supervisory roles on the production floor.
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Get Access To All JobsINTRODUCTION
Hims & Hers is the leading health and wellness platform, on a mission to help the world feel great through the power of better health. We are redefining healthcare by putting the customer first and delivering access to care that is affordable, accessible, and personal, from diagnosis to treatment to delivery. No two people are the same, so we provide access to personalized care designed for results. By normalizing health & wellness challenges and innovating on their solutions, we’re making better health outcomes easier to achieve.
Hims & Hers is a public company, traded on the NYSE under the ticker symbol “HIMS.” To learn more about the brand and offerings, you can visit hims.com/about and hims.com/how-it-works. For information on the company’s outstanding benefits, culture, and its talent-first flexible/remote work approach, see below and visit www.hims.com/careers-professionals.
ABOUT THE ROLE
The Supervisor, CGMP Manufacturing – Downstream leads day-to-day downstream peptide production at our cGMP facility, including preparative HPLC purification, lyophilization, and final packaging, delivering purified peptide API safely, on schedule, and in compliance with cGMP.
This is a hands-on role reporting to the Operations Manager, with direct authority over downstream production staff, scheduling, and floor execution. You will work closely with your upstream counterpart to hand off material smoothly and keep campaigns on schedule.
This role is based in Menlo Park, CA at our H&H Peptides facility.
YOU WILL:
Upstream Execution:
- Direct cGMP SPPS operations, including resin preparation, coupling and deprotection cycles, in-process checks, and resin washing and drying.
- Direct cleavage operations, including cocktail preparation, cleavage, filtration, precipitation, and isolation of crude peptide.
- Ensure upstream execution follows approved batch records, SOPs, and safety requirements, including safe handling of hazardous solvents and reagents (e.g., DMF, piperidine, TFA).
Downstream Execution:
- Direct cGMP purification operations, including prep HPLC column packing and equilibration, loading, gradient runs, fraction collection, and pooling.
- Direct lyophilization and final isolation operations, including cycle execution, unloading, and final packaging and labeling.
- Ensure downstream execution follows approved batch records, SOPs, and safety requirements, and coordinate with QC on in-process and release testing.
Equipment & Floor Operations:
- Oversee equipment readiness across upstream and downstream, including synthesizers, cleavage vessels, prep HPLC systems, lyophilizers, and packaging equipment, in coordination with Engineering and Maintenance.
- Oversee equipment qualification, preventive maintenance, and vendor relationships.
- Troubleshoot issues on the floor in real time and escalate appropriately.
Scheduling:
- Build and manage the integrated upstream and downstream production schedule, balancing synthesizer, vessel, column, and lyophilizer capacity, staffing, material availability, and QC turnaround.
- Plan campaigns across multiple concurrent products, and own schedule attainment and on-time delivery.
- Coordinate the hand-off of crude peptide from upstream to downstream, and work with Supply Chain and Quality to keep batches moving.
Process, Quality & Continuous Improvement:
- Lead investigations of deviations, failed batches, and process excursions; conduct root cause analysis and implement corrective and preventive actions.
- Author, review, and maintain master batch records, SOPs, and work instructions in partnership with Quality and Process Development.
- Support scale-up, tech transfer, and new product introductions, including process validation and PPQ campaigns, in partnership with Process Development.
- Drive yield, throughput, and cost-efficiency improvements, using process data and historical performance to set targets.
- Support the design, implementation, and continuous improvement of manufacturing systems, including electronic batch records, keeping them compliant, practical, and easy for front-line teams to use.
Audit Readiness & Compliance:
- Keep the area inspection-ready at all times; ensure batch records, logbooks, and equipment records are complete, accurate, and compliant with ALCOA+ and 21 CFR Part 11.
- Ensure manufacturing operations comply with cGMP, internal SOPs, and master batch records per 21 CFR 210/211 and ICH Q7.
- Support audits and regulatory inspections, including preparing the area, hosting walkthroughs, and owning responses, CAPAs, and follow-up commitments through on-time completion.
- Provide manufacturing data and documentation to support regulatory submissions, ensuring data integrity.
Team Development:
- Lead, coach, and develop chemists, operators, and technicians across upstream and downstream; set clear expectations and performance metrics, and conduct regular performance reviews.
- Own onboarding and GMP training, maintain training matrices and qualifications, and build cross-training and shift coverage.
- Lead hands-on: understand operations at the task level, observe workflows to find bottlenecks, and help solve problems directly on the floor when needed.
- Foster a culture of safety, initiative, accountability, and open communication where issues are raised early and resolved promptly.
YOU HAVE:
- Bachelor’s degree in chemistry, Biochemistry, Chemical Engineering, or a related discipline.
- 3+ years of cGMP manufacturing experience in pharmaceutical, biopharmaceutical, or peptide manufacturing.
- Hands-on experience with preparative HPLC purification and lyophilization.
- 1+ years in a leadership or supervisory role managing production teams.
- Strong working knowledge of cGMP batch execution, deviations, CAPAs, and data integrity.
- Strong problem-solving, communication, and organizational skills in a small, fast-moving environment.
PREFERRED QUALIFICATIONS:
- Experience with commercial-scale SPPS (upstream) or prep HPLC and lyophilization (downstream).
- Experience supporting process validation, PPQ campaigns, and tech transfer of new peptide products into GMP manufacturing.
- Experience with budget oversight, capital projects, vendor management, and staffing.
- Experience with MES/electronic batch record systems and continuous improvement initiatives.
OUR BENEFITS (there are more but here are some highlights):
- Competitive salary & equity compensation for full-time roles.
- Unlimited PTO, company holidays, and quarterly mental health days.
- Comprehensive health benefits including medical, dental & vision, and parental leave.
- Employee Stock Purchase Program (ESPP).
- 401k benefits with employer matching contribution.
- Offsite team retreats.
We are committed to building a workforce that reflects diverse perspectives and prioritizes ethics, wellness, and a strong sense of belonging. If you're excited about this role, we encourage you to apply—even if you're not sure if your background or experience is a perfect match.
Hims considers all qualified applicants for employment, including applicants with arrest or conviction records, in accordance with the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance, the California Fair Chance Act, and any similar state or local fair chance laws.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Hims & Hers is committed to providing reasonable accommodations for qualified individuals with disabilities and disabled veterans in our job application procedures. If you need assistance or an accommodation due to a disability, please contact us at accommodations@forhims.com and describe the needed accommodation. Your privacy is important to us, and any information you share will only be used for the legitimate purpose of considering your request for accommodation. Hims & Hers gives consideration to all qualified applicants without regard to any protected status, including disability. Please do not send resumes to this email address.
To learn more about how we collect, use, retain, and disclose Personal Information, please visit our Global Candidate Privacy Statement.
Compensation Range: $100K - $120K
INTRODUCTION
Hims & Hers is the leading health and wellness platform, on a mission to help the world feel great through the power of better health. We are redefining healthcare by putting the customer first and delivering access to care that is affordable, accessible, and personal, from diagnosis to treatment to delivery. No two people are the same, so we provide access to personalized care designed for results. By normalizing health & wellness challenges and innovating on their solutions, we’re making better health outcomes easier to achieve.
Hims & Hers is a public company, traded on the NYSE under the ticker symbol “HIMS.” To learn more about the brand and offerings, you can visit hims.com/about and hims.com/how-it-works. For information on the company’s outstanding benefits, culture, and its talent-first flexible/remote work approach, see below and visit www.hims.com/careers-professionals.
ABOUT THE ROLE
The Supervisor, CGMP Manufacturing – Downstream leads day-to-day downstream peptide production at our cGMP facility, including preparative HPLC purification, lyophilization, and final packaging, delivering purified peptide API safely, on schedule, and in compliance with cGMP.
This is a hands-on role reporting to the Operations Manager, with direct authority over downstream production staff, scheduling, and floor execution. You will work closely with your upstream counterpart to hand off material smoothly and keep campaigns on schedule.
This role is based in Menlo Park, CA at our H&H Peptides facility.
YOU WILL:
Upstream Execution:
- Direct cGMP SPPS operations, including resin preparation, coupling and deprotection cycles, in-process checks, and resin washing and drying.
- Direct cleavage operations, including cocktail preparation, cleavage, filtration, precipitation, and isolation of crude peptide.
- Ensure upstream execution follows approved batch records, SOPs, and safety requirements, including safe handling of hazardous solvents and reagents (e.g., DMF, piperidine, TFA).
Downstream Execution:
- Direct cGMP purification operations, including prep HPLC column packing and equilibration, loading, gradient runs, fraction collection, and pooling.
- Direct lyophilization and final isolation operations, including cycle execution, unloading, and final packaging and labeling.
- Ensure downstream execution follows approved batch records, SOPs, and safety requirements, and coordinate with QC on in-process and release testing.
Equipment & Floor Operations:
- Oversee equipment readiness across upstream and downstream, including synthesizers, cleavage vessels, prep HPLC systems, lyophilizers, and packaging equipment, in coordination with Engineering and Maintenance.
- Oversee equipment qualification, preventive maintenance, and vendor relationships.
- Troubleshoot issues on the floor in real time and escalate appropriately.
Scheduling:
- Build and manage the integrated upstream and downstream production schedule, balancing synthesizer, vessel, column, and lyophilizer capacity, staffing, material availability, and QC turnaround.
- Plan campaigns across multiple concurrent products, and own schedule attainment and on-time delivery.
- Coordinate the hand-off of crude peptide from upstream to downstream, and work with Supply Chain and Quality to keep batches moving.
Process, Quality & Continuous Improvement:
- Lead investigations of deviations, failed batches, and process excursions; conduct root cause analysis and implement corrective and preventive actions.
- Author, review, and maintain master batch records, SOPs, and work instructions in partnership with Quality and Process Development.
- Support scale-up, tech transfer, and new product introductions, including process validation and PPQ campaigns, in partnership with Process Development.
- Drive yield, throughput, and cost-efficiency improvements, using process data and historical performance to set targets.
- Support the design, implementation, and continuous improvement of manufacturing systems, including electronic batch records, keeping them compliant, practical, and easy for front-line teams to use.
Audit Readiness & Compliance:
- Keep the area inspection-ready at all times; ensure batch records, logbooks, and equipment records are complete, accurate, and compliant with ALCOA+ and 21 CFR Part 11.
- Ensure manufacturing operations comply with cGMP, internal SOPs, and master batch records per 21 CFR 210/211 and ICH Q7.
- Support audits and regulatory inspections, including preparing the area, hosting walkthroughs, and owning responses, CAPAs, and follow-up commitments through on-time completion.
- Provide manufacturing data and documentation to support regulatory submissions, ensuring data integrity.
Team Development:
- Lead, coach, and develop chemists, operators, and technicians across upstream and downstream; set clear expectations and performance metrics, and conduct regular performance reviews.
- Own onboarding and GMP training, maintain training matrices and qualifications, and build cross-training and shift coverage.
- Lead hands-on: understand operations at the task level, observe workflows to find bottlenecks, and help solve problems directly on the floor when needed.
- Foster a culture of safety, initiative, accountability, and open communication where issues are raised early and resolved promptly.
YOU HAVE:
- Bachelor’s degree in chemistry, Biochemistry, Chemical Engineering, or a related discipline.
- 3+ years of cGMP manufacturing experience in pharmaceutical, biopharmaceutical, or peptide manufacturing.
- Hands-on experience with preparative HPLC purification and lyophilization.
- 1+ years in a leadership or supervisory role managing production teams.
- Strong working knowledge of cGMP batch execution, deviations, CAPAs, and data integrity.
- Strong problem-solving, communication, and organizational skills in a small, fast-moving environment.
PREFERRED QUALIFICATIONS:
- Experience with commercial-scale SPPS (upstream) or prep HPLC and lyophilization (downstream).
- Experience supporting process validation, PPQ campaigns, and tech transfer of new peptide products into GMP manufacturing.
- Experience with budget oversight, capital projects, vendor management, and staffing.
- Experience with MES/electronic batch record systems and continuous improvement initiatives.
OUR BENEFITS (there are more but here are some highlights):
- Competitive salary & equity compensation for full-time roles.
- Unlimited PTO, company holidays, and quarterly mental health days.
- Comprehensive health benefits including medical, dental & vision, and parental leave.
- Employee Stock Purchase Program (ESPP).
- 401k benefits with employer matching contribution.
- Offsite team retreats.
We are committed to building a workforce that reflects diverse perspectives and prioritizes ethics, wellness, and a strong sense of belonging. If you're excited about this role, we encourage you to apply—even if you're not sure if your background or experience is a perfect match.
Hims considers all qualified applicants for employment, including applicants with arrest or conviction records, in accordance with the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance, the California Fair Chance Act, and any similar state or local fair chance laws.
It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.
Hims & Hers is committed to providing reasonable accommodations for qualified individuals with disabilities and disabled veterans in our job application procedures. If you need assistance or an accommodation due to a disability, please contact us at accommodations@forhims.com and describe the needed accommodation. Your privacy is important to us, and any information you share will only be used for the legitimate purpose of considering your request for accommodation. Hims & Hers gives consideration to all qualified applicants without regard to any protected status, including disability. Please do not send resumes to this email address.
To learn more about how we collect, use, retain, and disclose Personal Information, please visit our Global Candidate Privacy Statement.
Compensation Range: $100K - $120K
Manufacturing Supervisor Job Roles in California
See all 56+ Manufacturing Supervisor Jobs in California
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Search Manufacturing Supervisor Jobs in CaliforniaManufacturing Supervisor Jobs in California: Frequently Asked Questions
Which companies sponsor visas for manufacturing supervisors in California?
Large manufacturers with established immigration programs are the most consistent sponsors. In California, companies like Northrop Grumman, Raytheon, Intel, Flex, Abbott Laboratories, and Applied Materials have histories of sponsoring H-1B visa and other work visas for supervisory and operations roles. Food and beverage producers in the Central Valley, including Wonderful Company, also hire internationally for plant leadership positions.
Which visa types are most common for manufacturing supervisor roles in California?
The H-1B is the most common visa for manufacturing supervisors in California, though it requires the role to qualify as a specialty occupation, meaning a bachelor's degree in a relevant field like industrial engineering or operations management. The TN visa is available to Canadian and Mexican nationals in qualifying engineering-adjacent roles. L-1A intracompany transfers apply when a candidate is moving from an overseas facility within the same company.
How to find manufacturing supervisor visa sponsorship jobs in California?
Migrate Mate filters manufacturing supervisor jobs in California specifically by visa sponsorship eligibility, saving you the time of screening out roles that won't support international candidates. The platform surfaces positions from employers in California's aerospace, semiconductor, food processing, and medical device sectors. Searching by city, such as Los Angeles or San Jose, lets you narrow results to your preferred location.
Which cities in California have the most manufacturing supervisor sponsorship jobs?
Los Angeles and its surrounding region lead in volume, given its concentration of aerospace and defense manufacturers. San Jose and the broader Bay Area have strong demand in semiconductor and electronics manufacturing. Fresno and Stockton in the Central Valley are active in food and agricultural processing. San Diego has a growing cluster of biotech and medical device manufacturers that regularly recruit for supervisory production roles.
Are there any state-specific considerations for manufacturing supervisor sponsorship in California?
California's prevailing wage requirements under Department of Labor rules apply to H-1B sponsors, and the state's high cost of living in metro areas influences how employers structure compensation offers. California also has strict labor laws around shift scheduling and worker classification that employers factor into supervisory role definitions. Candidates should confirm that their specific job duties and degree field align with the specialty occupation standard before applying.
What is the prevailing wage for sponsored manufacturing supervisor jobs in California?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.