Senior Clinical Project Manager Jobs in USA with Visa Sponsorship
Senior Clinical Project Manager roles qualify as H-1B visa specialty occupations, requiring a bachelor's degree in a life sciences or health-related field. Sponsors file a Labor Condition Application with DOL before petitioning USCIS. CROs, pharma companies, and academic medical centers are among the most active sponsors for this title. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsCompany Description
Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. Learn more about Deciphera, a member of Ono Pharmaceutical Co., Ltd., by visiting our website: https://deciphera.com
Job Description
The Senior Clinical Project Manager leads the execution of complex global clinical studies, providing hands-on operational leadership across study teams and external partners. This role is responsible for driving study execution, managing timelines and budgets, and ensuring trials are delivered with quality and in compliance with applicable requirements.
The ideal candidate brings strong later-stage clinical trial experience, ideally including Phase III, and is comfortable taking ownership, working through challenges, and knowing when to engage others for support.
Key Responsibilities:
Clinical Trial Leadership & Execution
- Lead the planning, execution, and delivery of assigned global clinical studies, with responsibility for timelines, budgets, quality, and overall operational execution.
- Identify and address operational risks and challenges to keep studies on track.
Cross-Functional Leadership
- Lead cross-functional study teams, driving collaboration, accountability, decision-making, and problem-solving.
- Partner across Clinical Operations, Data Management, Regulatory, Clinical Supply, and other functions to support global study execution.
CRO & Vendor Management
- Oversee CROs and external vendors, monitoring performance and ensuring alignment with study timelines, budgets, quality expectations, and contractual obligations.
Stakeholder Communication & Operational Excellence
- Communicate study progress, risks, and key decisions clearly to internal stakeholders and Clinical Operations leadership.
- Contribute to Clinical Operations processes and ways of working that support efficient, high-quality study execution.
Other duties and responsibilities as assigned
Qualifications
- Bachelor’s degree in health science or a related field and 8+ years of clinical research experience, including meaningful responsibility for managing complex clinical trials.
- Strong global clinical trial and later-stage development experience, ideally including Phase III. Candidates with substantial experience leading large, complex Phase II studies will also be considered.
- Demonstrated ability to lead and influence cross-functional study teams.
- Hands-on experience managing CROs and vendors and proactively addressing operational risks.
- Strong working knowledge of GCP, ICH, FDA, and applicable global clinical trial requirements.
- Strong communication and problem-solving skills, with the ability to work independently, advocate for what is needed, and recognize when to engage others for support.
Preferred Capabilities:
- Phase III global study experience.
- Oncology or rare disease clinical development experience.
- Experience with eTMF, EDC, IWRS, and RBQM platforms.
- Experience managing clinical study budgets and contracts.
- Experience within a fast-paced biotechnology environment.
- PMP certification or equivalent project management training.
Role Specific Additional Information
Due to the global nature of the role, there may occasionally be a need for early-morning or evening meetings to accommodate teams and partners across time zones.
Travel of approximately 25% may be required, including travel to Boston approximately twice per year, as well as attendance at relevant conferences or study-related meetings.
Additional Information
Deciphera believes in providing a fair, equitable, and competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable).
Benefits:
- Competitive salary and annual bonus.
- Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
- Generous parental leave and family planning benefits.
- Outstanding culture and opportunities for personal and professional growth.
EQUAL EMPLOYMENT OPPORTUNITY INFORMATION
Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.
Company Description
Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. Learn more about Deciphera, a member of Ono Pharmaceutical Co., Ltd., by visiting our website: https://deciphera.com
Job Description
The Senior Clinical Project Manager leads the execution of complex global clinical studies, providing hands-on operational leadership across study teams and external partners. This role is responsible for driving study execution, managing timelines and budgets, and ensuring trials are delivered with quality and in compliance with applicable requirements.
The ideal candidate brings strong later-stage clinical trial experience, ideally including Phase III, and is comfortable taking ownership, working through challenges, and knowing when to engage others for support.
Key Responsibilities:
Clinical Trial Leadership & Execution
- Lead the planning, execution, and delivery of assigned global clinical studies, with responsibility for timelines, budgets, quality, and overall operational execution.
- Identify and address operational risks and challenges to keep studies on track.
Cross-Functional Leadership
- Lead cross-functional study teams, driving collaboration, accountability, decision-making, and problem-solving.
- Partner across Clinical Operations, Data Management, Regulatory, Clinical Supply, and other functions to support global study execution.
CRO & Vendor Management
- Oversee CROs and external vendors, monitoring performance and ensuring alignment with study timelines, budgets, quality expectations, and contractual obligations.
Stakeholder Communication & Operational Excellence
- Communicate study progress, risks, and key decisions clearly to internal stakeholders and Clinical Operations leadership.
- Contribute to Clinical Operations processes and ways of working that support efficient, high-quality study execution.
Other duties and responsibilities as assigned
Qualifications
- Bachelor’s degree in health science or a related field and 8+ years of clinical research experience, including meaningful responsibility for managing complex clinical trials.
- Strong global clinical trial and later-stage development experience, ideally including Phase III. Candidates with substantial experience leading large, complex Phase II studies will also be considered.
- Demonstrated ability to lead and influence cross-functional study teams.
- Hands-on experience managing CROs and vendors and proactively addressing operational risks.
- Strong working knowledge of GCP, ICH, FDA, and applicable global clinical trial requirements.
- Strong communication and problem-solving skills, with the ability to work independently, advocate for what is needed, and recognize when to engage others for support.
Preferred Capabilities:
- Phase III global study experience.
- Oncology or rare disease clinical development experience.
- Experience with eTMF, EDC, IWRS, and RBQM platforms.
- Experience managing clinical study budgets and contracts.
- Experience within a fast-paced biotechnology environment.
- PMP certification or equivalent project management training.
Role Specific Additional Information
Due to the global nature of the role, there may occasionally be a need for early-morning or evening meetings to accommodate teams and partners across time zones.
Travel of approximately 25% may be required, including travel to Boston approximately twice per year, as well as attendance at relevant conferences or study-related meetings.
Additional Information
Deciphera believes in providing a fair, equitable, and competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable).
Benefits:
- Competitive salary and annual bonus.
- Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
- Generous parental leave and family planning benefits.
- Outstanding culture and opportunities for personal and professional growth.
EQUAL EMPLOYMENT OPPORTUNITY INFORMATION
Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.
See all 1,143+ Senior Clinical Project Manager Jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Senior Clinical Project Manager roles.
Get Access To All JobsTips for Finding Visa Sponsorship as a Senior Clinical Project Manager
Align your credentials to specialty occupation standards
USCIS scrutinizes whether your degree directly relates to clinical project management. A degree in public health, nursing, biology, or health administration maps clearly. A business-only degree may trigger a Request for Evidence unless you document clinical coursework or relevant certifications like PMP or CCRP.
Target CROs and pharma over generalist employers
Contract research organizations and mid-size biotech firms file LCAs for Senior CPM roles far more consistently than hospitals or health IT companies. Their project pipelines depend on this title year-round, making sponsorship a standard part of their hiring process rather than an exception.
Use OFLC Wage Search to verify your prevailing wage tier
Senior CPM roles typically fall at wage level III or IV under DOL's prevailing wage methodology. Run your job location and title through OFLC Wage Search before interviews so you can negotiate from the correct baseline and flag any offer that sits below the certified LCA wage.
Find verified sponsors faster on Migrate Mate
Search Migrate Mate to browse Senior Clinical Project Manager roles posted by employers with confirmed LCA filing history. This filters out postings from companies that have never sponsored, saving you from pursuing roles where sponsorship is aspirational rather than operationally established.
Get the LCA filed before your OPT or status expires
Your employer must have a certified LCA from DOL before filing your H-1B I-129 petition with USCIS. DOL certifies most LCAs within seven business days, but allow three to four weeks total for internal HR approvals, attorney review, and any DOL audit holds that extend the window.
Clarify PERM eligibility early for EB-2 green card planning
Many pharma and CRO sponsors sponsor green cards for Senior CPMs through the EB-2 category, which requires PERM labor certification. Ask during the offer stage whether the company has an established PERM program and what the typical timeline from hire to I-140 filing looks like for your role level.
Frequently Asked Questions
Does a Senior Clinical Project Manager role qualify as an H-1B specialty occupation?
Yes. USCIS treats Senior Clinical Project Manager as a specialty occupation because the role requires at least a bachelor's degree in a directly related field such as life sciences, public health, nursing, or health administration. Employers document this requirement in the LCA and I-129 petition. A general management degree without clinical coursework may require additional evidence to satisfy the specialty occupation standard.
Which visa types are most commonly used to sponsor Senior Clinical Project Managers?
H-1B is the most common path, covering up to three years initially with extensions to six. If you're a Canadian or Mexican national, TN visa status under the USMCA applies if your role and degree map to a qualifying profession. F-1 students approaching the end of STEM OPT often target CRO and pharma sponsors who file H-1B petitions as a bridge to long-term status.
What degree does a Senior Clinical Project Manager need for visa sponsorship?
USCIS expects a bachelor's degree or higher in a field directly related to clinical research or healthcare management, such as life sciences, public health, pharmacology, nursing, or health administration. Some employers also accept a clinical credential like an RN license combined with substantial project management experience. A degree in pure business or unrelated fields makes specialty occupation approval harder to establish and may prompt a Request for Evidence.
How do I find Senior Clinical Project Manager jobs with verified visa sponsorship?
Browse Senior Clinical Project Manager roles on Migrate Mate, which lists employers with confirmed LCA filing history for this title. This lets you focus your applications on companies that have already committed to sponsoring the role rather than those still evaluating whether they'll support sponsorship at all.
Can a Senior Clinical Project Manager pursue a green card through employer sponsorship?
Yes. The EB-2 category is the most common path, requiring the employer to complete PERM labor certification with DOL before filing the I-140 petition with USCIS. EB-3 skilled worker is also available if the role requires at least two years of experience. For applicants born in India or China, priority date backlogs under the per-country cap can significantly extend the timeline, so starting the PERM process early matters.
What is the prevailing wage requirement for sponsored Senior Clinical Project Manager jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.