Clinical Trial Manager Jobs in Massachusetts
Clinical Trial Manager jobs in Massachusetts are among the most active in the country, concentrated in pharmaceutical development, biotechnology, and academic medical research with openings at every level from entry-level clinical research associate to senior trial manager. Boston, Cambridge, and Worcester are the primary hiring centers, anchored by large employers like Pfizer, Bristol Myers Squibb, and Massachusetts General Hospital. The most in-demand specialties include oncology trials, rare disease studies, and Phase II through Phase IV drug development. Find a role that fits below and apply directly.
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About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
About This Role
The Senior Manager, Clinical Trial Lead (CTL) is responsible for leading the operational planning, execution, and delivery of one or more clinical studies across the development lifecycle. This role manages study timelines, budgets, CRO and vendor partnerships, risk mitigation, and cross-functional collaboration through leadership of the Study Management Team (SMT). Key objectives include delivering studies on time, within budget, and in compliance with GCP, regulatory requirements, and quality standards while ensuring patient safety and data integrity. Acting as the central operational leader, the CTL drives protocol feasibility, study execution, and informed decision-making across stakeholders. The role brings value by ensuring operational excellence, proactive issue management, and successful study delivery that advances development program goals. As a core member of Clinical Operations, the CTL partners closely with Medical, Biostatistics, Regulatory, Data Management, and external partners to support broader program and asset strategies.
What You’ll Do:
- Lead the operational planning, execution, and delivery of one or more clinical studies.
- Chair the Study Management Team (SMT) and drive cross-functional study execution.
- Partner with Medical, Biostatistics, Regulatory, and other stakeholders to develop operationally feasible protocols and study strategies.
- Evaluate study feasibility and develop comprehensive operational, monitoring, quality, and risk management plans.
- Manage study timelines, budgets, forecasts, and governance deliverables to ensure on-time, on-budget execution.
- Identify, assess, and mitigate operational risks while maintaining patient safety, data integrity, and regulatory compliance.
- Oversee CROs, vendors, and outsourced partnerships, ensuring performance, milestone achievement, and effective issue resolution.
- Monitor study performance and conduct ongoing data reviews to identify and address quality, safety, or execution issues.
- Maintain accurate, inspection-ready study documentation and data within clinical trial management systems.
- Champion process improvements, operational excellence, and best practices across studies and development programs.
Who You Are:
You are a clinical operations leader who drives the successful planning, execution, and delivery of complex clinical trials, expertly managing timelines, budgets, CRO partnerships, risks, and cross-functional teams while maintaining the highest standards of quality, compliance, patient safety, and data integrity.
You thrive in a fast-paced development environment, leveraging your clinical trial management expertise, strategic problem-solving skills, and collaborative leadership style to ensure studies are delivered on time, within budget, and aligned with broader program objectives.
Required Skills
- Bachelors degree in a scientific discipline
- 6 + years in clinical operations management, overseeing outsourced clinical trials per quality, timeline, and budget expectations, preferably with a sponsor company and a CRO
- Scientific and clinical expertise with strong project management, risk assessment, contingency planning, and communication skills.
- Working knowledge of clinical development across Phase I-IV studies and cross-functional drug development.
- Demonstrated experience managing CROs, vendors, and outsourced clinical trials, including governance, performance oversight, budgets, quality, and outsourcing strategies.
- Expertise in GCP, ICH guidelines, and global regulatory requirements for clinical development.
- Proven ability to develop and execute operational plans that support successful clinical trial delivery.
Preferred Skills
- Experience in Immunology, Rare Disease, or Neurology
This position can be based in either Cambridge, MA or RTP, NC. The pay range posted encompasses the pay range for both potential work locations. Actual pay will be determined by the selected candidate’s work location, as well as relevant experience and qualifications.
Job Level: Management
Additional Information
Base salary offered is determined through an analytical approach utilizing a combination of factors including, but not limited to, relevant skills & experience, job location, and internal equity.
Regular employees are eligible to receive both short term and long-term incentives, including cash bonus and equity incentive opportunities, designed to reward recent achievements and recognize your future potential based on individual, business unit and company performance.
In addition to compensation, Biogen offers a full and highly competitive range of benefits designed to support our employees’ and their families physical, financial, emotional, and social well-being ; including, but not limited to:
- Medical, Dental, Vision, & Life insurances
- Fitness & Wellness programs including a fitness reimbursement
- Short- and Long-Term Disability insurance
- A minimum of 15 days of paid vacation and an additional end-of-year shutdown time off (Dec 26-Dec 31)
- Up to 12 company paid holidays + 3 paid days off for Personal Significance
- 80 hours of sick time per calendar year
- Paid Maternity and Parental Leave benefit
- 401(k) program participation with company matched contributions
- Employee stock purchase plan
- Tuition reimbursement of up to $10,000 per calendar year
- Employee Resource Groups participation
Why Biogen?
We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.
At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
See All 32 Clinical Trial Manager Jobs in Massachusetts
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Find Clinical Trial Manager JobsClinical Trial Manager Jobs by City in Massachusetts
Where Massachusetts roles are concentrated, by current openings.
Clinical Trial Manager Job Market in Massachusetts
A snapshot from current Massachusetts openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Science & Research
What Massachusetts Employers Look For
The qualifications that appear most often in clinical trial manager jobs across Massachusetts.
- Bachelor's degree in life sciences, nursing, or a related clinical field required
- Minimum two to five years of clinical research or CRA experience preferred
- Demonstrated knowledge of ICH-GCP guidelines and FDA regulatory requirements
- Experience managing site relationships, budgets, and trial timelines simultaneously
- Proficiency with clinical trial management systems such as Medidata or Veeva Vault
- Strong written communication skills for protocol documentation and regulatory submissions
Clinical Trial Manager Jobs in Massachusetts: Frequently Asked Questions
How do you become a clinical trial manager in Massachusetts?
Most clinical trial managers in Massachusetts start with a bachelor's degree in a life science, nursing, or health-related field and build experience as a clinical research associate or study coordinator before moving into management. While Massachusetts does not require a state-issued license specific to clinical trial management, many employers prioritize the Certified Clinical Research Professional credential from the Society of Clinical Research Associates. Candidates who gain experience at Massachusetts academic medical centers or contract research organizations typically have the strongest hiring prospects.
Which companies hire clinical trial managers in Massachusetts?
Employers hiring clinical trial managers in Massachusetts right now include Kymera Therapeutics, Centessa Pharmaceuticals, and Vision Source, based on current listings on Migrate Mate as of October 2026. Massachusetts's dense concentration of pharmaceutical headquarters and academic research hospitals means hiring activity is consistent year-round, with particularly strong demand in the Greater Boston and Cambridge biotech corridor.
Which Massachusetts cities have the most clinical trial manager jobs?
The cities with the most clinical trial manager openings in Massachusetts are Boston, Cambridge, and Watertown. Boston and Cambridge lead because of their concentration of major pharmaceutical companies, contract research organizations, and world-class academic medical centers, while Worcester draws consistent demand from UMass Memorial Health and its affiliated research programs.
Are there remote clinical trial manager jobs in Massachusetts?
Yes, and more than many clinical roles, since a meaningful portion of clinical trial management involves protocol oversight, vendor communication, and data review that can be done off-site. About 94% of clinical trial manager openings tied to Massachusetts are remote or hybrid as of October 2026, reflecting how common flexible arrangements have become in this field. Site-facing responsibilities like investigator meetings and on-site monitoring visits typically still require in-person presence.
How can I get hired as a clinical trial manager in Massachusetts with little or no experience?
The most realistic entry path is a clinical research coordinator or clinical research associate role at a Massachusetts academic medical center or contract research organization, where structured mentorship and exposure to multiple therapeutic areas build the skills hiring managers look for. Large Massachusetts institutions such as Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Boston Children's Hospital regularly post study coordinator openings that serve as direct pipelines into management. Pursuing the Clinical Research Coordinator certification early signals commitment and gives candidates an edge over others with similar experience levels.
Where can I find and apply to clinical trial manager jobs in Massachusetts?
You can find and apply to clinical trial manager jobs in Massachusetts on Migrate Mate, which lists current Massachusetts openings across pharmaceutical companies, contract research organizations, and academic medical centers. Search the listings, find roles that fit your experience and preferred location, and apply directly.
See All 32 Clinical Trial Manager Jobs in Massachusetts
Find roles in Massachusetts that match your experience and apply in just a few clicks.
Find Clinical Trial Manager Jobs