NP Jobs in Durham, NC
NP jobs in Durham, North Carolina are concentrated in the Research Triangle Park corridor, Duke University Medical Center district, and Southpoint areas, with strong demand across academic medicine, community health, and specialty care. Employers hiring right now include Duke Health, Thriveworks, and Crossover Health. Scan the live roles below and apply to whichever ones fit.
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As a part of Duke Health’s outpatient clinic network, you will enjoy competitive compensation, comprehensive benefits plans, convenient work hours, and many opportunities for career advancement. Become a part of a team that values and invests in you.
Duke Advanced Practice Highlights:
- The nation’s first Physician Assistant Program was created at Duke in 1965 and is consistently ranked No. 1 in the country.
- The Duke School of Nursing is consistently ranked as one of the top nursing schools and their MSN and DNP programs offers eight advanced practice registered nurse majors and specialty certifications, as well as post master’s certificates and certification alignment programs.
- Commitment to ongoing learning for APPs through annual CME funding and access to high-quality Duke CME offerings including APP Grand Rounds and a professional advancement program. APPs are leaders in multiple arenas within Duke.
- Duke offers APPs opportunities to practice within team based integrative care in a tremendous variety of specialties. APPs are expected to work to top of scope in order to contribute to Duke’s missions which include clinical practice, education, and research.
- Practice locations can include Duke Health’s three hospitals or over 140 primary care and specialty care clinics throughout North Carolina.
About
The Duke Center for Onco-Primary Care provides evidence-based, patient-centered, personalized health care across the cancer continuum – from cancer screening to survivorship. The clinicians partner with oncologists and primary care teams to provide whole-person care.
Job Location
The APPs associated with the Duke Center for Onco-Primary Care Program will practice at several locations as needed (DCI Cancer Center (Durham), Women’s Cancer Center (Macon Pond, Raleigh), Duke Primary Care Sites, Duke Family Medicine Center and/or telehealth.
After a period of on-site training, this role will be a hybrid position, with 1-2 days per week working remotely.
Job Summary
Survivorship Patients
Provides direct patient care in outpatient settings for adult cancer survivors. Develops individualized survivorship care plans to address the long-term and late effects of cancer treatment, counsel and screen for treatment-related sequalae, monitor for cancer recurrence or secondary cancers, and address psychosocial concerns. Patient population includes adults age 18 and older, with a primary focus on breast cancer survivors and adult survivors of childhood cancer, as well as survivors of other cancer types based on clinic needs.
Multi-Cancer Early Detection
Partners with patients in shared decision-making regarding multi-cancer early detection testing. Evaluates patient eligibility, orders appropriate testing, and follows established protocols for the evaluation and management of positive test results.
Elevated PSA Patients
Provides initial assessment, evaluation, and diagnostic decision-making for patients referred with suspected prostate cancer. Conducts protocol-driven assessments and coordinates appropriate follow-up care and diagnostic workup.
Job Duties and Responsibilities:
- Take patient histories, conduct physical examinations, and document care as required.
- Create cancer survivorship care plans for new patients and discuss long-term care with them.
- Communicate with the patients’ primary care providers in a shared care model.
- Review all labs, pathology and radiology reports and communicate relevant findings to supervising physician and to patients.
- Respond to triage nurse calls and all other InBasket inquiries / requests.
- Interact with scheduling staff to adjust clinic schedule as necessary to assure efficient clinic operations; this includes responding to and managing overbook requests.
- Order and schedule laboratory studies and screening tests (e.g., echocardiograms).
- Complete (or delegate where appropriate) forms (such as FMLA and disability, letters of medical necessity, peer to peer reviews) where permitted. Coordinate supervising physician signing of home health orders.
- Clinical assignments are to hold 7 clinical sessions per week. A session is typically defined as 4 hours of booked clinical time.
- You may also have other responsibilities as a member of the Survivorship team consistent with your position as a clinical provider.
Job Eligibility Requirements
Education
NP: Graduate of MSN or DNP accredited Nurse Practitioner Program
PA: Graduate of ARC accredited Master’s Degree or Doctoral Degree Physician Assistant Program
Certification
NP: Any NP certification that treats adults (FNP, ANP, AGNP, AGACNP, etc.)
PA: PA-C
Licensure
NP: Must have unrestricted RN licensure issued by or recognized by the NCBON with authorization to practice as a NP
PA: Must have unrestricted license issued by NCMB with authorization to practice as PA
Both: Federal and State DEA independent license with prescriptive authority
Experience
APP experience is preferred, ideally in Family Practice and/or Oncology, but recent or new grads graduating by May 2025 are welcome to apply.
Job Hours
8:00 am – 5:00 pm, Monday-Friday. No on-call, holiday, evening, or weekend coverage is required.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, (including pregnancy and pregnancy related conditions), sexual orientation, or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
As a part of Duke Health’s outpatient clinic network, you will enjoy competitive compensation, comprehensive benefits plans, convenient work hours, and many opportunities for career advancement. Become a part of a team that values and invests in you.
Duke Advanced Practice Highlights:
- The nation’s first Physician Assistant Program was created at Duke in 1965 and is consistently ranked No. 1 in the country.
- The Duke School of Nursing is consistently ranked as one of the top nursing schools and their MSN and DNP programs offers eight advanced practice registered nurse majors and specialty certifications, as well as post master’s certificates and certification alignment programs.
- Commitment to ongoing learning for APPs through annual CME funding and access to high-quality Duke CME offerings including APP Grand Rounds and a professional advancement program. APPs are leaders in multiple arenas within Duke.
- Duke offers APPs opportunities to practice within team based integrative care in a tremendous variety of specialties. APPs are expected to work to top of scope in order to contribute to Duke’s missions which include clinical practice, education, and research.
- Practice locations can include Duke Health’s three hospitals or over 140 primary care and specialty care clinics throughout North Carolina.
About
The Duke Center for Onco-Primary Care provides evidence-based, patient-centered, personalized health care across the cancer continuum – from cancer screening to survivorship. The clinicians partner with oncologists and primary care teams to provide whole-person care.
Job Location
The APPs associated with the Duke Center for Onco-Primary Care Program will practice at several locations as needed (DCI Cancer Center (Durham), Women’s Cancer Center (Macon Pond, Raleigh), Duke Primary Care Sites, Duke Family Medicine Center and/or telehealth.
After a period of on-site training, this role will be a hybrid position, with 1-2 days per week working remotely.
Job Summary
Survivorship Patients
Provides direct patient care in outpatient settings for adult cancer survivors. Develops individualized survivorship care plans to address the long-term and late effects of cancer treatment, counsel and screen for treatment-related sequalae, monitor for cancer recurrence or secondary cancers, and address psychosocial concerns. Patient population includes adults age 18 and older, with a primary focus on breast cancer survivors and adult survivors of childhood cancer, as well as survivors of other cancer types based on clinic needs.
Multi-Cancer Early Detection
Partners with patients in shared decision-making regarding multi-cancer early detection testing. Evaluates patient eligibility, orders appropriate testing, and follows established protocols for the evaluation and management of positive test results.
Elevated PSA Patients
Provides initial assessment, evaluation, and diagnostic decision-making for patients referred with suspected prostate cancer. Conducts protocol-driven assessments and coordinates appropriate follow-up care and diagnostic workup.
Job Duties and Responsibilities:
- Take patient histories, conduct physical examinations, and document care as required.
- Create cancer survivorship care plans for new patients and discuss long-term care with them.
- Communicate with the patients’ primary care providers in a shared care model.
- Review all labs, pathology and radiology reports and communicate relevant findings to supervising physician and to patients.
- Respond to triage nurse calls and all other InBasket inquiries / requests.
- Interact with scheduling staff to adjust clinic schedule as necessary to assure efficient clinic operations; this includes responding to and managing overbook requests.
- Order and schedule laboratory studies and screening tests (e.g., echocardiograms).
- Complete (or delegate where appropriate) forms (such as FMLA and disability, letters of medical necessity, peer to peer reviews) where permitted. Coordinate supervising physician signing of home health orders.
- Clinical assignments are to hold 7 clinical sessions per week. A session is typically defined as 4 hours of booked clinical time.
- You may also have other responsibilities as a member of the Survivorship team consistent with your position as a clinical provider.
Job Eligibility Requirements
Education
NP: Graduate of MSN or DNP accredited Nurse Practitioner Program
PA: Graduate of ARC accredited Master’s Degree or Doctoral Degree Physician Assistant Program
Certification
NP: Any NP certification that treats adults (FNP, ANP, AGNP, AGACNP, etc.)
PA: PA-C
Licensure
NP: Must have unrestricted RN licensure issued by or recognized by the NCBON with authorization to practice as a NP
PA: Must have unrestricted license issued by NCMB with authorization to practice as PA
Both: Federal and State DEA independent license with prescriptive authority
Experience
APP experience is preferred, ideally in Family Practice and/or Oncology, but recent or new grads graduating by May 2025 are welcome to apply.
Job Hours
8:00 am – 5:00 pm, Monday-Friday. No on-call, holiday, evening, or weekend coverage is required.
Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, (including pregnancy and pregnancy related conditions), sexual orientation, or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.
See All 162+ NP Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
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Who's Hiring
- Duke Health81
- Thriveworks32
- Crossover Health16
- LiveWell Homecare Agency16L
- Advanced Medaesthetic Partners16
NP Jobs in Durham: Frequently Asked Questions
How do I get a np job in Durham?
Durham's heaviest np hiring happens inside academic medical systems, federally qualified health centers, and specialty practices clustered near the Duke and UNC health corridors. Candidates with inpatient or urgent care experience gain an edge in Durham's competitive academic market, while those with community health backgrounds tend to find faster entry at local FQHCs. Tailoring your application to the specific clinical population each Durham employer serves makes a meaningful difference.
Which companies hire nps in Durham?
Employers hiring nps in Durham right now include Duke Health, Thriveworks, and Crossover Health, based on current listings on Migrate Mate as of September 2026. Durham's employer mix leans heavily toward large academic health systems, multispecialty group practices, and federally funded community clinics serving the Research Triangle's diverse and growing population.
Are there remote np jobs in Durham?
Yes, though only for a narrow subset of roles, since most np work requires direct patient care on site. About 100% of np openings tied to Durham are remote or hybrid as of September 2026, reflecting demand from telehealth platforms and utilization management teams based in the area. The functions most likely to allow remote work are chronic disease management, psychiatric care, and population health review.
How can I get a np job in Durham with little or no experience?
The most realistic entry path in Durham is through residency or fellowship programs at Duke Health or UNC Health, both of which recruit new-graduate nps into structured transition-to-practice tracks. Durham's federally qualified health centers and community clinics are also known for hiring early-career nps with strong primary care rotations. Completing clinical hours at a Durham-area site before graduation builds the local relationships that often lead directly to first offers.
Related Jobs in North Carolina
See All 162+ NP Jobs in Durham
Find roles in Durham that match your experience and apply in just a few clicks.
Find NP Jobs in Durham