Principal Scientist Jobs in North Dakota
Principal Scientist jobs in North Dakota are concentrated in Fargo, Bismarck, and Grand Forks, with the strongest demand in agricultural science, materials research, and environmental analysis. Employers with a lasting footprint in the state include USDA Agricultural Research Service facilities, Sanford Health, and the University of North Dakota research divisions. Openings range from senior individual contributors leading research programs to principal-level roles managing multi-year grant-funded projects. Find a role that fits below and apply directly.
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Showing 5 of 11+ Principal Scientist jobs
Are you ready to accelerate your potential and make a real difference within life sciences, diagnostics and biotechnology?
At Aldevron, one of Danaher’s 15+ operating companies, our work saves lives—and we’re all united by a shared commitment to innovate for tangible impact.
You’ll thrive in a culture of belonging where you and your unique viewpoint matter. And by harnessing Danaher’s system of continuous improvement, you help turn ideas into impact – innovating at the speed of life.
At Aldevron, we deliver world-class CDMO services that accelerate the development of groundbreaking therapies. Our mission is to be the engine of innovation for genomic medicine pioneers. As a member of our team, you’ll help bring life-changing innovations to life—impacting millions around the world. We bring together deep scientific expertise, an unwavering commitment to quality, and a collaborative spirit to drive progress. Whether you're launching your career or bringing years of experience, we value the unique perspective you bring. Join us and become part of a mission-driven team advancing science and unlocking human potential—one discovery at a time.
Senior Scientist II, Analytical Method Development (AMD), is part of the R&D department located in Fargo, ND and will be on-site. At Aldevron, we combine best-in-class products and service with the ideal operating environment to lay the groundwork for vital new discoveries worldwide.
This role will be a part of the AMD team and report to the Director, Analytical Development, be responsible for a small team focused on DNA, mRNA and lipid nanoparticle (LNP) analytics. A significant aspect of this role will include communication between the analytical teams (development, qualification and QC) and clients, facilitating all parties’ expectations. The role of Senior Scientist II, AMD is expected to be motivated and capable of efficient prioritization, planning, and scheduling multiple projects to effectively meet pre-determined deadlines.
In this role, you will have the opportunity to:
- Lead a team focused on the design and development of new services and technologies such as (not limited to) mRNA, sgRNA, and LNPs. Develop solutions for simple and complex problems requiring a high degree of ingenuity, creativity, and innovation.
- Lead the execution of experiments for bio-physical and chemical data analysis. Broaden existing knowledge in own field and expand capabilities to other areas relevant to team operations.
- Establish new site processes including preparation of a laboratory, installation/qualification of equipment, development of SOPs, provide technical review of analytical documents to support regulatory filings for our clients, etc.
- Create detailed project reports and present findings and recommendations to both clients and senior management.
- Liaise between clients and analytical teams to facilitate the efficient transfer of knowledge from Aldevron to the client, and from client to analytical teams.
The essential requirements of the job include:
- PhD in biotechnology, biochemistry, or related discipline with 5+ years of industry experience, MS with 7+ years of industry experience, or BS with 10+ years of experience in related industry. CDMO experience is preferred but not required.
- Experience in development and optimization (biologics), assay optimization, experimental design, data analysis, and concept presentation.
- Mastery of regulatory guidelines (compendial and non-compendial) related to phase-appropriate analytical method development and validation.
- Bio-analytical method development skills, including chromatographic or electrophoretic based separation methods, and biophysical / chemical characterization of biologics.
- Excellent communication skills and demonstrate the ability to organize presentations (e.g., PowerPoint), summarize findings, and troubleshoot issues during meetings with clients.
Travel:
Limited travel may be required (e.g., 2-4 weeks per year).
It would be a plus if you also possess previous experience in:
- Analytical method Validation/qualification and/or analytical method comparability·
- Analytical methods using Surface plasmon resonance or characterization using a4F-MALs·
- Experience in discussing, defending, or authoring analytical topics with/for auditors or regulators
Aldevron, a Danaher operating company, offers a broad array of comprehensive, competitive benefit programs that add value to our lives. Whether it’s a health care program or paid time off, our programs contribute to life beyond the job. Our benefits are listed at Danaher Benefits Info.
Join our winning team today. Together, we’ll accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life.
For more information, visit www.danaher.com.
Are you ready to accelerate your potential and make a real difference within life sciences, diagnostics and biotechnology?
At Aldevron, one of Danaher’s 15+ operating companies, our work saves lives—and we’re all united by a shared commitment to innovate for tangible impact.
You’ll thrive in a culture of belonging where you and your unique viewpoint matter. And by harnessing Danaher’s system of continuous improvement, you help turn ideas into impact – innovating at the speed of life.
At Aldevron, we deliver world-class CDMO services that accelerate the development of groundbreaking therapies. Our mission is to be the engine of innovation for genomic medicine pioneers. As a member of our team, you’ll help bring life-changing innovations to life—impacting millions around the world. We bring together deep scientific expertise, an unwavering commitment to quality, and a collaborative spirit to drive progress. Whether you're launching your career or bringing years of experience, we value the unique perspective you bring. Join us and become part of a mission-driven team advancing science and unlocking human potential—one discovery at a time.
Senior Scientist II, Analytical Method Development (AMD), is part of the R&D department located in Fargo, ND and will be on-site. At Aldevron, we combine best-in-class products and service with the ideal operating environment to lay the groundwork for vital new discoveries worldwide.
This role will be a part of the AMD team and report to the Director, Analytical Development, be responsible for a small team focused on DNA, mRNA and lipid nanoparticle (LNP) analytics. A significant aspect of this role will include communication between the analytical teams (development, qualification and QC) and clients, facilitating all parties’ expectations. The role of Senior Scientist II, AMD is expected to be motivated and capable of efficient prioritization, planning, and scheduling multiple projects to effectively meet pre-determined deadlines.
In this role, you will have the opportunity to:
- Lead a team focused on the design and development of new services and technologies such as (not limited to) mRNA, sgRNA, and LNPs. Develop solutions for simple and complex problems requiring a high degree of ingenuity, creativity, and innovation.
- Lead the execution of experiments for bio-physical and chemical data analysis. Broaden existing knowledge in own field and expand capabilities to other areas relevant to team operations.
- Establish new site processes including preparation of a laboratory, installation/qualification of equipment, development of SOPs, provide technical review of analytical documents to support regulatory filings for our clients, etc.
- Create detailed project reports and present findings and recommendations to both clients and senior management.
- Liaise between clients and analytical teams to facilitate the efficient transfer of knowledge from Aldevron to the client, and from client to analytical teams.
The essential requirements of the job include:
- PhD in biotechnology, biochemistry, or related discipline with 5+ years of industry experience, MS with 7+ years of industry experience, or BS with 10+ years of experience in related industry. CDMO experience is preferred but not required.
- Experience in development and optimization (biologics), assay optimization, experimental design, data analysis, and concept presentation.
- Mastery of regulatory guidelines (compendial and non-compendial) related to phase-appropriate analytical method development and validation.
- Bio-analytical method development skills, including chromatographic or electrophoretic based separation methods, and biophysical / chemical characterization of biologics.
- Excellent communication skills and demonstrate the ability to organize presentations (e.g., PowerPoint), summarize findings, and troubleshoot issues during meetings with clients.
Travel:
Limited travel may be required (e.g., 2-4 weeks per year).
It would be a plus if you also possess previous experience in:
- Analytical method Validation/qualification and/or analytical method comparability·
- Analytical methods using Surface plasmon resonance or characterization using a4F-MALs·
- Experience in discussing, defending, or authoring analytical topics with/for auditors or regulators
Aldevron, a Danaher operating company, offers a broad array of comprehensive, competitive benefit programs that add value to our lives. Whether it’s a health care program or paid time off, our programs contribute to life beyond the job. Our benefits are listed at Danaher Benefits Info.
Join our winning team today. Together, we’ll accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life.
For more information, visit www.danaher.com.
See All 11 Principal Scientist Jobs in North Dakota
Find roles in North Dakota that match your experience and apply in just a few clicks.
Find Principal Scientist JobsPrincipal Scientist Jobs by City in North Dakota
Where North Dakota roles are concentrated, by current openings.
Principal Scientist Job Market in North Dakota
A snapshot from current North Dakota openings, updated as new roles post.
Who's Hiring
What North Dakota Employers Look For
The qualifications that appear most often in principal scientist jobs across North Dakota.
- PhD in a physical, biological, or agricultural science field relevant to North Dakota research priorities
- Minimum five years of research experience with demonstrated scientific leadership in a relevant discipline
- Proven ability to design and lead multi-phase research studies or experimental programs independently
- Experience securing or contributing to grant proposals, federal contracts, or institutional research funding
- Proficiency with statistical analysis software and scientific data management tools used in laboratory settings
- Strong publication record or equivalent documentation of original research contributions in peer-reviewed contexts
Principal Scientist Jobs in North Dakota: Frequently Asked Questions
How do you become a principal scientist in North Dakota?
Most principal scientist roles in North Dakota require a doctoral degree in a relevant scientific discipline, followed by several years of postdoctoral or industry research experience. There is no single state-issued license specific to the title, but researchers working in regulated areas such as clinical laboratory science must hold licensure through the North Dakota Board of Clinical Laboratory Practice. Candidates coming from agricultural science backgrounds often gain traction through positions with NDSU Extension or USDA research stations before advancing to principal-level roles.
Which companies hire principal scientists in North Dakota?
North Dakota principal scientist roles are posted by Sanford Health, Essentia Health, and Aldevron and others right now, based on current listings on Migrate Mate as of November 2026. North Dakota's agricultural research infrastructure, energy sector, and university research programs generate the most consistent demand for senior scientific talent in the state.
Which North Dakota cities have the most principal scientist jobs?
Fargo, Jamestown, and Minot are the North Dakota cities with the most principal scientist openings. Fargo leads because it hosts North Dakota State University, Sanford Health's research operations, and a growing technology corridor, while Grand Forks draws openings through the University of North Dakota and federal research facilities, and Bismarck reflects demand from state government agencies and regional healthcare systems.
Are there remote principal scientist jobs in North Dakota?
Yes, but they are less common than in purely desk-based fields because principal scientist work often involves laboratory oversight, field research, or direct management of research teams. About 0% of principal scientist openings tied to North Dakota are remote or hybrid as of November 2026, which is notable given the hands-on nature of many roles. Positions in data analysis, regulatory science, and scientific writing tend to offer the most remote flexibility.
How can I get hired as a principal scientist in North Dakota with little or no experience?
The most realistic entry path is through a postdoctoral research appointment at the University of North Dakota or North Dakota State University, both of which regularly post postdoc openings that develop candidates toward principal-level responsibilities. Research associate and scientist I roles at USDA Agricultural Research Service facilities in Fargo and Mandan also serve as strong stepping-stones. Building a publication record and contributing to funded grant projects early in your career is the credential that moves candidates into principal-level consideration at North Dakota institutions.
Where can I find and apply to principal scientist jobs in North Dakota?
You can find and apply to principal scientist jobs in North Dakota on Migrate Mate, which lists current openings in the state. Find roles that fit your background and apply directly to the employers posting them.
See All 11 Principal Scientist Jobs in North Dakota
Find roles in North Dakota that match your experience and apply in just a few clicks.
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