Clinic Registered Nurse Jobs in Missouri

Clinic Registered Nurse jobs in Missouri are consistently in demand, with strong hiring across primary care clinics, federally qualified health centers, and specialty outpatient practices. Kansas City and St. Louis anchor most of the volume, with Columbia also an active market, and major systems like BJC HealthCare, Saint Luke's Health System, and Mercy Health drive a significant share of openings statewide. Family practice, chronic disease management, and pediatric clinic nursing are the sub-areas seeing the steadiest flow of new postings. Find a role that fits below and apply directly.

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Overview

Open roles84
Top employerUniversity of Missouri Health Care
Top cityColumbia, MO
Cities hiring29
Work type60% On-site
Top industryHealthcare

Showing 5 of 84+ Clinic Registered Nurse jobs

Registered Nurse - Program Specialist, Electrophysiology Cardiac Clinic
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Added 3d ago
Registered Nurse - Program Specialist, Electrophysiology Cardiac Clinic
SSM Health
Richmond Heights, Missouri
Content & Communications
Customer Service
Marketing
BLS Certification
10,000+

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Medical Assistant Certified / Registered - Orthopedic Clinic
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Added 4d ago
Medical Assistant Certified / Registered - Orthopedic Clinic
SSM Health
Bridgeton, Missouri
Healthcare Administration
Patient Services & Wellbeing
Public Health
BLS Certification
10,000+

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RN, Clinic - Neurospine
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Added 4d ago
RN, Clinic - Neurospine
Freeman Health System
Joplin, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
1,001-5,000

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RN Specialty Clinic - Urology Oncology (F/T Days)
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Added 5d ago
RN Specialty Clinic - Urology Oncology (F/T Days)
Mercy
Creve Coeur, Missouri
Healthcare Administration
Nursing
Patient Services & Wellbeing
CPR Certification
10,000+

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Registered Nurse (RN) – SW Blvd. Family Medicine Clinic – Jefferson City, MO
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Registered Nurse (RN) – SW Blvd. Family Medicine Clinic – Jefferson City, MO
University of Missouri Health Care
Jefferson City, Missouri
Healthcare Administration
Human Resources
Nursing
Patient Services & Wellbeing
$29.77 - $43.93/hr
5,001-10,000

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See All 84 Clinic Registered Nurse Jobs in Missouri

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Clinic Registered Nurse Jobs by City in Missouri

Where Missouri roles are concentrated, by current openings.

Columbia
17 jobs
St. Louis
13 jobs
Kansas City
13 jobs
Joplin
4 jobs
Springfield
4 jobs
Jefferson City
3 jobs
Ballwin
2 jobs
Bolivar
2 jobs
Lebanon
2 jobs

Clinic Registered Nurse Job Market in Missouri

A snapshot from current Missouri openings, updated as new roles post.

Who's Hiring

  • University of Missouri Health Care21
  • Mercy15
  • SSM Health12
  • University Health KC6
  • The University of Kansas Health System5

Top Industries Hiring

  • Healthcare & Medical Services

What Missouri Employers Look For

The qualifications that appear most often in clinic registered nurse jobs across Missouri.

  • Active registered nurse license issued or recognized by the Missouri State Board of Nursing
  • Associate or Bachelor of Science in Nursing degree from an accredited program
  • Current BLS certification required prior to patient care start date
  • One or more years of clinical nursing experience in an outpatient or ambulatory setting
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Strong patient assessment and care coordination skills for high-volume clinic environments

Clinic Registered Nurse Jobs in Missouri: Frequently Asked Questions

How do you become a clinic registered nurse in Missouri?

You become a clinic registered nurse in Missouri by earning an Associate Degree in Nursing or a Bachelor of Science in Nursing from an accredited program, passing the NCLEX-RN, and obtaining a license through the Missouri State Board of Nursing. Missouri participates in the Nurse Licensure Compact, so nurses licensed in other compact states can work in Missouri without a separate state license. Most clinic employers also expect current BLS certification before the first day.

How much do clinic registered nurses make in Missouri?

Clinic registered nurses in Missouri earn a median of about $81,780 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $63,230 for the lowest 10% to over $104,390 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire clinic registered nurses in Missouri?

Missouri clinic registered nurse roles are posted by University of Missouri Health Care, Mercy, and SSM Health and others right now, based on current listings on Migrate Mate as of October 2026. Missouri's mix of large integrated health systems, independent specialty clinics, and federally qualified health centers means openings are distributed across both major metros and smaller regional communities statewide.

Which Missouri cities have the most clinic registered nurse jobs?

Columbia, St. Louis, and Kansas City are the Missouri cities with the most clinic registered nurse openings. St. Louis and Kansas City lead because of the large hospital systems and specialty clinic networks headquartered there, while Columbia's concentration of academic medicine and University of Missouri Health Care drives a disproportionately large number of openings relative to its population.

Are there remote clinic registered nurse jobs in Missouri?

Yes, but they're rare. Clinic nursing is inherently hands-on, so most roles require on-site patient care. About 40% of clinic registered nurse openings tied to Missouri are remote or hybrid as of October 2026, and those positions tend to be in telephone triage, care management, or chronic disease coaching rather than direct patient examination.

How can I get hired as a clinic registered nurse in Missouri with little or no experience?

The most realistic entry path is a new-graduate residency or transition-to-practice program at a large Missouri health system. BJC HealthCare, Mercy Health, and Saint Luke's Health System run structured new-grad programs that include outpatient and clinic rotations. Candidates coming from medical assistant, licensed practical nurse, or patient care technician roles have a strong advantage because those lateral moves demonstrate clinic workflow familiarity. Holding an active Missouri nursing license or Nurse Licensure Compact license before applying, combined with BLS certification, is the credential combination that most quickly moves a new-grad application forward.

Where can I find and apply to clinic registered nurse jobs in Missouri?

You can find and apply to clinic registered nurse jobs in Missouri on Migrate Mate, which lists current Missouri openings across health systems, specialty clinics, and community health centers. Find the roles that fit your experience and location and apply directly.

See All 84 Clinic Registered Nurse Jobs in Missouri

Find roles in Missouri that match your experience and apply in just a few clicks.

Find Clinic Registered Nurse Jobs