Clinical Nurse Jobs in South Carolina

Clinical Nurse jobs in South Carolina concentrate heavily in acute care hospital systems, outpatient clinics, and rehabilitation facilities, with demand running from new graduates through senior bedside roles. The largest hiring activity is in Columbia, Greenville, and Charleston, where anchor systems such as Prisma Health, MUSC Health, and Bon Secours are consistently among the most active recruiters. Critical care, med-surg, and emergency nursing are the specialties drawing the most consistent openings statewide. See the openings below and apply to the ones that match your experience.

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Overview

Open roles43
Top employerPrisma Health
Top cityCharleston, SC
Cities hiring21
Work type100% On-site
Top industryHealthcare

Showing 5 of 43+ Clinical Nurse jobs

Registered Nurse -Lung Cancer Screening Clinical Coordinator
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Added 5d ago
Registered Nurse -Lung Cancer Screening Clinical Coordinator
US Department of Veterans Affairs
Charleston, South Carolina
Business Operations
Logistics & Fleet Management
Project Management
$68k - $138k/yr
On-Site
Doctoral degree
10,000+

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Clinical Nurse Coordinator Emergency Room RN
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Added 6d ago
Clinical Nurse Coordinator Emergency Room RN
HCA Healthcare Summerville Hospital
Summerville, South Carolina
Healthcare Administration
Patient Services & Wellbeing
Social Work & Counseling

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Hospital Registered Nurse Clinical Coordinator
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Added 6d ago
Hospital Registered Nurse Clinical Coordinator
DaVita
Sumter, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
Managed Registered Nurses (RNs)
10,000+

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Dialysis Clinical Manager Registered Nurse - RN
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Added 1w ago
Dialysis Clinical Manager Registered Nurse - RN
Fresenius Medical Care
West Columbia, South Carolina
Clinical Support
Healthcare Administration
Project Management
Managed Registered Nurses (RNs)
10,000+

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Nurse Clinical Care Lead, Behavioral Health Center
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Added 1w ago
Nurse Clinical Care Lead, Behavioral Health Center
Self Regional Healthcare
Greenwood, South Carolina
Healthcare Administration
Nursing
Patient Services & Wellbeing
1,001-5,000

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See All 43 Clinical Nurse Jobs in South Carolina

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Clinical Nurse Jobs by City in South Carolina

Where South Carolina roles are concentrated, by current openings.

Charleston
8 jobs
Greenville
7 jobs
Columbia
5 jobs
Aiken
3 jobs
Greenwood
3 jobs
Myrtle Beach
2 jobs
Irmo
1 job
Greer
1 job
Ladson
1 job

Clinical Nurse Job Market in South Carolina

A snapshot from current South Carolina openings, updated as new roles post.

Who's Hiring

Prisma Health6 open roles
Fresenius Medical Care6 open roles
HCA Healthcare Trident Hospital6 open roles

Top Industries Hiring

  • Healthcare & Medical Services

What South Carolina Employers Look For

The qualifications that appear most often in clinical nurse jobs across South Carolina.

  • Active South Carolina RN license or multistate compact license recognized in South Carolina
  • Associate or Bachelor of Science in Nursing from an accredited program
  • Current BLS certification required before start date
  • Minimum one year of acute care or clinical nursing experience preferred
  • ACLS certification required for critical care, emergency, or telemetry positions
  • Proficiency with electronic health record systems such as Epic or Cerner

Clinical Nurse Jobs in South Carolina: Frequently Asked Questions

How do you become a clinical nurse in South Carolina?

You become a clinical nurse in South Carolina by earning a nursing degree, passing the NCLEX-RN, and obtaining licensure through the South Carolina Board of Nursing. The board issues both single-state licenses and recognizes the Nurse Licensure Compact, which lets nurses licensed in other compact states practice in South Carolina without a separate application. Most hospital employers require at least an Associate Degree in Nursing, and many prefer a Bachelor of Science in Nursing for clinical floor roles.

How much do clinical nurses make in South Carolina?

Clinical nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire clinical nurses in South Carolina?

Employers hiring clinical nurses in South Carolina right now include Prisma Health, Fresenius Medical Care, and HCA Healthcare Trident Hospital, based on current listings on Migrate Mate as of October 2026. South Carolina's large integrated health systems and regional medical centers drive the majority of clinical nurse openings, particularly in the Columbia, Greenville, and Charleston metro areas.

Which South Carolina cities have the most clinical nurse jobs?

Charleston, Greenville, and Columbia have the most clinical nurse openings in South Carolina. Columbia leads as the state capital and home to major systems like Prisma Health and MUSC Health's network affiliates, while Greenville's growth as a healthcare and manufacturing hub keeps Bon Secours and other regional employers consistently hiring, and Charleston's academic medical center at MUSC anchors demand along the coast.

Are there remote clinical nurse jobs in South Carolina?

Yes, but they're rare. Clinical nursing is fundamentally a hands-on, patient-facing role, so most positions require on-site presence. About 0% of clinical nurse openings tied to South Carolina are remote or hybrid as of October 2026, and those positions typically involve telehealth triage, care coordination, or utilization review rather than direct bedside care.

How can I get hired as a clinical nurse in South Carolina with little or no experience?

The most realistic entry path is a new graduate residency program at one of South Carolina's large health systems. Prisma Health and MUSC Health both run structured nurse residency programs designed for nurses with no post-graduation experience, offering supervised rotations on med-surg or telemetry floors. Candidates who complete a clinical preceptorship at a South Carolina facility during nursing school and hold an active South Carolina RN license before their first interview are consistently ranked ahead of applicants who are still awaiting licensure.

Where can I find and apply to clinical nurse jobs in South Carolina?

You can find and apply to clinical nurse jobs in South Carolina on Migrate Mate, which lists current South Carolina openings across hospital systems, outpatient clinics, and rehabilitation facilities. Search the listings to find roles that match your specialty and experience level, then apply directly to the ones that fit.

See All 43 Clinical Nurse Jobs in South Carolina

Find roles in South Carolina that match your experience and apply in just a few clicks.

Find Clinical Nurse Jobs