Chief Commercial Officer Jobs in USA with Visa Sponsorship
Chief Commercial Officer roles attract H-1B visa and O-1A sponsorship from large corporations and growth-stage companies, but executive-level positions face extra USCIS scrutiny. Employers must document that the CCO role qualifies as a specialty occupation requiring a specific degree field. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsPOSITION TITLE: Chief Commercial Officer (CCO)
LOCATION: Cambridge, MA (hybrid)
This position reports to our global HQ in Cambridge, MA. Travel is expected domestically and internationally when needed.
Who We Are:
TriNetX connects healthcare organizations and researchers across the globe so they can transparently see what's happening in real patient populations. Our aim is simple and ambitious: Provide a clear path to trustworthy answers, whether your goal is to create promising new therapies, publish groundbreaking research, or improve health outcomes. We keep identifiable data where it belongs—inside more than 11,000+ clinical sites across 20+ countries—preserving security, provenance, and granularity. Our trusted partnerships with providers ensure high-fidelity data, and a properly governed linkage back to individual patients. At TriNetX, we enable life sciences, healthcare, and academic institutions to strengthen human health—with data you can trace, evidence you can defend, and answers you can trust.
Who We Are Looking For:
The Chief Commercial Officer (CCO) will serve as the senior executive commercial leader at TriNetX, responsible for driving the company's global revenue strategy and go-to-market execution. This executive will own and integrate critical commercial functions — marketing, commercial operations, healthcare organization (HCO) network operations, sales, and account management to deliver cohesive growth across all market segments. Reporting directly to the CEO, the CCO will be a key member of the executive leadership team and a champion of TriNetX's mission to strengthen human health with data you can trust.
What You Will Be Doing:
- Strategic Commercial Leadership: Define and execute TriNetX's global commercial strategy across all revenue-generating and network-building functions. Serve as the primary commercial voice on the executive leadership team, partnering with the CEO and Board on commercial direction, market positioning, and growth initiatives.
- Marketing & Brand: Lead the global marketing function, including product marketing, demand generation, content, communications, and brand strategy. Drive integrated go-to-market campaigns that build brand awareness, generate qualified pipeline, and differentiate TriNetX in the market.
- Commercial Operations: Oversee commercial operations including revenue operations, sales enablement, CRM strategy, forecasting, and compensation design. Ensure data-driven, scalable processes that allow the full commercial organization to operate with efficiency and accountability.
- HCO Network Operations: Own the healthcare organization (HCO) network operations function, responsible for acquiring, onboarding, expanding, and retaining TriNetX's global network of healthcare member organizations. Develop and execute strategies to deepen HCO engagement, maximize data contribution, and grow the value of the network for all stakeholders.
- Revenue Growth & Accountability: Set and achieve ambitious bookings and revenue targets across all commercial segments. Align Marketing, Commercial Operations, and HCO Network Operations with the Sales & Account Management organization to ensure seamless pipeline generation and client growth.
- Cross-Functional Partnership: Serve as the connective tissue between Commercial, Product, Finance, Legal, and Operations. Ensure product roadmap, pricing, and delivery are tightly integrated with market feedback and commercial priorities.
- Team Leadership & Organizational Development: Build, lead, and scale a high-performing commercial organization. Develop and mentor senior leaders across marketing, commercial ops, and HCO network functions. Champion a culture of accountability, inclusivity, collaboration, and continuous improvement.
- Market Intelligence & Competitive Positioning: Monitor industry trends, regulatory developments, and competitive dynamics across the global life sciences and real-world data landscape. Represent TriNetX at industry conferences, advisory boards, and strategic partner engagements.
What You Bring to TriNetX:
- Bachelor's degree required; MBA or advanced degree strongly preferred.
- 15+ years of progressive commercial leadership experience, with at least 5 years in a senior executive role (VP, SVP, or C-suite) within life sciences, health technology, SaaS, or real-world data/analytics.
- Proven track record of owning and scaling a commercial organization, with demonstrated success driving bookings and revenue growth across diverse market segments.
- Deep experience leading and integrating multiple commercial functions, including marketing, commercial or revenue operations, and network or partner development.
- Demonstrated ability to build, grow, and manage healthcare organization, health system, or strategic partner networks at scale.
- Experience working closely with and presenting to a Board of Directors and cross-functional executive leadership team.
- Exceptional strategic thinking, executive communication, and leadership presence — able to inspire internal teams and represent TriNetX externally at the highest levels.
- Strong analytical foundation with comfort owning commercial metrics, forecasting models, and performance reporting.
- Ability to thrive in a fast-paced, globally distributed, high-growth environment with complex stakeholder dynamics.
- Willingness to travel domestically and internationally as needed.
POSITION TITLE: Chief Commercial Officer (CCO)
LOCATION: Cambridge, MA (hybrid)
This position reports to our global HQ in Cambridge, MA. Travel is expected domestically and internationally when needed.
Who We Are:
TriNetX connects healthcare organizations and researchers across the globe so they can transparently see what's happening in real patient populations. Our aim is simple and ambitious: Provide a clear path to trustworthy answers, whether your goal is to create promising new therapies, publish groundbreaking research, or improve health outcomes. We keep identifiable data where it belongs—inside more than 11,000+ clinical sites across 20+ countries—preserving security, provenance, and granularity. Our trusted partnerships with providers ensure high-fidelity data, and a properly governed linkage back to individual patients. At TriNetX, we enable life sciences, healthcare, and academic institutions to strengthen human health—with data you can trace, evidence you can defend, and answers you can trust.
Who We Are Looking For:
The Chief Commercial Officer (CCO) will serve as the senior executive commercial leader at TriNetX, responsible for driving the company's global revenue strategy and go-to-market execution. This executive will own and integrate critical commercial functions — marketing, commercial operations, healthcare organization (HCO) network operations, sales, and account management to deliver cohesive growth across all market segments. Reporting directly to the CEO, the CCO will be a key member of the executive leadership team and a champion of TriNetX's mission to strengthen human health with data you can trust.
What You Will Be Doing:
- Strategic Commercial Leadership: Define and execute TriNetX's global commercial strategy across all revenue-generating and network-building functions. Serve as the primary commercial voice on the executive leadership team, partnering with the CEO and Board on commercial direction, market positioning, and growth initiatives.
- Marketing & Brand: Lead the global marketing function, including product marketing, demand generation, content, communications, and brand strategy. Drive integrated go-to-market campaigns that build brand awareness, generate qualified pipeline, and differentiate TriNetX in the market.
- Commercial Operations: Oversee commercial operations including revenue operations, sales enablement, CRM strategy, forecasting, and compensation design. Ensure data-driven, scalable processes that allow the full commercial organization to operate with efficiency and accountability.
- HCO Network Operations: Own the healthcare organization (HCO) network operations function, responsible for acquiring, onboarding, expanding, and retaining TriNetX's global network of healthcare member organizations. Develop and execute strategies to deepen HCO engagement, maximize data contribution, and grow the value of the network for all stakeholders.
- Revenue Growth & Accountability: Set and achieve ambitious bookings and revenue targets across all commercial segments. Align Marketing, Commercial Operations, and HCO Network Operations with the Sales & Account Management organization to ensure seamless pipeline generation and client growth.
- Cross-Functional Partnership: Serve as the connective tissue between Commercial, Product, Finance, Legal, and Operations. Ensure product roadmap, pricing, and delivery are tightly integrated with market feedback and commercial priorities.
- Team Leadership & Organizational Development: Build, lead, and scale a high-performing commercial organization. Develop and mentor senior leaders across marketing, commercial ops, and HCO network functions. Champion a culture of accountability, inclusivity, collaboration, and continuous improvement.
- Market Intelligence & Competitive Positioning: Monitor industry trends, regulatory developments, and competitive dynamics across the global life sciences and real-world data landscape. Represent TriNetX at industry conferences, advisory boards, and strategic partner engagements.
What You Bring to TriNetX:
- Bachelor's degree required; MBA or advanced degree strongly preferred.
- 15+ years of progressive commercial leadership experience, with at least 5 years in a senior executive role (VP, SVP, or C-suite) within life sciences, health technology, SaaS, or real-world data/analytics.
- Proven track record of owning and scaling a commercial organization, with demonstrated success driving bookings and revenue growth across diverse market segments.
- Deep experience leading and integrating multiple commercial functions, including marketing, commercial or revenue operations, and network or partner development.
- Demonstrated ability to build, grow, and manage healthcare organization, health system, or strategic partner networks at scale.
- Experience working closely with and presenting to a Board of Directors and cross-functional executive leadership team.
- Exceptional strategic thinking, executive communication, and leadership presence — able to inspire internal teams and represent TriNetX externally at the highest levels.
- Strong analytical foundation with comfort owning commercial metrics, forecasting models, and performance reporting.
- Ability to thrive in a fast-paced, globally distributed, high-growth environment with complex stakeholder dynamics.
- Willingness to travel domestically and internationally as needed.
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Get Access To All JobsTips for Finding Chief Commercial Officer Jobs
Target companies with established immigration programs
Large enterprises and well-funded startups with dedicated HR or legal teams process executive visa petitions far more smoothly than companies sponsoring for the first time. Smaller firms often lack the infrastructure to handle CCO-level H-1B filings.
Build a case for specialty occupation status
USCIS scrutinizes broad executive titles. Work with your employer's immigration counsel to show that the CCO role requires a specific degree field, such as business administration, marketing, or economics, not just any bachelor's degree.
Consider the O-1A if you have a strong track record
C-suite candidates with documented business achievements, high compensation history, or industry recognition may qualify for the O-1A extraordinary ability visa, which bypasses the H-1B lottery entirely and has no annual cap.
Prepare detailed evidence of your commercial leadership
Revenue growth figures, market expansion results, and team leadership scope strengthen both specialty occupation arguments and O-1A petitions. Quantifiable outcomes are far more persuasive to USCIS than job description language alone.
Clarify equity and compensation structure early
CCO roles often include equity, bonuses, and variable pay. Confirm with your employer how total compensation is structured in the Labor Condition Application, since the prevailing wage requirement applies to the base salary component.
Align your degree field with your commercial responsibilities
If your degree is in engineering or another technical field, your employer will need to explain how that background directly supports a commercial strategy role. A clear connection between your education and the CCO function strengthens the petition.
Frequently Asked Questions
Can a Chief Commercial Officer role qualify for H-1B sponsorship?
Yes, but the employer must demonstrate that the CCO position is a specialty occupation requiring a bachelor's degree or higher in a specific field. USCIS gives extra scrutiny to broad executive titles because they can appear to accept any degree. The petition is stronger when the job description ties commercial strategy responsibilities directly to a defined academic discipline such as business, economics, or marketing.
Is the O-1A visa a realistic option for a CCO candidate?
For experienced commercial executives, the O-1A is often the stronger path. It requires demonstrating extraordinary ability through criteria such as high compensation relative to peers, critical employment at a distinguished organization, significant contributions to the industry, or business media coverage. A CCO with a documented record of driving revenue growth or leading major market expansions can build a compelling O-1A case without entering the H-1B lottery.
What degree background do companies expect when sponsoring a CCO for a visa?
Most sponsoring employers expect a bachelor's degree at minimum in business administration, marketing, finance, economics, or a related commercial field, with an MBA common at larger companies. For H-1B purposes, the degree field must align directly with the duties of the CCO role. If your degree is in an unrelated discipline, three years of progressive work experience can substitute for each missing year of education under USCIS rules.
How common is visa sponsorship for Chief Commercial Officer positions?
Sponsorship at the CCO level is less common than for mid-level professional roles, primarily because many companies assume senior hires will already have work authorization. However, multinationals, private equity-backed companies, and high-growth technology firms do sponsor CCO candidates, particularly through L-1A intracompany transfers or H-1B petitions. Browse current openings on Migrate Mate to identify which companies are actively hiring internationally at the executive level.
What makes a CCO petition get denied, and how can candidates reduce that risk?
The most common denial reason is failing to establish specialty occupation status, where USCIS concludes that the role could be filled by someone with any bachelor's degree regardless of field. Petitions are also denied when the degree-to-job connection is vague or when employers cannot document that the position normally requires a specific credential. Working with experienced immigration counsel before filing, and ensuring the job description is written with specialty occupation requirements in mind, significantly reduces denial risk.
What is the prevailing wage requirement for sponsored Chief Commercial Officer jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.