Clinical Nurse Jobs in South Carolina
Clinical Nurse jobs in South Carolina are open across Columbia, Charleston, and West Columbia and other South Carolina metros, with employers like Medical University of South Carolina, Prisma Health, and Lexington Health hiring at every experience level. Find a role that fits below and apply directly.
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INTRODUCTION
Are you looking to thrive in a culture that inspires your personal and professional growth? Would you like to help teach, advocate, mentor, and educate the nursing staff of MUSC? Do you have a creative mind and a heart for students starting their nursing journey, are you detailed orientated, a good communicator, and have the patience to work with our nursing staff to help equip them to be a successful nurse? Does this sound like you? If so, we would love to have you on our team.
ROLE AND RESPONSIBILITIES
The Registered Nurse Clinical Educator serves as a clinical resource to our nursing staff, guiding nurses at the bedside, encouraging and being a professional mentor to our nursing students and newly graduated nurses. Assist the Director of Education with planning, and coordinating the educational needs and requirements of all new and tenured staff members of MUSC Catawba Division. Creates and organizes training schedules and conducts training programs for staff development. Works with the compliance department to ensure all required education elements are accomplished, and maintains records of compliance with regulatory agencies.
BASIC QUALIFICATIONS
- Minimum of two years experience of relevant experience
ADDITIONAL JOB DESCRIPTION
Education: Bachelor’s degree in nursing from an accredited college/university required. Master's degree in nursing preferred.
Licenses/Certifications: Licensure as a Registered Nurse by the South Carolina Board of Nursing or a compact state required. Current Basic Life Support (BLS) with American Heart Association (AHA) required.
If you like working with energetic enthusiastic individuals, you will enjoy your career with us!
The Medical University of South Carolina is an Equal Opportunity Employer. MUSC does not discriminate on the basis of race, color, religion or belief, age, sex, national origin, gender identity, sexual orientation, disability, protected veteran status, family or parental status, or any other status protected by state laws and/or federal regulations. All qualified applicants are encouraged to apply and will receive consideration for employment based upon applicable qualifications, merit and business need.
Medical University of South Carolina participates in the federal E-Verify program to confirm the identity and employment authorization of all newly hired employees. For further information about the E-Verify program, please click here: http://www.uscis.gov/e-verify/employees.
See All 312+ Clinical Nurse Jobs in South Carolina
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Find Clinical Nurse JobsClinical Nurse Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Clinical Nurse Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Medical University of South Carolina90

- Prisma Health68

- Lexington Health48

- National HealthCare Corporation17

- LifeStance Health15

Top Industries Hiring
- Healthcare & Medical Services229
- Education65
- Biotechnology & Pharmaceuticals9
- Consulting & Professional Services8
- Food & Beverage1
What South Carolina Employers Look For
The qualifications that appear most often in clinical nurse jobs across South Carolina.
- Active registered nurse (RN) license in the state of employment
- Current BLS certification required at time of hire
- Associate or Bachelor of Science in Nursing from an accredited program
- One to two years of acute care or specialty unit experience preferred
- ACLS certification required for critical care, telemetry, and procedural roles
- Proficiency with electronic health record systems such as Epic or Cerner
Clinical Nurse Jobs in South Carolina: Frequently Asked Questions
How many clinical nurse jobs are there in South Carolina?
There are 312+ clinical nurse openings in South Carolina on Migrate Mate as of June 2026, with the most roles in Columbia, Charleston, and West Columbia. New positions post regularly as employers across South Carolina hire.
How much do clinical nurses make in South Carolina?
Clinical nurses in South Carolina earn a median of about $82,360 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $66,860 for the lowest 10% to over $106,520 for the top 10%. Pay rises with experience, specialty, and employer.
Which South Carolina cities have the most clinical nurse jobs?
Columbia, Charleston, and West Columbia have the most clinical nurse openings in South Carolina right now, with additional roles spread across smaller metros statewide.
Which companies hire clinical nurses in South Carolina?
Employers hiring clinical nurses in South Carolina include Medical University of South Carolina, Prisma Health, and Lexington Health, based on current listings on Migrate Mate as of June 2026.
Are there remote clinical nurse jobs in South Carolina?
Yes. About 6% of clinical nurse openings tied to South Carolina are remote or hybrid as of June 2026. The rest are on-site roles based in South Carolina metros.
How do I apply for clinical nurse jobs in South Carolina?
You can apply to clinical nurse jobs in South Carolina directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Carolina location, then apply to each one that fits.
See All 312+ Clinical Nurse Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Clinical Nurse Jobs