Lead Nurse Practitioner Jobs

Lead Nurse Practitioner jobs are open across health systems, hospital networks, outpatient clinics, and federally qualified health centers, from staff-level NP roles to clinical lead and practice director positions, with specializations in primary care, urgent care, and behavioral health. Find a role that fits below and apply directly.

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Overview

Open roles3,742+
Top stateFlorida
Top employerCleveland Clinic
Top cityMiami, FL
Work type80% On-site
Top industryHealthcare

Showing 5 of 3,742+ Lead Nurse Practitioner jobs

Advanced Practice Professional (NP) Urogynecology (Troy Center for Speciality Care)
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Advanced Practice Professional (NP) Urogynecology (Troy Center for Speciality Care)
The University of Michigan
Ann Arbor, Michigan
Community & Nonprofit Services
Creative Arts & Performance
Sports & Fitness
$136k - $209k/yr
On-Site
BLS Certification
10,000+

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Advanced Practice Nurse (Nurse Anesthetist)
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New 3h ago
Advanced Practice Nurse (Nurse Anesthetist)
US Department of Veterans Affairs
Omaha, Nebraska
Business Operations
Logistics & Fleet Management
Project Management
$195k - $284k/yr
On-Site
Doctoral degree
10,000+

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Tele-Psychiatric Advanced Practice Provider (O-5 Billet) Non-Supervisory
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New 3h ago
Tele-Psychiatric Advanced Practice Provider (O-5 Billet) Non-Supervisory
U.S. Immigration and Customs Enforcement
Salt Lake City, Utah
IT Support
Project Management
Technical Program Management
$1 - $150k/yr
On-Site
CPR Certification

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Lead Advanced Practice Provider - MICU and Rapid Response Full Time Rotating
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New 3h ago
Lead Advanced Practice Provider - MICU and Rapid Response Full Time Rotating
Northwestern Medicine
Chicago, Illinois
AI (Artificial Intelligence)
Data Science
ML (Machine Learning)
$67.73 - $88.45/hr
BLS Certification
10,000+

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Advanced Practice Provider - Nurse Practitioner or Physician Assistant
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New 3h ago
Advanced Practice Provider - Nurse Practitioner or Physician Assistant
Specialists in Pain Management dba: Spine & Pain Associates
Ooltewah, Tennessee
Allied Health
Healthcare Administration
Nursing
On-Site
Master's degree in nursing

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Lead Nurse Practitioner Job Market

Who's Hiring

  • Cleveland Clinic86
  • TeamHealth82
  • OSF HealthCare79
  • UNC Health71
  • SSM Health56

Top Industries Hiring

  • Healthcare & Medical Services449
  • Education101
  • Science & Research19
  • Non-Profit & Social Services15
  • Insurance11

What Employers Look For

The qualifications that appear most often in lead nurse practitioner jobs.

  • Active, unrestricted nurse practitioner license in the state of practice
  • Board certification from AANP or ANCC in a relevant specialty
  • Minimum of three to five years of clinical NP experience post-certification
  • Current DEA registration with prescriptive authority
  • Experience with electronic health records such as Epic or Cerner
  • Demonstrated experience in clinical leadership, staff supervision, or quality improvement

Tips for Your Lead Nurse Practitioner Job Search

Tailor your resume to leadership scope

Lead NP roles expect evidence of clinical oversight, protocol development, or staff mentorship. Quantify the size of the team you guided, the patient volume you managed, or the quality improvement initiatives you led rather than listing general clinical duties.

Highlight your state licensure and DEA registration

Many lead nurse practitioner postings screen by state before reviewing credentials. List every active NP license and your DEA registration near the top of your resume so hiring managers can confirm eligibility instantly without digging.

Target postings by practice setting, not just title

Lead NP responsibilities differ sharply between a federally qualified health center, a hospital-employed group, and a private specialty practice. Filter openings by setting first, then read each job description to match your clinical background and leadership style.

Apply early to roles that fit

Migrate Mate lists lead nurse practitioner openings from across the United States in one place, so you can find roles that match and apply directly to each listing.

Prepare for clinical scenario and leadership questions

Lead NP interviews often pair clinical case questions with situational leadership prompts. Practice walking through a time you resolved a scope-of-practice dispute, implemented a clinical protocol, or coached an underperforming provider before your first screening call.

Negotiate practice agreements and malpractice coverage

Before accepting an offer, confirm whether the role requires a collaborative or supervisory physician agreement in your state and ask who carries the malpractice policy. These details directly affect your clinical autonomy and are often negotiable at the offer stage.

Lead Nurse Practitioner Jobs: Frequently Asked Questions

Which companies are hiring the most lead nurse practitioners?

The most active employers for lead nurse practitioners right now are Cleveland Clinic, TeamHealth, and OSF HealthCare, and the most openings are in Florida, Texas, and North Carolina, based on current listings on Migrate Mate as of November 2026. Health systems and large multisite outpatient groups tend to post the most lead NP roles because they need clinical oversight across multiple locations.

How many lead nurse practitioner jobs are remote?

About 20% of lead nurse practitioner openings are fully remote or hybrid as of November 2026, though fully remote positions are most common in telehealth, utilization management, and clinical quality roles rather than direct patient care. Lead NPs in administrative or population health functions have the broadest access to remote arrangements.

How do you become a lead nurse practitioner?

Start by earning a Master of Science in Nursing or Doctor of Nursing Practice, then pass a national board certification exam through AANP or ANCC in your chosen specialty. Build several years of clinical NP experience, then actively seek out roles involving protocol development, peer mentorship, or quality improvement projects that demonstrate readiness for a lead position.

Can you get hired as a lead nurse practitioner with little experience?

Most lead NP postings require prior NP clinical experience, but you can strengthen a thinner clinical record by emphasizing any formal leadership experience, charge nurse roles, or quality improvement projects from your RN years. Smaller independent practices and federally qualified health centers sometimes offer lead titles to candidates who bring strong clinical skills and a willingness to take on administrative responsibility early.

What does the lead nurse practitioner interview process look like?

Most lead NP hiring processes include an initial phone screen with HR or a recruiter, followed by a panel interview with the medical director, nursing leadership, and sometimes a practice manager. Expect a combination of clinical scenario questions, behavioral leadership prompts, and a review of your approach to staff oversight or protocol development. Some employers also request a brief presentation on a quality improvement topic.

Where can I find and apply to lead nurse practitioner jobs?

You can find and apply to lead nurse practitioner jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your specialty, state licensure, and practice setting, then apply directly to each listing from the job page.

See All 3,742+ Lead Nurse Practitioner Jobs

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