Clinical Registered Nurse Jobs in South Dakota
Clinical Registered Nurse jobs in South Dakota are open across Sioux Falls, Rapid City, and Sd and other South Dakota metros, with employers like Monument Health, Sanford Bismarck, and Sanford Health hiring at every experience level. Find a role that fits below and apply directly.
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PRIMARY LOCATION
Rapid City, SD USA
DEPARTMENT
RCH NCCTG
SCHEDULED WEEKLY HOURS
40
STARTING PAY RATE RANGE
$32.00 - $40.00
(Determined by the knowledge, skills, and experience of the applicant.)
JOB SUMMARY
Function as a readily approachable and effective "clinical resource" for the extended clinical research team. Provide clinical leadership through mentorship, education and provide direction for the activities of other research team members. Responsible for the research of and following through on clinical questions which arise. Responsible for the investigation and following through of clinical questions which may arise within areas of focus. Work with administrative, clinical and medical leadership to develop, implement, and facilitate the evolution of systems that ensure adherence to research protocols, institutional policies, local/state/federal regulations, and "Good Clinical Practices". Responsible for the full implementation and management of trials in direct collaboration with administrative and clinical leadership, investigators, sponsors, and clinical research organizations.
Monument Health offers competitive wages and benefits on qualifying positions. Some of those benefits can include:
- Supportive work culture
- Medical, Vision and Dental Coverage
- Retirement Plans, Health Savings Account, and Flexible Spending Account
- Instant pay is available for qualifying positions
- Paid Time Off Accrual Bank
- Opportunities for growth and advancement
- Tuition assistance/reimbursement
- Excellent pay differentials on qualifying positions
- Flexible scheduling
JOB DESCRIPTION
ESSENTIAL FUNCTIONS:
- Coordinates the efforts of case finding and recruitment of study patients.
- Discusses protocol participation with patients, completes eligibility forms and assures completion of informed consent.
- Identifies educational needs of study patients and their families, providing needed education or resources to meet learning needs. Utilizes critical thinking in implementing and coordinating medical and nursing interventions.
- Initiates interdisciplinary collaboration to assure treatments are administered and modified according to protocol requirements and necessary testing is completed.
- Organizes and completes data collection. Develops forms when needed.
- Assists with adverse drug reaction reports. Responds appropriately to emergency situations, basing patient management decisions on individual patient needs.
- Prepares for record reviews and audits with on site teams, FDA, NCI, IRB or other agencies and sponsors when requested.
- Initiates interdisciplinary collaboration with clinical trials research team and medical/radiation therapy treatment team to provide access to new treatments when appropriate. Enhances and documents participation in standard treatments through active navigation of patients/families.
- All other duties as assigned.
ADDITIONAL REQUIREMENTS
Required:
Education - Completion of a nursing education program that is approved by a board of nursing
Certification - Registered Nurse (RN) - South Dakota Board of Nursing
Preferred:
Education - Bachelors degree in Nursing
Certification - Clinical Research Coordinator Certification - Accredited University or accredited training professional; and Human Subject Protection (HSP) - Collaborative Institutional Training Initiative (CITI); and Good Clinical Practice (GCP) - Collaborative Institutional Training Initiative (CITI)
Experience - 1+ years Registered Nurse; 1+ years Clinical Research
Physical Requirements:
Medium work - Exerting up to 50 pounds of force occasionally, and/or up to 30 pounds of force frequently, and/or up to 10 pounds of force constantly to move objects.
JOB CATEGORY
Education and Research
JOB FAMILY
Research
SHIFT
Requires the ability to work assigned schedules and hours as determined by the department
EMPLOYEE TYPE
Regular
10 Monument Health Rapid City Hospital, Inc.
Make a difference. Every day.
Monument Health is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, or protected Veteran status.
See All 8 Clinical Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find JobsClinical Registered Nurse Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Clinical Registered Nurse Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Monument Health2

- Sanford Bismarck2

- Sanford Health2

- Sioux Center Health2

Top Industries Hiring
- Healthcare & Medical Services8
What South Dakota Employers Look For
The qualifications that appear most often in clinical registered nurse jobs across South Dakota.
- Active RN licensure in the state of employment or compact license eligibility
- Current BLS and ACLS certification from an approved provider
- Associate or bachelor's degree in nursing from an accredited program
- Minimum one to two years of clinical nursing experience in an acute care setting
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong clinical assessment skills and experience with patient care documentation
Clinical Registered Nurse Jobs in South Dakota: Frequently Asked Questions
How many clinical registered nurse jobs are there in South Dakota?
There are 8+ clinical registered nurse openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Sioux Falls, Rapid City, and Sd. New positions post regularly as employers across South Dakota hire.
How much do clinical registered nurses make in South Dakota?
Clinical registered nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Dakota cities have the most clinical registered nurse jobs?
Sioux Falls, Rapid City, and Sd have the most clinical registered nurse openings in South Dakota right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical registered nurses in South Dakota?
Employers hiring clinical registered nurses in South Dakota include Monument Health, Sanford Bismarck, and Sanford Health, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical registered nurse jobs in South Dakota?
Yes. About 0% of clinical registered nurse openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.
How do I apply for clinical registered nurse jobs in South Dakota?
You can apply to clinical registered nurse jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.
See All 8 Clinical Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
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