Green Card Systems Integration Specialist Jobs
Systems Integration Specialist roles qualify for EB-2 or EB-3 green card sponsorship through PERM labor certification, which requires your employer to document that no qualified U.S. worker is available for the position. Employers in defense contracting, healthcare IT, and enterprise software regularly file PERM for these roles due to sustained domestic talent shortages.
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Freenome is hiring a Senior Systems Integration Engineer to provide technical leadership and drive hands on contribution to the development of next generation NGS assays/products for early cancer detection. You will work in a Product Development team of world-class Scientists and Engineers focused on delivering Freenome’s IVD assay portfolio. If you are passionate about deploying the power of NGS-based diagnostics in clinical care, have a high sense of ownership, and take pride in providing technical leadership to a growing team of Systems Integration Engineers, while continuing to make an individual impact, we would love to speak with you! As part of a dynamic, flexible company you will be adapting to rapid technological progress and change, and help the team building the platform do the same. The role reports to the Senior Manager, Systems Integration. This role will be an onsite role based in our Brisbane, California headquarters.
What You’ll Do
- Lead Functional Integration strategy and execute end to end assay workflows, system verification and validation activities while maintaining a strong hands on role in automation platform operation and system level testing.
- Independently define study scope, validation strategies, success criteria, and execution plans. Develop and execute system level protocols, analyze results against User Needs, Design Input Requirements and Product Requirements, and communicate conclusions to inform AV/CV and development exit readiness.
- Partner with Development, SW Test Engineering, Automation, and SLIMS to align test coverage, entry and exit criteria, and deployment derisking strategies. Incorporate qualified software releases into Functional Integration and coordinate or execute lab deployment and fleet wide configuration verification.
- Drive the System Reliability program and lead its cross functional core team. Establish reliability metrics, trend recurring failure modes, prioritize and triage risks, and coordinate mitigation follow through with accountable subsystem owners. Lead prioritized technical investigations and communicate improvement opportunities, mitigation status, and resource needs.
- Evaluate system performance, proactively identify roadblocks, characterize root causes, and apply analytical problem solving skills to develop and execute scalable solutions for prioritized reagent, workflow, automation, hardware, software, and system integration issues.
- Author and review system level requirements, test strategies, validation protocols, traceability documentation, technical reports, and other design control documentation within the Design Control framework and Design History Files.
- Provide subject matter expertise to system level dFMEA, pFMEA, risk management, hazard assessment, and design review activities; identify hardware, firmware, software, workflow, and process mitigations with accountable subsystem owners to support adequate risk control measures.
- Build cross functional buy in by clearly communicating opportunities, risks, needs, problems, proposed solutions, and results in the appropriate forums. Facilitate project debriefs to improve future integration and validation activities.
- Provide technical guidance and mentorship to SI engineers in study design, hands on execution, troubleshooting, and documentation while maintaining individual ownership of assigned deliverables.
Must Haves
- Bachelor’s degree with 8+ years of relevant work experience, Master’s degree with 6+ years of relevant work experience, or Doctoral degree with 3+ years of relevant work experience; or equivalent experience.
- Education or equivalent experience in a relevant field such as Biology, Biochemistry, Bioengineering, Biomedical Engineering, Systems Engineering, Mechanical Engineering, Electrical Engineering, or a related discipline.
- Direct experience developing, integrating, or evaluating NGS assays and/or NGS based diagnostics, including hands on experience with automated NGS workflows.
- Experience driving hands on system integration activities, including assay workflow execution, automation platform operation, system evaluation, troubleshooting, performance characterization, and validation or verification testing.
- Experience developing and executing system level test plans and protocols, including data analysis, interpretation of test results, assessment of requirements conformance, failure investigation, and root cause analysis.
- Data analysis expertise and experience with various data analysis software packages, including well developed statistical analysis skills and design of experiments (DOE), using JMP, R, or equivalent tools. Knowledge of SQL, Python, R, or other programming languages is highly desired.
- Experience analyzing reliability data, identifying recurring failure modes, and coordinating cross functional investigations and mitigation follow through.
- Direct experience working in an FDA regulated, IVD, medical device, diagnostics, or other regulated product development environment.
- Strong working knowledge of requirements management, design controls, risk management, traceability, technical report authoring, Design History Files, and applicable quality system requirements.
- Demonstrated ability to operate independently on complex technical assignments, lead key projects, prioritize work based on company objectives and available resources, provide technical guidance to others, and build cross functional buy in.
Benefits And Additional Information
The US target range of our base salary for new hires is $156,750 - $200,025. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
- Family & Medical Leave Act (FMLA)
- Equal Employment Opportunity (EEO)
- Employee Polygraph Protection Act (EPPA)
California applicants please review the CCPA Notice at Collection here:
- California Consumer Privacy Act (CCPA)
About This Opportunity
Freenome is hiring a Senior Systems Integration Engineer to provide technical leadership and drive hands on contribution to the development of next generation NGS assays/products for early cancer detection. You will work in a Product Development team of world-class Scientists and Engineers focused on delivering Freenome’s IVD assay portfolio. If you are passionate about deploying the power of NGS-based diagnostics in clinical care, have a high sense of ownership, and take pride in providing technical leadership to a growing team of Systems Integration Engineers, while continuing to make an individual impact, we would love to speak with you! As part of a dynamic, flexible company you will be adapting to rapid technological progress and change, and help the team building the platform do the same. The role reports to the Senior Manager, Systems Integration. This role will be an onsite role based in our Brisbane, California headquarters.
What You’ll Do
- Lead Functional Integration strategy and execute end to end assay workflows, system verification and validation activities while maintaining a strong hands on role in automation platform operation and system level testing.
- Independently define study scope, validation strategies, success criteria, and execution plans. Develop and execute system level protocols, analyze results against User Needs, Design Input Requirements and Product Requirements, and communicate conclusions to inform AV/CV and development exit readiness.
- Partner with Development, SW Test Engineering, Automation, and SLIMS to align test coverage, entry and exit criteria, and deployment derisking strategies. Incorporate qualified software releases into Functional Integration and coordinate or execute lab deployment and fleet wide configuration verification.
- Drive the System Reliability program and lead its cross functional core team. Establish reliability metrics, trend recurring failure modes, prioritize and triage risks, and coordinate mitigation follow through with accountable subsystem owners. Lead prioritized technical investigations and communicate improvement opportunities, mitigation status, and resource needs.
- Evaluate system performance, proactively identify roadblocks, characterize root causes, and apply analytical problem solving skills to develop and execute scalable solutions for prioritized reagent, workflow, automation, hardware, software, and system integration issues.
- Author and review system level requirements, test strategies, validation protocols, traceability documentation, technical reports, and other design control documentation within the Design Control framework and Design History Files.
- Provide subject matter expertise to system level dFMEA, pFMEA, risk management, hazard assessment, and design review activities; identify hardware, firmware, software, workflow, and process mitigations with accountable subsystem owners to support adequate risk control measures.
- Build cross functional buy in by clearly communicating opportunities, risks, needs, problems, proposed solutions, and results in the appropriate forums. Facilitate project debriefs to improve future integration and validation activities.
- Provide technical guidance and mentorship to SI engineers in study design, hands on execution, troubleshooting, and documentation while maintaining individual ownership of assigned deliverables.
Must Haves
- Bachelor’s degree with 8+ years of relevant work experience, Master’s degree with 6+ years of relevant work experience, or Doctoral degree with 3+ years of relevant work experience; or equivalent experience.
- Education or equivalent experience in a relevant field such as Biology, Biochemistry, Bioengineering, Biomedical Engineering, Systems Engineering, Mechanical Engineering, Electrical Engineering, or a related discipline.
- Direct experience developing, integrating, or evaluating NGS assays and/or NGS based diagnostics, including hands on experience with automated NGS workflows.
- Experience driving hands on system integration activities, including assay workflow execution, automation platform operation, system evaluation, troubleshooting, performance characterization, and validation or verification testing.
- Experience developing and executing system level test plans and protocols, including data analysis, interpretation of test results, assessment of requirements conformance, failure investigation, and root cause analysis.
- Data analysis expertise and experience with various data analysis software packages, including well developed statistical analysis skills and design of experiments (DOE), using JMP, R, or equivalent tools. Knowledge of SQL, Python, R, or other programming languages is highly desired.
- Experience analyzing reliability data, identifying recurring failure modes, and coordinating cross functional investigations and mitigation follow through.
- Direct experience working in an FDA regulated, IVD, medical device, diagnostics, or other regulated product development environment.
- Strong working knowledge of requirements management, design controls, risk management, traceability, technical report authoring, Design History Files, and applicable quality system requirements.
- Demonstrated ability to operate independently on complex technical assignments, lead key projects, prioritize work based on company objectives and available resources, provide technical guidance to others, and build cross functional buy in.
Benefits And Additional Information
The US target range of our base salary for new hires is $156,750 - $200,025. You will also be eligible to receive equity, cash bonuses, and a full range of medical, financial, and other benefits depending on the position offered. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on several factors, including but not limited to, location, skill level, years and depth of relevant experience, and education.
Freenome is proud to be an equal-opportunity employer, and we value diversity. Freenome does not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.
Applicants have rights under Federal Employment Laws.
- Family & Medical Leave Act (FMLA)
- Equal Employment Opportunity (EEO)
- Employee Polygraph Protection Act (EPPA)
California applicants please review the CCPA Notice at Collection here:
- California Consumer Privacy Act (CCPA)
See all 84+ Green Card Systems Integration Specialist Jobs
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Get Access To All JobsTips for Finding Green Card Sponsorship as a Systems Integration Specialist
Document your systems integration project history
PERM audits frequently request evidence that your experience matches the job's requirements. Compile signed project summaries, architecture diagrams, and client acceptance records that map directly to the SOC 15-1299 job zone before your employer files.
Target employers with active PERM filing history
Defense primes, large hospital systems, and ERP implementation firms file PERM for Systems Integration Specialists at higher rates than generalist IT shops. Search Migrate Mate to filter roles by employers with documented green card sponsorship activity in this occupation.
Verify your degree field against PERM requirements
DOL requires the employer to specify an exact minimum qualification in the PERM job description. If your degree is in a tangential field like electrical engineering rather than computer science, confirm with your employer that their job description language will accommodate your credential before filing begins.
Clarify your EB-2 versus EB-3 category early
EB-2 requires a master's degree or a bachelor's plus five years of progressive experience in systems integration. EB-3 covers bachelor's-level professionals. Your category affects priority date queues, so confirm your classification with your employer's counsel before USCIS submits the I-140.
Ask about concurrent I-485 filing eligibility
If your priority date is current when the I-140 is approved, you can file for adjustment of status simultaneously rather than waiting. For EB-3 applicants from most countries outside India and China, this concurrent filing path is often available and shortens your wait for work authorization.
Confirm your employer's prevailing wage compliance
DOL uses the OFLC Wage Search to set the wage level your employer must pay throughout the PERM process and beyond. Request the wage determination your employer received and verify it matches the Level II or Level III wage appropriate for your integration seniority before the application goes in.
Green Card Systems Integration Specialist: Frequently Asked Questions
Does a Systems Integration Specialist role typically qualify as a specialty occupation for green card purposes?
Yes. Systems integration work requires a theoretical and practical application of highly specialized knowledge, typically a bachelor's degree or higher in computer science, information systems, or engineering. DOL and USCIS consistently classify this occupation under SOC 15-1299, which sits in Job Zone 4 on O*NET, supporting both EB-2 and EB-3 petition approval.
How does green card sponsorship through PERM differ from H-1B sponsorship for this role?
H-1B visa is a temporary status with a three-year initial period, an annual lottery, and no path to permanence on its own. PERM-based green card sponsorship has no annual cap at the EB-3 level for most nationalities, no lottery, and results in lawful permanent residency rather than a temporary authorization. The trade-off is a longer overall timeline, typically three to five years from PERM filing to I-485 approval for non-backlogged countries.
Which industries are most likely to sponsor a Systems Integration Specialist for a green card?
Defense contractors, federal IT services firms, hospital and healthcare network operators, and large-scale ERP implementation consultancies file PERM for Systems Integration Specialists at the highest rates. These employers face persistent hiring gaps for professionals who can bridge legacy infrastructure with modern platforms, which satisfies the DOL market test that underpins every PERM application.
Where can I find Systems Integration Specialist jobs where the employer is already open to green card sponsorship?
Migrate Mate filters job listings specifically by employers with employment-based green card sponsorship history, so you're not cold-applying and hoping the subject comes up. Searching by this occupation on Migrate Mate surfaces roles where PERM sponsorship is an established part of the employer's hiring practice, not a one-off exception they need to be convinced to attempt.
Can I switch employers after my PERM is filed but before my green card is approved?
Changing employers after PERM approval but before I-485 approval is possible under AC21 portability if your I-140 has been approved and your I-485 has been pending for at least 180 days, and the new role is in the same or a similar occupational classification. Switching before the I-140 is approved typically requires restarting the PERM process with the new employer.