NP Jobs in Mississippi
NP jobs in Mississippi are concentrated in primary care, rural health, and behavioral health settings, with demand anchored by a state that has among the highest rates of chronic disease and provider shortages in the country. Most hiring is centered in Jackson, Hattiesburg, and Gulfport, where large systems like University of Mississippi Medical Center, Ochsner Health, and Merit Health operate across inpatient and outpatient settings. Family practice, psychiatric-mental health, and acute care are the most consistently in-demand NP specialties across the state. See the openings below and apply to the ones that match your experience.
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- Practice at the top of your license with a high level of clinical autonomy.
- Build meaningful, long-term relationships with patients and families.
- Focus on quality of life, symptom management, and personalized care planning.
- Collaborate with physicians, home health, hospice, and interdisciplinary care teams.
- Help reduce avoidable hospitalizations through proactive, coordinated care.
- Competitive compensation and comprehensive benefits package.
- Opportunities for professional development and career growth.
- Conduct comprehensive in-home assessments, including physical, psychosocial, and functional evaluations.
- Develop, implement, and adjust individualized care plans focused on symptom management and quality of life.
- Evaluate and manage pain, shortness of breath, nausea, anxiety, fatigue, and other complex symptoms.
- Prescribe medications, order diagnostic testing, and provide clinical interventions within your scope of practice.
- Monitor patient progress and adjust treatment plans in collaboration with physicians and interdisciplinary partners.
- Participate in occasional on-call responsibilities as needed.
- Collaborate closely with physicians, specialists, home health, hospice, social workers, and other community partners.
- Facilitate referrals to hospice, home health, behavioral health, and community resources when appropriate.
- Coordinate care that supports patient goals while helping reduce unnecessary emergency department visits and hospitalizations.
- Communicate proactively with patients, caregivers, and referring providers to ensure continuity of care.
- Lead conversations around advance care planning, goals of care, and advance directives.
- Educate patients and families about disease progression, treatment options, symptom management, and available resources.
- Provide compassionate guidance and emotional support during complex healthcare decisions.
- Maintain accurate, timely documentation within the electronic medical record.
- Ensure compliance with clinical guidelines, regulatory requirements, collaborative practice agreements, and organizational policies.
- Participate in case conferences, quality improvement initiatives, and interdisciplinary team meetings.
- Master's or Doctoral degree from an accredited Nurse Practitioner program.
- Current Nurse Practitioner license in the state of practice.
- National certification through AANP or ANCC.
- Current BLS certification.
- Valid driver's license and reliable transportation for home visits.
- Strong clinical assessment, critical thinking, and communication skills.
- Ability to work independently while managing a mobile patient caseload.
- Experience in palliative care, hospice, geriatrics, internal medicine, family practice, or chronic disease management.
- Certification in Hospice and Palliative Care (ACHPN) or willingness to pursue certification.
- Experience conducting advance care planning and goals-of-care discussions.
- Proficiency with electronic medical records and mobile documentation platforms.
- Compassionate, empathetic, and relationship-driven.
- Comfortable caring for medically complex patients.
- Skilled in difficult conversations with patients and families.
- Confident practicing independently while collaborating with interdisciplinary teams.
- Passionate about improving quality of life and supporting patient-centered decision-making.
- Adaptable, organized, and committed to delivering exceptional care in the home setting.
See All 35 NP Jobs in Mississippi
Find roles in Mississippi that match your experience and apply in just a few clicks.
Find NP JobsNP Jobs by City in Mississippi
Where Mississippi roles are concentrated, by current openings.
NP Job Market in Mississippi
A snapshot from current Mississippi openings, updated as new roles post.
Who's Hiring


Top Industries Hiring
- Insurance
- Healthcare & Medical Services
What Mississippi Employers Look For
The qualifications that appear most often in NP jobs across Mississippi.
- Active Mississippi nurse practitioner license issued by the Mississippi Board of Nursing
- National certification from ANCC, AANP, or an equivalent recognized certifying body
- Current graduate degree in nursing, MSN or DNP, with an NP concentration
- Active DEA registration or eligibility to obtain one prior to start date
- Current BLS certification, with ACLS required for acute or emergency practice settings
- Experience with electronic health records, including Epic, Cerner, or similar platforms
NP Jobs in Mississippi: Frequently Asked Questions
How do you become a np in Mississippi?
To become an NP in Mississippi, you must hold an active registered nurse license, complete an accredited graduate NP program at the MSN or DNP level, and pass a national certification exam through ANCC or AANP. You then apply for advanced practice licensure through the Mississippi Board of Nursing, which also requires a collaborating physician agreement under Mississippi's collaborative practice law. A DEA registration is required for prescriptive authority.
Which companies hire nps in Mississippi?
Companies currently hiring nps in Mississippi include Clear Choice Global Support Solutions, Optum, and Baptist Memorial Health Care, per current listings on Migrate Mate as of October 2026. Mississippi's largest health systems, federally qualified health centers, and rural health clinic networks are the most consistent sources of NP openings across the state.
Which Mississippi cities have the most np jobs?
Gulfport, Jackson, and Madison have the most NP openings in Mississippi. Jackson leads because it anchors the state's largest academic medical center and regional hospital network, while Hattiesburg and Gulfport draw volume from their own major health systems serving South Mississippi's coastal and inland communities.
Are there remote np jobs in Mississippi?
Yes, but they're rare. NP roles are predominantly clinical and require in-person patient contact, so fully remote positions are a small fraction of total openings. About 46% of np openings tied to Mississippi are remote or hybrid as of October 2026, and those positions are most often in telemedicine, behavioral health, or utilization review rather than direct primary care.
How can I get hired as a np in Mississippi with little or no experience?
The most realistic entry path is applying directly to new-graduate NP programs at large Mississippi health systems, particularly University of Mississippi Medical Center and Ochsner Health, both of which onboard new NPs through structured transition-to-practice programs. Federally qualified health centers and rural health clinics across Mississippi often prefer to hire new graduates who are willing to work in underserved areas and provide supervision support. Holding an active Mississippi NP license with prescriptive authority and a completed national certification exam before applying gives candidates a clear edge over those still pending credentialing.
Where can I find and apply to np jobs in Mississippi?
You can find and apply to NP jobs in Mississippi on Migrate Mate, which lists current Mississippi openings from employers actively hiring. Search the listings to find roles that match your specialty, experience level, and preferred location, then apply directly to the ones that fit.
See All 35 NP Jobs in Mississippi
Find roles in Mississippi that match your experience and apply in just a few clicks.
Find NP Jobs