H-1B1 Singapore Visa Medical Director Jobs
Medical Director roles qualify for H-1B1 Singapore visa sponsorship as specialty occupations requiring an advanced medical degree and executive clinical oversight. Singaporean physicians pursuing U.S. health system leadership can apply directly at the consulate, bypassing the H-1B lottery, with an annual cap of 5,400 visas that has never been exhausted.
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Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
The Medical Director/Senior Medical Director at Calico will report to the Head of Clinical Sciences and will be responsible for providing strategic input to the translational and clinical development of projects related to Calico’s mission to improve human health span by understanding aging and age-related diseases. This position is focused on neurologic/neuropsychiatric indications.
Position Responsibilities
- Leads cross-functional teams which develop the strategy to translate preclinical mechanistic data to humans and to develop translational biomarkers for novel targets in neurological/neuropsychiatric indications
- Actively interfaces with research and drug development leaders, at Calico and outside of Calico, to inform disease indication strategies for novel targets
- Utilizes clinical expertise to guide the development and utilization of preclinical models in close collaboration with discovery and biomarker scientists at Calico and Calico’s business partners
- Works closely with other drug developmental functional areas to shape new clinical programs at multiple points in their evolution, with an emphasis on translational/early clinical development (Phase 0 through Phase 2)
- Designs and executes experimental medicine studies to demonstrate proof-of-mechanism of novel targets in neuropsychiatric diseases
- Designs and executes early clinical development plans to demonstrate proof-of-concept in various neuropsychiatric indications
- Provides scientific/medical content and other input as appropriate for protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents
Position Requirements
- Scientifically minded Physician (M.D.) or Physician-Scientist (M.D./Ph.D.)
- At least 5 years of translational, clinical trial, or drug development experience in the biotech/pharmaceutical industry, academia, or equivalent
- Board-certified/eligible in Neurology and/or Pediatric Neurology highly preferred
- Clinical/translational research and/or drug development experience across various neuropsychiatric disease areas
- Medical knowledge in treating patients across various neuropsychiatric or neurological indications
- Working knowledge or direct experience in early clinical trial methodology (Phase 0, Phase 1, Phase 2)
- Proven leadership skills and ability to bring out the best in others on a cross-functional team
- Able to provide effective leadership through influence in a highly matrixed environment, including various drug development functions within Calico and its development partners
- Must possess excellent oral and written English communication skills
- Must be willing to work onsite at least 4 days a week
The estimated base salary range for this role is $335,000 - $400,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
Who We Are
Calico (Calico Life Sciences LLC) is an Alphabet-founded research and development company whose mission is to harness advanced technologies and model systems to increase our understanding of the biology that controls human aging. Calico will use that knowledge to devise interventions that enable people to lead longer and healthier lives. Calico’s highly innovative technology labs, its commitment to curiosity-driven discovery science and, with academic and industry partners, its vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.
Position Description
The Medical Director/Senior Medical Director at Calico will report to the Head of Clinical Sciences and will be responsible for providing strategic input to the translational and clinical development of projects related to Calico’s mission to improve human health span by understanding aging and age-related diseases. This position is focused on neurologic/neuropsychiatric indications.
Position Responsibilities
- Leads cross-functional teams which develop the strategy to translate preclinical mechanistic data to humans and to develop translational biomarkers for novel targets in neurological/neuropsychiatric indications
- Actively interfaces with research and drug development leaders, at Calico and outside of Calico, to inform disease indication strategies for novel targets
- Utilizes clinical expertise to guide the development and utilization of preclinical models in close collaboration with discovery and biomarker scientists at Calico and Calico’s business partners
- Works closely with other drug developmental functional areas to shape new clinical programs at multiple points in their evolution, with an emphasis on translational/early clinical development (Phase 0 through Phase 2)
- Designs and executes experimental medicine studies to demonstrate proof-of-mechanism of novel targets in neuropsychiatric diseases
- Designs and executes early clinical development plans to demonstrate proof-of-concept in various neuropsychiatric indications
- Provides scientific/medical content and other input as appropriate for protocols, Investigator Brochures, Clinical Study reports, regulatory submissions and responses, and other program documents
Position Requirements
- Scientifically minded Physician (M.D.) or Physician-Scientist (M.D./Ph.D.)
- At least 5 years of translational, clinical trial, or drug development experience in the biotech/pharmaceutical industry, academia, or equivalent
- Board-certified/eligible in Neurology and/or Pediatric Neurology highly preferred
- Clinical/translational research and/or drug development experience across various neuropsychiatric disease areas
- Medical knowledge in treating patients across various neuropsychiatric or neurological indications
- Working knowledge or direct experience in early clinical trial methodology (Phase 0, Phase 1, Phase 2)
- Proven leadership skills and ability to bring out the best in others on a cross-functional team
- Able to provide effective leadership through influence in a highly matrixed environment, including various drug development functions within Calico and its development partners
- Must possess excellent oral and written English communication skills
- Must be willing to work onsite at least 4 days a week
The estimated base salary range for this role is $335,000 - $400,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.
See all H-1B1 Singapore Visa Medical Director Jobs
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Get Access To All JobsTips for Finding Medical Director Jobs
Verify your credentials meet specialty occupation standards
USCIS requires Medical Director roles to demonstrate that a specific advanced degree is a normal requirement for the position. Document that your Singapore medical qualifications and any subspecialty board certifications map directly to the clinical leadership scope of the U.S. role.
Target health systems with existing H-1B1 filing history
Use Migrate Mate to filter employers by H-1B1 Labor Condition Application filings in clinical leadership job categories, so you focus your applications on health systems that have already navigated the H-1B1 Singapore process for physician executives.
Request a prevailing wage review before negotiating your offer
Your employer must certify your offered salary meets the DOL prevailing wage for Medical Directors in your region. Run the OFLC Wage Search using the correct SOC code for medical and health services managers before accepting any offer, so you enter negotiations informed.
Clarify whether your role requires state medical licensure before filing
Some U.S. states require an active medical license even for Medical Directors who won't see patients. Confirm with the hiring organization whether clinical licensure in that state is a condition of employment, since unresolved licensing can stall your LCA certification.
Confirm your employer is prepared to file the LCA promptly after your offer
The H-1B1 visa consular process moves faster than H-1B, but your employer must submit the Labor Condition Application to DOL before you can book your visa interview. Ask the hiring team directly whether they have immigration counsel on retainer and an estimated LCA filing timeline.
Check your O*NET occupation profile to anticipate specialty occupation scrutiny
Consular officers may ask how your role aligns with a recognized specialty occupation definition. Reviewing the O*NET profile for medical and health services managers lets you speak precisely to the degree requirements and clinical oversight duties central to Medical Director positions.
Frequently Asked Questions
Does a Medical Director role qualify as a specialty occupation for H-1B1 Singapore purposes?
Yes. Medical Director positions typically require an M.D. or D.O. plus relevant clinical or subspecialty training, satisfying the USCIS specialty occupation standard that the role normally demands a specific baccalaureate or higher degree. The clinical oversight and executive responsibilities embedded in most Medical Director job descriptions reinforce this qualification, though your employer's LCA must clearly articulate the degree requirement for the specific position.
How does the H-1B1 Singapore visa compare to the H-1B for Singaporean physicians pursuing Medical Director roles?
The H-1B1 Singapore visa skips the H-1B lottery entirely, which means your application is processed on its own merits rather than by random selection. The annual cap is 5,400 visas and has never filled. You apply at the consulate rather than through USCIS, which typically means faster processing. The trade-off is that the H-1B1 doesn't confer dual intent, so maintaining clear nonimmigrant intent is essential throughout the process.
How can I find U.S. employers actively willing to sponsor H-1B1 Singapore visas for Medical Director positions?
Migrate Mate lets you search for Medical Director roles filtered by employers with verified H-1B1 visa Labor Condition Application filing history, so you're targeting health systems and hospital networks that have already sponsored Singaporean professionals rather than educating employers from scratch about the visa category.
Can I hold an H-1B1 Singapore visa while pursuing permanent residency as a Medical Director?
The H-1B1 Singapore visa does not carry dual intent, unlike the standard H-1B. This means you must maintain a genuine nonimmigrant intent and cannot simultaneously pursue a green card through an employer-sponsored immigrant petition while holding H-1B1 status. Physicians pursuing permanent residency alongside a Medical Director role should discuss this distinction carefully with qualified immigration counsel before filing.
What happens if my Medical Director H-1B1 application requires additional administrative processing at the consulate?
Administrative processing, sometimes called a 221(g) hold, pauses your visa issuance while the consulate conducts further review. For Medical Director applicants, this can arise from national security checks or credential verification queries. There's no fixed timeline, but you should avoid giving notice to your Singapore employer or booking international flights until you hold an approved visa in hand.