Senior Clinical Informatics Specialist Jobs
Senior Clinical Informatics Specialist jobs are open across health systems, hospitals, academic medical centers, and health IT vendors, from mid-level to senior and lead, with specializations in EHR implementation, clinical decision support, and data analytics. Find a role that fits from the openings below and apply directly.
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INTRODUCTION
We are searching for a Sr. Clinical Informatics Specialist to join our Physician Organization at Texas Children's. In this position, you will serve as a frontline technology support resource for medical staff and a key operational extension of the Physician Informaticist team. This role leverages deep clinical practice knowledge to design, evaluate, and support clinical technology solutions used by providers.
The position ensures that clinical technology tools—including Epic and related systems—are optimized to support safe, efficient, and effective workflows. This individual delivers concierge-level support, translates provider needs into system design, and advances key Clinical Informatics initiatives aligned with organizational strategy.
Duties & Job Responsibilities:
- Participate in the evaluation, selection, design, and implementation of clinical systems impacting clinicians and the Physician Organization.
- Collaborate across departments to ensure system enhancements reflect real-world clinical practice.
- Serve as a primary resource for medical staff on clinical information systems.
- Drive system optimization through enhancements, training partnerships, workflow evaluations, and ongoing frontline support.
- Facilitate strong clinician engagement in system improvement efforts.
- Lead troubleshooting efforts and coordinate downtime procedures.
- Evaluate system performance using process improvement methodologies.
- Conduct provider shadowing and develop reports to assess system impact.
- Support quality, safety, and performance improvement initiatives related to clinical systems.
- Assist with regulatory readiness and documentation improvement efforts.
- Enhance clinical decision support tools and data integration.
- Lead multiple, complex clinical informatics projects simultaneously.
- Define scope, timelines, resources, and success metrics.
- Act as system administrator for clinical informatics applications.
- Provide real-time, concierge-level support to physicians and advanced practice providers.
- Align system design with Physician Informaticist direction and Clinical Informatics strategy.
- Develop and execute testing scenarios that accurately reflect clinical workflows.
- Extract, analyze, and interpret data from Epic and other systems to support key initiatives.
- Develop and maintain dashboards, reports, and performance metrics.
- Partner with physician informaticists to define meaningful KPIs (e.g., provider efficiency, documentation quality, patient safety).
- Translate data into actionable insights for system and workflow optimization.
Knowledge & Skills:
- Strong understanding of clinical workflows, health IT systems, and Epic applications.
- Proficiency in data analysis and visualization tools.
- Knowledge of healthcare systems, interfaces, and software environments.
- Experience with device integration and clinical technologies.
- Strong project management, leadership, and organizational skills.
- Excellent written and verbal communication abilities.
- Ability to work independently and analyze system functionality against business needs.
Minimum Qualifications
- Bachelor’s degree in computer science, Business Administration, Healthcare Administration, Nursing, or a related field required.
- Licenses & Certifications (One of the Following Required)
- Registered Nurse (RN) – Texas Board of Nursing or Nurse Licensure Compact
- Nurse Practitioner (NP, PNP, NNP, FNP) – State of Texas
- Respiratory Care Practitioner (RCP)
- Occupational Therapist (OT) or Physical Therapist (PT)
- Pharmacist (RPh)
- Epic Certification (any module)
- Informatics Nursing Certification (RN-BC)
- AMIA Health Informatics Certification
- 7 years of experience in clinical informatics, clinical systems support, or healthcare IT within a hospital or healthcare setting required.
- 3 years in a dedicated informatics role required.
- 2 years managing medium to large-scale information services projects preferred.
- 5 years of information systems-related experience (e.g., super user roles, committees, or implementation support) preferred.
INTRODUCTION
We are searching for a Sr. Clinical Informatics Specialist to join our Physician Organization at Texas Children's. In this position, you will serve as a frontline technology support resource for medical staff and a key operational extension of the Physician Informaticist team. This role leverages deep clinical practice knowledge to design, evaluate, and support clinical technology solutions used by providers.
The position ensures that clinical technology tools—including Epic and related systems—are optimized to support safe, efficient, and effective workflows. This individual delivers concierge-level support, translates provider needs into system design, and advances key Clinical Informatics initiatives aligned with organizational strategy.
Duties & Job Responsibilities:
- Participate in the evaluation, selection, design, and implementation of clinical systems impacting clinicians and the Physician Organization.
- Collaborate across departments to ensure system enhancements reflect real-world clinical practice.
- Serve as a primary resource for medical staff on clinical information systems.
- Drive system optimization through enhancements, training partnerships, workflow evaluations, and ongoing frontline support.
- Facilitate strong clinician engagement in system improvement efforts.
- Lead troubleshooting efforts and coordinate downtime procedures.
- Evaluate system performance using process improvement methodologies.
- Conduct provider shadowing and develop reports to assess system impact.
- Support quality, safety, and performance improvement initiatives related to clinical systems.
- Assist with regulatory readiness and documentation improvement efforts.
- Enhance clinical decision support tools and data integration.
- Lead multiple, complex clinical informatics projects simultaneously.
- Define scope, timelines, resources, and success metrics.
- Act as system administrator for clinical informatics applications.
- Provide real-time, concierge-level support to physicians and advanced practice providers.
- Align system design with Physician Informaticist direction and Clinical Informatics strategy.
- Develop and execute testing scenarios that accurately reflect clinical workflows.
- Extract, analyze, and interpret data from Epic and other systems to support key initiatives.
- Develop and maintain dashboards, reports, and performance metrics.
- Partner with physician informaticists to define meaningful KPIs (e.g., provider efficiency, documentation quality, patient safety).
- Translate data into actionable insights for system and workflow optimization.
Knowledge & Skills:
- Strong understanding of clinical workflows, health IT systems, and Epic applications.
- Proficiency in data analysis and visualization tools.
- Knowledge of healthcare systems, interfaces, and software environments.
- Experience with device integration and clinical technologies.
- Strong project management, leadership, and organizational skills.
- Excellent written and verbal communication abilities.
- Ability to work independently and analyze system functionality against business needs.
Minimum Qualifications
- Bachelor’s degree in computer science, Business Administration, Healthcare Administration, Nursing, or a related field required.
- Licenses & Certifications (One of the Following Required)
- Registered Nurse (RN) – Texas Board of Nursing or Nurse Licensure Compact
- Nurse Practitioner (NP, PNP, NNP, FNP) – State of Texas
- Respiratory Care Practitioner (RCP)
- Occupational Therapist (OT) or Physical Therapist (PT)
- Pharmacist (RPh)
- Epic Certification (any module)
- Informatics Nursing Certification (RN-BC)
- AMIA Health Informatics Certification
- 7 years of experience in clinical informatics, clinical systems support, or healthcare IT within a hospital or healthcare setting required.
- 3 years in a dedicated informatics role required.
- 2 years managing medium to large-scale information services projects preferred.
- 5 years of information systems-related experience (e.g., super user roles, committees, or implementation support) preferred.
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Find JobsSenior Clinical Informatics Specialist Job Market
A snapshot from current openings nationwide, updated as new roles post.
Who's Hiring
- Revolution Medicines2
- Cepheid1
- Colgate-Palmolive1
- Eli Lilly1
- Incyte Corporation1
Top Industries Hiring
- Biotechnology & Pharmaceuticals4
- Chemicals & Materials1
- Education1
- Insurance1
- Manufacturing1
What Employers Look For
The qualifications that appear most often in senior clinical informatics specialist jobs.
- Epic, Cerner, or Meditech EHR proficiency with hands-on implementation or optimization experience
- Clinical background such as an RN, PharmD, or other licensed clinical credential
- Bachelor's or master's degree in health informatics, nursing, or a related clinical or information science field
- CPHIMS, CHDA, or vendor-specific EHR certification such as Epic certification
- Experience with clinical decision support design, workflow analysis, or clinical data governance
- Proficiency in healthcare data standards including HL7, FHIR, or ICD-10 coding systems
Tips for Your Senior Clinical Informatics Specialist Job Search
Tailor your resume to EHR specifics
Recruiters scan for the exact EHR platform by name, so list Epic, Cerner, or Meditech prominently and note the modules you've configured or trained on. Generic "EHR experience" without specifics gets filtered out before a human reads it.
Highlight clinical background alongside IT skills
Many postings require clinical licensure or a clinical degree, not just technical credentials. Lead with your RN, PharmD, or other clinical credential early in your resume so hiring managers don't assume you're a pure IT candidate and pass you over.
Apply early to roles that fit
Migrate Mate lists senior clinical informatics specialist openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target postings that match your certification tier
Roles specifying CPHIMS, CHDA, or Epic certification have narrower candidate pools and often faster hiring timelines. Filter your search by certification requirement so you're competing where your credentials give you a concrete advantage.
Prepare a workflow redesign case study for interviews
Interviewers consistently ask for a concrete example of a clinical workflow you improved using informatics tools. Prepare one case study with a before-and-after narrative, the data that drove your decision, and the clinical outcome, so you can adapt it to any panel format.
Negotiate scope before accepting an offer
Senior informatics roles vary widely in decision-making authority, from analyst-level execution to strategy ownership. Ask directly about governance committee access, project leadership autonomy, and whether the role has a path to informatics management before you accept.
Senior Clinical Informatics Specialist Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical informatics specialists?
The companies hiring the most senior clinical informatics specialists right now include Revolution Medicines, Cepheid, and Colgate-Palmolive, with the largest share of openings in Pennsylvania, Texas, and Indiana, based on current listings on Migrate Mate as of June 2026. Health systems, academic medical centers, and health IT vendors consistently account for the majority of postings.
How many senior clinical informatics specialist jobs are remote?
About 44% of senior clinical informatics specialist openings are fully remote or hybrid as of June 2026, making this one of the more flexible specialties in clinical operations. Roles centered on EHR optimization, clinical decision support build, and data analytics tend to offer the most remote flexibility, while positions tied to go-live support or end-user training are more likely to require on-site presence.
How do you become a senior clinical informatics specialist?
Start with a clinical degree or licensure, such as nursing or pharmacy, combined with a health informatics credential or graduate coursework. Gain hands-on EHR experience in a clinical or analyst role, then pursue a vendor certification like Epic or a professional credential like CPHIMS. Move into informatics analyst or specialist roles, build a portfolio of workflow improvement projects, and accumulate enough system-level experience to qualify for senior designations.
Can you get hired as a senior clinical informatics specialist with little informatics experience?
It's difficult to enter directly at the senior level without informatics experience, but strong clinical experience on a major EHR platform can substitute in some organizations. Candidates who have served as super-users, led department-level EHR training, or worked on go-live teams often move into junior or mid-level informatics roles first and reach senior designation within a few years of dedicated informatics work.
What does the senior clinical informatics specialist interview process look like?
Most hiring processes include an initial recruiter screen, a technical interview with the informatics or IT team covering EHR platform knowledge and workflow analysis, and a panel interview with clinical stakeholders. Many employers add a practical component where candidates walk through a workflow redesign scenario or demonstrate familiarity with clinical data standards. Final rounds often include a conversation with informatics leadership focused on strategic thinking and cross-departmental communication.
Where can I find and apply to senior clinical informatics specialist jobs?
You can find and apply to senior clinical informatics specialist jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your EHR platform experience, clinical background, and certification level, then apply directly to each listing that fits.
See All Senior Clinical Informatics Specialist Jobs
Jump back to the full list of openings and apply to any senior clinical informatics specialist role that fits.
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