Senior Clinical Informatics Specialist Jobs
Senior Clinical Informatics Specialist jobs are open across health systems, hospitals, academic medical centers, and health IT vendors, from mid-level to senior and lead, with specializations in EHR implementation, clinical decision support, and data analytics. Find a role that fits from the openings below and apply directly.
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About Crossover Health
Crossover Health is creating the future of health as it should be. A national, team-based medical group with a focus on wellbeing and prevention that extends beyond traditional sick care, the company delivers an entirely new model of healthcare—Primary Health—built on the foundation of trusted relationships, an interdisciplinary care team approach, and outcomes-based payment. Crossover’s Primary Health model integrates primary care, physical medicine, mental health, health coaching, care navigation and more, and delivers care in surround-sound—in-person, virtually and via asynchronous messaging. Together we are building a community of members that embraces healthcare as a proactive part of their lifestyle.
Job Summary
Job Responsibilities
The Clinical Application & Informatics Specialist plays a key role in supporting and optimizing clinical systems, particularly EHR and related applications. This mid-level role combines informatics strategy with hands-on application support and cross-functional collaboration. You’ll serve as both a systems expert and a clinical operations partner—helping bridge technology with real-world care delivery.
Informatics & Strategic Enablement:
Lead clinical informatics initiatives that support the integration and optimization of EHR and other clinical systems.
Collaborate with product, IT, and data teams to ensure clinical requirements are reflected in platform design and functionality.
Gather and prioritize provider and clinical staff feedback to support system improvements and user experience enhancements.
Contribute to interoperability efforts, including the evaluation of data exchange standards, APIs, and vendor integrations.
Application Configuration & Support:
Configure and maintain clinical applications (e.g., Athenahealth, Elation) to align with evolving workflows.
Provide tier-2 support for application-related issues and escalate to vendors or IT when needed.
Participate in software upgrades, testing, and system validation.
Assist in managing vendor relationships and ensuring service-level expectations are met.
Training & Adoption:
Develop training materials, job aids, and tip sheets to support user onboarding and change management.
Deliver training and go-live support to providers, nurses, and operational staff.
Document clinical workflows and maintain system configuration records.
Project Coordination:
Support project timelines, testing plans, and implementation checklists for system changes or new tool rollouts.
Track KPIs and performance metrics related to system usage and provider satisfaction.
Participate in informatics and operations meetings to align on organizational goals and identify opportunities for improvement.
Required Qualifications
Bachelor’s degree in Healthcare, Health Informatics, Nursing, Information Systems, or related field.
3–5+ years of experience in clinical informatics, clinical application support, or health IT.
Hands-on experience configuring and supporting EHR systems; experience with Athenahealth is a strong plus.
Familiarity with healthcare interoperability standards (e.g., HL7, FHIR, APIs).
Excellent communication and change management skills, with experience translating clinical needs into technical solutions.
Strong problem-solving abilities and a collaborative mindset.
Preferred Qualifications
Master's preferred.
Preferred certifications: CPHIMS, PMP, Athena or Epic certifications, or relevant technical training.
Crossover Health is committed to Equal Employment Opportunity regardless of race, color, national origin, gender, sexual orientation, age, religion, veteran status, disability, history of disability or perceived disability. If you need assistance or an accommodation due to a disability, you may email us at careers@crossoverhealth.com.
To all recruitment agencies: We do not accept unsolicited agency resumes and are not responsible for any fees related to unsolicited resumes.
#LI-RemoteAbout Crossover Health
Crossover Health is creating the future of health as it should be. A national, team-based medical group with a focus on wellbeing and prevention that extends beyond traditional sick care, the company delivers an entirely new model of healthcare—Primary Health—built on the foundation of trusted relationships, an interdisciplinary care team approach, and outcomes-based payment. Crossover’s Primary Health model integrates primary care, physical medicine, mental health, health coaching, care navigation and more, and delivers care in surround-sound—in-person, virtually and via asynchronous messaging. Together we are building a community of members that embraces healthcare as a proactive part of their lifestyle.
Job Summary
Job Responsibilities
The Clinical Application & Informatics Specialist plays a key role in supporting and optimizing clinical systems, particularly EHR and related applications. This mid-level role combines informatics strategy with hands-on application support and cross-functional collaboration. You’ll serve as both a systems expert and a clinical operations partner—helping bridge technology with real-world care delivery.
Informatics & Strategic Enablement:
Lead clinical informatics initiatives that support the integration and optimization of EHR and other clinical systems.
Collaborate with product, IT, and data teams to ensure clinical requirements are reflected in platform design and functionality.
Gather and prioritize provider and clinical staff feedback to support system improvements and user experience enhancements.
Contribute to interoperability efforts, including the evaluation of data exchange standards, APIs, and vendor integrations.
Application Configuration & Support:
Configure and maintain clinical applications (e.g., Athenahealth, Elation) to align with evolving workflows.
Provide tier-2 support for application-related issues and escalate to vendors or IT when needed.
Participate in software upgrades, testing, and system validation.
Assist in managing vendor relationships and ensuring service-level expectations are met.
Training & Adoption:
Develop training materials, job aids, and tip sheets to support user onboarding and change management.
Deliver training and go-live support to providers, nurses, and operational staff.
Document clinical workflows and maintain system configuration records.
Project Coordination:
Support project timelines, testing plans, and implementation checklists for system changes or new tool rollouts.
Track KPIs and performance metrics related to system usage and provider satisfaction.
Participate in informatics and operations meetings to align on organizational goals and identify opportunities for improvement.
Required Qualifications
Bachelor’s degree in Healthcare, Health Informatics, Nursing, Information Systems, or related field.
3–5+ years of experience in clinical informatics, clinical application support, or health IT.
Hands-on experience configuring and supporting EHR systems; experience with Athenahealth is a strong plus.
Familiarity with healthcare interoperability standards (e.g., HL7, FHIR, APIs).
Excellent communication and change management skills, with experience translating clinical needs into technical solutions.
Strong problem-solving abilities and a collaborative mindset.
Preferred Qualifications
Master's preferred.
Preferred certifications: CPHIMS, PMP, Athena or Epic certifications, or relevant technical training.
Crossover Health is committed to Equal Employment Opportunity regardless of race, color, national origin, gender, sexual orientation, age, religion, veteran status, disability, history of disability or perceived disability. If you need assistance or an accommodation due to a disability, you may email us at careers@crossoverhealth.com.
To all recruitment agencies: We do not accept unsolicited agency resumes and are not responsible for any fees related to unsolicited resumes.
#LI-RemoteSenior Clinical Informatics Specialist Jobs by Experience Level
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Find JobsSenior Clinical Informatics Specialist Job Market
Who's Hiring
- Providence13
- CVS Health10
- Cone Health5
- Sutter Health5
- Medpace4
Top Industries Hiring
- Healthcare & Medical Services25
- Science & Research4
- Technology & Software4
- Biotechnology & Pharmaceuticals4
- Education3
What Employers Look For
The qualifications that appear most often in senior clinical informatics specialist jobs.
- Epic, Cerner, or Meditech EHR proficiency with hands-on implementation or optimization experience
- Clinical background such as an RN, PharmD, or other licensed clinical credential
- Bachelor's or master's degree in health informatics, nursing, or a related clinical or information science field
- CPHIMS, CHDA, or vendor-specific EHR certification such as Epic certification
- Experience with clinical decision support design, workflow analysis, or clinical data governance
- Proficiency in healthcare data standards including HL7, FHIR, or ICD-10 coding systems
Tips for Your Senior Clinical Informatics Specialist Job Search
Tailor your resume to EHR specifics
Recruiters scan for the exact EHR platform by name, so list Epic, Cerner, or Meditech prominently and note the modules you've configured or trained on. Generic "EHR experience" without specifics gets filtered out before a human reads it.
Highlight clinical background alongside IT skills
Many postings require clinical licensure or a clinical degree, not just technical credentials. Lead with your RN, PharmD, or other clinical credential early in your resume so hiring managers don't assume you're a pure IT candidate and pass you over.
Apply early to roles that fit
Migrate Mate lists senior clinical informatics specialist openings from across the United States in one place, so you can find roles that match and apply directly to each listing.
Target postings that match your certification tier
Roles specifying CPHIMS, CHDA, or Epic certification have narrower candidate pools and often faster hiring timelines. Filter your search by certification requirement so you're competing where your credentials give you a concrete advantage.
Prepare a workflow redesign case study for interviews
Interviewers consistently ask for a concrete example of a clinical workflow you improved using informatics tools. Prepare one case study with a before-and-after narrative, the data that drove your decision, and the clinical outcome, so you can adapt it to any panel format.
Negotiate scope before accepting an offer
Senior informatics roles vary widely in decision-making authority, from analyst-level execution to strategy ownership. Ask directly about governance committee access, project leadership autonomy, and whether the role has a path to informatics management before you accept.
Senior Clinical Informatics Specialist Jobs: Frequently Asked Questions
Which companies are hiring the most senior clinical informatics specialists?
The companies hiring the most senior clinical informatics specialists right now include Providence, CVS Health, and Cone Health, with the largest share of openings in California, Texas, and North Carolina, based on current listings on Migrate Mate as of September 2026. Health systems, academic medical centers, and health IT vendors consistently account for the majority of postings.
How many senior clinical informatics specialist jobs are remote?
About 60% of senior clinical informatics specialist openings are fully remote or hybrid as of September 2026, making this one of the more flexible specialties in clinical operations. Roles centered on EHR optimization, clinical decision support build, and data analytics tend to offer the most remote flexibility, while positions tied to go-live support or end-user training are more likely to require on-site presence.
How do you become a senior clinical informatics specialist?
Start with a clinical degree or licensure, such as nursing or pharmacy, combined with a health informatics credential or graduate coursework. Gain hands-on EHR experience in a clinical or analyst role, then pursue a vendor certification like Epic or a professional credential like CPHIMS. Move into informatics analyst or specialist roles, build a portfolio of workflow improvement projects, and accumulate enough system-level experience to qualify for senior designations.
Can you get hired as a senior clinical informatics specialist with little informatics experience?
It's difficult to enter directly at the senior level without informatics experience, but strong clinical experience on a major EHR platform can substitute in some organizations. Candidates who have served as super-users, led department-level EHR training, or worked on go-live teams often move into junior or mid-level informatics roles first and reach senior designation within a few years of dedicated informatics work.
What does the senior clinical informatics specialist interview process look like?
Most hiring processes include an initial recruiter screen, a technical interview with the informatics or IT team covering EHR platform knowledge and workflow analysis, and a panel interview with clinical stakeholders. Many employers add a practical component where candidates walk through a workflow redesign scenario or demonstrate familiarity with clinical data standards. Final rounds often include a conversation with informatics leadership focused on strategic thinking and cross-departmental communication.
Where can I find and apply to senior clinical informatics specialist jobs?
You can find and apply to senior clinical informatics specialist jobs on Migrate Mate, which lists current openings from across the United States. Find roles that match your EHR platform experience, clinical background, and certification level, then apply directly to each listing that fits.
See All 166+ Senior Clinical Informatics Specialist Jobs
Find roles that match your experience and apply in just a few clicks.
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