Green Card COO Jobs
COO roles qualify for EB-2 and EB-3 green card sponsorship when the position requires an advanced degree or equivalent credentials in business, operations, or a related field. Your employer files a PERM labor certification with DOL before submitting the I-140 petition, starting the path to permanent U.S. residency rather than a temporary status.
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Get Access To All JobsINTRODUCTION
Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
ROLE AND RESPONSIBILITIES
This position will provide quality oversight of Denali’s external manufacturing network (CMO). This position will also support batch release, investigations, change management and documentation for given outsourced project activities.
Key Accountabilities/Core Job Responsibilities:
- Oversee both clinical and commercial GMP and GLP quality operations at CMOs, including quality documentation reviews and approvals, from Manufacturing and Quality Control, such as batch records, change controls and specifications of Denali products.
- Oversee end to end product quality management across the entire supply chain and distribution networks from GLP tox batches to Commercial release.
- Accountable for batch release disposition across the clinical and commercial product portfolio.
- Support CMC development including review and approval of specifications, stability studies, method validation, QC test methods, process validation and material distribution activities.
- Support CMC commercial operations including establishing infrastructure, SOPs and execution for Product Launch activities.
- Write and approve SOPs and Policies related to compliance and quality.
- Provide Quality expertise for regulatory inspections, inspection-readiness activities, and responses to regulatory observations.
- Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.
BASIC QUALIFICATIONS
- Typically requires a BS in a scientific discipline (MS preferred) with 12+ years of GMP experience in the Pharmaceutical industry, including 10+ years of coaching, mentoring and direct people management experience.
- A professional certification in quality, compliance and/or regulatory is a plus.
- Experience with CMOs, and CMC development. Large molecule and commercialization experience is a plus.
- Current and strong working knowledge of 21 CFR 210-211, Part 11, 610 & 820 cGMP/GLPs; EU cGMP/GLPs; and ICH quality and development guidelines.
- Experience with electronic QMS/LMS platforms such as Veeva, Master Control, ComplianceWire or equivalent desirable.
- Able to travel domestically and internationally.
COMPENSATION
- Salary Range: $229,000.00 to $297,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
INTRODUCTION
Denali Therapeutics Inc. is a biotechnology company pioneering a new class of biotherapeutics designed to cross the blood-brain barrier (BBB) using its proprietary TransportVehicle™ platform. With the first FDA-approved biologic specifically designed to cross the BBB, a clinically validated delivery platform and a growing portfolio of therapeutic candidates across all stages of development, we are advancing toward our goal of delivering effective medicines to transform the lives of people living with neurodegenerative diseases, lysosomal storage disorders and other serious diseases.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
ROLE AND RESPONSIBILITIES
This position will provide quality oversight of Denali’s external manufacturing network (CMO). This position will also support batch release, investigations, change management and documentation for given outsourced project activities.
Key Accountabilities/Core Job Responsibilities:
- Oversee both clinical and commercial GMP and GLP quality operations at CMOs, including quality documentation reviews and approvals, from Manufacturing and Quality Control, such as batch records, change controls and specifications of Denali products.
- Oversee end to end product quality management across the entire supply chain and distribution networks from GLP tox batches to Commercial release.
- Accountable for batch release disposition across the clinical and commercial product portfolio.
- Support CMC development including review and approval of specifications, stability studies, method validation, QC test methods, process validation and material distribution activities.
- Support CMC commercial operations including establishing infrastructure, SOPs and execution for Product Launch activities.
- Write and approve SOPs and Policies related to compliance and quality.
- Provide Quality expertise for regulatory inspections, inspection-readiness activities, and responses to regulatory observations.
- Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.
BASIC QUALIFICATIONS
- Typically requires a BS in a scientific discipline (MS preferred) with 12+ years of GMP experience in the Pharmaceutical industry, including 10+ years of coaching, mentoring and direct people management experience.
- A professional certification in quality, compliance and/or regulatory is a plus.
- Experience with CMOs, and CMC development. Large molecule and commercialization experience is a plus.
- Current and strong working knowledge of 21 CFR 210-211, Part 11, 610 & 820 cGMP/GLPs; EU cGMP/GLPs; and ICH quality and development guidelines.
- Experience with electronic QMS/LMS platforms such as Veeva, Master Control, ComplianceWire or equivalent desirable.
- Able to travel domestically and internationally.
COMPENSATION
- Salary Range: $229,000.00 to $297,000.00. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits.
This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.
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Get Access To All JobsTips for Finding Green Card Sponsorship in COO
Document your cross-functional leadership scope
PERM requires the employer to prove the COO role has specific educational and experiential requirements. Compile evidence of your advanced degree, executive credentials, and measurable operational outcomes before entering any sponsorship conversation.
Target companies with active PERM histories
Focus on employers who have sponsored foreign nationals for senior leadership roles before. Prior PERM filings for executive-level positions signal that HR and legal are already set up to run the process for a COO.
Verify your role qualifies under EB-2
COO positions typically qualify under EB-2 if the employer documents an advanced-degree requirement. Use O*NET to confirm the occupation's standard educational baseline, then work with your employer to align the job description accordingly.
Search COO roles on Migrate Mate
Filter by green card sponsorship eligibility to surface COO openings at employers actively filing PERM petitions. Migrate Mate surfaces verified sponsorship signals so you're not guessing which companies will support your EB-2 or EB-3 case.
Negotiate PERM filing into your offer terms
Before signing, confirm the employer will initiate PERM within a defined window after your start date. Executive hires sometimes face delays when legal and HR treat the green card as an afterthought rather than part of onboarding.
Understand how priority dates affect your COO timeline
USCIS assigns a priority date when the I-140 is approved. For nationals from backlogged countries, EB-2 and EB-3 wait times diverge significantly. Check the OFLC Wage Search to confirm prevailing wage levels, then review current USCIS visa bulletin data to model realistic residency timelines.
Green Card COO: Frequently Asked Questions
Does a COO role qualify for EB-2 or EB-3 green card sponsorship?
COO positions typically qualify under EB-2 when the employer requires an advanced degree in business administration, operations management, or a related field. If the role is structured as a skilled position requiring at least a bachelor's degree, EB-3 is an option. The employer's PERM labor certification must document the specific degree requirement to support whichever category you pursue.
How does the PERM green card process differ from H-1B sponsorship for a COO?
H-1B visa provides temporary status with a six-year cap, subject to annual lottery selection. PERM-based sponsorship leads to permanent residency with no cap lottery at the EB-2 or EB-3 level. The tradeoff is time: PERM requires DOL labor market testing before USCIS can adjudicate the I-140 petition, so the full process typically runs two to four years or longer depending on your country of birth and the visa bulletin.
What documentation should I prepare before approaching an employer about green card sponsorship?
Gather your advanced degree transcripts, any executive certifications, and a clear record of operational scope such as P&L responsibility, headcount managed, and measurable business outcomes. PERM requires the employer to match the job's requirements to your credentials, so having this documentation organized speeds up the job description drafting process and reduces back-and-forth with the employer's immigration counsel.
How do I find COO openings at employers who will sponsor a green card?
Migrate Mate lets you search COO roles specifically filtered by green card sponsorship eligibility, surfacing employers with active or prior PERM filing histories in leadership positions. This saves significant time compared to applying broadly and only discovering sponsorship posture after multiple interview rounds.
Can a foreign national start as COO before the green card is approved?
Yes. You can work in the COO role on a valid work-authorized status such as H-1B while the PERM and I-140 process runs in parallel. Once the I-140 is approved and a visa number is available, you file I-485 to adjust status to permanent resident. The green card approval does not need to precede your start date.