COO Jobs in San Francisco, CA

COO jobs in San Francisco are in strong demand, concentrated in SoMa, the Financial District, and Mission Bay across technology, venture-backed startups, and financial services. Employers hiring right now include Genentech, CRUSOE, and Ripple. Find a role that fits below and apply directly.

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Overview

Open roles487+
Top employerGenentech
Work type44% On-site
Top credentialMaster's degree in business administration
Companies hiring50

Showing 5 of 487+ COO jobs

City and County of San Francisco
Chief Operating Officer
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City and County of San Francisco
Added 2d ago
Chief Operating Officer
City and County of San Francisco
San Francisco, California
Executive Leadership & C-Suite
Project & Program Management
Human Resources
Business Operations
Compliance & Legal
Project Management
$201k - $256k/yr
On-Site
Bachelor's

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IQVIA
Sr. Strategic Operations Director
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IQVIA
Added 2d ago
Sr. Strategic Operations Director
IQVIA
San Francisco, California
Business Operations
Program Management
Project Management
$123k - $344k/yr
Remote (US)
10,000+

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City and County of San Francisco
Chief Operating Officer (0953 - Deputy Director III) - San Francisco Public Library
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City and County of San Francisco
Added 2d ago
Chief Operating Officer (0953 - Deputy Director III) - San Francisco Public Library
City and County of San Francisco
San Francisco, California
Business Operations
Executive Leadership & C-Suite
Project Management
$201k - $256k/yr
Bachelor's degree in social work
5,001-10,000

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Genentech
Senior Director, Business Operations & Portfolio Controls
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Genentech
Added 5d ago
Senior Director, Business Operations & Portfolio Controls
Genentech
San Francisco, California
Content & Communications
Creative & Design
Marketing
$189k - $352k/yr
Bachelor's degree in construction management
10,000+

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gate group
Director Culinary Operations
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gate group
Added 5d ago
Director Culinary Operations
gate group
San Francisco, California
Business Development
Customer Success
Program Management
Project Management
$150k - $160k/yr
Bachelor's degree in industrial engineering

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See All 487+ COO Jobs in San Francisco

Find roles in San Francisco that match your experience and apply in just a few clicks.

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COO Job Market in San Francisco

Who's Hiring

  • Genentech
    Genentech33
  • CRUSOE
    CRUSOE17
  • Ripple
    Ripple17
  • DoorDash
    DoorDash17
  • Gap
    Gap17

Top Industries Hiring

  • Technology & Software50
  • Banking & Financial Services33
  • Retail17
  • Consulting & Professional Services17
  • Medical Devices8

COO Jobs in San Francisco: Frequently Asked Questions

How do I get a coo job in San Francisco?

San Francisco coo hiring centers on technology companies, venture-backed startups, and financial services firms in SoMa, the Financial District, and Mission Bay. Candidates with direct P&L ownership, experience scaling operations through a funding round or acquisition, and a network in the local startup ecosystem have a clear edge. Demonstrating familiarity with San Francisco's founder-driven culture and fast-growth environments strengthens your candidacy significantly.

Which companies hire coos in San Francisco?

San Francisco coo roles are posted by Genentech, CRUSOE, and Ripple and others right now, based on current listings on Migrate Mate as of August 2026. San Francisco's employer base skews heavily toward high-growth technology firms, Series B-plus startups, and established financial services companies, all of which regularly recruit experienced operations leaders.

Are there remote coo jobs in San Francisco?

Yes, though remote availability is limited for a role that typically requires cross-functional leadership and in-person executive presence. About 56% of coo openings tied to San Francisco are remote or hybrid as of August 2026, with hybrid arrangements being far more common than fully remote. Strategic planning and board reporting functions tend to be the most location-flexible parts of the role.

How can I get a coo job in San Francisco with little or no experience?

The most realistic entry path in San Francisco is through an operations manager or chief of staff role at a seed-stage or Series A startup in SoMa or Mission Bay, where early employees often grow into executive positions quickly. San Francisco's dense startup ecosystem means smaller companies frequently promote from within, so targeting high-growth companies before they scale gives candidates the best opportunity to step into broader operational leadership without an extensive prior executive background.

Which industries hire the most coos in San Francisco?

Most coo openings in San Francisco sit in Technology & Software, Banking & Financial Services, and Retail, per current listings on Migrate Mate as of August 2026. San Francisco's concentration of venture capital funding and enterprise technology headquarters drives sustained demand for operations leadership across those sectors throughout the year.

See All 487+ COO Jobs in San Francisco

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