Green Card HR Director Jobs
HR Director roles qualify for EB-2 and EB-3 green card sponsorship through PERM labor certification, which requires employers to document recruitment efforts before filing an I-140 petition. Most HR Director positions meet the advanced-degree threshold for EB-2, and multinational employers with established HR infrastructure are often most prepared to run the full sponsorship process.
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Get Access To All JobsCompany Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.
Position Overview: We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy.
Responsibilities:
As a Program Manager:
- Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program
- Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support
- Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
- Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
- Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans
- Facilitate strong cross-functional communication by building strong working relationships across the organization
- Develop materials and present program updates/progress at internal company meetings
Enhancing the Program Management function:
- Responsible for the management and communication of Prime’s discovery-stage program plans
- Facilitate cross-functional communication, including input to Leadership Team on program progress
- Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums
- Reinforce high standards and high performing teams to advance our science
- Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises
- Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable
Qualifications
- Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs
- Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired
- Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict
- Proficient in prioritizing and driving complex programs to milestone completion
- Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management
- Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines.
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $219,000—$232,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
Company Overview: Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types. Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities.
Position Overview: We’re looking for an outstanding program manager with experience advancing early discovery programs through IND approval. This leader will refine and reinforce our program management methodology and lead program management in our early research teams. This role reports to the Vice President, Programs and Strategy.
Responsibilities:
As a Program Manager:
- Working in partnership with research team leadership to develop and guide program strategy, set program goals and facilitate team decision making for the program
- Lead a range of program management activities across programs, including development of project plans, timeline and milestones tracking, team meeting management/minutes, and decision-making support
- Efficiently and collaboratively drive execution of program strategy and the integrated development plan with a sense of urgency
- Proactively identify risks, gaps, and resource bottlenecks; and develop and implement mitigation plans
- Develop and manage the program budget, and long-range plan, including scenario planning as needed, monitor program financials and resourcing plans
- Facilitate strong cross-functional communication by building strong working relationships across the organization
- Develop materials and present program updates/progress at internal company meetings
Enhancing the Program Management function:
- Responsible for the management and communication of Prime’s discovery-stage program plans
- Facilitate cross-functional communication, including input to Leadership Team on program progress
- Support strategic scenario planning discussions, develop risk/mitigation plans, and drive key program decisions through our governance forums
- Reinforce high standards and high performing teams to advance our science
- Support strategic & tactical program planning in partnership with Finance and Strategy/ Portfolio Management, to inform the long-range planning process, detailed investment planning, and portfolio prioritization exercises
- Ensure cross-functional and cross-program sharing of key learnings, and drive change management as applicable
Qualifications
- Direct experience in program management/program leadership for discovery through early clinical development programs; 6+ years in industry with 3+ years managing programs
- Bachelor’s degree in relevant scientific area required, additional business training or education strongly desired; genetic medicines experience highly desired
- Excellent verbal and written communication skills and strong interpersonal skills to manage relationships, set expectations, facilitate dialogue, and resolve conflict
- Proficient in prioritizing and driving complex programs to milestone completion
- Demonstrated proficiency in program management tools and methodology. Willingness to constantly improve PM tools, implement best practices, and foster change management
- Strategic and financial acumen with the ability to develop and manage program plans, budgets, and timelines.
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity). Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits—including medical, dental, vision, life insurance, a 401(k) match, and equity programs—along with generous paid time off, wellness days, and company-wide recharge breaks. Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range $219,000—$232,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.
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Get Access To All JobsTips for Finding Green Card Sponsorship in HR Director
Frame your credentials for EB-2 eligibility
HR Director roles typically require a master's degree in human resources, business, or a related field for EB-2 classification. If your degree is from outside the U.S., get a credential evaluation completed before you begin targeting employers.
Target employers with existing PERM infrastructure
Multinational corporations and large publicly traded companies already run PERM processes for other roles. Applying to organizations with in-house immigration counsel shortens sponsor approval timelines and avoids employers learning the process on your case.
Search green card sponsoring employers on Migrate Mate
Use Migrate Mate to filter HR Director openings by employers with active employment-based green card filing history. This removes guesswork about which companies will commit to PERM sponsorship before you invest time in the application process.
Understand how PERM recruitment requirements affect your timeline
PERM requires the employer to run DOL-mandated recruitment for at least 30 days before filing. This means your green card process won't start on your first day. Clarify the employer's intended PERM start date during offer negotiations.
Verify the offered role's SOC code before signing
The DOL ties prevailing wage determinations to the Standard Occupational Classification code assigned to your role. Use O*NET to confirm your HR Director duties match SOC 11-3121, and use the OFLC Wage Search to check that your offered salary meets the prevailing wage before PERM is filed.
Negotiate I-140 filing as a contract term
PERM approval alone doesn't protect your green card priority date. Push to have I-140 filing included in your employment agreement or offer letter so USCIS adjudication begins promptly after PERM is certified, preserving your place in the visa queue.
Green Card HR Director: Frequently Asked Questions
Do HR Director roles qualify for EB-2 or EB-3 green card sponsorship?
Most HR Director positions qualify for EB-2 because the role typically requires a master's degree or a bachelor's degree plus at least five years of progressive experience in human resources. Employers file under EB-3 when the role's minimum requirements fall below the EB-2 advanced-degree threshold. Your offer letter and the employer's PERM job description determine which category applies.
How does green card sponsorship differ from H-1B sponsorship for an HR Director?
Green card sponsorship through PERM leads to lawful permanent residency rather than a temporary status. Unlike H-1B visa, there's no annual lottery and EB-3 professional cases for many nationalities don't face the same multi-year backlogs as EB-2 India or China. The tradeoff is timeline: PERM labor certification adds months before USCIS even receives the I-140 petition, whereas an H-1B can be approved within weeks using premium processing.
What does the PERM process look like for an HR Director specifically?
The employer posts the HR Director role through DOL-required channels, including a Sunday newspaper ad, an internal posting, and three additional recruitment steps, for at least 30 days. DOL then reviews the recruitment record before certifying the PERM application. Because HR Directors often oversee the very department that manages PERM filings, some employers have policies about sponsoring HR staff to avoid conflicts of interest, so clarifying this early matters.
How do I find HR Director jobs where the employer is willing to sponsor a green card?
Use Migrate Mate to search HR Director openings filtered by employers with verified employment-based green card filing history. This approach surfaces companies that have already committed to PERM sponsorship for similar roles rather than those that only sponsor H-1B visas or haven't sponsored foreign nationals before, which saves significant time during your job search.
Can I change employers after PERM is filed but before I receive my green card?
Yes, under AC21 portability rules you can change employers once your I-140 is approved and your I-485 adjustment of status petition has been pending for at least 180 days, provided the new role is in the same or a similar occupational classification. For HR Directors, USCIS evaluates whether the new role involves substantially similar human resources leadership responsibilities, not whether the job title matches exactly.