Automation Jobs in San Francisco, CA
Automation jobs in San Francisco are concentrated in SoMa, Mission Bay, and the Financial District, with strong demand across advanced manufacturing, biotech, and enterprise software. Companies actively hiring include Siemens, DoorDash, and CRUSOE. See the openings below and apply to the ones that match your experience.
Find Automation JobsOverview
Open roles417+
Top employerSiemens
Work type54% Remote
Top credentialBachelor's degree
Companies hiring26
Showing 5 of 417+ Automation jobs
Senior Automation Systems Lead
We won't show you this job again
New 6h ago
PSC Biotech
Senior Automation Systems Lead
San Francisco, California
New 6h ago
Senior Building Automation Systems Specialist
We won't show you this job again
Added 2d ago
Siemens
Senior Building Automation Systems Specialist
San Francisco, California
Added 2d ago
Associate Manager, Marketing Product Ops, CRM Automation
We won't show you this job again
Added 4d ago
DoorDash
Associate Manager, Marketing Product Ops, CRM Automation
San Francisco, California
Added 4d ago
Senior Backend Software Engineer (Confluence Cloud AI Automation and Search)
We won't show you this job again
Added 5d ago
Atlassian
Senior Backend Software Engineer (Confluence Cloud AI Automation and Search)
San Francisco, California
Added 5d ago
Associate Principal Scientist, Automation & Screening (Biologics Discovery)
We won't show you this job again
Added 1w ago
Merck
Associate Principal Scientist, Automation & Screening (Biologics Discovery)
San Francisco, California
Added 1w ago
New 6h ago
Senior Automation Systems Lead
PSC Biotech·San Francisco, California
Job functions:
$190k - $215k/yr
51-200 employees
Job Description
Job Information
- Date Opened 11/02/2026
- Job Type Full time
- Industry Pharma
- Work Experience 10+ years
- City San Francisco
- State/Province California
- Country United States
Job Description
PSC Biotech provides the life sciences with essential services to ensure that health care products are developed, manufactured, and distributed to the highest standards, in compliance with all applicable regulatory requirements.
Our goal is to skyrocket our clients’ success, and you can be a part of our team’s achievements. Employing a global team of skilled professionals and experts that span across strategically located offices in North America, Europe, Asia and the Middle East, we are proud of the roles we have fulfilled to help our clients achieve success.
The Experience
With operations spanning the globe and featuring a multi-cultural team, PSC Biotech® is passionate about bringing the best and brightest together in an effort to form something truly special. When you decide join our team, you will be offered the ability to feel inspired in your career, explore your professional passions, and work alongside a group of people who will value and nurture your talents.
We are firm believers in coaching and developing the next generation of industry leaders and influencers. As such, you will not only be offered compensation and benefits structure that rewards you, but also be provided with the tools that will help you grow and learn.
At PSC Biotech®, it’s about more than just a job—it’s about your career and your future.
Your Role
The Senior Automation Systems Lead will provide technical and operational leadership for the support, maintenance, reliability, and continuous improvement of GxP manufacturing automation systems within a highly regulated life sciences manufacturing environment. This role will serve as a key technical lead for Process Control Systems (PCS), SCADA infrastructure, historian platforms, and associated OT technologies.
The Senior Automation Systems Lead will oversee day-to-day automation service delivery, complex troubleshooting, system lifecycle activities, preventive maintenance, and change management while ensuring systems remain reliable, compliant, secure, and available to manufacturing operations. The individual will work cross-functionally with Manufacturing, Engineering, Quality, Validation, IT/OT Infrastructure, system owners, and managed service teams to resolve issues and implement sustainable system improvements.
-
Provide technical and operational leadership for GxP manufacturing automation and control systems, including Process Control Systems, SCADA platforms, historians, and supporting OT infrastructure.
-
Serve as a primary technical point of contact for system owners, manufacturing stakeholders, Quality, Engineering, IT/OT, and managed service personnel.
-
Lead support activities for Rockwell PLCs, FactoryTalk View SE, FactoryTalk AssetCentre, Ignition SCADA, MQTT infrastructure, Unified Namespace (UNS) architecture, and AVEVA PI Historian systems.
-
Manage automation-related incidents, problems, service requests, and escalations within a 24x7 manufacturing support environment.
-
Coordinate advanced troubleshooting, root cause investigations, and resolution of complex automation, controls, infrastructure, and system-integration issues.
-
Monitor system availability, performance, alarm health, infrastructure status, and overall system reliability.
-
Lead operational reviews and service reporting to ensure appropriate response, restoration, and issue-resolution expectations are achieved.
-
Review technical solutions, system modifications, and enhancements to ensure alignment with business, engineering, quality, and compliance requirements.
-
Support firmware upgrades, software lifecycle activities, system patching, platform modernization, and technology refresh initiatives.
-
Drive continuous improvement and reliability initiatives across manufacturing automation systems.
-
Develop and maintain preventive maintenance strategies, system health checks, lifecycle roadmaps, and obsolescence management plans.
-
Coordinate cybersecurity, patch management, backup verification, and disaster recovery activities for automation systems.
-
Ensure automation work is executed in accordance with applicable GxP requirements, site procedures, and established change-control processes.
-
Support deviations, CAPAs, root cause investigations, audit responses, and other quality-related activities involving automation systems.
-
Author and review change impact assessments, technical documentation, procedures, and SOPs.
-
Ensure applicable data integrity, audit trail, backup, recovery, and system security requirements are maintained.
-
Partner with Validation and Quality teams to determine appropriate testing, qualification, and validation requirements for system changes.
-
Provide technical direction and oversight to engineers, contractors, and managed service resources supporting automation systems.
- Support knowledge-transfer activities and managed services transitions to maintain effective and sustainable long-term system support.
Requirements
-
10+ years of experience supporting automation systems within GMP-regulated pharmaceutical, biotechnology, or life sciences manufacturing environments.
- 5+ years of experience leading automation support, engineering, or managed services teams.
-
Demonstrated experience supporting business-critical manufacturing automation systems in a 24x7 operational environment.
-
Strong hands-on experience with Rockwell Automation technologies, including FactoryTalk View SE and Rockwell PLC platforms, preferably ControlLogix.
-
Experience with FactoryTalk AssetCentre and automation asset-management practices.
-
Strong experience supporting Ignition SCADA platforms.
-
Experience with MQTT-based architectures and Unified Namespace (UNS) concepts.
-
Strong knowledge of AVEVA PI System and historian technologies; system administration experience is preferred.
-
Experience supporting Windows Server environments and working with OT networking fundamentals.
-
Knowledge of automation system backup, restoration, disaster recovery, patching, and lifecycle-management processes.
-
Strong understanding of GMP documentation and change-control requirements for manufacturing automation systems.
-
Working knowledge of GAMP 5, CSV/CSA methodologies, 21 CFR Part 11, EU Annex 11, and ALCOA+ data integrity principles.
-
Experience supporting Change Control, CAPA, deviation management, validation lifecycle, and audit activities.
-
Demonstrated ability to troubleshoot complex automation and system-integration issues and lead structured root cause investigations.
-
Ability to coordinate activities across Manufacturing, Engineering, Quality, Validation, IT/OT, vendors, and managed service teams.
-
Strong technical leadership, communication, documentation, and stakeholder-management skills.
Preferred Qualifications
-
Rockwell Automation certifications.
-
Inductive Automation Ignition certification.
-
AVEVA PI System administration experience.
-
Experience with electronic quality and validation systems such as Veeva Vault, Kneat, or comparable platforms.
-
Experience supporting both pilot-scale and commercial pharmaceutical or biotechnology manufacturing operations.
- Experience leading managed services transitions, support-model implementations, and knowledge-transfer programs.
Benefits
Offering a full suite of benefits, PSC Biotech™ is firmly focused on diligently investing in our employees who enable our company to fulfill our mission and achieve success. We want to promote balance, so you not only enjoy your work, but also have the time and resources to live your life happy and healthy.
- Medical, Dental, and Vision - PSC pays 100% of all qualifying employee medical premiums and 50% for qualifying dependents
-
Insurance options for Employee Assistance Programs, Basic Life Insurance, Long Term Disability and more
-
401(k) and 401(k) matching
-
PTO, Sick Time, and Paid Holidays
-
Education Assistance
-
Pet Insurance
-
Fitness Perks and Discounted Rates
-
Financial Perks and Discounts
Adhering to the requirements of U.S laws on pay transparency, the salary range expected for this role is set between $190,000 - $215,000. The rate offered may be adjusted based on various factors such as the applicant's qualifications, skills, and professional experience.
Equal Opportunity Employment Statement
PSC is committed to is committed to a policy of Equal Employment Opportunity with respect to all employees, interns, and applicants for employment. Consistent with this commitment, our policy is to comply with all applicable federal, state and local laws concerning employment discrimination. Accordingly, the company prohibits discrimination against qualified employees, interns and applicants in all aspects of employment including, but not limited to: recruitment, interviewing, hiring (or failure or refusal to hire), evaluation, compensation, promotion, job assignment, transfer, demotion, training, leaves of absence, layoff, benefits, use of facilities, working conditions, termination and employer-sponsored activities and programs, including wellness, social and recreational programs. Employment decisions will be made without regard to an applicant’s, employee’s, or intern’s actual or perceived: race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), national origin, age (40 or older), disability, genetic information, or any other status protected by law.
#LI-JL1
PSC Biotech
Senior Automation Systems Lead
San Francisco, California
New 6h ago51-200 employees
Job functions:
$190k - $215k/yr
Job Description
Job Information
- Date Opened 11/02/2026
- Job Type Full time
- Industry Pharma
- Work Experience 10+ years
- City San Francisco
- State/Province California
- Country United States
Job Description
PSC Biotech provides the life sciences with essential services to ensure that health care products are developed, manufactured, and distributed to the highest standards, in compliance with all applicable regulatory requirements.
Our goal is to skyrocket our clients’ success, and you can be a part of our team’s achievements. Employing a global team of skilled professionals and experts that span across strategically located offices in North America, Europe, Asia and the Middle East, we are proud of the roles we have fulfilled to help our clients achieve success.
The Experience
With operations spanning the globe and featuring a multi-cultural team, PSC Biotech® is passionate about bringing the best and brightest together in an effort to form something truly special. When you decide join our team, you will be offered the ability to feel inspired in your career, explore your professional passions, and work alongside a group of people who will value and nurture your talents.
We are firm believers in coaching and developing the next generation of industry leaders and influencers. As such, you will not only be offered compensation and benefits structure that rewards you, but also be provided with the tools that will help you grow and learn.
At PSC Biotech®, it’s about more than just a job—it’s about your career and your future.
Your Role
The Senior Automation Systems Lead will provide technical and operational leadership for the support, maintenance, reliability, and continuous improvement of GxP manufacturing automation systems within a highly regulated life sciences manufacturing environment. This role will serve as a key technical lead for Process Control Systems (PCS), SCADA infrastructure, historian platforms, and associated OT technologies.
The Senior Automation Systems Lead will oversee day-to-day automation service delivery, complex troubleshooting, system lifecycle activities, preventive maintenance, and change management while ensuring systems remain reliable, compliant, secure, and available to manufacturing operations. The individual will work cross-functionally with Manufacturing, Engineering, Quality, Validation, IT/OT Infrastructure, system owners, and managed service teams to resolve issues and implement sustainable system improvements.
-
Provide technical and operational leadership for GxP manufacturing automation and control systems, including Process Control Systems, SCADA platforms, historians, and supporting OT infrastructure.
-
Serve as a primary technical point of contact for system owners, manufacturing stakeholders, Quality, Engineering, IT/OT, and managed service personnel.
-
Lead support activities for Rockwell PLCs, FactoryTalk View SE, FactoryTalk AssetCentre, Ignition SCADA, MQTT infrastructure, Unified Namespace (UNS) architecture, and AVEVA PI Historian systems.
-
Manage automation-related incidents, problems, service requests, and escalations within a 24x7 manufacturing support environment.
-
Coordinate advanced troubleshooting, root cause investigations, and resolution of complex automation, controls, infrastructure, and system-integration issues.
-
Monitor system availability, performance, alarm health, infrastructure status, and overall system reliability.
-
Lead operational reviews and service reporting to ensure appropriate response, restoration, and issue-resolution expectations are achieved.
-
Review technical solutions, system modifications, and enhancements to ensure alignment with business, engineering, quality, and compliance requirements.
-
Support firmware upgrades, software lifecycle activities, system patching, platform modernization, and technology refresh initiatives.
-
Drive continuous improvement and reliability initiatives across manufacturing automation systems.
-
Develop and maintain preventive maintenance strategies, system health checks, lifecycle roadmaps, and obsolescence management plans.
-
Coordinate cybersecurity, patch management, backup verification, and disaster recovery activities for automation systems.
-
Ensure automation work is executed in accordance with applicable GxP requirements, site procedures, and established change-control processes.
-
Support deviations, CAPAs, root cause investigations, audit responses, and other quality-related activities involving automation systems.
-
Author and review change impact assessments, technical documentation, procedures, and SOPs.
-
Ensure applicable data integrity, audit trail, backup, recovery, and system security requirements are maintained.
-
Partner with Validation and Quality teams to determine appropriate testing, qualification, and validation requirements for system changes.
-
Provide technical direction and oversight to engineers, contractors, and managed service resources supporting automation systems.
- Support knowledge-transfer activities and managed services transitions to maintain effective and sustainable long-term system support.
Requirements
-
10+ years of experience supporting automation systems within GMP-regulated pharmaceutical, biotechnology, or life sciences manufacturing environments.
- 5+ years of experience leading automation support, engineering, or managed services teams.
-
Demonstrated experience supporting business-critical manufacturing automation systems in a 24x7 operational environment.
-
Strong hands-on experience with Rockwell Automation technologies, including FactoryTalk View SE and Rockwell PLC platforms, preferably ControlLogix.
-
Experience with FactoryTalk AssetCentre and automation asset-management practices.
-
Strong experience supporting Ignition SCADA platforms.
-
Experience with MQTT-based architectures and Unified Namespace (UNS) concepts.
-
Strong knowledge of AVEVA PI System and historian technologies; system administration experience is preferred.
-
Experience supporting Windows Server environments and working with OT networking fundamentals.
-
Knowledge of automation system backup, restoration, disaster recovery, patching, and lifecycle-management processes.
-
Strong understanding of GMP documentation and change-control requirements for manufacturing automation systems.
-
Working knowledge of GAMP 5, CSV/CSA methodologies, 21 CFR Part 11, EU Annex 11, and ALCOA+ data integrity principles.
-
Experience supporting Change Control, CAPA, deviation management, validation lifecycle, and audit activities.
-
Demonstrated ability to troubleshoot complex automation and system-integration issues and lead structured root cause investigations.
-
Ability to coordinate activities across Manufacturing, Engineering, Quality, Validation, IT/OT, vendors, and managed service teams.
-
Strong technical leadership, communication, documentation, and stakeholder-management skills.
Preferred Qualifications
-
Rockwell Automation certifications.
-
Inductive Automation Ignition certification.
-
AVEVA PI System administration experience.
-
Experience with electronic quality and validation systems such as Veeva Vault, Kneat, or comparable platforms.
-
Experience supporting both pilot-scale and commercial pharmaceutical or biotechnology manufacturing operations.
- Experience leading managed services transitions, support-model implementations, and knowledge-transfer programs.
Benefits
Offering a full suite of benefits, PSC Biotech™ is firmly focused on diligently investing in our employees who enable our company to fulfill our mission and achieve success. We want to promote balance, so you not only enjoy your work, but also have the time and resources to live your life happy and healthy.
- Medical, Dental, and Vision - PSC pays 100% of all qualifying employee medical premiums and 50% for qualifying dependents
-
Insurance options for Employee Assistance Programs, Basic Life Insurance, Long Term Disability and more
-
401(k) and 401(k) matching
-
PTO, Sick Time, and Paid Holidays
-
Education Assistance
-
Pet Insurance
-
Fitness Perks and Discounted Rates
-
Financial Perks and Discounts
Adhering to the requirements of U.S laws on pay transparency, the salary range expected for this role is set between $190,000 - $215,000. The rate offered may be adjusted based on various factors such as the applicant's qualifications, skills, and professional experience.
Equal Opportunity Employment Statement
PSC is committed to is committed to a policy of Equal Employment Opportunity with respect to all employees, interns, and applicants for employment. Consistent with this commitment, our policy is to comply with all applicable federal, state and local laws concerning employment discrimination. Accordingly, the company prohibits discrimination against qualified employees, interns and applicants in all aspects of employment including, but not limited to: recruitment, interviewing, hiring (or failure or refusal to hire), evaluation, compensation, promotion, job assignment, transfer, demotion, training, leaves of absence, layoff, benefits, use of facilities, working conditions, termination and employer-sponsored activities and programs, including wellness, social and recreational programs. Employment decisions will be made without regard to an applicant’s, employee’s, or intern’s actual or perceived: race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), national origin, age (40 or older), disability, genetic information, or any other status protected by law.
#LI-JL1
See All 417+ Automation Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Automation JobsAutomation Job Market in San Francisco
Who's Hiring
- Siemens40
- DoorDash40
- CRUSOE27
- ELVE13
- Uber13
Top Industries Hiring
- Technology & Software
Automation Jobs in San Francisco: Frequently Asked Questions
How do I get a automation job in San Francisco?
The strongest path into San Francisco's automation market runs through biotech and life sciences employers in Mission Bay, robotics and hardware startups in SoMa, and enterprise software companies in the Financial District. Candidates with hands-on experience in industrial control systems, PLC programming, or test automation frameworks stand out locally. Targeting mid-size tech-adjacent manufacturers and contract research organizations gives entry-level and mid-career applicants the best foothold in this market.
Which companies hire automations in San Francisco?
Companies currently hiring automations in San Francisco include Siemens, DoorDash, and CRUSOE, per current listings on Migrate Mate as of November 2026. San Francisco's employer mix skews toward biotech, robotics, and cloud infrastructure companies, many of which maintain automation teams ranging from small embedded engineering pods to large-scale test and deployment operations.
Are there remote automation jobs in San Francisco?
Yes, though it depends heavily on the type of automation work: software test automation and CI/CD pipeline roles can often be done remotely, while hands-on roles involving physical equipment, lab instrumentation, or factory systems are typically on-site. About 85% of automation openings tied to San Francisco are remote or hybrid as of November 2026, with the strongest remote concentration in QA automation and DevOps-adjacent roles.
How can I get a automation job in San Francisco with little or no experience?
The most realistic entry point in San Francisco is a QA or software test automation role at a SoMa-based startup or a Mission Bay biotech, where employers often hire candidates who can demonstrate scripting fundamentals in Python or JavaScript even without a formal automation title. Lateral moves from manual QA, IT operations, or lab technician roles are common. Building a small portfolio of automation scripts on public repositories and targeting companies with junior engineering programs significantly improves your chances in this market.
Which industries hire the most automations in San Francisco?
San Francisco automation roles concentrate in Technology & Software, based on current listings on Migrate Mate as of November 2026. San Francisco's density of biotech research facilities, cloud platform companies, and hardware-software hybrid startups creates sustained, year-round demand across all experience levels in automation.
Related Jobs in California
Cloud Consultant JobsCalifornia
Data Governance Specialist JobsCalifornia
Payroll Manager JobsCalifornia
Senior Total Rewards Specialist JobsCalifornia
Customer Experience Specialist JobsCalifornia
Data Center Engineer JobsCalifornia
Proposal Manager JobsCalifornia
Commercial Real Estate JobsCalifornia
Head Of Partnerships JobsCalifornia
See All 417+ Automation Jobs in San Francisco
Find roles in San Francisco that match your experience and apply in just a few clicks.
Find Automation Jobs