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What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
This role can be onsite at our Cambridge, MA site. Or if you are over 30 miles away remote with travel 3-4 days per month.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $228,000 - $310,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
What if... We could harness the power of Flagship's scientific platforms and create novel treatment options that benefit more patients, sooner?
ABOUT PIONEERING MEDICINES
Pioneering Medicines, Flagship Pioneering's in-house drug development unit, is dedicated to conceiving and developing a broad portfolio of life-changing treatments for patients built from Flagship's innovative platforms. Harnessing the drug development expertise of its team together with the power of Flagship's multiple scientific platforms, Pioneering Medicines explores and identifies new product concepts which are then advanced jointly with Flagship's bioplatform companies. Within Flagship's Innovation Supply Chain partnerships, Pioneering Medicines works with external collaborators to apply its unique approach to partners' R&D priorities. These partnerships are highly co-creative strategic alliances that accelerate therapeutic innovation by bringing together partners spanning the full spectrum of drug discovery, development, and production.
Position Summary
The Senior Director, Head of Toxicology will lead and build the toxicology function within Pioneering Medicines, defining and executing nonclinical safety strategies across a diverse and rapidly evolving portfolio. This role provides scientific and strategic leadership across both investigative and regulatory toxicology, supporting a broad range of therapeutic modalities.
Working in a dynamic venture creation environment, you will collaborate closely with multidisciplinary teams to optimize candidate selection, guide preclinical development, and ensure regulatory readiness. This is a high-impact role requiring strong analytical thinking, scientific rigor, and clear communication, influencing programs from discovery through early clinical development.
This role can be onsite at our Cambridge, MA site. Or if you are over 30 miles away remote with travel 3-4 days per month.
Key Responsibilities
Functional Leadership & Capability Building
- Lead, build, and scale the toxicology function, including internal team development and external partnerships
- Define fit-for-purpose operating models spanning investigative and regulatory toxicology
- Serve as the primary internal expert for nonclinical safety, ensuring quality, consistency, and scalability across the portfolio
Portfolio & Program Strategy
- Define and drive toxicology strategies across multiple programs and modalities
- Translate findings into clear risk assessments, mitigation strategies, and IND/CTA-enabling plans
- Enable transparent, data-driven decision-making by articulating risks, assumptions, and trade-offs to program teams
- Oversee the design, execution, and interpretation of non-GLP and GLP toxicology studies
- Partner cross-functionally (DMPK, pharmacology, CMC, clinical) to integrate safety into development strategy
- Support diligence and evaluation of new programs within Flagship's ecosystem
External Partnerships & Regulatory
- Build and manage a high-performing CRO and consultant network, ensuring quality, timelines, and cost efficiency
- Leverage and contribute to the Flagship ecosystem, fostering knowledge sharing and collaboration across platform companies
- Lead nonclinical regulatory strategy and documentation (INDs, IBs, briefing materials)
- Ensure regulatory readiness through clear and scientifically robust safety narratives
- Represent toxicology in regulatory interactions as appropriate
Qualifications
- PhD, DVM, or equivalent in Toxicology, Pathology, Pharmacology, or related field
- ~10-15+ years of experience in nonclinical safety in biotech/pharma
- Proven track record advancing programs through IND and into clinical development
- Experience across multiple modalities preferred
- Strong experience managing CROs and external collaborations
- Experience leading or building a toxicology function or team, including management of internal scientists and/or external partners, is a plus
Leadership Profile
- Enterprise mindset; able to operate across a portfolio in a fast-paced, collaborative environment
- Analytical and goal-oriented, with the ability to operate with urgency while maintaining high standards of scientific rigor and ethics
- Strong communicator who can translate complex toxicology into clear, audience-appropriate risk assessments, from early-stage teams to large pharma partners
About Flagship
Flagship Pioneering is a scientific innovation engine that invents and builds companies that change the world. We bring together the greatest scientific minds with entrepreneurial company builders and assemble the capital to allow them to take courageous leaps in human health, sustainability, and beyond.
What sets Flagship apart is our ability to advance biotechnology by uniting life science innovation, company creation, and capital investment under one roof in a way that is largely without precedent. Our team of scientists, entrepreneurial leaders, and professional capital managers are each aligned around an institutionalized process that enables us to innovate and create breakthroughs for the benefit of people and planet. Many of the companies Flagship has founded have addressed humanity's most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.
Flagship has been recognized twice on FORTUNE's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been named four times to Fast Company's annual list of the World's Most Innovative Companies.
At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.
The salary range for this role is $228,000 - $310,000. Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Pioneering Medicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Pioneering Medicines's good faith estimate as of the date of publication and may be modified in the future.
Privacy Notice for Applicants: When you apply for a role at Flagship Pioneering or one of its portfolio companies, we collect and use personal information you provide (such as your name, contact details, work history, and application materials) to evaluate your application, communicate with you, and comply with legal obligations. Your application data is processed through Greenhouse, our applicant tracking system, and may also be reviewed using AI-assisted screening tools. We do not sell your personal information. California residents have rights under the CCPA/CPRA including to know, delete, and opt out of the sharing of their personal information. If you are located in the EU or UK, we process your data under GDPR and you have rights to access, rectify, and erase your data. To exercise your rights or for questions, contact privacy@flagshippioneering.com.
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Find Director Head Of JobsDirector Head Of Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- Citi7
- BlackRock4
- Lonza3
- Apollo2
- BeOne Medicines2
Top Industries Hiring
- Investment & Asset Management14
- Banking & Financial Services13
- Biotechnology & Pharmaceuticals13
- Technology & Software9
- Construction & Real Estate8
What Employers Look For
The qualifications that appear most often in director head of jobs.
- 10 or more years of progressive experience in a relevant function or industry
- Demonstrated experience leading cross-functional or multi-team organizations
- Proven ability to build and execute strategic plans with measurable outcomes
- Experience managing budgets, headcount planning, and resource allocation
- Strong executive communication and stakeholder management skills
- Bachelor's degree required, with MBA or advanced degree often preferred
Tips for Your Director Head Of Job Search
Quantify scope before listing responsibilities
Director and head of roles demand evidence of scale. Replace vague bullet points with team sizes, budget ownership, and business outcomes you drove. Hiring committees at this level screen for leaders who can own a P&L or a function, not just manage tasks.
Match your resume to the reporting line
A head of role reporting to the CEO reads differently than one reporting to a VP. Tailor your positioning to show the right level of strategic autonomy. Boards and executives want to see that you operate at their altitude, not one rung below.
Target companies at a stage that fits your experience
A head of growth at a seed-stage startup and a director of growth at a Fortune 500 require fundamentally different skill sets. Filter openings by company size and funding stage so you apply where your specific experience is a genuine fit, not a stretch.
Apply early to roles that fit
Migrate Mate lists director head of openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Prepare a point of view for every first interview
Directors and heads of are expected to arrive with a perspective, not just answers to questions. Research the company's current challenge in your function and come ready to share a concrete, informed take. It signals that you already think like someone in the role.
Negotiate scope before you negotiate compensation
At director and head of level, your title, reporting structure, and charter matter as much as pay. Clarify what the role owns, what resources it controls, and whether those expand over time before you discuss numbers, so you enter compensation talks from a position of full information.
Director Head Of Jobs: Frequently Asked Questions
Which companies are hiring the most director head ofs?
The companies hiring the most director head ofs right now include Citi, BlackRock, and Lonza, with the largest share of openings in California, New York, and Massachusetts, based on current listings on Migrate Mate as of June 2026. Demand is concentrated in technology, healthcare, and financial services sectors.
How many director head of jobs are remote?
About 32% of director head of openings are fully remote or hybrid as of June 2026, making remote work a realistic option for many candidates. Sub-areas such as product, marketing, and people operations tend to offer the highest proportion of remote and hybrid arrangements compared to operations or manufacturing-aligned roles.
How do you become a director head of?
Most director and head of roles require a progression from individual contributor to manager to senior manager before stepping into a functional leadership position. Build a record of leading teams, owning meaningful outcomes, and operating across departments. Seeking stretch assignments that put you in front of executives accelerates the path, as does developing a clear point of view on the function you want to lead.
Can you get hired as a director head of with limited experience?
It is possible to move into a director or head of role earlier than the typical timeline by targeting smaller companies or early-stage organizations where the title reflects broad ownership rather than decades of tenure. Demonstrating that you have already led a team, managed a budget, or owned a business outcome end-to-end matters more than years on a resume. Clarity about what you have built and why it worked is what closes the experience gap.
What does the director head of interview process look like?
The process typically starts with a recruiter screen, followed by a hiring manager conversation focused on leadership philosophy and functional expertise. Subsequent rounds often include a panel with peers or direct reports, a case study or strategic presentation to senior leadership, and a final conversation with an executive or board member. Reference checks at this level are thorough and usually involve former managers, peers, and direct reports.
Where can I find and apply to director head of jobs?
You can find and apply to director head of jobs on Migrate Mate, which lists current openings from across the United States. Search the listings to find roles that match your background and apply directly to each one that fits.
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