Clinic Registered Nurse Jobs in South Dakota
Clinic Registered Nurse jobs in South Dakota are concentrated in Sioux Falls, Rapid City, and Aberdeen, where Sanford Health, Avera Health, and Monument Health anchor the largest clinic and outpatient networks in the state. Demand is strongest for nurses with experience in primary care, chronic disease management, and pediatric clinic settings, with openings at every level from new graduate to senior care coordinator. South Dakota's growing rural health initiative has also created consistent clinic RN roles in smaller communities served by regional health systems. Scan the live roles below and apply to whichever ones fit.
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Showing 5 of 75+ Clinic Registered Nurse jobs
Careers With Purpose
Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland.
Facility: Medical Building 3
Location: Sioux Falls, SD
Address: 1500 W 22nd St, Sioux Falls, SD 57105, USA
Shift: Day
Job Schedule: PRN
Weekly Hours: Varies
Salary Range: $29.50 - $44.50
Department Details
Great opportunity to join a vibrant and highly specialized Urogynecology Clinic where every day brings the chance to make a real impact. Our team treats and supports patients with pelvic floor disorders, offering truly meaningful and life changing care. With a small, close knit staff—including one physician and talented APPs—the clinic has a warm, family like culture where teamwork shines and every voice matters. This fast paced, very procedural environment is the perfect place to grow your skills, learn something new, and stay engaged. You’ll enjoy excellent work–life balance with no weekends, nights, or holidays, and the opportunity to build strong, lasting relationships with patients who return for ongoing treatments. If you’re looking for a supportive team, a dynamic environment, and room to grow—this is the place for you!
Job Summary
The Registered Nurse (RN) is responsible for utilizing the nursing process (assessment, diagnosis, outcomes/planning, implementation and evaluation) to provide individualized nursing care to patients. Responsible for the coordination of care, patient assessment, patient education, triage, and various other nursing interventions. Collaborates with other inter-professional colleagues, including physicians, to plan, implement and evaluate care. Demonstrates competency and practices within the full scope of nursing expertise/knowledge and utilizes appropriate age and population specific standards as designated in their assigned clinical setting. Functions within the scopes and standards of nursing practice as outlined in the Nurse Practice Act and Administrative Rules in state of practice and licensure. The Sanford Professional Nursing Practice recognizes the Scope and Standards of Practice and the Code of Ethics for Nurses with Interpretive Statements as published by the American Nurses Association as the foundation of nursing care delivery and professional conduct.
Qualifications
Graduate from an accredited nursing program preferred, including, but not limited to, American Association of Colleges of Nursing (AACN), Accreditation Commission for Education in Nursing (ACEN), and National League for Nursing Commission for Nursing Education Accreditation (NLN CNEA). Bachelor’s Degree in nursing preferred.
Currently holds an unencumbered RN license with the State Board of Nursing where the practice of nursing is occurring and/or possess multistate licensure if in a Nurse Licensure Compact (NLC) state. Obtains and subsequently maintains required department specific licensure, competencies and certifications.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org .
Sanford has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0271878
Job Function: Nursing
Featured: No
Careers With Purpose
Sanford Health, the largest rural health system in the United States, is dedicated to transforming the health care experience and providing access to world-class health care in America’s heartland.
Facility: Medical Building 3
Location: Sioux Falls, SD
Address: 1500 W 22nd St, Sioux Falls, SD 57105, USA
Shift: Day
Job Schedule: PRN
Weekly Hours: Varies
Salary Range: $29.50 - $44.50
Department Details
Great opportunity to join a vibrant and highly specialized Urogynecology Clinic where every day brings the chance to make a real impact. Our team treats and supports patients with pelvic floor disorders, offering truly meaningful and life changing care. With a small, close knit staff—including one physician and talented APPs—the clinic has a warm, family like culture where teamwork shines and every voice matters. This fast paced, very procedural environment is the perfect place to grow your skills, learn something new, and stay engaged. You’ll enjoy excellent work–life balance with no weekends, nights, or holidays, and the opportunity to build strong, lasting relationships with patients who return for ongoing treatments. If you’re looking for a supportive team, a dynamic environment, and room to grow—this is the place for you!
Job Summary
The Registered Nurse (RN) is responsible for utilizing the nursing process (assessment, diagnosis, outcomes/planning, implementation and evaluation) to provide individualized nursing care to patients. Responsible for the coordination of care, patient assessment, patient education, triage, and various other nursing interventions. Collaborates with other inter-professional colleagues, including physicians, to plan, implement and evaluate care. Demonstrates competency and practices within the full scope of nursing expertise/knowledge and utilizes appropriate age and population specific standards as designated in their assigned clinical setting. Functions within the scopes and standards of nursing practice as outlined in the Nurse Practice Act and Administrative Rules in state of practice and licensure. The Sanford Professional Nursing Practice recognizes the Scope and Standards of Practice and the Code of Ethics for Nurses with Interpretive Statements as published by the American Nurses Association as the foundation of nursing care delivery and professional conduct.
Qualifications
Graduate from an accredited nursing program preferred, including, but not limited to, American Association of Colleges of Nursing (AACN), Accreditation Commission for Education in Nursing (ACEN), and National League for Nursing Commission for Nursing Education Accreditation (NLN CNEA). Bachelor’s Degree in nursing preferred.
Currently holds an unencumbered RN license with the State Board of Nursing where the practice of nursing is occurring and/or possess multistate licensure if in a Nurse Licensure Compact (NLC) state. Obtains and subsequently maintains required department specific licensure, competencies and certifications.
Sanford is an EEO/AA Employer M/F/Disability/Vet. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-877-673-0854 or send an email to talent@sanfordhealth.org .
Sanford has a Drug Free Workplace Policy. An accepted offer will require a drug screen and pre-employment background screening as a condition of employment.
Req Number: R-0271878
Job Function: Nursing
Featured: No
See All 75 Clinic Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse JobsClinic Registered Nurse Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Clinic Registered Nurse Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Avera Health43
- Sanford Health21
- Avera St. Mary's3A
- Urology Specialists2
- Monument Health1
Top Industries Hiring
- Healthcare & Medical Services
What South Dakota Employers Look For
The qualifications that appear most often in clinic registered nurse jobs across South Dakota.
- Active registered nurse license issued or recognized by the South Dakota Board of Nursing
- Associate or bachelor's degree in nursing from an accredited program
- Current BLS certification required before or at time of hire
- One or more years of clinical or outpatient nursing experience preferred
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong patient communication skills and ability to triage in a clinic environment
Clinic Registered Nurse Jobs in South Dakota: Frequently Asked Questions
How do you become a clinic registered nurse in South Dakota?
You become a clinic registered nurse in South Dakota by earning an associate or bachelor's degree in nursing, passing the NCLEX-RN exam, and obtaining a license through the South Dakota Board of Nursing. South Dakota participates in the Nurse Licensure Compact, so nurses licensed in other compact states can practice without obtaining a separate South Dakota license. Clinic employers typically expect BLS certification and may prefer candidates with ambulatory care or outpatient experience.
How much do clinic registered nurses make in South Dakota?
Clinic registered nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinic registered nurses in South Dakota?
Employers hiring clinic registered nurses in South Dakota right now include Avera Health, Sanford Health, and Avera St. Mary's, based on current listings on Migrate Mate as of August 2026. Sanford Health and Avera Health together operate the largest network of outpatient clinics across the state, making them consistently among the most active hirers of clinic RNs in South Dakota.
Which South Dakota cities have the most clinic registered nurse jobs?
Sioux Falls, Aberdeen, and Pierre have the most clinic registered nurse openings in South Dakota. Sioux Falls drives the largest share of listings as home to the Sanford and Avera flagship campuses and their associated specialty clinics, while Rapid City's growth is anchored by Monument Health's expanding outpatient network, and Aberdeen reflects steady demand from regional Avera and Sanford clinic operations serving the northeast corridor.
Are there remote clinic registered nurse jobs in South Dakota?
Yes, but they're rare. Clinic nursing is fundamentally a hands-on, patient-facing role, so most positions require physical presence in a clinic setting. About 33% of clinic registered nurse openings tied to South Dakota are remote or hybrid as of August 2026, and those tend to be in telephone triage, care coordination, or chronic disease management roles where direct patient contact is not required every shift.
How can I get hired as a clinic registered nurse in South Dakota with little or no experience?
The most realistic entry path is applying to new graduate nurse residency programs run by Sanford Health and Avera Health, both of which accept NCLEX-eligible candidates and provide structured outpatient and clinic rotations. Lateral moves from roles such as medical assistant, LPN, or patient care technician at a South Dakota clinic are common stepping stones. Holding a compact Nurse Licensure Compact license and a current BLS certification will give applicants a clear edge over candidates still awaiting state board results.
Where can I find and apply to clinic registered nurse jobs in South Dakota?
You can find and apply to clinic registered nurse jobs in South Dakota on Migrate Mate, which lists current openings across Sioux Falls, Rapid City, Aberdeen, and smaller South Dakota communities. Search the roles available, identify the ones that match your experience and preferred setting, and apply directly to the employers posting them.
See All 75 Clinic Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse Jobs