Commercial Lead Jobs in USA with Visa Sponsorship
Commercial Lead roles attract H-1B and O-1 visa sponsorship from employers in tech, finance, and enterprise software. Most positions qualify as specialty occupations requiring a bachelor's degree in business, economics, or a related field, making them strong candidates for visa approval. For detailed occupation requirements, see the O*NET profile.
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Get Access To All JobsROLE SUMMARY
At Pfizer Oncology, we are committed to “Outdo Cancer” by advancing transformative medicines wherever we can make a profound difference in the lives of patients. Today, Pfizer Oncology has an industry-leading pipeline that includes the combined legacy Pfizer and Seagen portfolio across breast, genitourinary, hematology-oncology and thoracic therapeutic areas. Thoracic represents a crucial component to achieve Pfizer’s overarching strategic ambition in Oncology; thoracic is estimated to represent ~25% of Pfizer Oncology’s 2030 global sales. Collectively, our focus is on building upon our foundation in lung precision medicine to accelerate new standards of care in broader populations.
Despite therapeutic advances in lung cancer, there remains significant unmet patient need. Each year, there are ~2.7 million new lung cancer cases globally. The lung cancer therapies market is expected to grow from $45B in 2025 to $70B in 2030 globally. Core to Pfizer’s lung cancer strategy is realizing the potential of our first-in-class antibody drug conjugates (ADCs), including fetrastobart vedotin (fetra-v), a PD-L1–directed, vedotin-based ADC. The first commercial launch of fetrastobart vedotin 2L+ NSCLC is being planned for 2028.
This role provides an excellent opportunity to shape and drive the fetrastobart vedotin global commercial potential and address the significant unmet needs of lung cancer patients. In Global Marketing, we translate science into value for patients. Our remit is to own the strategic direction across the asset lifecycle, ensure long-term value creation and preservation, and drive brand consistency across markets and efficiencies in execution. This role will report to the Vice President, Global Franchise Lead for Hematology, Thoracic and Gastrointestinal, and will have both direct and matrix leadership. Key focus will be to drive commercial thought leadership on fetrastobart vedotin brand strategy and launch strategy to ensure a successful global launch. The role requires experience in global or US marketing, launch excellence, commercial strategy and market development.
ROLE RESPONSIBILITIES
- Own fetrastobart vedotin global launch strategy inclusive of brand positioning and messaging, market development, customer specific strategies, and country launch sequence.
- Represent Global Commercial voice and point of view on fetrastobart vedotin Global Product Team (GPT) and partner closely with Clinical Development, Regulatory, Global Access & Value, Global Medical Affairs to ensure key opportunities and risks in the clinical development plan meet the target product profile.
- Partner with CSI to drive thought leadership on lifecycle commercial potential, including key risk/opportunity identification that factors competitive landscape dynamics, to ensure value creation for the mid-to-long term horizon.
- Contribute to Global Thoracic Commercial Strategy in partnership with fellow Global Commercial Leads to ensure aligned portfolio positioning and brand positioning.
- Collaborate effectively with R&D, Regulatory, Global Access & Value, Global Medical Affairs, Customer Analytics & Insights, Finance, PGS, US, and International.
- Deliver Global Guidance for OP/LRF forecast assumptions, reflective of brand aspiration as well as risk/benefit.
- Lead fetrastobart vedotin Global Governance Team (GGT) and align brand strategies and deliver core promotional resources and tactics to US and International Commercial Office.
- Partner with Global Access Strategy & Pricing and International Commercial Office on global pricing approval decisions and country access strategies that optimize and preserve value of lifecycle.
- Establish core global launch team.
- Develop detailed, strategic commercialization roadmaps and plans to ensure launch readiness and appropriate planning assessments by partnering closely with CMO Launch Excellence team.
- Ensure proactive translation of key competitive intelligence insights into action; and prepare senior leadership communications when appropriate.
- Collaborate with PGS on global supply and demand planning, as well as packaging decisions.
- Engage, coach and develop others through creation of a high-performance culture focused on Courage, Excellence, Equity and Joy.
- Conduct all activities and makes decisions that are in accordance with Company policies and SOPs, Pfizer Values & global regulatory guidelines, and requests consultation when navigating uncertain situations.
BASIC QUALIFICATIONS
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
- Bachelor’s degree
- 12+ years of commercial experience in the pharmaceutical industry
- 5+ years of experience managing or leading marketing colleagues at all levels (Manager to Director) and commitment to fostering team engagement, team culture and the growth and development of people
- Expertise in leading and executing a successful global pharmaceutical/biotech launch, preference is an Oncology launch
- Ability to work independently across senior level stakeholders and demonstrates judgement of what needs to be escalated
- Strong team player with demonstrated ability to engage experts from a wide range of functional areas to improve business performance and find a path forward
- Strong strategic thinking, analytical skills, detail and action oriented, creative, flexible, self-motivated
- Proven track record of translating key insights into meaningful strategies and tactics
- Excellent verbal and written communication skills for a wide range of audiences
- Solid understanding of today’s Global and US pharmaceutical environment, including Regulatory, Legal and Compliance
- Is a role model for the Pfizer Values
PREFERRED QUALIFICATIONS
- Advanced degree
- Launch and lifecycle management experience
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Ability to travel approximately 20% of the time
OTHER JOB DETAILS
Additional Location Information: Pfizer Office Location- NY HQ, Collegeville Bothell or Cambridge
Relocation might be offered
LAST DAY TO APPLY March 27 2026
This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week or more as needed.
The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
ROLE SUMMARY
At Pfizer Oncology, we are committed to “Outdo Cancer” by advancing transformative medicines wherever we can make a profound difference in the lives of patients. Today, Pfizer Oncology has an industry-leading pipeline that includes the combined legacy Pfizer and Seagen portfolio across breast, genitourinary, hematology-oncology and thoracic therapeutic areas. Thoracic represents a crucial component to achieve Pfizer’s overarching strategic ambition in Oncology; thoracic is estimated to represent ~25% of Pfizer Oncology’s 2030 global sales. Collectively, our focus is on building upon our foundation in lung precision medicine to accelerate new standards of care in broader populations.
Despite therapeutic advances in lung cancer, there remains significant unmet patient need. Each year, there are ~2.7 million new lung cancer cases globally. The lung cancer therapies market is expected to grow from $45B in 2025 to $70B in 2030 globally. Core to Pfizer’s lung cancer strategy is realizing the potential of our first-in-class antibody drug conjugates (ADCs), including fetrastobart vedotin (fetra-v), a PD-L1–directed, vedotin-based ADC. The first commercial launch of fetrastobart vedotin 2L+ NSCLC is being planned for 2028.
This role provides an excellent opportunity to shape and drive the fetrastobart vedotin global commercial potential and address the significant unmet needs of lung cancer patients. In Global Marketing, we translate science into value for patients. Our remit is to own the strategic direction across the asset lifecycle, ensure long-term value creation and preservation, and drive brand consistency across markets and efficiencies in execution. This role will report to the Vice President, Global Franchise Lead for Hematology, Thoracic and Gastrointestinal, and will have both direct and matrix leadership. Key focus will be to drive commercial thought leadership on fetrastobart vedotin brand strategy and launch strategy to ensure a successful global launch. The role requires experience in global or US marketing, launch excellence, commercial strategy and market development.
ROLE RESPONSIBILITIES
- Own fetrastobart vedotin global launch strategy inclusive of brand positioning and messaging, market development, customer specific strategies, and country launch sequence.
- Represent Global Commercial voice and point of view on fetrastobart vedotin Global Product Team (GPT) and partner closely with Clinical Development, Regulatory, Global Access & Value, Global Medical Affairs to ensure key opportunities and risks in the clinical development plan meet the target product profile.
- Partner with CSI to drive thought leadership on lifecycle commercial potential, including key risk/opportunity identification that factors competitive landscape dynamics, to ensure value creation for the mid-to-long term horizon.
- Contribute to Global Thoracic Commercial Strategy in partnership with fellow Global Commercial Leads to ensure aligned portfolio positioning and brand positioning.
- Collaborate effectively with R&D, Regulatory, Global Access & Value, Global Medical Affairs, Customer Analytics & Insights, Finance, PGS, US, and International.
- Deliver Global Guidance for OP/LRF forecast assumptions, reflective of brand aspiration as well as risk/benefit.
- Lead fetrastobart vedotin Global Governance Team (GGT) and align brand strategies and deliver core promotional resources and tactics to US and International Commercial Office.
- Partner with Global Access Strategy & Pricing and International Commercial Office on global pricing approval decisions and country access strategies that optimize and preserve value of lifecycle.
- Establish core global launch team.
- Develop detailed, strategic commercialization roadmaps and plans to ensure launch readiness and appropriate planning assessments by partnering closely with CMO Launch Excellence team.
- Ensure proactive translation of key competitive intelligence insights into action; and prepare senior leadership communications when appropriate.
- Collaborate with PGS on global supply and demand planning, as well as packaging decisions.
- Engage, coach and develop others through creation of a high-performance culture focused on Courage, Excellence, Equity and Joy.
- Conduct all activities and makes decisions that are in accordance with Company policies and SOPs, Pfizer Values & global regulatory guidelines, and requests consultation when navigating uncertain situations.
BASIC QUALIFICATIONS
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
- Bachelor’s degree
- 12+ years of commercial experience in the pharmaceutical industry
- 5+ years of experience managing or leading marketing colleagues at all levels (Manager to Director) and commitment to fostering team engagement, team culture and the growth and development of people
- Expertise in leading and executing a successful global pharmaceutical/biotech launch, preference is an Oncology launch
- Ability to work independently across senior level stakeholders and demonstrates judgement of what needs to be escalated
- Strong team player with demonstrated ability to engage experts from a wide range of functional areas to improve business performance and find a path forward
- Strong strategic thinking, analytical skills, detail and action oriented, creative, flexible, self-motivated
- Proven track record of translating key insights into meaningful strategies and tactics
- Excellent verbal and written communication skills for a wide range of audiences
- Solid understanding of today’s Global and US pharmaceutical environment, including Regulatory, Legal and Compliance
- Is a role model for the Pfizer Values
PREFERRED QUALIFICATIONS
- Advanced degree
- Launch and lifecycle management experience
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Ability to travel approximately 20% of the time
OTHER JOB DETAILS
Additional Location Information: Pfizer Office Location- NY HQ, Collegeville Bothell or Cambridge
Relocation might be offered
LAST DAY TO APPLY March 27 2026
This is a hybrid role requiring you to live within commuting distance and work on-site an average of 2.5 days per week or more as needed.
The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.
Relocation assistance may be available based on business needs and/or eligibility.
Sunshine Act
Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.
EEO & Employment Eligibility
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.
Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned.
How to Get Visa Sponsorship in Commercial Lead
Target employers with a sponsorship track record
Companies that have filed H-1B petitions for commercial roles before are far more likely to sponsor again. Look for employers in enterprise software, consulting, and financial services, where Commercial Lead positions are well-established and sponsorship infrastructure already exists.
Align your degree to the role's field requirements
USCIS requires your degree to directly relate to the Commercial Lead function. Degrees in business administration, economics, finance, or marketing map cleanly. If your degree is in an unrelated field, relevant work experience and advanced credentials can strengthen your petition.
Get the specialty occupation framing right
Commercial Lead roles must clear the specialty occupation bar. Emphasize that the position requires theoretical and practical application of business strategy, revenue operations, or market analysis, not just general management skills that any bachelor's degree holder could perform.
Negotiate sponsorship terms before accepting an offer
Confirm whether the employer covers H-1B filing fees, legal costs, and premium processing before signing. Large employers legally cannot pass certain fees to employees, but smaller companies may try. Get sponsorship commitments in writing as part of your offer discussion.
Factor in H-1B lottery timing for your job search
H-1B registrations open in March for an October 1 start date. If you're on OPT or a grace period, map your offer timeline against lottery dates. Cap-exempt employers, nonprofits, universities, and government research organizations, can file year-round without lottery constraints.
Consider O-1A if your commercial track record is strong
Commercial Leads with documented revenue impact, industry awards, high-profile client wins, or media coverage may qualify for the O-1A extraordinary ability visa. It bypasses the H-1B lottery entirely and can be filed any time of year with no annual cap.
Commercial Lead jobs are hiring across the US. Find yours.
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Sign up for free to unlock all listings, filter by visa type, and get alerts for new Commercial Lead roles.
Get Access To All JobsFrequently Asked Questions
Does a Commercial Lead role qualify as an H-1B specialty occupation?
Yes, in most cases. USCIS evaluates whether the position normally requires at least a bachelor's degree in a specific field, business, finance, economics, or marketing all qualify. The key is that the job description must demonstrate the role requires specialized theoretical knowledge, not just general business experience any degree could support. Roles focused on revenue strategy, enterprise deal structuring, or market expansion typically clear this bar.
What visa options are available for Commercial Lead roles beyond H-1B?
Australians can use the E-3 visa, which has no lottery and 10,500 annual slots that have never been exhausted. Canadians and Mexicans may qualify under the TN visa for management consultants or economists, depending on how the role is scoped. O-1A is an option for candidates with a verifiable track record of commercial success, client impact, or industry recognition. L-1A covers transfers for those already employed by a multinational.
Where can I find Commercial Lead jobs that offer visa sponsorship?
Migrate Mate is built specifically for international candidates who need sponsorship, every listing is from employers open to visa sponsorship, so you're not filtering through hundreds of roles that won't work for your situation. Commercial Lead positions appear regularly in tech, SaaS, and financial services verticals on the platform.
Does my degree need to be in a specific field to support a Commercial Lead H-1B petition?
It needs to relate to the work being performed, but the field doesn't have to be an exact match. A degree in business administration, economics, finance, marketing, or even engineering can support a Commercial Lead petition if the role involves business development, revenue operations, or market strategy. A general studies or unrelated degree creates risk, your employer's immigration attorney will typically flag this early in the process.
How does job-hopping between commercial roles affect my visa situation?
Each employer change on an H-1B requires a new petition unless you're transferring to a cap-exempt employer. Your new employer must file before you start, and the 60-day grace period after leaving a job gives you limited runway. For E-3 holders, you need to secure a new Labor Condition Application and typically return to a consulate for a new visa stamp. Plan the transition before you resign, not after.
What is the prevailing wage requirement for sponsored Commercial Lead jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.
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