ICU Registered Nurse Jobs in Columbia, SC

ICU Registered Nurse jobs in Columbia, South Carolina are concentrated across the Midlands medical corridor, with demand anchored in Five Points, the Rosewood District, and the broader Forest Acres area serving major health systems and regional critical care centers. Employers hiring right now include Prisma Health, Medical University of South Carolina, and Lexington Health. Scan the live roles below and apply to whichever ones fit.

Find ICU Registered Nurse Jobs

Overview

Open roles21
Top employerPrisma Health
Work type100% On-site
Top credentialAssociate's
Companies hiring4

Showing 5 of 21+ ICU Registered Nurse jobs

Prisma Health
Registered Nurse (RN) - Acute Care, Cardiopulmonary ICU, FT, Nights
We won't show you this job again
Prisma Health
New 1m ago
Registered Nurse (RN) - Acute Care, Cardiopulmonary ICU, FT, Nights
Prisma Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

Have you applied for this role?

V
Travel RN-ICU-Intensive Care Unit in Columbia, South Carolina
We won't show you this job again
V
New 1m ago
Travel RN-ICU-Intensive Care Unit in Columbia, South Carolina
Voyage Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
$1,789 - $1,883/wk

Have you applied for this role?

Prisma Health
Registered Nurse (RN) - Acute Care, Neurosurgical ICU, FT, Days
We won't show you this job again
Prisma Health
New 1m ago
Registered Nurse (RN) - Acute Care, Neurosurgical ICU, FT, Days
Prisma Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Nursing Diploma
10,000+

Have you applied for this role?

Medical University of South Carolina
Registered Nurse- ICU - Days
We won't show you this job again
Medical University of South Carolina
New 1m ago
Registered Nurse- ICU - Days
Medical University of South Carolina
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

Have you applied for this role?

Prisma Health
Registered Nurse (RN) - Acute Care, Cardiovascular ICU, FT, Nights
We won't show you this job again
Prisma Health
New 1m ago
Registered Nurse (RN) - Acute Care, Cardiovascular ICU, FT, Nights
Prisma Health
Columbia, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Bachelor's degree in nursing
10,000+

Have you applied for this role?

See All 21 ICU Registered Nurse Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find ICU Registered Nurse Jobs

ICU Registered Nurse Job Market in Columbia

Who's Hiring

  • Prisma Health
    Prisma Health9
  • Medical University of South Carolina
    Medical University of South Carolina8
  • Lexington Health
    Lexington Health3
  • V
    Voyage Health1

Top Industries Hiring

  • Healthcare & Medical Services13
  • Education5

ICU Registered Nurse Jobs in Columbia: Frequently Asked Questions

How do I get a icu registered nurse job in Columbia?

Columbia's critical care hiring centers on its large academic health systems, community hospitals, and specialty surgical centers concentrated along the Midlands medical corridor. Candidates with CCRN certification and experience in cardiac or trauma ICU units stand out most with local employers. Applying directly to system-level postings and connecting with unit nurse managers at Columbia's teaching hospitals gives you a practical edge over applicants going through generic channels.

Which companies hire icu registered nurses in Columbia?

Employers hiring icu registered nurses in Columbia right now include Prisma Health, Medical University of South Carolina, and Lexington Health, based on current listings on Migrate Mate as of July 2026. Columbia's market is shaped by a mix of large integrated health systems, regional community hospitals, and specialty care facilities serving the Midlands population.

Are there remote icu registered nurse jobs in Columbia?

Remote work is rare for icu registered nurses, since the role requires direct bedside patient care in a critical care unit. About 0% of icu registered nurse openings tied to Columbia are remote or hybrid as of July 2026, and those positions typically involve tele-ICU monitoring or clinical care coordination roles rather than hands-on floor assignments.

How can I get a icu registered nurse job in Columbia with little or no experience?

The most realistic entry path in Columbia is completing a new graduate residency or critical care fellowship program at one of the city's larger health systems, which regularly recruit new RNs into structured ICU transition programs. Starting in a step-down or progressive care unit at a Columbia community hospital and rotating into critical care is a common local ladder. A BSN, current BLS and ACLS certifications, and any clinical hours logged in ICU or high-acuity settings during nursing school all strengthen a new grad application.

Which industries hire the most icu registered nurses in Columbia?

Most icu registered nurse openings in Columbia sit in Healthcare & Medical Services and Education, per current listings on Migrate Mate as of July 2026. Columbia's role as the state capital and home to a major research university health system drives sustained critical care demand across both acute inpatient and specialty surgical settings in the Midlands region.

See All 21 ICU Registered Nurse Jobs in Columbia

Find roles in Columbia that match your experience and apply in just a few clicks.

Find ICU Registered Nurse Jobs