Principal Engineer Jobs in Ohio
Principal Engineer jobs in Ohio are open across Columbus, Cincinnati, and Cleveland and other Ohio metros, with employers like American Electric Power, Geosyntec Consultants, and Arcadis hiring at every experience level. Find a role that fits below and apply directly.
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INTRODUCTION
We are seeking a highly experienced and technically accomplished Principal Engineer to serve as the technical leader for Oral Solid Dosage (OSD) platform within our Manufacturing Science & Technology (MSAT) organization.
This role will lead the site’s OSD commercial manufacturing technical support activities, technology transfers, and continuous improvement initiatives. The Principal Engineer will be responsible for solving complex technical challenges, strengthening process understanding, and ensuring robust, compliant, and efficient manufacturing processes.
This position is designed for a deep technical expert who thrives in solving complex problems, influencing cross-functional teams, and driving meaningful improvements in cost, yield, and product quality.
Why join Team Alkermes?
Alkermes applies its decades of deep neuroscience expertise to develop medicines designed to help people living with complex and difficult-to-treat psychiatric and neurological disorders. A global biopharmaceutical company, headquartered in Ireland with U.S. locations in Massachusetts and Ohio, we seek to make a meaningful difference in the way people manage their diseases. We have a portfolio of proprietary commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy, and a pipeline of clinical and preclinical candidates in development for various psychiatric and neurological disorders.
We are proud to have been recognized as an employer of choice by many national organizations. In 2024 and 2025, we were certified as a Great Place to Work in the U.S. and named one of Massachusetts’ Top Places to Work by the Boston Globe, a Best Place to Work in Greater Cincinnati by the Cincinnati Business Courier and recognized as a Best Place to Work in BioPharma by Fortune Magazine.
BASIC QUALIFICATIONS
- Bachelor's Degree
Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any qualified applicant or employee because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other characteristic protected by local, state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.
See All 42 Principal Engineer Jobs in Ohio
Find roles in Ohio that match your experience and apply in just a few clicks.
Find Principal Engineer JobsPrincipal Engineer Jobs by City in Ohio
Where Ohio roles are concentrated, by current openings.
Principal Engineer Job Market in Ohio
A snapshot from current Ohio openings, updated as new roles post.
Who's Hiring
- American Electric Power8

- Geosyntec Consultants4

- Arcadis3

- Medpace3

- CVS Health2

Top Industries Hiring
- Energy9
- Consulting & Professional Services7
- Technology & Software7
- Banking & Financial Services4
- Healthcare & Medical Services4
What Ohio Employers Look For
The qualifications that appear most often in principal engineer jobs across Ohio.
- 10 or more years of software engineering experience with 3 or more years in a senior technical leadership role
- Deep expertise in distributed systems, microservices architecture, or large-scale platform design
- Proficiency in at least one primary language such as Java, Python, Go, or C++ at production scale
- Experience defining technical roadmaps, engineering standards, and cross-team architectural direction
- Strong background in cloud infrastructure on AWS, Azure, or Google Cloud including networking and reliability patterns
- Bachelor's or master's degree in computer science, software engineering, or a closely related field
Principal Engineer Jobs in Ohio: Frequently Asked Questions
How many principal engineer jobs are there in Ohio?
There are 42+ principal engineer openings in Ohio on Migrate Mate as of June 2026, with the most roles in Columbus, Cincinnati, and Cleveland. New positions post regularly as employers across Ohio hire.
Which Ohio cities have the most principal engineer jobs?
Columbus, Cincinnati, and Cleveland have the most principal engineer openings in Ohio right now, with additional roles spread across smaller metros statewide.
Which companies hire principal engineers in Ohio?
Employers hiring principal engineers in Ohio include American Electric Power, Geosyntec Consultants, and Arcadis, based on current listings on Migrate Mate as of June 2026.
Are there remote principal engineer jobs in Ohio?
Yes. About 17% of principal engineer openings tied to Ohio are remote or hybrid as of June 2026. The rest are on-site roles based in Ohio metros.
How do I apply for principal engineer jobs in Ohio?
You can apply to principal engineer jobs in Ohio directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Ohio location, then apply to each one that fits.
See All 42 Principal Engineer Jobs in Ohio
Find roles in Ohio that match your experience and apply in just a few clicks.
Find Principal Engineer Jobs