Science & Research H-1B1 Singapore Sponsorship Jobs in Massachusetts
Science and research H-1B1 Singapore sponsorship jobs in Massachusetts are concentrated in the Boston and Cambridge corridor, home to institutions like MIT, Harvard, Broad Institute, and Pfizer's research campuses. Biotech hubs in Worcester and Lexington also draw Singaporean researchers in life sciences, computational biology, and materials science.
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Get Access To All JobsINTRODUCTION
We are seeking a Principal Scientist, DS Process Development & Manufacturing, to join our growing Drug Substance group at Generate:Biomedicines. This role will support monoclonal antibody (mAb) drug substance development with a strong MS&T focus, bridging process development, scale-up, tech transfer, and GMP manufacturing execution. The position offers broad exposure across upstream and downstream operations, CDMO management, and quality systems.
ROLE AND RESPONSIBILITIES
- Support Drug Substance process development and manufacturing activities (e.g., upstream expression, purification, UF/DF, viral clearance)
- Design and execute scale-up, process characterization, and PPQ-enabling studies
- Own tech transfer and support GMP campaigns at CDMO (person-in-plant support as needed)
- Review and/or author GMP documentation including batch records, change controls, deviations and CAPAs
- Provide technical leadership for GMP manufacturing, including troubleshooting and data-driven decision making
- Partner cross-functionally across CMC, QA, Regulatory, and Supply Chain to drive program execution
- Drive continuous process improvement and process robustness initiatives
- Leverage AI-driven tools for knowledge management and data analysis to enable efficient and scalable CMC workflows
BASIC QUALIFICATIONS
- PhD or MS in Chemical Engineering, Biochemistry, or related field with relevant industry experience in biologics manufacturing
- 5–8 years of industry experience in Drug Substance process development and/or GMP manufacturing in a biotech/pharma setting
- Strong attention to detail with the ability to analyze complex technical data
- Excellent communication and strong technical writing skills
- Experience working with CDMOs, supporting tech transfer, and regulatory submissions
- Hands-on experience with GMP documentation (eg: executed Batch Records) and quality systems (deviations, change control, CAPA)
- Demonstrated ability to lead complex technical programs and collaborate effectively in cross-functional teams
- Familiarity of regulatory issues pertaining to the manufacture of biologics, process validation, QbD principles and industry trends
PREFERRED QUALIFICATIONS
- Experience supporting BLA/IND submissions
- Exposure to accelerated development environments for early to late-stage program transitions
LOCATION
This role is based out of Somerville, MA with flexibility for hybrid work (1-2 days a week in the office).
WHY JOIN US?
This is an opportunity to contribute to the development of innovative biologics at a company transforming medicine through Generative Biology™. At Generate Biomedicines, you'll work closely with cross-functional teams and external partners to support the delivery of high-quality Drug Substance for clinical programs. You'll gain or broaden your exposure to late-stage CMC activities, collaborate with leading CDMOs, and play a key role in ensuring robust documentation and data integrity for products that matter to patients.
ABOUT GENERATE BIOMEDICINES
We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.
Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.
At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
INTRODUCTION
We are seeking a Principal Scientist, DS Process Development & Manufacturing, to join our growing Drug Substance group at Generate:Biomedicines. This role will support monoclonal antibody (mAb) drug substance development with a strong MS&T focus, bridging process development, scale-up, tech transfer, and GMP manufacturing execution. The position offers broad exposure across upstream and downstream operations, CDMO management, and quality systems.
ROLE AND RESPONSIBILITIES
- Support Drug Substance process development and manufacturing activities (e.g., upstream expression, purification, UF/DF, viral clearance)
- Design and execute scale-up, process characterization, and PPQ-enabling studies
- Own tech transfer and support GMP campaigns at CDMO (person-in-plant support as needed)
- Review and/or author GMP documentation including batch records, change controls, deviations and CAPAs
- Provide technical leadership for GMP manufacturing, including troubleshooting and data-driven decision making
- Partner cross-functionally across CMC, QA, Regulatory, and Supply Chain to drive program execution
- Drive continuous process improvement and process robustness initiatives
- Leverage AI-driven tools for knowledge management and data analysis to enable efficient and scalable CMC workflows
BASIC QUALIFICATIONS
- PhD or MS in Chemical Engineering, Biochemistry, or related field with relevant industry experience in biologics manufacturing
- 5–8 years of industry experience in Drug Substance process development and/or GMP manufacturing in a biotech/pharma setting
- Strong attention to detail with the ability to analyze complex technical data
- Excellent communication and strong technical writing skills
- Experience working with CDMOs, supporting tech transfer, and regulatory submissions
- Hands-on experience with GMP documentation (eg: executed Batch Records) and quality systems (deviations, change control, CAPA)
- Demonstrated ability to lead complex technical programs and collaborate effectively in cross-functional teams
- Familiarity of regulatory issues pertaining to the manufacture of biologics, process validation, QbD principles and industry trends
PREFERRED QUALIFICATIONS
- Experience supporting BLA/IND submissions
- Exposure to accelerated development environments for early to late-stage program transitions
LOCATION
This role is based out of Somerville, MA with flexibility for hybrid work (1-2 days a week in the office).
WHY JOIN US?
This is an opportunity to contribute to the development of innovative biologics at a company transforming medicine through Generative Biology™. At Generate Biomedicines, you'll work closely with cross-functional teams and external partners to support the delivery of high-quality Drug Substance for clinical programs. You'll gain or broaden your exposure to late-stage CMC activities, collaborate with leading CDMOs, and play a key role in ensuring robust documentation and data integrity for products that matter to patients.
ABOUT GENERATE BIOMEDICINES
We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creation—one grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation, this approach aims to reduce the uncertainty, time, and cost associated with developing protein-based medicines.
Founded in 2018, we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model, we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.
At Generate:Biomedicines, we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need, faster, guided by our values and leadership behaviors.
Generate:Biomedicines is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Company's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.
Science & Research Job Roles in Massachusetts
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Search Science & Research Jobs in MassachusettsScience & Research Jobs in Massachusetts: Frequently Asked Questions
Which science and research companies sponsor H-1B1 Singapore visas in Massachusetts?
Massachusetts employers with active science and research hiring that have filed H-1B1 visa Labor Condition Applications include major pharmaceutical and biotech companies such as Moderna, Biogen, and Vertex Pharmaceuticals, alongside research hospitals like Massachusetts General Hospital and Dana-Farber Cancer Institute. Academic institutions including MIT and Harvard also sponsor researchers through this visa category for qualifying specialty occupation roles.
Which cities in Massachusetts have the most science and research H-1B1 Singapore sponsorship jobs?
Cambridge and Boston account for the highest concentration, driven by the Kendall Square biotech cluster and affiliated research hospitals. Worcester has a growing life sciences corridor anchored by UMass Medical School and pharmaceutical manufacturers. Lexington and Waltham host several established research and development campuses, making the Route 128 technology belt a secondary but significant source of H-1B1 Singapore sponsorship activity.
What types of science and research roles typically qualify for H-1B1 Singapore sponsorship?
Roles that typically qualify are those requiring at least a bachelor's degree in a directly related scientific field. Common qualifying positions include research scientist, computational biologist, biochemist, materials scientist, and clinical research associate. The H-1B1 Singapore category requires the role to meet the specialty occupation standard, meaning a specific theoretical and practical body of knowledge in the natural sciences, engineering, or a related discipline must be a minimum requirement for entry.
How do I find science & research H-1B1 Singapore sponsorship jobs in Massachusetts?
Migrate Mate is built specifically for this search, letting you filter science and research jobs in Massachusetts by H-1B1 Singapore sponsorship history. Because Migrate Mate surfaces employer Labor Condition Application filing data from DOL records, you can see which Massachusetts research institutions and biotech companies have actually sponsored this visa category rather than relying on employer self-reporting. That makes it far more efficient than general job searches for H-1B1 Singapore candidates.
Are there any Massachusetts-specific considerations for H-1B1 Singapore sponsorship in science and research?
Massachusetts has a high density of research employers accustomed to international sponsorship, which means many HR and legal teams already have H-1B1 Singapore filing experience. State-level rules do not alter the federal H-1B1 process, but Massachusetts public research institutions may be subject to state procurement guidelines that can affect hiring timelines. Researchers on sponsored grants should also confirm that grant terms allow for H-1B1 Singapore holders, as some federal funding agreements have specific work-authorization requirements for research personnel.
What is the prevailing wage for H-1B1 Singapore science & research jobs in Massachusetts?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.