Green Card Asset Manager Jobs
Asset Manager roles qualify for EB-2 and EB-3 green card sponsorship through the PERM labor certification process, which requires your employer to document that no qualified U.S. worker is available for the position. Portfolio management, institutional investment, and real estate asset management roles regularly clear this bar, making direct permanent residency sponsorship achievable without lottery risk.
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Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. Prime Medicine is a clinical-stage biotechnology company pioneering Prime Editing, a novel and precise "search-and-replace" gene editing technology capable of correcting the vast majority of disease-causing genetic mutations. Our approach allows us to make virtually any type of genetic edit — insertions, deletions, and all base-to-base conversions — without introducing double-strand breaks or requiring a separate donor DNA template. We are advancing a broad pipeline of Prime Editing–based therapies, including in vivo liver-directed programs and ex vivo approaches for ultra-rare disease, with a mission to develop one-time, curative genetic therapies for patients with limited or no treatment options today.
Position Overview
Location: Cambridge, MA (hybrid — min. 3-days a week onsite)
Reports to: VP, Programs and Strategy
Level: VP
Prime Medicine is seeking an experienced, strategic, and operationally rigorous Development Asset Leader to assume leadership of our in vivo LNP-delivered liver programs as they advance from early clinical development through licensure, beginning with our Wilson's Disease and Alpha-1 Antitrypsin Deficiency programs. The Asset Leader will step in seamlessly once a liver program has cleared IND and owns the asset through clinical PoC and regulatory approval/licensure. As Prime's liver portfolio grows, this leader is expected to scale from single-asset ownership into a franchise-level leadership capability, building the processes, governance, and team structure to efficiently deploy our capital to advance multiple concurrent clinical assets. The ideal candidate is equally comfortable engaging with both internal (executive management and Board) and external (regulatory authorities, KOLs, CRO/CDMO leadership) stakeholders as they are running a cohesive cross-functional team, building genuine esprit de corps across a lean organization while holding the asset accountable to timeline, budget, and scientific rigor.
Primary Responsibilities
- Own the Integrated Development Plan for liver assets from IND acceptance through regulatory approval/licensure, including trial design input, data package strategy, and key go/no-go decision points
- Anticipate, frame, and escalate the critical considerations that materially change the asset's risk/value profile to executive management
- Lead a matrixed team spanning Clinical, Regulatory, CMC/Manufacturing, Biostatistics, Pharmacovigilance, Med Affairs/Patient Advocacy, and Commercial
- Deploy, where appropriate, AI-enabled project management tooling (timelines, risk registers, cross-functional dashboarding)
- As the liver franchise expands, help design the team structure, governance cadence, and knowledge-transfer processes to advance Prime’s portfolio
- Serve as a key point of contact with CROs/CDMOs, KOLs, and patient advocacy groups for the asset, and represent the asset in regulatory interactions alongside Regulatory Affairs
Preferred Qualifications
- Advanced degree in life sciences, medicine, or related field (PhD, MD, PharmD) preferred; equivalent industry experience considered
- 12+ years of drug development experience in biotech/pharma, with demonstrated leadership of a clinical-stage asset from IND through late-stage development
- Direct experience in genetic medicines (gene/gene editing therapies, RNA-based therapeutics) or rare disease preferred; liver-directed or LNP delivery experience a strong plus
- Track record of cross-functional program leadership and accountability spanning Clinical, Regulatory, CMC, and Nonclinical
- Demonstrated ability to influence without formal authority, build team culture, and manage external partners (consultants, CROs, KOLs) as an extension of the internal team
- Experience or genuine interest in applying AI tools to project/portfolio management
- Comfort operating in a lean, resource-constrained organization where the Asset Leader is expected to build capability
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $360,000—$408,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. Prime Medicine is a clinical-stage biotechnology company pioneering Prime Editing, a novel and precise "search-and-replace" gene editing technology capable of correcting the vast majority of disease-causing genetic mutations. Our approach allows us to make virtually any type of genetic edit — insertions, deletions, and all base-to-base conversions — without introducing double-strand breaks or requiring a separate donor DNA template. We are advancing a broad pipeline of Prime Editing–based therapies, including in vivo liver-directed programs and ex vivo approaches for ultra-rare disease, with a mission to develop one-time, curative genetic therapies for patients with limited or no treatment options today.
Position Overview
Location: Cambridge, MA (hybrid — min. 3-days a week onsite)
Reports to: VP, Programs and Strategy
Level: VP
Prime Medicine is seeking an experienced, strategic, and operationally rigorous Development Asset Leader to assume leadership of our in vivo LNP-delivered liver programs as they advance from early clinical development through licensure, beginning with our Wilson's Disease and Alpha-1 Antitrypsin Deficiency programs. The Asset Leader will step in seamlessly once a liver program has cleared IND and owns the asset through clinical PoC and regulatory approval/licensure. As Prime's liver portfolio grows, this leader is expected to scale from single-asset ownership into a franchise-level leadership capability, building the processes, governance, and team structure to efficiently deploy our capital to advance multiple concurrent clinical assets. The ideal candidate is equally comfortable engaging with both internal (executive management and Board) and external (regulatory authorities, KOLs, CRO/CDMO leadership) stakeholders as they are running a cohesive cross-functional team, building genuine esprit de corps across a lean organization while holding the asset accountable to timeline, budget, and scientific rigor.
Primary Responsibilities
- Own the Integrated Development Plan for liver assets from IND acceptance through regulatory approval/licensure, including trial design input, data package strategy, and key go/no-go decision points
- Anticipate, frame, and escalate the critical considerations that materially change the asset's risk/value profile to executive management
- Lead a matrixed team spanning Clinical, Regulatory, CMC/Manufacturing, Biostatistics, Pharmacovigilance, Med Affairs/Patient Advocacy, and Commercial
- Deploy, where appropriate, AI-enabled project management tooling (timelines, risk registers, cross-functional dashboarding)
- As the liver franchise expands, help design the team structure, governance cadence, and knowledge-transfer processes to advance Prime’s portfolio
- Serve as a key point of contact with CROs/CDMOs, KOLs, and patient advocacy groups for the asset, and represent the asset in regulatory interactions alongside Regulatory Affairs
Preferred Qualifications
- Advanced degree in life sciences, medicine, or related field (PhD, MD, PharmD) preferred; equivalent industry experience considered
- 12+ years of drug development experience in biotech/pharma, with demonstrated leadership of a clinical-stage asset from IND through late-stage development
- Direct experience in genetic medicines (gene/gene editing therapies, RNA-based therapeutics) or rare disease preferred; liver-directed or LNP delivery experience a strong plus
- Track record of cross-functional program leadership and accountability spanning Clinical, Regulatory, CMC, and Nonclinical
- Demonstrated ability to influence without formal authority, build team culture, and manage external partners (consultants, CROs, KOLs) as an extension of the internal team
- Experience or genuine interest in applying AI tools to project/portfolio management
- Comfort operating in a lean, resource-constrained organization where the Asset Leader is expected to build capability
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $360,000—$408,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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Get Access To All JobsTips for Finding Green Card Sponsorship as an Asset Manager
Align your credentials with EB-2 requirements
A master's degree in finance, economics, or a related field positions you for EB-2 classification. If you hold a bachelor's plus five or more years of progressive asset management experience, document that progression carefully before your employer files the PERM application.
Target employers with PERM filing history
Asset management firms that have previously sponsored foreign professionals through PERM already have established legal processes and in-house or retained immigration counsel. Prioritize those employers early in your job search rather than introducing the sponsorship conversation cold.
Use Migrate Mate to find sponsoring employers
Filter asset management roles by green card sponsorship history using Migrate Mate. This surfaces firms that have actively filed PERM applications for investment professionals, saving you from pursuing roles at companies with no prior sponsorship infrastructure.
Verify prevailing wage before accepting an offer
Your employer must pay at least the DOL prevailing wage for your specific role and location before PERM certification is granted. Use the OFLC Wage Search to check the applicable wage level for Asset Manager roles in your target city before negotiations close.
Clarify the PERM job description during offer negotiation
The PERM application locks in a specific job description that must match your actual duties. Ask your employer to define the role requirements narrowly around your credentials so USCIS reviewers see a clean alignment between your qualifications and the sponsored position.
File I-140 concurrently to protect your priority date
Once PERM is certified, push your employer to file the I-140 immigrant petition promptly. Your green card priority date is set at I-140 filing, not at PERM approval, and earlier filing gives you more flexibility if you change employers using AC21 portability.
Green Card Asset Manager: Frequently Asked Questions
Does an Asset Manager role qualify for EB-2 or EB-3 sponsorship?
Asset Manager positions typically qualify for both EB-2 and EB-3 depending on the employer's requirements. If the role requires a master's degree or equivalent advanced credentials, EB-2 applies. Roles requiring a bachelor's degree with relevant experience generally qualify under EB-3. Your employer defines the minimum requirements in the PERM application, so that language directly determines which category applies to you.
How does green card sponsorship differ from H-1B for an Asset Manager?
H-1B visa sponsorship is temporary and subject to an annual lottery, while PERM-based green card sponsorship leads to permanent residency with no cap concerns at the EB-3 level for most countries. The tradeoff is timeline: PERM, I-140, and adjustment of status can take two to four years or longer depending on your country of birth, compared to H-1B approval in a few months. Green card sponsorship also requires the employer to demonstrate no qualified U.S. worker was available for the role.
What does the PERM process require from Asset Manager candidates?
PERM requires your employer to conduct a supervised recruitment process and document that no qualified U.S. applicant was available for the position. For Asset Manager roles, the DOL scrutinizes job requirements closely, so your employer must ensure the posted requirements genuinely reflect the role rather than being written to exclude domestic candidates. USCIS then reviews the I-140 petition that follows, which is where your individual qualifications are assessed.
How do I find Asset Manager jobs where the employer will sponsor a green card?
Search for employers with verified PERM filing history in investment management, real estate, and institutional finance. Migrate Mate lets you filter Asset Manager roles by green card sponsorship history, surfacing firms that have actively sponsored foreign professionals through PERM rather than companies with no prior sponsorship track record. This narrows your search to employers already equipped to navigate the process.
Can I change employers after my green card process has started?
Yes, once your I-140 is approved and your adjustment of status application has been pending for at least 180 days, AC21 portability lets you move to a new employer in a same or similar occupational role without restarting the green card process. For Asset Managers, a move from one portfolio management role to a comparable one at a different firm generally qualifies, but your new employer and immigration counsel should confirm the roles are sufficiently similar before you transition.