Clinical Operations Director Jobs in USA with Visa Sponsorship

Clinical Operations Directors oversee trial execution, site management, and regulatory compliance across drug development programs. Employers sponsor H-1B visa and O-1 visas for this role regularly. A graduate degree in a life sciences or clinical field strengthens both your candidacy and your visa petition substantially. For detailed occupation requirements, see the O*NET profile.

Find Clinical Operations Director Jobs

Overview

Open Jobs62+
Top Visa TypeH-1B
Work Type79% On-site
Top LocationRedwood City, CA
Most JobsRevolution Medicines, Inc.

Showing 5 of 62+ Clinical Operations Director jobs

AccentCare
Clinical Operations Director RN, Hospice
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AccentCare
Added 4d ago
Clinical Operations Director RN, Hospice
AccentCare
Renton, Washington
Nursing
Healthcare Administration
Patient Services & Wellbeing
Caregiving & Elderly Support
$140k - $170k/yr
On-Site
Bachelor's
10,000+

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Bryan Health
Clinical Operations Director
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Bryan Health
Added 1mo ago
Clinical Operations Director
Bryan Health
Lincoln, Nebraska
Healthcare Administration
Human Resources
Business Operations
Project & Program Management
Compliance & Legal
On-Site
Bachelor's
5,001-10,000

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Genentech
Senior Clinical Operations Asset Director
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Genentech
Added 3w ago
Senior Clinical Operations Asset Director
Genentech
San Francisco, California
Clinical Support
Healthcare Administration
Project & Program Management
Project Management
$215k - $399k/yr
Hybrid
Bachelor's
10,000+

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Kindred Hospitals
Chief Clinical Officer/Chief Operating Officer
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Kindred Hospitals
Added 1mo ago
Chief Clinical Officer/Chief Operating Officer
Kindred Hospitals
Rahway, New Jersey
Healthcare Administration
Executive Leadership & C-Suite
Human Resources
$143k - $179k/yr
On-Site
Master's
10,000+

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Cambia Health Solutions
Director Clinical Operations and Medical Policy
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Cambia Health Solutions
New 11h ago
Director Clinical Operations and Medical Policy
Cambia Health Solutions
Fargo, North Dakota
Healthcare Administration
Clinical Support
Allied Health
Pharmacy
$148k - $275k/yr
Hybrid
Bachelor's
5,001-10,000

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Tips for Finding Clinical Operations Director Jobs

Lead with regulatory and trial management credentials

Employers filing H-1B petitions for Clinical Operations Directors need to justify specialty occupation status. ICH-GCP certification, FDA regulatory experience, and Phase II–III trial oversight make that case clearly and reduce the risk of a USCIS Request for Evidence.

Target sponsors with active IND or NDA pipelines

Biotechs and CROs with active investigational or new drug applications have the most urgent hiring need. Companies mid-trial can't afford gaps in clinical operations leadership, which makes them more willing to initiate or transfer a visa petition quickly.

Understand that your degree field matters as much as your level

USCIS expects a direct relationship between your degree and the role. A master's in clinical research, public health, or a biomedical field supports the petition more cleanly than an unrelated degree supplemented by experience alone, even for senior candidates.

Position O-1A as a parallel path if you have extraordinary credentials

Clinical Operations Directors with published research, named authorship on clinical trial protocols, or speaking records at major industry conferences may qualify for O-1A, which has no lottery and no cap. It's worth evaluating alongside H-1B before the registration window.

Demonstrate cross-functional scope in your application materials

Employers sponsoring this role want evidence you can own CRO relationships, manage IRB submissions, and align operations with regulatory timelines. Framing your resume around trial outcomes and site performance metrics makes the sponsorship conversation easier to initiate.

Start the H-1B conversation before an offer is finalized

H-1B cap-subject petitions can only be filed once per year, with a lottery in March and an October 1 start date. Raising sponsorship early lets employers plan around the timeline instead of treating it as a late obstacle that complicates the hire.

Frequently Asked Questions

Does a Clinical Operations Director role qualify as a specialty occupation for H-1B purposes?

Yes, in most cases. USCIS evaluates whether the position normally requires a bachelor's degree or higher in a specific field. Clinical Operations Directors typically require degrees in life sciences, clinical research, nursing, or public health, and the role involves complex regulatory and scientific judgment that supports the specialty occupation standard. Sponsors should document these requirements clearly in the H-1B visa petition to reduce RFE risk.

What visa types do employers typically sponsor for Clinical Operations Directors?

H-1B is the most common path for Clinical Operations Directors hired from abroad. Employers with a demonstrated history of trial sponsorship sometimes also support O-1A petitions for candidates with exceptional credentials, such as authorship on published clinical protocols or regulatory guidance documents. TN visa classification is available for Canadian and Mexican nationals whose degree aligns with a qualifying USMCA occupation. Browse current openings on Migrate Mate to see which employers are actively sponsoring.

Does a three-year bachelor's degree qualify for an H-1B petition in this field?

It can, but the evaluation is case-by-case. USCIS accepts three-year degrees from recognized institutions when a credential evaluation confirms equivalency to a U.S. four-year bachelor's degree. For Clinical Operations Directors, a three-year life sciences degree paired with relevant postgraduate work or significant clinical trial experience is generally treated more favorably than a standalone three-year degree in an unrelated field.

How do CROs compare to pharmaceutical companies as H-1B sponsors for this role?

Both sponsor regularly, but the dynamic differs. Large pharmaceutical companies typically have established immigration programs and legal teams that handle petitions efficiently. CROs vary more widely. Some sponsor frequently due to high clinical headcount, while smaller CROs may be sponsoring for the first time. Either way, the strength of the petition depends more on how the role is documented than on the type of employer.

Can I transfer an existing H-1B to a new Clinical Operations Director role without starting over?

Yes. H-1B portability allows you to begin working for a new employer as soon as they file a transfer petition, without waiting for USCIS approval, provided you've maintained valid status. The new employer files a fresh I-129 petition describing the new role. If the job duties or degree requirements differ significantly from your original petition, the new employer should document the specialty occupation basis carefully.

What is the prevailing wage requirement for sponsored Clinical Operations Director jobs?

U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.