COO Jobs in San Diego, CA

COO jobs in San Diego are in strong demand, concentrated in Sorrento Valley, Downtown San Diego, and the UTC corridor across defense technology, biotech, and digital media. Employers actively hiring include Travere Therapeutics, Artiva Biotherapeutics, and Janux Therapeutics. Find a role that fits below and apply directly.

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Overview

Open roles487+
Top employerTravere Therapeutics
Work type50% Remote
Top credentialBachelor's degree
Companies hiring24

Showing 5 of 487+ COO jobs

Marriott International
Director of Hotel Operations
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Marriott International
Added 1d ago
Director of Hotel Operations
Marriott International
San Diego, California
Business Operations
Business Strategy
Consulting & Professional Services
$79k - $87k/yr
10,000+

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Artiva Biotherapeutics
Associate Director, Biomarker Operations
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Artiva Biotherapeutics
Added 2d ago
Associate Director, Biomarker Operations
Artiva Biotherapeutics
San Diego, California
Business Development
Partnerships & Business Development
Sales
$175k - $185k/yr
Master's degree in biology

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Simon Property Group
Director, Operations-VI
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Simon Property Group
Added 2d ago
Director, Operations-VI
Simon Property Group
San Diego, California
Business Operations
Program Management
Project Management
$113k.62 - $212k.19/yr
Bachelor's degree
1,001-5,000

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PracticeTek
Director, HR Operations
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PracticeTek
Added 5d ago
Director, HR Operations
PracticeTek
San Diego, California
Customer Service
Customer Support
$165k - $175k/yr
Hybrid
Bachelor's degree in business administration

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UC San Diego
Director of Dining Operations
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UC San Diego
Added 5d ago
Director of Dining Operations
UC San Diego
San Diego, California
Customer Service
Customer Support
$53.3 - $101.1/hr
10,000+

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See All 487+ COO Jobs in San Diego

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COO Job Market in San Diego

Who's Hiring

  • Travere Therapeutics
    Travere Therapeutics76
  • Artiva Biotherapeutics
    Artiva Biotherapeutics46
  • Janux Therapeutics
    Janux Therapeutics30
  • Bridge Home Health and Hospice
    Bridge Home Health and Hospice30
  • Advantest
    Advantest15

Top Industries Hiring

  • Education46
  • Automotive15
  • Electronics & Hardware15
  • Non-Profit & Social Services15
  • Healthcare & Medical Services15

COO Jobs in San Diego: Frequently Asked Questions

How do I get a coo job in San Diego?

The clearest path is targeting San Diego's most active hiring sectors: defense technology, biotech, and digital media companies clustered in Sorrento Valley and the UTC corridor. Candidates who stand out here typically have direct P&L ownership experience and familiarity with the operational demands of scaling a mid-market or venture-backed company. Building relationships with the region's active startup and investor community also opens doors that job boards alone won't.

Which companies hire coos in San Diego?

Companies currently hiring coos in San Diego include Travere Therapeutics, Artiva Biotherapeutics, and Janux Therapeutics, per current listings on Migrate Mate as of August 2026. San Diego's hiring mix leans toward growth-stage technology firms, life sciences companies, and defense contractors, many of which promote from senior VP or general manager roles into the coo seat.

Are there remote coo jobs in San Diego?

Yes, though remote availability is limited for this role since coos typically oversee day-to-day operations that require in-person presence. About 67% of coo openings tied to San Diego are remote or hybrid as of August 2026, with hybrid arrangements most common at digital media and software companies headquartered downtown or in the UTC area.

How can I get a coo job in San Diego with little or no experience?

The most realistic entry path is moving up through a director of operations or VP of operations role at one of San Diego's mid-size biotech or defense tech firms, where operational complexity creates clear promotion pipelines. Companies in the Torrey Pines and Sorrento Valley corridors frequently hire operations managers who grow into senior leadership. Demonstrated experience owning a budget, managing cross-functional teams, and improving measurable processes carries more weight than tenure alone.

Which industries hire the most coos in San Diego?

The sectors hiring the most coos in San Diego are Education, Automotive, and Electronics & Hardware, based on current listings on Migrate Mate as of August 2026. San Diego's deep concentration of defense contractors, life sciences firms, and venture-backed technology companies creates consistent demand for operational executives who can manage complex, regulated, or rapidly scaling businesses.

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