Operations Excellence Manager Jobs in USA with Visa Sponsorship
Operations Excellence Managers improve organizational efficiency through process optimization, Lean and Six Sigma methodologies, and cross-functional leadership. Employers sponsor this role most commonly under the H-1B visa, which requires a relevant bachelor's degree and an approved Labor Condition Application before filing. For detailed occupation requirements, see the O*NET profile.
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INTRODUCTION
Are you motivated to participate in a dynamic, multi-tasking environment? Do you want to join a company that invests in its employees? Are you seeking a position where you can use your skills while continuing to be challenged and learn? Then we encourage you to dive deeper into this opportunity. We believe in career development and empowering our employees. Not only do we provide career coaches internally, but we offer many training opportunities to expand your knowledge base! We have highly competitive benefits with a variety of HMO and PPO options. We have company 401k match along with an Employee Stock Purchase Program. We have tuition reimbursement, leadership development, and even start employees off with 16 days of paid time off plus holidays. We offer wellness courses and have highly engaged employee resource groups. Come join the Neo team and be part of our amazing World Class Culture!
ROLE AND RESPONSIBILITIES
NeoGenomics is looking for an Operations Excellence Manager – Supply Chain based out of our lab in Aliso Viejo, CA who wants to continue to learn in order to allow our company to grow.
Shift: Hybrid (Remote + Onsite), Monday-Friday
Position Summary: The Operational Excellence Manager will spearhead continuous improvement initiatives to drive operational excellence across NeoGenomics' core functions, with dual emphasis on supply chain excellence and optimization of laboratory operations processes. This role focuses on enhancing efficiency, reducing costs, improving quality and turnaround times, and ensuring reliable supply of reagents, consumables, and equipment to support high-complexity oncology testing (NGS, FISH, flow cytometry, IHC, etc.). Leveraging Lean, Six Sigma, and change management principles, you will lead projects that eliminate waste, streamline end-to-end processes, and foster a culture of sustained improvement — while supporting the effective implementation and qualification of new systems and technologies in a fast-paced, CLIA/CAP-regulated diagnostics environment. Ultimately, these efforts contribute to faster, more accurate patient results and better support for oncologists and pharma partners.
Core Responsibilities:
- Lead and execute operational excellence programs with primary accountability for supply chain excellence, including procurement optimization, inventory management, vendor performance, logistics, and risk mitigation to ensure uninterrupted availability of critical materials for clinical and pharma services testing.
- Drive targeted supply chain improvements in key metrics such as on-time-in-full delivery, inventory turns, cost per test, supplier quality, waste reduction, and supply chain resilience (e.g., through supplier consolidation, demand forecasting enhancements, and contract negotiations).
- Optimize laboratory operations processes by conducting value stream mapping, bottleneck analysis, and root cause investigations across pre-analytical, analytical, and post-analytical workflows; implement solutions to reduce turnaround time (TAT), minimize errors, and improve throughput in high-volume testing environments.
- Apply Lean/Six Sigma tools (DMAIC, Kaizen events, 5S, visual management, standardized work, SMED, etc.) to redesign lab processes, including sample accessioning, testing workflows, result reporting, and equipment utilization.
- Partner with laboratory operations, quality/regulatory, supply chain, IT, and finance teams to integrate improvements — such as automation adoption, LIMS/ERP enhancements, digital tools for workflow tracking, and process standardization — while maintaining CLIA, CAP, and other compliance requirements.
- Support systems implementation and qualification initiatives by collaborating on the rollout of new laboratory systems, equipment, or automated workflows; contribute to planning and execution of Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ) activities to ensure validated, reliable performance post-implementation.
- Assist in change management and risk assessments during systems implementations, identifying potential impacts on lab ops and supply chain processes, and driving process optimizations to maximize ROI and minimize validation-related downtime or rework.
- Identify and lead cross-functional projects that bridge supply chain and lab ops, e.g., just-in-time inventory models for reagents tied to test volume forecasting, preventive maintenance programs for instruments to reduce downtime, or waste reduction in consumable usage aligned with new system qualifications.
- Facilitate training, coaching, and capability building for supply chain, lab supervisors, and operations teams on continuous improvement methodologies, change management, and data-driven problem-solving (including basics of systems qualification in regulated settings).
- Monitor and report on project outcomes, including quantifiable savings (cost avoidance/reduction), efficiency gains (e.g., TAT reductions, productivity increases), quality improvements, and ROI; present insights and recommendations to senior leadership.
- Support broader organizational goals, such as scaling operations for growth, enhancing patient-centric outcomes, and embedding a culture of accountability, innovation, and excellence aligned with NeoGenomics' values (Teamwork, Accountability, Quality, Integrity, Innovation).
POSITION OBJECTIVES
- Uses effective questioning techniques; demonstrates effective two-way dialogue and negotiation skills
- Develops basic understanding of company products
- Responsive and professional to all levels internally and externally
- Completes individual and/or department objectives and goals assigned by leadership and meets agreed upon deadlines
- Provides quality service to the company’s internal and external customers
- Effectively schedules and manages resources to meet department goals
- Adheres to NeoGenomics' core values, safety and HR and Compliance policies and procedures
BASIC QUALIFICATIONS
- Bachelor’s degree or equivalent work experience required.
- 5+ years’ experience in Project Management related roles required. Experience in clinical labs, Bachelor's degree in Business, Supply Chain Management, Engineering, Life Sciences, or related field (Master's or MBA preferred).
- 5+ years of progressive experience in operational excellence, process improvement, or lean/six sigma roles, with significant time (3+ years) in supply chain and/or laboratory operations within diagnostics, clinical lab, biotech, pharma, or regulated manufacturing settings.
- Certification in Lean Six Sigma (Green Belt required; Black Belt strongly preferred) and demonstrated success leading DMAIC/Kaizen projects with measurable results.
- Proven track record delivering improvements in supply chain (e.g., cost savings, inventory optimization, supplier reliability) and lab processes (e.g., TAT reduction, workflow efficiency, error minimization biotech), or pharma is highly desirable.

INTRODUCTION
Are you motivated to participate in a dynamic, multi-tasking environment? Do you want to join a company that invests in its employees? Are you seeking a position where you can use your skills while continuing to be challenged and learn? Then we encourage you to dive deeper into this opportunity. We believe in career development and empowering our employees. Not only do we provide career coaches internally, but we offer many training opportunities to expand your knowledge base! We have highly competitive benefits with a variety of HMO and PPO options. We have company 401k match along with an Employee Stock Purchase Program. We have tuition reimbursement, leadership development, and even start employees off with 16 days of paid time off plus holidays. We offer wellness courses and have highly engaged employee resource groups. Come join the Neo team and be part of our amazing World Class Culture!
ROLE AND RESPONSIBILITIES
NeoGenomics is looking for an Operations Excellence Manager – Supply Chain based out of our lab in Aliso Viejo, CA who wants to continue to learn in order to allow our company to grow.
Shift: Hybrid (Remote + Onsite), Monday-Friday
Position Summary: The Operational Excellence Manager will spearhead continuous improvement initiatives to drive operational excellence across NeoGenomics' core functions, with dual emphasis on supply chain excellence and optimization of laboratory operations processes. This role focuses on enhancing efficiency, reducing costs, improving quality and turnaround times, and ensuring reliable supply of reagents, consumables, and equipment to support high-complexity oncology testing (NGS, FISH, flow cytometry, IHC, etc.). Leveraging Lean, Six Sigma, and change management principles, you will lead projects that eliminate waste, streamline end-to-end processes, and foster a culture of sustained improvement — while supporting the effective implementation and qualification of new systems and technologies in a fast-paced, CLIA/CAP-regulated diagnostics environment. Ultimately, these efforts contribute to faster, more accurate patient results and better support for oncologists and pharma partners.
Core Responsibilities:
- Lead and execute operational excellence programs with primary accountability for supply chain excellence, including procurement optimization, inventory management, vendor performance, logistics, and risk mitigation to ensure uninterrupted availability of critical materials for clinical and pharma services testing.
- Drive targeted supply chain improvements in key metrics such as on-time-in-full delivery, inventory turns, cost per test, supplier quality, waste reduction, and supply chain resilience (e.g., through supplier consolidation, demand forecasting enhancements, and contract negotiations).
- Optimize laboratory operations processes by conducting value stream mapping, bottleneck analysis, and root cause investigations across pre-analytical, analytical, and post-analytical workflows; implement solutions to reduce turnaround time (TAT), minimize errors, and improve throughput in high-volume testing environments.
- Apply Lean/Six Sigma tools (DMAIC, Kaizen events, 5S, visual management, standardized work, SMED, etc.) to redesign lab processes, including sample accessioning, testing workflows, result reporting, and equipment utilization.
- Partner with laboratory operations, quality/regulatory, supply chain, IT, and finance teams to integrate improvements — such as automation adoption, LIMS/ERP enhancements, digital tools for workflow tracking, and process standardization — while maintaining CLIA, CAP, and other compliance requirements.
- Support systems implementation and qualification initiatives by collaborating on the rollout of new laboratory systems, equipment, or automated workflows; contribute to planning and execution of Installation Qualification (IQ), Operational Qualification (OQ), and Performance Qualification (PQ) activities to ensure validated, reliable performance post-implementation.
- Assist in change management and risk assessments during systems implementations, identifying potential impacts on lab ops and supply chain processes, and driving process optimizations to maximize ROI and minimize validation-related downtime or rework.
- Identify and lead cross-functional projects that bridge supply chain and lab ops, e.g., just-in-time inventory models for reagents tied to test volume forecasting, preventive maintenance programs for instruments to reduce downtime, or waste reduction in consumable usage aligned with new system qualifications.
- Facilitate training, coaching, and capability building for supply chain, lab supervisors, and operations teams on continuous improvement methodologies, change management, and data-driven problem-solving (including basics of systems qualification in regulated settings).
- Monitor and report on project outcomes, including quantifiable savings (cost avoidance/reduction), efficiency gains (e.g., TAT reductions, productivity increases), quality improvements, and ROI; present insights and recommendations to senior leadership.
- Support broader organizational goals, such as scaling operations for growth, enhancing patient-centric outcomes, and embedding a culture of accountability, innovation, and excellence aligned with NeoGenomics' values (Teamwork, Accountability, Quality, Integrity, Innovation).
POSITION OBJECTIVES
- Uses effective questioning techniques; demonstrates effective two-way dialogue and negotiation skills
- Develops basic understanding of company products
- Responsive and professional to all levels internally and externally
- Completes individual and/or department objectives and goals assigned by leadership and meets agreed upon deadlines
- Provides quality service to the company’s internal and external customers
- Effectively schedules and manages resources to meet department goals
- Adheres to NeoGenomics' core values, safety and HR and Compliance policies and procedures
BASIC QUALIFICATIONS
- Bachelor’s degree or equivalent work experience required.
- 5+ years’ experience in Project Management related roles required. Experience in clinical labs, Bachelor's degree in Business, Supply Chain Management, Engineering, Life Sciences, or related field (Master's or MBA preferred).
- 5+ years of progressive experience in operational excellence, process improvement, or lean/six sigma roles, with significant time (3+ years) in supply chain and/or laboratory operations within diagnostics, clinical lab, biotech, pharma, or regulated manufacturing settings.
- Certification in Lean Six Sigma (Green Belt required; Black Belt strongly preferred) and demonstrated success leading DMAIC/Kaizen projects with measurable results.
- Proven track record delivering improvements in supply chain (e.g., cost savings, inventory optimization, supplier reliability) and lab processes (e.g., TAT reduction, workflow efficiency, error minimization biotech), or pharma is highly desirable.
How to Get Visa Sponsorship as an Operations Excellence Manager
Target industries with established sponsorship programs
Manufacturing, healthcare systems, logistics, and financial services companies sponsor Operations Excellence Managers most consistently. Large enterprises with dedicated HR and immigration infrastructure are far more likely to manage the H-1B process than smaller organizations.
Frame your credentials around specialty occupation standards
USCIS requires the role to normally require a bachelor's degree in a specific field. Degrees in industrial engineering, operations management, or business administration with a quantitative focus strengthen the specialty occupation argument for this position significantly.
Highlight Lean, Six Sigma, and process improvement certifications
Certifications like Six Sigma Black Belt or Green Belt, PMP, or Lean practitioner credentials signal measurable technical expertise. These credentials reinforce that the role requires specialized knowledge, which supports the employer's specialty occupation case with USCIS.
Engage employers before the H-1B lottery window opens
H-1B registrations open in March for an October start date. Securing an offer by January or February gives your employer time to prepare the petition, file the Labor Condition Application, and work with immigration counsel before the deadline passes.
Ask directly about cap-exempt employer options
Universities, nonprofit research institutions, and certain government-affiliated organizations are exempt from the H-1B cap and lottery. Operations roles exist within these institutions, and cap-exempt filings can be submitted year-round without waiting for the annual registration window.
Browse Migrate Mate for sponsorship-confirmed roles
Not every job posting discloses sponsorship willingness upfront. Migrate Mate filters specifically for employers who sponsor visas, so you can focus your applications on companies already willing to support the H-1B process for this role.
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Get Access To All JobsFrequently Asked Questions
Does Operations Excellence Manager qualify as a specialty occupation for H-1B?
It can, but the classification isn't automatic. USCIS evaluates whether the specific role normally requires a bachelor's degree in a particular field. Operations Excellence Manager roles grounded in industrial engineering, process engineering, or quantitative business analysis generally pass this standard. Generalist management positions with no degree field requirement are harder to support.
Which visa types are most commonly used to sponsor Operations Excellence Managers?
The H-1B is the most common path. Australians may qualify for the E-3, which bypasses the lottery entirely and has a much shorter processing timeline. Canadian and Mexican nationals working in qualifying operations roles may be eligible for TN status. L-1A is an option for managers transferring from an overseas office of the same employer.
What degree does an employer need me to have for H-1B sponsorship in this role?
Most employers require a bachelor's degree in industrial engineering, operations management, supply chain management, or a related quantitative field. An MBA can strengthen your case, particularly if your undergraduate degree is in a related discipline. Degrees in unrelated fields make sponsorship harder to support, even with strong work experience.
How competitive is H-1B sponsorship for Operations Excellence roles compared to tech jobs?
The H-1B lottery selects roughly 25% of registrations regardless of job title. Operations roles face the same lottery odds as any other position. However, because fewer candidates in this discipline compete for registrations compared to software engineering, some employers in manufacturing and logistics have more capacity to sponsor and support the petition process.
Where can I find employers who will sponsor an Operations Excellence Manager visa?
Migrate Mate is built specifically for this search. Rather than filtering through thousands of general job postings, Migrate Mate surfaces roles from employers with a confirmed track record of visa sponsorship. Searching there for operations or process improvement roles saves significant time and improves the quality of your applications.
What is the prevailing wage requirement for sponsored Operations Excellence Manager jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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