H-1B Visa Executive Management Jobs
Executive Management roles qualify for H-1B visa sponsorship when the position requires a bachelor's degree or higher in a directly related field. Large corporations, private equity-backed firms, and multinational subsidiaries are the most active sponsors, filing LCAs that certify wages at or above the DOL prevailing wage for your metro area and SOC code.
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The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers.
This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis.
Key Duties & Responsibilities:
- Provide strategic and operational leadership to multiple cross-functional teams, spanning research, clinical, and marketed products.
- Lead and mentor Senior Directors and PPM staff across at least one additional disease area (“player/coach” model).
- Drive synergies and scalability across disease areas, optimizing resource allocation to deliver on Vertex portfolio priorities.
- Set strategy and oversee decision-making for high-priority and complex programs, ensuring alignment with corporate objectives.
- Champion organizational design principles to enable agile, scalable teams and career development opportunities.
- Represent PPM on governance forums and with senior leaders, influencing strategic direction and portfolio growth.
- Propose and implement innovative approaches and process improvements to maximize operational excellence.
- Oversee financial and human resource accountability for expanded teams (direct and indirect reports).
- Ensure integration of research, development and commercialization of program management efforts with DST strategy.
Basic Requirements
- Bachelor’s degree in Life Sciences or a relevant field.
- Typically requires 15+ years of experience, including 7+ years of management experience, or the equivalent combination of education and experience.
- Demonstrated experience leading large, complex teams and programs at a global level.
Knowledge and Skills:
- Deep expertise in portfolio and program management, strategic planning, risk management and resource management across multiple disease areas.
- Proven ability to lead and mentor senior program managers and high-level professionals.
- Advanced business management and financial acumen to drive value creation.
- Exceptional communication and collaboration skills with internal and external stakeholders.
- Strong organizational skills and ability to manage multiple priorities in a dynamic environment.
- Pharmaceutical drug discovery and development expertise across disciplines.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$260,800 - $391,200
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
Job Description
The Executive Director, Portfolio & Program Management is a global leadership role within the Program and Portfolio Management (PPM) organization. The role is accountable for all program management efforts across the drug development lifecycle and commercialization, including Disease Area Strategy Teams (DST), Program Teams (PT), and research PTs, ensuring end-to-end integration with DST strategy for a subset of Vertex’s portfolio diseases. This role drives organizational design, strategic growth, and operational excellence, with expanded scope to lead multiple disease areas and mentor senior program managers.
This position is based in our Boston, MA location (Seaport area) and requires a hybrid work schedule with 3 days in office / 2 days remote on a weekly basis.
Key Duties & Responsibilities:
- Provide strategic and operational leadership to multiple cross-functional teams, spanning research, clinical, and marketed products.
- Lead and mentor Senior Directors and PPM staff across at least one additional disease area (“player/coach” model).
- Drive synergies and scalability across disease areas, optimizing resource allocation to deliver on Vertex portfolio priorities.
- Set strategy and oversee decision-making for high-priority and complex programs, ensuring alignment with corporate objectives.
- Champion organizational design principles to enable agile, scalable teams and career development opportunities.
- Represent PPM on governance forums and with senior leaders, influencing strategic direction and portfolio growth.
- Propose and implement innovative approaches and process improvements to maximize operational excellence.
- Oversee financial and human resource accountability for expanded teams (direct and indirect reports).
- Ensure integration of research, development and commercialization of program management efforts with DST strategy.
Basic Requirements
- Bachelor’s degree in Life Sciences or a relevant field.
- Typically requires 15+ years of experience, including 7+ years of management experience, or the equivalent combination of education and experience.
- Demonstrated experience leading large, complex teams and programs at a global level.
Knowledge and Skills:
- Deep expertise in portfolio and program management, strategic planning, risk management and resource management across multiple disease areas.
- Proven ability to lead and mentor senior program managers and high-level professionals.
- Advanced business management and financial acumen to drive value creation.
- Exceptional communication and collaboration skills with internal and external stakeholders.
- Strong organizational skills and ability to manage multiple priorities in a dynamic environment.
- Pharmaceutical drug discovery and development expertise across disciplines.
At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.
Pay Range:
$260,800 - $391,200
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Hybrid-Eligible Or On-Site Eligible
Flex Eligibility Status:
In this Hybrid-Eligible role, you can choose to be designated as:
- Hybrid: work remotely up to two days per week; or select
- On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.
LI-Hybrid
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com
See all 44+ H-1B Visa Executive Management Jobs
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Get Access To All JobsTips for Finding H-1B Visa Sponsorship in Executive Management
Verify your role meets specialty occupation
USCIS scrutinizes executive titles more than most. Pull the O*NET profile for your SOC code and confirm the standard entry requirement lists a specific bachelor's field, not just any degree. Generic "management experience" won't satisfy the specialty occupation standard.
Target subsidiaries of multinational corporations
Foreign-headquartered companies with U.S. subsidiaries sponsor H-1B holders at higher rates for executive roles because parent-company transfers and global mobility programs already have immigration infrastructure in place. Prioritize those with dedicated in-house immigration teams.
Search verified H-1B sponsors on Migrate Mate
Use Migrate Mate to filter Executive Management roles by employers with confirmed LCA filing history. This surfaces companies that have already cleared DOL certification for your occupation code, cutting out employers who have never sponsored at this level.
Benchmark your offer against DOL prevailing wage
Before accepting an offer, run your job title, location, and experience level through OFLC Wage Search. Your employer must pay at least the Level II or Level III prevailing wage; an offer below that threshold will block LCA certification regardless of how strong your candidacy is.
Clarify H-1B filing timeline before signing
Cap-subject H-1B petitions have an April 1 filing window tied to the October 1 start date. If you're negotiating an offer outside that window, confirm whether the employer will use premium processing and how your start date aligns with USCIS adjudication timelines.
Document degree-to-role alignment in your application
Compile a credentials packet before interviews: degree transcripts, credential evaluations for foreign degrees, and a role description that maps your specific field of study to the executive function. Employers filing at this level face RFEs if the degree-to-role connection isn't explicit.
H-1B Visa Executive Management: Frequently Asked Questions
Do Executive Management roles qualify for H-1B sponsorship?
They can, but USCIS applies strict specialty occupation scrutiny to executive titles. The position must require a bachelor's degree or higher in a specific field directly related to the job duties. Broad management roles that accept any degree regardless of field are frequently challenged. A well-drafted job description that ties your executive function to a defined academic discipline is essential for approval.
Which employers sponsor H-1B visas for Executive Management positions?
Multinational corporations, private equity portfolio companies, and large publicly traded firms are the most consistent sponsors at the executive level because they have existing immigration programs and legal teams. Use Migrate Mate to identify employers with verified LCA filing history in executive management SOC codes before investing time in applications.
How does the H-1B prevailing wage requirement affect executive offers?
The employer must certify through a DOL Labor Condition Application that your offered compensation meets or exceeds the prevailing wage for your role, experience level, and work location. Executive roles in major metro areas carry high wage levels. You can verify the applicable threshold using OFLC Wage Search before your offer stage so you're not surprised during LCA filing.
Can an H-1B holder be promoted to an executive role without refiling?
A material change in duties, title, or location typically requires an amended H-1B petition. Moving into a new executive function with substantially different responsibilities is considered a material change by USCIS, which means your employer needs to file an amended I-129 before or shortly after the role change takes effect. Confirm this with your employer's immigration counsel before accepting an internal promotion.
Does an executive-level role affect H-1B cap exemption eligibility?
Title and seniority don't determine cap exemption status. Cap exemption depends on the employer type, specifically whether the organization is a qualifying institution of higher education, a nonprofit affiliated with such an institution, or a governmental research organization. Most private-sector executive employers are cap-subject, meaning your petition must enter the annual lottery.