Risk Management Director Jobs in Pennsylvania
Risk Management Director jobs in Pennsylvania are in steady demand, concentrated in financial services, healthcare, insurance, and energy sectors, with openings at every level from newly promoted directors to senior enterprise risk leaders. Philadelphia, Pittsburgh, and Harrisburg are the primary hiring hubs, anchored by large employers such as Comcast, UPMC, and The Hartford, which maintain significant Pennsylvania operations and consistently recruit for risk management leadership. The most in-demand specialties include enterprise risk management, operational risk, and compliance-driven risk oversight. Find a role that fits below and apply directly.
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About the Position
Cabaletta Bio is seeking a Director, Enterprise Risk Management to establish and lead the company's enterprise risk management (ERM) program as we advance toward BLA submission and commercial launch. Reporting to the Chief Compliance Officer, this role will build a structured, company-wide approach to identifying, assessing, mitigating, and monitoring risk across clinical, regulatory, quality, and commercial operations. A core focus of the role is quality risk management across the product lifecycle, including risk-based oversight of the company's external manufacturing network of three CDMOs, ensuring the risk management framework scales with the organization as it prepares for its first product launch.
This is a highly visible, cross-functional role suited to someone who can stand up a program from the ground floor, engage executive leadership and functional heads, and translate risk insights into practical, prioritized action.
Responsibilities Include
Enterprise Risk Management
- Design, implement, and lead the enterprise risk management framework, including governance structure, risk taxonomy, risk appetite statements, and escalation pathways
- Facilitate periodic enterprise risk assessments with executive leadership and functional owners; maintain the corporate risk register and heat maps
- Partner with functional leaders (Clinical, Regulatory, Quality, CMC, Commercial, IT, Finance, Legal) to identify emerging risks, define mitigation plans, and track remediation to closure
- Develop and deliver risk reporting to the executive team and, as appropriate, the Board or Board committees
- Integrate risk management with related programs, including quality risk management (ICH Q9 principles), business continuity, third-party/vendor risk, and inspection readiness
- Monitor the external environment (regulatory enforcement trends, industry events, evolving guidance) and translate implications into the risk program
Quality Risk Management & External Manufacturing Oversight
- Lead the application of quality risk management principles (ICH Q9(R1)) across the product lifecycle, including risk assessments supporting manufacturing, supply chain, and quality operations
- Establish and maintain a risk-based framework for oversight of the company's external manufacturing network, including three CDMOs, spanning vendor risk assessments, ongoing risk monitoring, and periodic risk reviews
- Partner with CMC, Quality, and Supply Chain to assess and manage risks associated with CDMO performance, including deviations, change control, capacity, technology transfer, comparability, and business continuity
- Integrate CDMO and third-party risk into the corporate risk register with clear ownership, mitigation plans, and escalation criteria; ensure risk considerations are reflected in quality agreements and governance forums (e.g., joint steering committees, quality business reviews)
- Support risk-based prioritization of vendor audits and person-in-plant or oversight activities in partnership with GxP Quality Audit
- Ensure risk documentation supporting external manufacturing is inspection-ready and aligned with BLA submission expectations
Program Leadership
- Serve as a trusted advisor to the CCO and functional leadership on risk matters
- Contribute to inspection readiness and BLA-related activities where risk management documentation and governance are in scope
- Build scalable tools, templates, and processes appropriate for a clinical-stage company transitioning to commercial operations
- Potential to build and manage a small team as the function grows
Required Qualifications
- Bachelor's degree in life sciences, business, finance, or related field
- 10+ years of progressive experience in the biopharmaceutical industry, with significant experience in enterprise risk management and quality risk management
- Demonstrated experience designing or leading an ERM program (framework development, risk assessments, risk registers, executive reporting)
- Hands-on experience applying quality risk management (ICH Q9) in a GxP environment, including risk assessments supporting external/contract manufacturing
- Experience managing or overseeing risk across multiple CDMOs or contract manufacturing partners, including vendor risk assessment and governance
- Experience supporting or operating within a pre-launch or newly commercial organization
- Strong facilitation, analytical, and communication skills; able to engage credibly with executives and functional experts alike
- Comfort with ambiguity and a hands-on, roll-up-your-sleeves orientation appropriate for a clinical-stage company
Preferred Qualifications
- Advanced degree (MBA, MS) or relevant certification (e.g., CRMP, ARM, CQA)
- Experience in cell and gene therapy, rare disease, or other specialty/complex products
- Experience with cell therapy or viral vector external manufacturing networks and associated supply chain risk
- Experience presenting to boards or board committees
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
About the Position
Cabaletta Bio is seeking a Director, Enterprise Risk Management to establish and lead the company's enterprise risk management (ERM) program as we advance toward BLA submission and commercial launch. Reporting to the Chief Compliance Officer, this role will build a structured, company-wide approach to identifying, assessing, mitigating, and monitoring risk across clinical, regulatory, quality, and commercial operations. A core focus of the role is quality risk management across the product lifecycle, including risk-based oversight of the company's external manufacturing network of three CDMOs, ensuring the risk management framework scales with the organization as it prepares for its first product launch.
This is a highly visible, cross-functional role suited to someone who can stand up a program from the ground floor, engage executive leadership and functional heads, and translate risk insights into practical, prioritized action.
Responsibilities Include
Enterprise Risk Management
- Design, implement, and lead the enterprise risk management framework, including governance structure, risk taxonomy, risk appetite statements, and escalation pathways
- Facilitate periodic enterprise risk assessments with executive leadership and functional owners; maintain the corporate risk register and heat maps
- Partner with functional leaders (Clinical, Regulatory, Quality, CMC, Commercial, IT, Finance, Legal) to identify emerging risks, define mitigation plans, and track remediation to closure
- Develop and deliver risk reporting to the executive team and, as appropriate, the Board or Board committees
- Integrate risk management with related programs, including quality risk management (ICH Q9 principles), business continuity, third-party/vendor risk, and inspection readiness
- Monitor the external environment (regulatory enforcement trends, industry events, evolving guidance) and translate implications into the risk program
Quality Risk Management & External Manufacturing Oversight
- Lead the application of quality risk management principles (ICH Q9(R1)) across the product lifecycle, including risk assessments supporting manufacturing, supply chain, and quality operations
- Establish and maintain a risk-based framework for oversight of the company's external manufacturing network, including three CDMOs, spanning vendor risk assessments, ongoing risk monitoring, and periodic risk reviews
- Partner with CMC, Quality, and Supply Chain to assess and manage risks associated with CDMO performance, including deviations, change control, capacity, technology transfer, comparability, and business continuity
- Integrate CDMO and third-party risk into the corporate risk register with clear ownership, mitigation plans, and escalation criteria; ensure risk considerations are reflected in quality agreements and governance forums (e.g., joint steering committees, quality business reviews)
- Support risk-based prioritization of vendor audits and person-in-plant or oversight activities in partnership with GxP Quality Audit
- Ensure risk documentation supporting external manufacturing is inspection-ready and aligned with BLA submission expectations
Program Leadership
- Serve as a trusted advisor to the CCO and functional leadership on risk matters
- Contribute to inspection readiness and BLA-related activities where risk management documentation and governance are in scope
- Build scalable tools, templates, and processes appropriate for a clinical-stage company transitioning to commercial operations
- Potential to build and manage a small team as the function grows
Required Qualifications
- Bachelor's degree in life sciences, business, finance, or related field
- 10+ years of progressive experience in the biopharmaceutical industry, with significant experience in enterprise risk management and quality risk management
- Demonstrated experience designing or leading an ERM program (framework development, risk assessments, risk registers, executive reporting)
- Hands-on experience applying quality risk management (ICH Q9) in a GxP environment, including risk assessments supporting external/contract manufacturing
- Experience managing or overseeing risk across multiple CDMOs or contract manufacturing partners, including vendor risk assessment and governance
- Experience supporting or operating within a pre-launch or newly commercial organization
- Strong facilitation, analytical, and communication skills; able to engage credibly with executives and functional experts alike
- Comfort with ambiguity and a hands-on, roll-up-your-sleeves orientation appropriate for a clinical-stage company
Preferred Qualifications
- Advanced degree (MBA, MS) or relevant certification (e.g., CRMP, ARM, CQA)
- Experience in cell and gene therapy, rare disease, or other specialty/complex products
- Experience with cell therapy or viral vector external manufacturing networks and associated supply chain risk
- Experience presenting to boards or board committees
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
See All 22 Risk Management Director Jobs in Pennsylvania
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Find Risk Management Director JobsRisk Management Director Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Risk Management Director Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Energy
- Science & Research
- Agriculture & Farming
- Technology & Software
What Pennsylvania Employers Look For
The qualifications that appear most often in risk management director jobs across Pennsylvania.
- Bachelor's degree in finance, business administration, or a related field required
- Professional certification such as CRM, FRM, or ARM strongly preferred by Pennsylvania employers
- Minimum of seven to ten years of progressive risk management experience in a relevant industry
- Demonstrated leadership experience managing risk teams and presenting to executive stakeholders
- Deep knowledge of regulatory frameworks common to Pennsylvania's financial, healthcare, or energy sectors
- Strong analytical skills with proficiency in enterprise risk management platforms and reporting tools
Risk Management Director Jobs in Pennsylvania: Frequently Asked Questions
How do you become a risk management director in Pennsylvania?
Becoming a risk management director in Pennsylvania typically starts with a bachelor's degree in finance, business, or a related field, followed by progressive experience in risk analysis or compliance roles. Pennsylvania does not require a state-issued license specific to this role, but employers strongly favor credentials such as the Certified Risk Manager designation or the Financial Risk Manager certification. Most candidates move into director-level positions after building expertise within financial services, healthcare systems, or insurance carriers operating in the state.
How much do risk management directors make in Pennsylvania?
Risk management directors in Pennsylvania earn a median of about $103,040 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $64,700 for the lowest 10% to over $172,820 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire risk management directors in Pennsylvania?
Employers hiring risk management directors in Pennsylvania right now include Chubb Insurance, PNC Financial Services, and BNY, based on current listings on Migrate Mate as of August 2026. Pennsylvania's concentration of major insurance carriers, integrated health systems, and Fortune 500 headquarters makes it one of the more consistent states for director-level risk hiring year-round.
Which Pennsylvania cities have the most risk management director jobs?
Pittsburgh, Philadelphia, and Pennsylvania account for the largest share of risk management director openings in Pennsylvania. Philadelphia drives the most volume, fueled by its dense cluster of financial institutions, insurance companies, and large hospital networks, while Pittsburgh's strength in healthcare and energy draws steady demand, and Harrisburg's role as the state capital brings in government-adjacent risk and compliance positions.
Are there remote risk management director jobs in Pennsylvania?
Yes, and more than many senior leadership roles, since risk management director work centers on analysis, reporting, and stakeholder communication rather than physical site presence. About 71% of risk management director openings tied to Pennsylvania are remote or hybrid as of August 2026, reflecting broader flexibility in financial and analytical leadership functions. Enterprise risk and compliance-focused roles tend to offer the most remote flexibility, while operational or site-specific risk positions lean toward in-person or hybrid arrangements.
How can I get hired as a risk management director in Pennsylvania with little or no experience?
The most realistic entry path is moving into a risk analyst or compliance analyst role first, then building toward director level over time. Large Pennsylvania employers such as UPMC, Lincoln Financial Group, and Cigna regularly recruit for risk analyst and internal audit positions that serve as structured pipelines into leadership. Earning an entry-level credential such as the Associate in Risk Management while working in adjacent roles like financial analysis, insurance underwriting, or regulatory compliance strengthens a candidate's profile considerably before stepping into a director position.
Where can I find and apply to risk management director jobs in Pennsylvania?
You can find and apply to risk management director jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings updated regularly. Search the available roles, find the ones that match your experience and target industry, and apply directly to each position that fits.
See All 22 Risk Management Director Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
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