Clinical Nurse Jobs in South Carolina

Clinical Nurse jobs in South Carolina are open across Columbia, Charleston, and West Columbia and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and Lexington Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles312+
Top cityColumbia, SC
Cities hiring52
Work type94% On-site
Top industryHealthcare

Showing 5 of 312+ Clinical Nurse jobs

Medical University of South Carolina
Clinical Nurse Educator
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Medical University of South Carolina
Added 2w ago
Clinical Nurse Educator
Medical University of South Carolina
Lancaster, South Carolina
Nursing
Healthcare Administration
Corporate Training & Learning Development
On-Site
Bachelor's
10,000+

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Medical University of South Carolina
Clinical Practice Nurse Expert
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Medical University of South Carolina
Added 3w ago
Clinical Practice Nurse Expert
Medical University of South Carolina
Orangeburg, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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PruittHealth
Registered Nurse Clinical Manager
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PruittHealth
Added 1mo ago
Registered Nurse Clinical Manager
PruittHealth
Columbia, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
Caregiving & Elderly Support
On-Site
None
10,000+

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Medical University of South Carolina
Clinical Practice Nurse Expert
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Medical University of South Carolina
Added 1mo ago
Clinical Practice Nurse Expert
Medical University of South Carolina
Orangeburg, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Bachelor's
10,000+

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Self Regional Healthcare
Nurse Clinical Care Lead
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Self Regional Healthcare
Added 4mo ago
Nurse Clinical Care Lead
Self Regional Healthcare
Greenwood, South Carolina
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Associate's

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See All 312+ Clinical Nurse Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

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Clinical Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Columbia
61 jobs
Charleston
54 jobs
West Columbia
25 jobs
Greenville
24 jobs
Florence
17 jobs
Greenwood
10 jobs
Bluffton
9 jobs
Lexington
9 jobs
Mount Pleasant
9 jobs

Clinical Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

  • Medical University of South Carolina
    Medical University of South Carolina90
  • Prisma Health
    Prisma Health68
  • Lexington Health
    Lexington Health48
  • National HealthCare Corporation
    National HealthCare Corporation17
  • LifeStance Health
    LifeStance Health15

Top Industries Hiring

  • Healthcare & Medical Services229
  • Education65
  • Biotechnology & Pharmaceuticals9
  • Consulting & Professional Services8
  • Food & Beverage1

What South Carolina Employers Look For

The qualifications that appear most often in clinical nurse jobs across South Carolina.

  • Active registered nurse (RN) license in the state of employment
  • Current BLS certification required at time of hire
  • Associate or Bachelor of Science in Nursing from an accredited program
  • One to two years of acute care or specialty unit experience preferred
  • ACLS certification required for critical care, telemetry, and procedural roles
  • Proficiency with electronic health record systems such as Epic or Cerner

Clinical Nurse Jobs in South Carolina: Frequently Asked Questions

How many clinical nurse jobs are there in South Carolina?

There are 312+ clinical nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and West Columbia. New positions post regularly as employers across South Carolina hire.

How much do clinical nurses make in South Carolina?

Clinical nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Carolina cities have the most clinical nurse jobs?

Columbia, Charleston, and West Columbia have the most clinical nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.

Which companies hire clinical nurses in South Carolina?

Employers hiring clinical nurses in South Carolina include Medical University of South Carolina, Prisma Health, and Lexington Health, based on current listings on Migrate Mate as of June 2026.

Are there remote clinical nurse jobs in South Carolina?

Yes. About 6% of clinical nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.

How do I apply for clinical nurse jobs in South Carolina?

You can apply to clinical nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.

See All 312+ Clinical Nurse Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs