Senior Full Stack Engineer Jobs in Missouri
Senior Full Stack Engineer jobs in Missouri are in steady demand, with the strongest concentration in financial technology, healthcare IT, and enterprise software sectors that anchor the state's tech economy. Kansas City and St. Louis drive the most hiring, with Leawood-based Garmin, Emerson Electric, and Mastercard's technology operations among the established Missouri employers consistently seeking engineers at this level. Cloud architecture, React and Node.js development, and API integration are the specialties appearing most often in active postings. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 13+ Senior Full Stack Engineer jobs
#LI-Remote
- Lead the design and delivery of secure, high-performance Java microservices and cloud-native applications on Google Cloud Platform to power critical patient care experiences.
- Build modern, responsive front-end user interfaces using Next.js, React, and TypeScript to ensure intuitive digital journeys for clinicians and patients.
- Design, deploy, and manage scalable RESTful APIs and distributed systems following strict test-driven development and architectural best practices.
- Conduct thorough code reviews and enforce automated unit testing to guarantee platform security, high availability, and code quality.
- Mentor junior engineers through paired programming and design discussions to foster technical growth and engineering excellence across the team.
- High school diploma/GED with 2 years of experience, or Associate's degree, or Bachelor's degree required.
- 1 year of experience required.
- 4 years of experience preferred.
- 2 years of leadership or management experience preferred.
- 5 years of professional fullstack software development experience building cloud-native applications in an Agile environment.
- Expert-level proficiency in Java and Spring Boot paired with strong hands-on experience in Next.js or React.js, JavaScript, and TypeScript.
- Documented experience building microservices and managing cloud infrastructure within Google Cloud Platform (GCP).
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process. Our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
E-Verify statement
Benefits:
Various health insurance options & wellness plans
Retirement benefits including employer match plans
Long-term & short-term disability
Employee assistance programs (EAP)
Parental leave & adoption assistance
Tuition reimbursement
Ways to give back to your community
Benefit options and eligibility vary by position. Compensation varies based on factors including, but not limited to, experience, skills, education, performance, location and salary range at the time of the offer.
#LI-Remote
- Lead the design and delivery of secure, high-performance Java microservices and cloud-native applications on Google Cloud Platform to power critical patient care experiences.
- Build modern, responsive front-end user interfaces using Next.js, React, and TypeScript to ensure intuitive digital journeys for clinicians and patients.
- Design, deploy, and manage scalable RESTful APIs and distributed systems following strict test-driven development and architectural best practices.
- Conduct thorough code reviews and enforce automated unit testing to guarantee platform security, high availability, and code quality.
- Mentor junior engineers through paired programming and design discussions to foster technical growth and engineering excellence across the team.
- High school diploma/GED with 2 years of experience, or Associate's degree, or Bachelor's degree required.
- 1 year of experience required.
- 4 years of experience preferred.
- 2 years of leadership or management experience preferred.
- 5 years of professional fullstack software development experience building cloud-native applications in an Agile environment.
- Expert-level proficiency in Java and Spring Boot paired with strong hands-on experience in Next.js or React.js, JavaScript, and TypeScript.
- Documented experience building microservices and managing cloud infrastructure within Google Cloud Platform (GCP).
Equal employment opportunity employer
Ascension provides Equal Employment Opportunities (EEO) to all associates and applicants for employment without regard to race, color, religion, sex/gender, sexual orientation, gender identity or expression, pregnancy, childbirth, and related medical conditions, lactation, breastfeeding, national origin, citizenship, age, disability, genetic information, veteran status, marital status, all as defined by applicable law, and any other legally protected status or characteristic in accordance with applicable federal, state and local laws. For further information, view the EEO Know Your Rights (English) poster or EEO Know Your Rights (Spanish) poster.
Fraud prevention notice
Prospective applicants should be vigilant against fraudulent job offers and interview requests. Scammers may use sophisticated tactics to impersonate Ascension employees. To ensure your safety, please remember: Ascension will never ask for payment or to provide banking or financial information as part of the job application or hiring process. Our legitimate email communications will always come from an @ascension.org email address; do not trust other domains, and an official offer will only be extended to candidates who have completed a job application through our authorized applicant tracking system.
E-Verify statement
Benefits:
Various health insurance options & wellness plans
Retirement benefits including employer match plans
Long-term & short-term disability
Employee assistance programs (EAP)
Parental leave & adoption assistance
Tuition reimbursement
Ways to give back to your community
Benefit options and eligibility vary by position. Compensation varies based on factors including, but not limited to, experience, skills, education, performance, location and salary range at the time of the offer.
See All 13 Senior Full Stack Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find JobsSenior Full Stack Engineer Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Senior Full Stack Engineer Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Technology & Software
- Banking & Financial Services
- Consulting & Professional Services
What Missouri Employers Look For
The qualifications that appear most often in senior full stack engineer jobs across Missouri.
- 5+ years of professional full stack development experience with proven technical leadership
- Proficiency in at least one modern frontend framework such as React, Angular, or Vue
- Strong backend experience in Node.js, Java, Python, or a comparable server-side language
- Experience designing and maintaining cloud infrastructure on AWS, Azure, or Google Cloud
- Demonstrated ability to architect scalable systems and mentor junior engineering team members
- Bachelor's degree in Computer Science, Software Engineering, or a closely related technical field
Senior Full Stack Engineer Jobs in Missouri: Frequently Asked Questions
How do you become a senior full stack engineer in Missouri?
Senior full stack engineer roles in Missouri require no state-issued license or registration, so the path runs through education and experience. Most hiring managers expect a bachelor's degree in Computer Science, Software Engineering, or a related field, though strong candidates with associate degrees and substantial project portfolios do get hired. Missouri employers like Cerner, Edward Jones, and Garmin typically promote from mid-level roles after engineers demonstrate leadership and end-to-end ownership of complex systems.
How much do senior full stack engineers make in Missouri?
Senior full stack engineers in Missouri earn a median of about $126,120 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $72,570 for the lowest 10% to over $169,340 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior full stack engineers in Missouri?
Missouri senior full stack engineer roles are posted by Equifax, Infosys, and Ascension and others right now, based on current listings on Migrate Mate as of August 2026. Missouri's mix of Fortune 500 headquarters, large healthcare IT firms, and growing fintech companies creates consistent demand for experienced full stack engineers across both Kansas City and St. Louis metro areas.
Which Missouri cities have the most senior full stack engineer jobs?
St. Louis, Mexico, and O'Fallon have the most senior full stack engineer openings in Missouri. Kansas City leads because of its dense fintech and healthcare technology sector, anchored by large employers including Garmin, H&R Block, and Children's Mercy, while St. Louis draws demand from Emerson Electric, Mastercard's technology hub, and a cluster of healthcare IT and logistics technology companies concentrated in the metro.
Are there remote senior full stack engineer jobs in Missouri?
Yes, and more than most fields. About 75% of senior full stack engineer openings tied to Missouri are remote or hybrid as of August 2026, reflecting how naturally the work adapts to distributed teams. Frontend development, API design, and cloud infrastructure work are the areas where remote arrangements appear most often in Missouri postings.
How can I get hired as a senior full stack engineer in Missouri with little or no experience?
The most realistic path is landing a junior or mid-level software engineer role at a Missouri tech employer and building toward senior over two to three years. Companies like Cerner, World Wide Technology, and Mastercard's Kansas City operations run associate engineer and new-grad programs that bring in candidates with strong portfolios and internship experience. Roles in QA engineering, DevOps, or frontend development at Missouri-based insurance or logistics firms are common lateral starting points, and earning a cloud certification from AWS or Google adds measurable credibility early in the career.
Where can I find and apply to senior full stack engineer jobs in Missouri?
You can find and apply to senior full stack engineer jobs in Missouri on Migrate Mate, which lists current openings across the state. Search the listings for roles that match your stack and experience level and apply directly to the ones that fit.
See All 13 Senior Full Stack Engineer Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
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