Senior Software Developer Jobs in South Carolina
Senior Software Developer jobs in South Carolina concentrate in enterprise software, financial technology, defense contracting, and healthcare IT, with steady demand at the mid-senior and principal levels. Columbia, Charleston, and Greenville account for the bulk of openings, anchored by employers such as BlueCross BlueShield of South Carolina, Booz Allen Hamilton, and Blackbaud. Roles requiring expertise in cloud architecture, full-stack development, and DevOps draw the most consistent hiring across the state. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 23+ Senior Software Developer jobs
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
Work Schedule
Standard (Mon-Fri)Environmental Conditions
OfficeJob Description
We are seeking a Senior Staff Software Engineer to help architect and build the data platform and backend services for our healthcare SaaS solutions. This is a hands-on technical leadership role requiring deep expertise in database and data architecture, cloud-native backend development, scalability, security, and healthcare interoperability.
The ideal candidate combines strong software engineering skills with the ability to design secure, high-performance data architectures for large-scale, multi-tenant applications handling sensitive healthcare data.
Key Responsibilities
- Architect and develop scalable backend services and data platforms for multi-tenant SaaS applications.
- Design and optimize relational and non-relational database architectures, data models, and storage strategies.
- Build scalable data ingestion, integration, and processing capabilities for large and complex healthcare datasets.
- Design cloud-native data architectures incorporating databases, data lakes/lakehouses, and distributed data platforms.
- Develop APIs and integration capabilities supporting healthcare interoperability, including HL7 and FHIR.
- Ensure appropriate architecture for security, encryption, access control, auditability, data governance, retention, and regulatory compliance.
- Design for high availability, disaster recovery, performance, and scalability.
- Provide technical leadership and architectural guidance while remaining hands-on with design and development.
- Collaborate with Software Engineering, Product, Security, Quality, and Regulatory teams.
Required Qualifications
- Bachelor’s or Master’s degree in Computer Science, Engineering, Information Systems, or related field.
- 10+ years of software engineering experience, including significant backend and data-platform development.
- Deep experience designing and optimizing relational databases such as PostgreSQL, SQL Server, or MySQL.
- Experience with NoSQL technologies such as MongoDB, Cosmos DB, or equivalent.
- Strong experience with cloud platforms (Azure, AWS, or GCP) and cloud-native architectures.
- Experience with modern data pipelines, ingestion frameworks, data lakes/lakehouses, and distributed data architectures.
- Strong understanding of multi-tenant SaaS architecture, APIs, scalability, security, and data governance.
- Experience designing systems that handle sensitive or regulated data.
Preferred Qualifications
- Healthcare software or regulated-industry experience.
- Experience with HL7, FHIR, EHR/EMR integration, or healthcare interoperability.
- Experience with Databricks, Azure Data Factory, Kafka, Spark, or similar technologies.
- Experience with containerized environments such as Docker and Kubernetes.
Compensation and Benefits
The salary range estimated for this position based in Indiana is $135,800.00–$203,750.00.This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:
A choice of national medical and dental plans, and a national vision plan, including health incentive programs
Employee assistance and family support programs, including commuter benefits and tuition reimbursement
At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy
Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan
Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount
For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards
See All 23 Senior Software Developer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find JobsSenior Software Developer Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Senior Software Developer Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Banking & Financial Services
What South Carolina Employers Look For
The qualifications that appear most often in senior software developer jobs across South Carolina.
- Bachelor's degree in computer science, software engineering, or a closely related field required
- Five or more years of professional software development experience in production environments
- Proficiency in at least one major language such as Java, Python, C#, or JavaScript
- Experience designing and deploying cloud-based solutions on AWS, Azure, or Google Cloud
- Demonstrated ability to lead technical projects and mentor junior developers on the team
- Strong knowledge of agile methodologies, CI/CD pipelines, and version control with Git
Senior Software Developer Jobs in South Carolina: Frequently Asked Questions
How do you become a senior software developer in South Carolina?
Software development has no state-issued license in South Carolina, so the path runs through education and demonstrated experience. Most hiring managers expect a bachelor's degree in computer science, software engineering, or a related technical field, followed by several years of progressive development work. South Carolina employers in defense and government contracting frequently require a federal security clearance, and candidates who pursue certifications in cloud platforms or cybersecurity gain a concrete edge in the Columbia and Charleston markets.
How much do senior software developers make in South Carolina?
Senior software developers in South Carolina earn a median of about $129,450 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $76,010 for the lowest 10% to over $212,460 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire senior software developers in South Carolina?
Companies currently hiring senior software developers in South Carolina include Booz Allen Hamilton, PEMCCO, and Shutterfly, per current listings on Migrate Mate as of November 2026. South Carolina's defense, health insurance, and nonprofit technology sectors mean demand is spread across both large government contractors and established regional institutions headquartered in the state.
Which South Carolina cities have the most senior software developer jobs?
Fort Mill, Charleston, and Hanahan lead for senior software developer openings in South Carolina. Columbia concentrates demand through state government agencies, BlueCross BlueShield of South Carolina, and federal contractors, while Charleston's growing defense and technology corridor attracts companies like Booz Allen Hamilton, and Greenville draws openings from the region's expanding advanced manufacturing and healthcare IT base.
Are there remote senior software developer jobs in South Carolina?
Yes, and more than most fields. About 57% of senior software developer openings tied to South Carolina are remote or hybrid as of November 2026, reflecting the desk-based and collaborative nature of the work. Roles in application development, cloud engineering, and front-end development tend to be the most remote-friendly, while positions at defense contractors or those tied to classified systems typically require on-site presence.
How can I get hired as a senior software developer in South Carolina with little or no experience?
The most realistic starting point is an entry-level software engineer or associate developer role, which many South Carolina employers use as a pipeline into senior positions. Blackbaud in Charleston and BlueCross BlueShield of South Carolina in Columbia both run structured internship and new-graduate programs that feed into full-time development tracks. Building a portfolio of personal or open-source projects and earning a cloud certification, such as AWS Certified Developer, strengthens applications considerably for candidates without a lengthy professional history.
Where can I find and apply to senior software developer jobs in South Carolina?
You can find and apply to senior software developer jobs in South Carolina on Migrate Mate, which lists current openings from employers across the state. Search the listings, identify the roles that match your experience and preferred location or work arrangement, and apply directly to the ones that fit.
See All 23 Senior Software Developer Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
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