COO Jobs in San Diego, CA

COO jobs in San Diego are in strong demand, concentrated in Sorrento Valley, Downtown San Diego, and the UTC corridor across defense technology, biotech, and digital media. Employers actively hiring include Illumina, Travere Therapeutics, and BD. Find a role that fits below and apply directly.

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Overview

Open roles451+
Top employerIllumina
Work type70% Remote
Top credentialBachelor's degree
Companies hiring25

Showing 5 of 451+ COO jobs

Director, Segment Operations
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Added 1d ago
Director, Segment Operations
Berkley
San Diego, California
Business Operations
$140k - $180k/yr
Bachelor's degree in finance

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Senior Manager / Associate Director, People Operations
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Added 1d ago
Senior Manager / Associate Director, People Operations
ADARx Pharmaceuticals
San Diego, California
Human Resources
Human Resources (HR) — Generalist
$165k - $185k/yr
Bachelor's degree in business administration

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Director, Business Operations & Strategy (Site Head)
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Added 2d ago
Director, Business Operations & Strategy (Site Head)
BioLabs
San Diego, California
Account Management
Customer Service
Customer Success
$110k - $160k/yr
Bachelor's degree
11-50

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Executive Director, Clinical Operations
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Added 3d ago
Executive Director, Clinical Operations
Fate Therapeutics Inc.
San Diego, California
Project & Program Management
Healthcare Administration
Project Management
$300k/yr
On-Site
Bachelor's

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Executive Director, Clinical Operations
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Added 3d ago
Executive Director, Clinical Operations
Fate Therapeutics
San Diego, California
Program Management
Project & Program Management
Project Management
$280k - $300k/yr
Bachelor of Science
51-200

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See All 451+ COO Jobs in San Diego

Find roles in San Diego that match your experience and apply in just a few clicks.

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COO Job Market in San Diego

Who's Hiring

  • Illumina33
  • Travere Therapeutics33
  • BD17
  • Tr1x17
  • Erasca17

Top Industries Hiring

  • Sports & Recreation
  • Biotechnology & Pharmaceuticals

COO Jobs in San Diego: Frequently Asked Questions

How do I get a coo job in San Diego?

The clearest path is targeting San Diego's most active hiring sectors: defense technology, biotech, and digital media companies clustered in Sorrento Valley and the UTC corridor. Candidates who stand out here typically have direct P&L ownership experience and familiarity with the operational demands of scaling a mid-market or venture-backed company. Building relationships with the region's active startup and investor community also opens doors that job boards alone won't.

Which companies hire coos in San Diego?

Companies currently hiring coos in San Diego include Illumina, Travere Therapeutics, and BD, per current listings on Migrate Mate as of November 2026. San Diego's hiring mix leans toward growth-stage technology firms, life sciences companies, and defense contractors, many of which promote from senior VP or general manager roles into the coo seat.

Are there remote coo jobs in San Diego?

Yes, though remote availability is limited for this role since coos typically oversee day-to-day operations that require in-person presence. About 90% of coo openings tied to San Diego are remote or hybrid as of November 2026, with hybrid arrangements most common at digital media and software companies headquartered downtown or in the UTC area.

How can I get a coo job in San Diego with little or no experience?

The most realistic entry path is moving up through a director of operations or VP of operations role at one of San Diego's mid-size biotech or defense tech firms, where operational complexity creates clear promotion pipelines. Companies in the Torrey Pines and Sorrento Valley corridors frequently hire operations managers who grow into senior leadership. Demonstrated experience owning a budget, managing cross-functional teams, and improving measurable processes carries more weight than tenure alone.

Which industries hire the most coos in San Diego?

The sectors hiring the most coos in San Diego are Sports & Recreation and Biotechnology & Pharmaceuticals, based on current listings on Migrate Mate as of November 2026. San Diego's deep concentration of defense contractors, life sciences firms, and venture-backed technology companies creates consistent demand for operational executives who can manage complex, regulated, or rapidly scaling businesses.

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