Head Of Technology Jobs in USA with Visa Sponsorship
Head of Technology roles attract H-1B visa, O-1A, and L-1A visa sponsorship from U.S. employers, particularly in tech, finance, and healthcare. Executives leading engineering or product organizations often qualify for priority worker or extraordinary ability classifications, which bypass the H-1B lottery entirely. For detailed occupation requirements, see the O*NET profile.
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Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking a Head of Global Manufacturing Science & Technology as part of the Manufacturing Science & Technology team based in Bridgewater, NJ.
ROLE OVERVIEW
The Head of Global Manufacturing Science & Technology (MSAT) is the enterprise technical leader responsible for ensuring the robustness, scalability, capability, and continuous improvement of manufacturing processes across the product lifecycle. The role establishes the global MSAT strategy and provides technical leadership from late-stage development and technology transfer through commercial manufacturing and lifecycle management. The Head of Global Manufacturing Science & Technology ensures that manufacturing processes are scientifically understood, technically capable, operationally robust, scalable, and continuously improved to support reliable supply, product quality, patient needs, and business growth.
As the enterprise technical authority for manufacturing processes, the Head of Global Manufacturing Science & Technology drives process robustness, technology transfer, process validation, continued process verification, technical investigations, manufacturing optimization, and advanced manufacturing capabilities across the global network. The incumbent will be a member of the GMS Leadership Team.
KEY RESPONSIBILITIES
Global MSAT Strategy & Technical Leadership
- Define and execute the global MSAT strategy and operating model aligned with business, portfolio, and manufacturing priorities.
- Establish global technical standards, capabilities, and governance for manufacturing processes across internal and external sites.
- Serve as the senior technical authority for process capability, robustness, scalability, and manufacturing performance.
Process Technology & Manufacturing Performance
- Own the technical strategy for process characterization, validation, process capability, continued process verification, and process monitoring.
- Drive consistency and systematic improvement of manufacturing processes to increase yield, reliability, capacity, throughput, consistency, and cost efficiency.
- Provide technical leadership for manufacturing investigations, process deviations, and recurring performance issues.
- Establish science- and data-based approaches to identify process risks and proactively improve manufacturing performance.
Technology Transfer & Commercialization
- Provide MSAT leadership for technology transfer and manufacturing readiness from development into commercial operations.
- Ensure effective transfer of process knowledge, control strategies, technical standards, and manufacturing capabilities into internal and external manufacturing networks.
- Partner with CMC and R&D to ensure development programs are designed for commercial scalability, manufacturability, and process robustness.
- Provide technical input to major manufacturing network, capacity, and commercialization decisions.
Lifecycle Management & Continuous Improvement
- Own the MSAT strategy for the technical lifecycle of commercial products, including process improvements, scale-up/scale-out, site transfers, capacity expansion, and manufacturing optimization.
- Identify and prioritize opportunities to improve quality, yield, throughput, cost, cycle time, and supply resilience.
- Lead implementation of advanced process technologies, automation, modeling, analytics, and digital manufacturing capabilities.
- Ensure manufacturing knowledge and process data are systematically leveraged to drive continuous improvement.
Manufacturing & Global Network
- Provide technical leadership, support and governance for MSAT activities at internal sites, CMOs/CDMOs and other external manufacturing partners.
- Ensure consistent technical standards, process understanding, technology transfer, and lifecycle management across the global manufacturing network.
- Partner with Manufacturing leadership to resolve technical, process, and performance issues.
Innovation, Digital & Advanced Manufacturing
- Establish the strategic roadmap for advanced manufacturing technologies, automation, digital manufacturing, process analytics, and data science.
- Accelerate adoption of emerging technologies that improve manufacturing control, predictability, flexibility, and efficiency.
- Promote the use of data-driven and predictive approaches to enhance process understanding and manufacturing performance.
Executive Leadership & Organization
- Build and lead a high-performing global MSAT organization with the technical depth and capabilities required to support a growing pipeline and commercial portfolio.
- Develop organizational capabilities, talent, succession, and technical leadership across the global manufacturing network.
- Serve as a senior member of the Global Manufacturing & Supply Leadership Team, contributing to manufacturing strategy, investment decisions, portfolio priorities, and supply resilience.
- Act as a trusted technical advisor to senior leadership on major manufacturing, technology, process, and investment decisions.
- Represent the company with strategic partners, regulators, industry organizations, and external technical forums.
REQUIREMENTS
- Advanced degree, preferably PhD in Chemical Engineering, Biological Sciences, Pharmaceutical Sciences, or related discipline.
- 20+ years of progressive experience in MSAT, process development, manufacturing science, technical operations, or related biopharmaceutical functions, including significant global leadership experience.
- Proven global experience leading MSAT for commercial biopharmaceutical products, preferably including cell therapy, gene therapy, or other advanced modalities.
- Strong expertise in process characterization, validation, technology transfer, CPV, process optimization, manufacturing technology, and lifecycle management.
- Proven ability to lead complex technical decisions across R&D, CMC, Manufacturing, Quality, Regulatory, Engineering, and Supply Chain.
- Enterprise technical leadership with strong business judgment.
- Strong strategic thinking combined with technical depth.
- Executive presence and ability to influence across functions and organizational boundaries.
- Data-driven, scientifically rigorous, and highly pragmatic.
- Strong innovation and continuous improvement mindset.
- Develops people, builds capabilities, and creates a culture of technical excellence, accountability, and innovation.
WORK AUTHORIZATION & EMPLOYMENT ELIGIBILITY
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO STATEMENT
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
INTRODUCTION
Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking a Head of Global Manufacturing Science & Technology as part of the Manufacturing Science & Technology team based in Bridgewater, NJ.
ROLE OVERVIEW
The Head of Global Manufacturing Science & Technology (MSAT) is the enterprise technical leader responsible for ensuring the robustness, scalability, capability, and continuous improvement of manufacturing processes across the product lifecycle. The role establishes the global MSAT strategy and provides technical leadership from late-stage development and technology transfer through commercial manufacturing and lifecycle management. The Head of Global Manufacturing Science & Technology ensures that manufacturing processes are scientifically understood, technically capable, operationally robust, scalable, and continuously improved to support reliable supply, product quality, patient needs, and business growth.
As the enterprise technical authority for manufacturing processes, the Head of Global Manufacturing Science & Technology drives process robustness, technology transfer, process validation, continued process verification, technical investigations, manufacturing optimization, and advanced manufacturing capabilities across the global network. The incumbent will be a member of the GMS Leadership Team.
KEY RESPONSIBILITIES
Global MSAT Strategy & Technical Leadership
- Define and execute the global MSAT strategy and operating model aligned with business, portfolio, and manufacturing priorities.
- Establish global technical standards, capabilities, and governance for manufacturing processes across internal and external sites.
- Serve as the senior technical authority for process capability, robustness, scalability, and manufacturing performance.
Process Technology & Manufacturing Performance
- Own the technical strategy for process characterization, validation, process capability, continued process verification, and process monitoring.
- Drive consistency and systematic improvement of manufacturing processes to increase yield, reliability, capacity, throughput, consistency, and cost efficiency.
- Provide technical leadership for manufacturing investigations, process deviations, and recurring performance issues.
- Establish science- and data-based approaches to identify process risks and proactively improve manufacturing performance.
Technology Transfer & Commercialization
- Provide MSAT leadership for technology transfer and manufacturing readiness from development into commercial operations.
- Ensure effective transfer of process knowledge, control strategies, technical standards, and manufacturing capabilities into internal and external manufacturing networks.
- Partner with CMC and R&D to ensure development programs are designed for commercial scalability, manufacturability, and process robustness.
- Provide technical input to major manufacturing network, capacity, and commercialization decisions.
Lifecycle Management & Continuous Improvement
- Own the MSAT strategy for the technical lifecycle of commercial products, including process improvements, scale-up/scale-out, site transfers, capacity expansion, and manufacturing optimization.
- Identify and prioritize opportunities to improve quality, yield, throughput, cost, cycle time, and supply resilience.
- Lead implementation of advanced process technologies, automation, modeling, analytics, and digital manufacturing capabilities.
- Ensure manufacturing knowledge and process data are systematically leveraged to drive continuous improvement.
Manufacturing & Global Network
- Provide technical leadership, support and governance for MSAT activities at internal sites, CMOs/CDMOs and other external manufacturing partners.
- Ensure consistent technical standards, process understanding, technology transfer, and lifecycle management across the global manufacturing network.
- Partner with Manufacturing leadership to resolve technical, process, and performance issues.
Innovation, Digital & Advanced Manufacturing
- Establish the strategic roadmap for advanced manufacturing technologies, automation, digital manufacturing, process analytics, and data science.
- Accelerate adoption of emerging technologies that improve manufacturing control, predictability, flexibility, and efficiency.
- Promote the use of data-driven and predictive approaches to enhance process understanding and manufacturing performance.
Executive Leadership & Organization
- Build and lead a high-performing global MSAT organization with the technical depth and capabilities required to support a growing pipeline and commercial portfolio.
- Develop organizational capabilities, talent, succession, and technical leadership across the global manufacturing network.
- Serve as a senior member of the Global Manufacturing & Supply Leadership Team, contributing to manufacturing strategy, investment decisions, portfolio priorities, and supply resilience.
- Act as a trusted technical advisor to senior leadership on major manufacturing, technology, process, and investment decisions.
- Represent the company with strategic partners, regulators, industry organizations, and external technical forums.
REQUIREMENTS
- Advanced degree, preferably PhD in Chemical Engineering, Biological Sciences, Pharmaceutical Sciences, or related discipline.
- 20+ years of progressive experience in MSAT, process development, manufacturing science, technical operations, or related biopharmaceutical functions, including significant global leadership experience.
- Proven global experience leading MSAT for commercial biopharmaceutical products, preferably including cell therapy, gene therapy, or other advanced modalities.
- Strong expertise in process characterization, validation, technology transfer, CPV, process optimization, manufacturing technology, and lifecycle management.
- Proven ability to lead complex technical decisions across R&D, CMC, Manufacturing, Quality, Regulatory, Engineering, and Supply Chain.
- Enterprise technical leadership with strong business judgment.
- Strong strategic thinking combined with technical depth.
- Executive presence and ability to influence across functions and organizational boundaries.
- Data-driven, scientifically rigorous, and highly pragmatic.
- Strong innovation and continuous improvement mindset.
- Develops people, builds capabilities, and creates a culture of technical excellence, accountability, and innovation.
WORK AUTHORIZATION & EMPLOYMENT ELIGIBILITY
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO STATEMENT
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
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Get Access To All JobsTips for Finding Head Of Technology Jobs
Position yourself as a strategic leader, not just a technical one
Employers sponsoring a Head of Technology need to justify the role requires specialized expertise at the executive level. Document your P&L ownership, team size, and cross-functional influence to strengthen the specialty occupation and executive classification arguments.
Explore O-1A if you have industry recognition
If you've spoken at major conferences, published technical work, led award-winning teams, or been cited in industry media, you may qualify for an O-1A visa. It has no annual cap, no lottery, and is frequently approved for senior technology executives.
Target companies with established immigration programs
Large technology, financial services, and healthcare employers typically have in-house immigration counsel and predictable sponsorship pipelines. These organizations process H-1B and L-1 visa petitions routinely, reducing approval risk and administrative friction compared to first-time sponsors.
L-1A is viable if you're transferring within a multinational
Heads of Technology moving from a foreign parent, subsidiary, or affiliate to a U.S. entity qualify for the L-1A intracompany transferee visa. It requires one year of qualifying employment abroad and directly supports an EB-1C green card pathway afterward.
Document your team's size, budget, and organizational scope
For both H-1B specialty occupation and L-1A managerial classification, USCIS scrutinizes whether the role genuinely requires executive-level authority. Org charts, budget responsibility documentation, and board-level reporting relationships materially strengthen your petition.
Start sponsorship conversations before accepting an offer
H-1B cap-subject petitions are filed in April for an October start date. If you're not already in H-1B status or cap-exempt, timing matters significantly. Raising visa requirements early prevents mismatched expectations and allows employers to plan around filing deadlines.
Frequently Asked Questions
What visas can sponsor a Head of Technology role in the U.S.?
The most common options are the H-1B visa, O-1A, and L-1A. The H-1B applies broadly to specialty occupations requiring a bachelor's degree or higher in a specific field. The O-1A suits executives with demonstrable industry recognition, while the L-1A applies to intracompany transferees in managerial or executive roles. You can browse Head of Technology roles with active sponsorship on Migrate Mate.
Does a Head of Technology role qualify as a specialty occupation for H-1B purposes?
Generally yes, but the role definition matters. USCIS requires that the position normally requires a bachelor's degree or higher in a specific specialty such as computer science, information systems, or engineering management. Roles framed purely as general management without a technical degree requirement face higher scrutiny. A well-drafted job description tying the role's duties to specific technical disciplines significantly reduces RFE risk.
What degree is typically required for H-1B sponsorship as a Head of Technology?
A bachelor's degree or higher in computer science, information technology, electrical engineering, or a closely related field is the standard. Advanced degrees in business combined with an undergraduate technical degree are also accepted. Equivalent experience can substitute under the three-for-one rule, where three years of progressive technical experience replaces one year of formal education, though documentation requirements are stricter.
Can a Head of Technology qualify for an EB-1 green card without employer sponsorship?
Yes, through the EB-1A extraordinary ability category, which is self-petitioned and requires no employer sponsor. Qualifying evidence includes major awards, press coverage, high compensation relative to peers, judging others' work, and authorship of influential technical publications. Heads of Technology with significant industry profiles, patents, or executive leadership at well-known companies are strong candidates. An immigration attorney can assess your evidence before filing.
How competitive is H-1B sponsorship for senior technology executive roles?
Senior roles fare better than mid-level positions because employers have stronger business justification and are more willing to invest in legal fees and premium processing. However, cap-subject H-1B petitions still enter the annual lottery regardless of seniority. Many Heads of Technology pursue O-1A or L-1A pathways specifically to avoid the lottery. USCIS approval rates for properly documented specialty occupation petitions in technology remain above 85%.
What is the prevailing wage requirement for sponsored Head Of Technology jobs?
U.S. employers sponsoring a visa must pay at least the prevailing wage, which is what workers in the same role, area, and experience level typically earn. The Department of Labor sets this rate to make sure companies aren't hiring foreign workers simply because they'd accept lower pay than a U.S. worker. It varies by job title, location, and experience. You can look up current prevailing wage rates for any occupation and location using the OFLC Wage Search page.