H-1B Visa Quality Control Manager Jobs
Quality Control Manager roles qualify for H-1B visa sponsorship as specialty occupations requiring a bachelor's degree in engineering, science, or a related field. Employers in manufacturing, pharmaceuticals, medical devices, and aerospace regularly file LCAs for this title. The 85,000-cap lottery applies, and most petitions fall under the regular cap rather than the master's cap exemption.
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Get Access To All JobsINTRODUCTION
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
THE POSITION
Arrowhead Pharmaceuticals is seeking a Scientist I, Quality Control to join our growing Quality organization in Verona, Wisconsin. In this role, you will support analytical method validation, method transfer, and quality control testing for pharmaceutical raw materials, in-process manufacturing samples, drug substance, drug product, and stability studies across our innovative RNAi therapeutic pipeline. This position offers the opportunity to work in a fast-paced GMP laboratory, applying advanced analytical techniques while collaborating closely with Analytical Development and Manufacturing. You'll serve as a technical resource within the laboratory, contribute to scientific problem-solving, and help ensure the quality and integrity of products advancing through development and commercialization. This role is 2nd shift and eligible for a 10% shift differential.
Responsibilities
- Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated analytical methods.
- Execute method validation, method transfer, and routine QC testing activities in accordance with cGMP requirements and ICH guidelines.
- Operate, troubleshoot, and interpret data from analytical instrumentation, including:
- LC-MS
- HPLC/UHPLC (RP and AEX)
- Gas Chromatography (GC)
- Karl Fischer titration
- FTIR
- Endotoxin/LAL testing
- Raman spectroscopy
- Analyze and interpret analytical data, including stability trends and degradation profiles.
- Independently investigate analytical results and make sound scientific decisions while ensuring data quality and compliance.
- Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality teams to support product development and manufacturing activities.
- Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous process improvements.
- Train and mentor laboratory colleagues on analytical techniques, instrumentation, and laboratory best practices.
- Maintain accurate documentation in compliance with cGMP, Good Documentation Practices (GDP), and internal procedures.
- Support laboratory investigations, method improvements, and other Quality Control initiatives as needed.
REQUIREMENTS
- Bachelor's degree in Chemistry or a related scientific discipline with 5+ years of relevant laboratory experience, or Master's degree in Chemistry or a related scientific discipline with 3+ years of relevant laboratory experience.
- Fully knowledgeable of cGMP and ICH laboratory requirements and operations.
- Strong attention to detail and good documentation practices; comfort working against defined hold times and turnaround targets.
- Prior experience testing oligonucleotides, peptides, or other synthetic biomolecules.
- Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
- Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
- Proficient and demonstrated experience with analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and typical cGMP policies/practices.
COMPENSATION
- Wisconsin pay range: $90,000 USD - $108,000 USD
Arrowhead provides competitive salaries and an excellent benefit package. Candidates must have current, valid authorization to work in the country where this role is located.
California Applicant Privacy Policy
INTRODUCTION
Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead’s RNAi-based therapeutics leverage this natural pathway of gene silencing. Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates. Arrowhead’s corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.
THE POSITION
Arrowhead Pharmaceuticals is seeking a Scientist I, Quality Control to join our growing Quality organization in Verona, Wisconsin. In this role, you will support analytical method validation, method transfer, and quality control testing for pharmaceutical raw materials, in-process manufacturing samples, drug substance, drug product, and stability studies across our innovative RNAi therapeutic pipeline. This position offers the opportunity to work in a fast-paced GMP laboratory, applying advanced analytical techniques while collaborating closely with Analytical Development and Manufacturing. You'll serve as a technical resource within the laboratory, contribute to scientific problem-solving, and help ensure the quality and integrity of products advancing through development and commercialization. This role is 2nd shift and eligible for a 10% shift differential.
Responsibilities
- Perform analytical testing of raw materials, in-process samples, drug substances, drug products, and stability samples using validated analytical methods.
- Execute method validation, method transfer, and routine QC testing activities in accordance with cGMP requirements and ICH guidelines.
- Operate, troubleshoot, and interpret data from analytical instrumentation, including:
- LC-MS
- HPLC/UHPLC (RP and AEX)
- Gas Chromatography (GC)
- Karl Fischer titration
- FTIR
- Endotoxin/LAL testing
- Raman spectroscopy
- Analyze and interpret analytical data, including stability trends and degradation profiles.
- Independently investigate analytical results and make sound scientific decisions while ensuring data quality and compliance.
- Collaborate cross-functionally with Analytical Development, Manufacturing, and Quality teams to support product development and manufacturing activities.
- Lead technical discussions, troubleshoot analytical challenges, and contribute to continuous process improvements.
- Train and mentor laboratory colleagues on analytical techniques, instrumentation, and laboratory best practices.
- Maintain accurate documentation in compliance with cGMP, Good Documentation Practices (GDP), and internal procedures.
- Support laboratory investigations, method improvements, and other Quality Control initiatives as needed.
REQUIREMENTS
- Bachelor's degree in Chemistry or a related scientific discipline with 5+ years of relevant laboratory experience, or Master's degree in Chemistry or a related scientific discipline with 3+ years of relevant laboratory experience.
- Fully knowledgeable of cGMP and ICH laboratory requirements and operations.
- Strong attention to detail and good documentation practices; comfort working against defined hold times and turnaround targets.
- Prior experience testing oligonucleotides, peptides, or other synthetic biomolecules.
- Hands-on experience with LCMS, AEX-HPLC, RP-HPLC/UHPLC, Karl Fischer titration, or LAL/endotoxin testing.
- Experience supporting in-process (real-time) testing in a manufacturing-adjacent QC lab.
- Proficient and demonstrated experience with analytical instrumentation, test methodology/validations/transfers, data acquisition systems, and typical cGMP policies/practices.
COMPENSATION
- Wisconsin pay range: $90,000 USD - $108,000 USD
Arrowhead provides competitive salaries and an excellent benefit package. Candidates must have current, valid authorization to work in the country where this role is located.
California Applicant Privacy Policy
See all 529+ H-1B Visa Quality Control Manager Jobs
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Get Access To All JobsTips for Finding H-1B Visa Sponsorship as a Quality Control Manager
Verify your degree matches QC specialty occupation
H-1B approval hinges on your degree field directly relating to quality control work. Engineering, chemistry, biology, and materials science degrees typically satisfy USCIS specialty occupation requirements. A business or general management degree alone often triggers an RFE for this role.
Research LCA filings by industry sector
Pharmaceutical, medical device, and aerospace manufacturers file the most H-1B LCAs for Quality Control Managers. Filter employer searches by these NAICS codes to find sponsors with recent DOL-certified filings rather than targeting companies with no history of this role.
Search verified sponsors on Migrate Mate
Use Migrate Mate to filter Quality Control Manager jobs by employers with confirmed H-1B LCA filing history. This surfaces companies that have already navigated DOL certification for this specific title, saving you from applying to roles where sponsorship is uncertain.
Confirm prevailing wage tier before negotiating
Your offered salary must meet the DOL prevailing wage for Quality Control Managers in your work location. Run your SOC code and metro area through the OFLC Wage Search before salary discussions so you enter negotiations knowing the floor the LCA must certify.
Ask employers about E-Verify enrollment early
Some manufacturers, especially federal contractors, are already E-Verify enrolled, which streamlines I-9 verification after your H-1B is approved. Confirming E-Verify status during screening signals you understand the onboarding process and avoids surprises at the start date.
Account for cap-gap if transitioning from OPT
If you're moving from F-1 OPT to H-1B, your cap-gap protection covers you only until October 1 of the fiscal year your petition is approved. Quality Control Manager roles with long onboarding timelines need an offer letter and I-129 filing timed to that window.
H-1B Visa Quality Control Manager: Frequently Asked Questions
Does a Quality Control Manager role qualify as an H-1B specialty occupation?
Yes, provided the position requires a bachelor's degree or higher in a specific field such as engineering, chemistry, biology, or materials science. USCIS evaluates the job duties, not just the title. If the role involves statistical process control, regulatory compliance, or quality systems management at a technical level, it typically satisfies specialty occupation criteria. A general management description without technical requirements can draw an RFE.
Which industries most commonly sponsor H-1B visas for Quality Control Managers?
Pharmaceutical manufacturers, medical device companies, aerospace firms, and automotive suppliers file the highest volumes of H-1B LCAs for Quality Control Manager titles. These industries operate under FDA, FAA, or ISO regulatory frameworks that require technically credentialed managers. Food and beverage manufacturing and semiconductor fabrication also sponsor this role regularly. Use Migrate Mate to browse open positions filtered by employers with verified LCA filing history in these sectors.
How does the DOL prevailing wage apply to Quality Control Manager H-1B petitions?
Your employer must certify on the LCA that your offered wage meets or exceeds the DOL prevailing wage for your SOC code and work location. Quality Control Managers fall under SOC 11-3051, and the prevailing wage varies significantly by metro area and experience level. You can verify the applicable wage using the OFLC Wage Search before accepting an offer to confirm your employer's LCA will clear DOL certification.
Can a Quality Control Manager petition use the master's cap exemption?
Only if you hold a U.S. master's degree or higher, or a foreign equivalent evaluated as such. The 20,000-slot master's cap exemption is separate from the regular 65,000 cap and improves lottery selection odds. Many Quality Control Manager candidates hold bachelor's degrees in engineering or science and compete in the regular cap. If you have a relevant U.S. master's degree, confirm with your employer that the petition is filed under the master's exemption.
What documentation should a Quality Control Manager prepare before H-1B filing?
Assemble your academic credentials first, as USCIS requires a degree evaluation for foreign transcripts. Gather employment verification letters that describe technical duties tied to your degree field, not just job titles. Certifications such as ASQ Certified Quality Manager or ISO 9001 Lead Auditor credentials support the specialty occupation argument. Your employer will need your work location zip code and start date to complete the LCA before submitting the I-129 to USCIS.