Risk Management Specialist Jobs in Pennsylvania
Risk Management Specialist jobs in Pennsylvania are in steady demand, concentrated in financial services, insurance, healthcare, and higher education, with openings at every level from entry-level analyst to senior enterprise risk officer. Philadelphia, Pittsburgh, and Harrisburg are the primary hiring centers, home to major employers like Comcast, UPMC, and Lincoln Financial Group, all of which maintain active risk functions. The most sought-after specialties in Pennsylvania listings include enterprise risk management, insurance and liability analysis, and regulatory compliance. Find a role that fits below and apply directly.
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Showing 5 of 22+ Risk Management Specialist jobs
About the Position
Cabaletta Bio is seeking a Director, Enterprise Risk Management to establish and lead the company's enterprise risk management (ERM) program as we advance toward BLA submission and commercial launch. Reporting to the Chief Compliance Officer, this role will build a structured, company-wide approach to identifying, assessing, mitigating, and monitoring risk across clinical, regulatory, quality, and commercial operations. A core focus of the role is quality risk management across the product lifecycle, including risk-based oversight of the company's external manufacturing network of three CDMOs, ensuring the risk management framework scales with the organization as it prepares for its first product launch.
This is a highly visible, cross-functional role suited to someone who can stand up a program from the ground floor, engage executive leadership and functional heads, and translate risk insights into practical, prioritized action.
Responsibilities Include
Enterprise Risk Management
- Design, implement, and lead the enterprise risk management framework, including governance structure, risk taxonomy, risk appetite statements, and escalation pathways
- Facilitate periodic enterprise risk assessments with executive leadership and functional owners; maintain the corporate risk register and heat maps
- Partner with functional leaders (Clinical, Regulatory, Quality, CMC, Commercial, IT, Finance, Legal) to identify emerging risks, define mitigation plans, and track remediation to closure
- Develop and deliver risk reporting to the executive team and, as appropriate, the Board or Board committees
- Integrate risk management with related programs, including quality risk management (ICH Q9 principles), business continuity, third-party/vendor risk, and inspection readiness
- Monitor the external environment (regulatory enforcement trends, industry events, evolving guidance) and translate implications into the risk program
Quality Risk Management & External Manufacturing Oversight
- Lead the application of quality risk management principles (ICH Q9(R1)) across the product lifecycle, including risk assessments supporting manufacturing, supply chain, and quality operations
- Establish and maintain a risk-based framework for oversight of the company's external manufacturing network, including three CDMOs, spanning vendor risk assessments, ongoing risk monitoring, and periodic risk reviews
- Partner with CMC, Quality, and Supply Chain to assess and manage risks associated with CDMO performance, including deviations, change control, capacity, technology transfer, comparability, and business continuity
- Integrate CDMO and third-party risk into the corporate risk register with clear ownership, mitigation plans, and escalation criteria; ensure risk considerations are reflected in quality agreements and governance forums (e.g., joint steering committees, quality business reviews)
- Support risk-based prioritization of vendor audits and person-in-plant or oversight activities in partnership with GxP Quality Audit
- Ensure risk documentation supporting external manufacturing is inspection-ready and aligned with BLA submission expectations
Program Leadership
- Serve as a trusted advisor to the CCO and functional leadership on risk matters
- Contribute to inspection readiness and BLA-related activities where risk management documentation and governance are in scope
- Build scalable tools, templates, and processes appropriate for a clinical-stage company transitioning to commercial operations
- Potential to build and manage a small team as the function grows
Required Qualifications
- Bachelor's degree in life sciences, business, finance, or related field
- 10+ years of progressive experience in the biopharmaceutical industry, with significant experience in enterprise risk management and quality risk management
- Demonstrated experience designing or leading an ERM program (framework development, risk assessments, risk registers, executive reporting)
- Hands-on experience applying quality risk management (ICH Q9) in a GxP environment, including risk assessments supporting external/contract manufacturing
- Experience managing or overseeing risk across multiple CDMOs or contract manufacturing partners, including vendor risk assessment and governance
- Experience supporting or operating within a pre-launch or newly commercial organization
- Strong facilitation, analytical, and communication skills; able to engage credibly with executives and functional experts alike
- Comfort with ambiguity and a hands-on, roll-up-your-sleeves orientation appropriate for a clinical-stage company
Preferred Qualifications
- Advanced degree (MBA, MS) or relevant certification (e.g., CRMP, ARM, CQA)
- Experience in cell and gene therapy, rare disease, or other specialty/complex products
- Experience with cell therapy or viral vector external manufacturing networks and associated supply chain risk
- Experience presenting to boards or board committees
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
About the Position
Cabaletta Bio is seeking a Director, Enterprise Risk Management to establish and lead the company's enterprise risk management (ERM) program as we advance toward BLA submission and commercial launch. Reporting to the Chief Compliance Officer, this role will build a structured, company-wide approach to identifying, assessing, mitigating, and monitoring risk across clinical, regulatory, quality, and commercial operations. A core focus of the role is quality risk management across the product lifecycle, including risk-based oversight of the company's external manufacturing network of three CDMOs, ensuring the risk management framework scales with the organization as it prepares for its first product launch.
This is a highly visible, cross-functional role suited to someone who can stand up a program from the ground floor, engage executive leadership and functional heads, and translate risk insights into practical, prioritized action.
Responsibilities Include
Enterprise Risk Management
- Design, implement, and lead the enterprise risk management framework, including governance structure, risk taxonomy, risk appetite statements, and escalation pathways
- Facilitate periodic enterprise risk assessments with executive leadership and functional owners; maintain the corporate risk register and heat maps
- Partner with functional leaders (Clinical, Regulatory, Quality, CMC, Commercial, IT, Finance, Legal) to identify emerging risks, define mitigation plans, and track remediation to closure
- Develop and deliver risk reporting to the executive team and, as appropriate, the Board or Board committees
- Integrate risk management with related programs, including quality risk management (ICH Q9 principles), business continuity, third-party/vendor risk, and inspection readiness
- Monitor the external environment (regulatory enforcement trends, industry events, evolving guidance) and translate implications into the risk program
Quality Risk Management & External Manufacturing Oversight
- Lead the application of quality risk management principles (ICH Q9(R1)) across the product lifecycle, including risk assessments supporting manufacturing, supply chain, and quality operations
- Establish and maintain a risk-based framework for oversight of the company's external manufacturing network, including three CDMOs, spanning vendor risk assessments, ongoing risk monitoring, and periodic risk reviews
- Partner with CMC, Quality, and Supply Chain to assess and manage risks associated with CDMO performance, including deviations, change control, capacity, technology transfer, comparability, and business continuity
- Integrate CDMO and third-party risk into the corporate risk register with clear ownership, mitigation plans, and escalation criteria; ensure risk considerations are reflected in quality agreements and governance forums (e.g., joint steering committees, quality business reviews)
- Support risk-based prioritization of vendor audits and person-in-plant or oversight activities in partnership with GxP Quality Audit
- Ensure risk documentation supporting external manufacturing is inspection-ready and aligned with BLA submission expectations
Program Leadership
- Serve as a trusted advisor to the CCO and functional leadership on risk matters
- Contribute to inspection readiness and BLA-related activities where risk management documentation and governance are in scope
- Build scalable tools, templates, and processes appropriate for a clinical-stage company transitioning to commercial operations
- Potential to build and manage a small team as the function grows
Required Qualifications
- Bachelor's degree in life sciences, business, finance, or related field
- 10+ years of progressive experience in the biopharmaceutical industry, with significant experience in enterprise risk management and quality risk management
- Demonstrated experience designing or leading an ERM program (framework development, risk assessments, risk registers, executive reporting)
- Hands-on experience applying quality risk management (ICH Q9) in a GxP environment, including risk assessments supporting external/contract manufacturing
- Experience managing or overseeing risk across multiple CDMOs or contract manufacturing partners, including vendor risk assessment and governance
- Experience supporting or operating within a pre-launch or newly commercial organization
- Strong facilitation, analytical, and communication skills; able to engage credibly with executives and functional experts alike
- Comfort with ambiguity and a hands-on, roll-up-your-sleeves orientation appropriate for a clinical-stage company
Preferred Qualifications
- Advanced degree (MBA, MS) or relevant certification (e.g., CRMP, ARM, CQA)
- Experience in cell and gene therapy, rare disease, or other specialty/complex products
- Experience with cell therapy or viral vector external manufacturing networks and associated supply chain risk
- Experience presenting to boards or board committees
How to Apply
Please click the link at the bottom of the posting to submit an application.
Benefits
Our most important asset is our people and we offer competitive benefits including health and retirement, PTO, and stock option plans.
Equal Opportunity Employer
Cabaletta Bio is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability, protected veteran status or any other basis protected by applicable law.
See All 22 Risk Management Specialist Jobs in Pennsylvania
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Find JobsRisk Management Specialist Jobs by City in Pennsylvania
Where Pennsylvania roles are concentrated, by current openings.
Risk Management Specialist Job Market in Pennsylvania
A snapshot from current Pennsylvania openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Energy
- Science & Research
- Agriculture & Farming
- Technology & Software
What Pennsylvania Employers Look For
The qualifications that appear most often in risk management specialist jobs across Pennsylvania.
- Bachelor's degree in finance, business, or a related field required by most Pennsylvania employers
- Professional certification such as ARM, CRISC, or CRM strongly preferred in Pennsylvania listings
- Three or more years of risk assessment or compliance experience in financial services or insurance
- Proficiency with enterprise risk management software and risk reporting frameworks like COSO or ISO 31000
- Strong analytical skills with experience building risk models and presenting findings to leadership
- Familiarity with Pennsylvania insurance regulations and state-specific compliance requirements preferred
Risk Management Specialist Jobs in Pennsylvania: Frequently Asked Questions
How do you become a risk management specialist in Pennsylvania?
Most Pennsylvania employers require a bachelor's degree in finance, business administration, risk management, or a related field as the foundation. While Pennsylvania does not issue a state license specific to risk management specialists, employers strongly favor candidates holding the Associate in Risk Management (ARM) credential issued by The Institutes, which is headquartered in Malvern, Pennsylvania. Building experience in insurance, compliance, or financial analysis roles in Philadelphia or Pittsburgh anchors most career paths into the specialty.
How much do risk management specialists make in Pennsylvania?
Risk management specialists in Pennsylvania earn a median of about $103,040 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $64,700 for the lowest 10% to over $172,820 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire risk management specialists in Pennsylvania?
Employers hiring risk management specialists in Pennsylvania right now include Chubb Insurance, PNC Financial Services, and BNY, based on current listings on Migrate Mate as of August 2026. Pennsylvania's concentration of large insurers, regional banks, health systems, and Fortune 500 headquarters in the Philadelphia and Pittsburgh corridors makes it one of the more consistent markets for this role.
Which Pennsylvania cities have the most risk management specialist jobs?
Pittsburgh, Philadelphia, and Pennsylvania lead Pennsylvania for risk management specialist openings. Philadelphia dominates because of its dense cluster of insurance carriers, asset managers, and large health systems, while Pittsburgh draws risk talent into its healthcare, technology, and financial services sectors, and Harrisburg openings are driven largely by state government agencies and regulated utilities that maintain formal risk management functions.
Are there remote risk management specialist jobs in Pennsylvania?
Yes, and more than most fields, since risk management is primarily an analytical and advisory function that translates well to remote work. About 71% of risk management specialist openings tied to Pennsylvania are remote or hybrid as of August 2026, reflecting the desk-based nature of most of the work. Roles focused on enterprise risk reporting, vendor risk assessment, and compliance monitoring are the most likely to be fully remote.
How can I get hired as a risk management specialist in Pennsylvania with little or no experience?
The most realistic entry path is through an insurance analyst, compliance associate, or internal audit role at a Pennsylvania employer, then moving laterally once you have exposure to risk frameworks. UPMC, Lincoln Financial Group, and Independence Blue Cross each hire entry-level analysts and rotational program associates who work alongside risk teams. Completing the ARM designation through The Institutes in Malvern while working in an adjacent role signals commitment and gives candidates a concrete credential edge without prior specialist experience.
Where can I find and apply to risk management specialist jobs in Pennsylvania?
You can find and apply to risk management specialist jobs in Pennsylvania on Migrate Mate, which lists current Pennsylvania openings across industries and experience levels. Find a role that fits and apply directly.
See All 22 Risk Management Specialist Jobs in Pennsylvania
Find roles in Pennsylvania that match your experience and apply in just a few clicks.
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