E-3 Visa Commercial Director Jobs
Commercial Director roles in the U.S. require demonstrating specialty occupation status, which means showing your degree directly aligns with strategic commercial leadership. The E-3 visa gives Australian professionals a clear path to sponsorship with no lottery and indefinite two-year renewals, so the focus is entirely on finding the right employer.
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Get Access To All JobsLocation: Wilmington
Hybrid Policy: 3 days a week onsite
As Global Commercial Director, ImmunoOncology, this role shapes how ground-breaking oncology medicines reach patients worldwide. Working across a broad and innovative pipeline, the position blends commercial competence with scientific understanding to bring novel treatments to those who need them most. It leads the commercial strategy for key immuno-oncology disease areas, with a particular focus on the end-to-end launch and sustained performance of the MATTERHORN gastric cancer programme. Operating at the centre of cross-functional collaboration, this role drives focused execution, informed decision-making and ambitious, insight-led choices that influence outcomes for patients, markets and the business. Ready to challenge convention, test new ideas and guide a high-performing team to deliver impact at scale?
Accountabilities
- Lead the creation, execution and continuous refinement of a long-term commercial vision and strategy for immuno-oncology disease area(s), ensuring robust lifecycle management from prelaunch through postlaunch.
- Chair and direct the IO disease area(s) Global Brand Team (GBT), setting clear priorities, driving accountability and ensuring coordinated delivery across functions and phases of launch.
- Hold global budget accountability for the disease area, including development of the annual operating plan, budget phasing, investment prioritisation.
- Own global commercial leadership of the MATTERHORN gastric cancer launch, ensuring launch excellence, sustained performance and delivery against strategic and financial objectives.
- Lead all aspects of postlaunch performance by monitoring uptake, driven dynamics, access and executional efficiency, initiating data-driven course corrections and reallocating resources where needed.
- Represent and articulate the commercial and marketing strategic vision for the disease area(s) within the Global Portfolio Team (GPT), influencing key decisions and trade-offs.
- Partner closely with the Global Medicines Lead (GML) to align commercial and medical strategies, ensuring integrated planning and coordinated resource deployment.
- Develop and implement commercial strategies that optimise revenue, volume, margin and access across geographies within agreed budget envelopes.
- Engage regional and key market stakeholders to drive launch readiness, build capabilities and ensure effective deployment of global and local budgets.
- Act as indication lead in senior forums, communicating commercial performance, financial outlooks and investment trade-offs to senior executives and governance committees.
- Deliver Phase 3 and prelaunch marketing strategies that set up successful launches and maintain strong postlaunch momentum.
- Collaborate with extended teams to develop and implement sustainable pricing and access strategies across multiple indications.
- Lead the development and global implementation of brand strategy, positioning, launch plans, forecasts, critical metrics and ongoing financial and performance analytics for the disease area(s).
Essential Skills/Experience
- Strong strategic thinking, judgment, and influencing skills to lead across regions and markets with clear financial accountability.
- Demonstrated experience owning or leading significant global commercial budgets, including investment prioritization, phasing, and governance.
- Confirmed ability to use performance and financial analytics to inform decision making and drive course corrections.
- Bachelor’s degree required; preferably a business or scientific graduate degree with a business related postgraduate qualification. Postgraduate degree in biological, chemical, or pharmacological sciences strongly desired.
- 10+ years’ experience in the pharmaceutical industry, including at least 5 years in oncology/immuno-oncology marketing, strategy, or life sciences consulting.
- Strong leadership capabilities to set direction, inspire commitment, balance short and long-term financial and strategic needs, and resolve complex issues.
- Strong business acumen and complex problem solving skills.
- Experience developing and delivering short and long-term strategic plans for oncology portfolios, including postlaunch performance and budget management.
The annual base pay for this position ranges from $231,988.80 - $347,983.20 USD Annual and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe.
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Apply now!
Location: Wilmington
Hybrid Policy: 3 days a week onsite
As Global Commercial Director, ImmunoOncology, this role shapes how ground-breaking oncology medicines reach patients worldwide. Working across a broad and innovative pipeline, the position blends commercial competence with scientific understanding to bring novel treatments to those who need them most. It leads the commercial strategy for key immuno-oncology disease areas, with a particular focus on the end-to-end launch and sustained performance of the MATTERHORN gastric cancer programme. Operating at the centre of cross-functional collaboration, this role drives focused execution, informed decision-making and ambitious, insight-led choices that influence outcomes for patients, markets and the business. Ready to challenge convention, test new ideas and guide a high-performing team to deliver impact at scale?
Accountabilities
- Lead the creation, execution and continuous refinement of a long-term commercial vision and strategy for immuno-oncology disease area(s), ensuring robust lifecycle management from prelaunch through postlaunch.
- Chair and direct the IO disease area(s) Global Brand Team (GBT), setting clear priorities, driving accountability and ensuring coordinated delivery across functions and phases of launch.
- Hold global budget accountability for the disease area, including development of the annual operating plan, budget phasing, investment prioritisation.
- Own global commercial leadership of the MATTERHORN gastric cancer launch, ensuring launch excellence, sustained performance and delivery against strategic and financial objectives.
- Lead all aspects of postlaunch performance by monitoring uptake, driven dynamics, access and executional efficiency, initiating data-driven course corrections and reallocating resources where needed.
- Represent and articulate the commercial and marketing strategic vision for the disease area(s) within the Global Portfolio Team (GPT), influencing key decisions and trade-offs.
- Partner closely with the Global Medicines Lead (GML) to align commercial and medical strategies, ensuring integrated planning and coordinated resource deployment.
- Develop and implement commercial strategies that optimise revenue, volume, margin and access across geographies within agreed budget envelopes.
- Engage regional and key market stakeholders to drive launch readiness, build capabilities and ensure effective deployment of global and local budgets.
- Act as indication lead in senior forums, communicating commercial performance, financial outlooks and investment trade-offs to senior executives and governance committees.
- Deliver Phase 3 and prelaunch marketing strategies that set up successful launches and maintain strong postlaunch momentum.
- Collaborate with extended teams to develop and implement sustainable pricing and access strategies across multiple indications.
- Lead the development and global implementation of brand strategy, positioning, launch plans, forecasts, critical metrics and ongoing financial and performance analytics for the disease area(s).
Essential Skills/Experience
- Strong strategic thinking, judgment, and influencing skills to lead across regions and markets with clear financial accountability.
- Demonstrated experience owning or leading significant global commercial budgets, including investment prioritization, phasing, and governance.
- Confirmed ability to use performance and financial analytics to inform decision making and drive course corrections.
- Bachelor’s degree required; preferably a business or scientific graduate degree with a business related postgraduate qualification. Postgraduate degree in biological, chemical, or pharmacological sciences strongly desired.
- 10+ years’ experience in the pharmaceutical industry, including at least 5 years in oncology/immuno-oncology marketing, strategy, or life sciences consulting.
- Strong leadership capabilities to set direction, inspire commitment, balance short and long-term financial and strategic needs, and resolve complex issues.
- Strong business acumen and complex problem solving skills.
- Experience developing and delivering short and long-term strategic plans for oncology portfolios, including postlaunch performance and budget management.
The annual base pay for this position ranges from $231,988.80 - $347,983.20 USD Annual and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program. Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe.
When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That’s why we work, on average, a minimum of three days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Apply now!
See all 24+ Commercial Director jobs
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Commercial Director roles.
Get Access To All JobsTips for Finding E-3 Visa Sponsorship as a Commercial Director
Frame your credentials around specialty occupation
Your Australian bachelor's degree qualifies, but the E-3 application requires showing it's directly tied to commercial leadership, not just general management. Pull together transcripts, role descriptions, and a CV that connects your economics, business, or marketing degree to the specific strategic functions of the role.
Target companies with existing LCA filing history
Employers who've filed Labor Condition Applications before already understand the DOL certification process and won't treat your visa as an unknown risk. Search OFLC disclosure data to identify companies that have sponsored similar senior commercial roles in recent fiscal years.
Address the specialty occupation question directly with hiring managers
Commercial Director titles can trigger skepticism because some employers assume broad leadership roles don't meet USCIS specialty occupation criteria. Clarify early that your role requires a specific degree field, not just any bachelor's, and that E-3 sponsorship doesn't involve a lottery or quota wait.
Get your offer letter to specify degree requirements
The LCA and DS-160 both depend on the job being defined as a specialty occupation. Your offer letter should state that the role requires a bachelor's degree in a specific field like business, economics, or marketing. A vague letter saying 'degree preferred' can cause problems at the consulate.
Use Migrate Mate's E-3 filing service to manage the LCA and consulate prep
Once you have an offer, the employer files the LCA with DOL and you handle the DS-160 and consulate appointment. Migrate Mate's E-3 filing service manages the entire process from offer to consulate appointment, so neither you nor your employer needs to navigate the paperwork solo.
Prepare for nonimmigrant intent scrutiny at your interview
Senior commercial roles can attract additional consular scrutiny because officers sometimes question whether an executive-level candidate intends to return to Australia. Have clear, specific answers about your employment contract duration, your employer's U.S. operations, and what your role's scope looks like beyond initial tenure.
Commercial Director jobs are hiring across the US. Find yours.
Find Commercial Director JobsCommercial Director E-3 Visa: Frequently Asked Questions
How do I find Commercial Director jobs in the U.S. that offer E-3 visa sponsorship?
Migrate Mate is built specifically for Australian professionals searching for roles with E-3 sponsorship, so you can filter directly for Commercial Director positions with employers already open to the visa. Most general job boards don't filter by visa type, which means you're often applying to roles where the hiring team has never heard of the E-3. Starting with a platform designed around sponsorship saves significant time at the offer stage.
How much does it cost to get an E-3 visa?
Migrate Mate's E-3 filing service covers the entire process for $499, including the Labor Condition Application, visa document preparation, and consulate appointment guidance. Traditional immigration lawyers charge $2,000–$5,000+ for the same work. The E-3 has less paperwork than most work visas, so paying thousands for legal help is usually unnecessary.
Does a Commercial Director role qualify as a specialty occupation under E-3 rules?
It can qualify, but the title alone isn't enough. USCIS looks at whether the role normally requires a bachelor's degree in a specific field, not just any degree or general experience. A Commercial Director position grounded in commercial strategy, market analysis, or business development with a clear degree requirement in economics, business, or marketing will typically satisfy the specialty occupation standard. Broad C-suite titles without a defined degree field are harder to support.
How does the E-3 compare to the H-1B for Commercial Director roles?
The E-3 has no annual lottery and no cap that creates wait times, which makes it substantially more predictable for senior hires. H-1B selection is random and capped at 85,000 per year, meaning your employer could sponsor you and still not get a visa slot. E-3 renewals are indefinite in two-year increments as long as you hold a qualifying role, so there's no forced transition pressure that often affects H-1B holders waiting on green card priority dates.
What happens to my E-3 status if I change employers or get promoted?
Changing employers requires a new LCA filing and a fresh E-3 application, which typically means returning to Australia for a consulate appointment unless you're already inside the U.S. and your new employer files promptly. A promotion within the same company is generally fine if the role still meets specialty occupation criteria, but a significant title change that shifts your core duties may warrant a new LCA to stay covered.
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