COO Jobs in San Francisco, CA

COO jobs in San Francisco are in strong demand, concentrated in SoMa, the Financial District, and Mission Bay across technology, venture-backed startups, and financial services. Employers hiring right now include Genentech, IREN, and oura. Find a role that fits below and apply directly.

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Overview

Open roles445+
Top employerGenentech
Work type48% Hybrid
Top credentialMaster's degree in business administration
Companies hiring40

Showing 5 of 445+ COO jobs

Bon Appétit
Director of Operations
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Bon Appétit
Added 2d ago
Director of Operations
Bon Appétit
San Francisco, California
Business Operations
Business Strategy
Project Management
$120k - $130k/yr
Bachelor's degree in business administration
10,000+

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City and County of San Francisco
Chief Operating Officer
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City and County of San Francisco
Added 2d ago
Chief Operating Officer
City and County of San Francisco
San Francisco, California
Executive Leadership & C-Suite
Project & Program Management
Business Operations
Human Resources
$350k/yr
On-Site
Master's

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San Francisco Department of Public Health
CHIEF OPERATING OFFICER (1165-Manager, Department of Public Health)
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San Francisco Department of Public Health
Added 3d ago
CHIEF OPERATING OFFICER (1165-Manager, Department of Public Health)
San Francisco Department of Public Health
San Francisco, California
Business Analysis
Data Analytics
Quality Assurance & Testing (QA Testing)
$274k - $350k/yr
On-Site
Master's degree in public administration

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City and County of San Francisco
CHIEF OPERATING OFFICER (1165-Manager, Department of Public Health)
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City and County of San Francisco
Added 3d ago
CHIEF OPERATING OFFICER (1165-Manager, Department of Public Health)
City and County of San Francisco
San Francisco, California
Business Operations
Business Strategy
Consulting & Professional Services
$274k - $350k/yr
On-Site
Master's degree in public administration
5,001-10,000

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SteppingStone
Chief Operating Officer
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SteppingStone
Added 3d ago
Chief Operating Officer
SteppingStone
San Francisco, California
Business Strategy
Project Management
Strategy & Corporate Development
$150k - $160k/yr
On-Site

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See All 445+ COO Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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COO Job Market in San Francisco

Who's Hiring

  • Genentech
    Genentech27
  • IREN
    IREN18
  • oura
    oura18
  • NURIX
    NURIX18
  • Autodesk
    Autodesk18

Top Industries Hiring

  • Banking & Financial Services18
  • Science & Research9
  • Technology & Software9
  • Government & Public Sector9
  • Biotechnology & Pharmaceuticals9

COO Jobs in San Francisco: Frequently Asked Questions

How do I get a coo job in San Francisco?

San Francisco coo hiring centers on technology companies, venture-backed startups, and financial services firms in SoMa, the Financial District, and Mission Bay. Candidates with direct P&L ownership, experience scaling operations through a funding round or acquisition, and a network in the local startup ecosystem have a clear edge. Demonstrating familiarity with San Francisco's founder-driven culture and fast-growth environments strengthens your candidacy significantly.

Which companies hire coos in San Francisco?

San Francisco coo roles are posted by Genentech, IREN, and oura and others right now, based on current listings on Migrate Mate as of September 2026. San Francisco's employer base skews heavily toward high-growth technology firms, Series B-plus startups, and established financial services companies, all of which regularly recruit experienced operations leaders.

Are there remote coo jobs in San Francisco?

Yes, though remote availability is limited for a role that typically requires cross-functional leadership and in-person executive presence. About 56% of coo openings tied to San Francisco are remote or hybrid as of September 2026, with hybrid arrangements being far more common than fully remote. Strategic planning and board reporting functions tend to be the most location-flexible parts of the role.

How can I get a coo job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through an operations manager or chief of staff role at a seed-stage or Series A startup in SoMa or Mission Bay, where early employees often grow into executive positions quickly. San Francisco's dense startup ecosystem means smaller companies frequently promote from within, so targeting high-growth companies before they scale gives candidates the best opportunity to step into broader operational leadership without an extensive prior executive background.

Which industries hire the most coos in San Francisco?

Most coo openings in San Francisco sit in Banking & Financial Services, Science & Research, and Technology & Software, per current listings on Migrate Mate as of September 2026. San Francisco's concentration of venture capital funding and enterprise technology headquarters drives sustained demand for operations leadership across those sectors throughout the year.

See All 445+ COO Jobs in San Francisco

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