Clinic Registered Nurse Jobs in South Dakota

Clinic Registered Nurse jobs in South Dakota are concentrated in Sioux Falls, Rapid City, and Aberdeen, where Sanford Health, Avera Health, and Monument Health anchor the largest clinic and outpatient networks in the state. Demand is strongest for nurses with experience in primary care, chronic disease management, and pediatric clinic settings, with openings at every level from new graduate to senior care coordinator. South Dakota's growing rural health initiative has also created consistent clinic RN roles in smaller communities served by regional health systems. Scan the live roles below and apply to whichever ones fit.

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Overview

Open roles75
Top employerAvera Health
Top citySioux Falls, SD
Cities hiring14
Top industryHealthcare
Companies hiring9

Showing 5 of 75+ Clinic Registered Nurse jobs

Registered Nurse (RN) | Pediatric Endocrinology Clinic
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New 21h ago
Registered Nurse (RN) | Pediatric Endocrinology Clinic
Avera Health
Sioux Falls, South Dakota
Healthcare Administration
Nursing
Patient Services & Wellbeing
$27.75 - $41.25/hr
10,000+

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Registered Nurse (RN) or Licensed Practical Nurse (LPN) | Hematology & Bone Marrow Transplant Clinic
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Added 1d ago
Registered Nurse (RN) or Licensed Practical Nurse (LPN) | Hematology & Bone Marrow Transplant Clinic
Avera Health
Sioux Falls, South Dakota
Healthcare Administration
Nursing
Patient Services & Wellbeing
$22.5 - $41.25/hr
10,000+

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RN - Registered Nurse - Pain Management Clinic
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Added 3d ago
RN - Registered Nurse - Pain Management Clinic
Sanford Health
Rapid City, South Dakota
Healthcare Administration
Nursing
Patient Services & Wellbeing
$25.5 - $38.5/hr
Bachelor's degree
10,000+

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Registered Nurse (RN) or Licensed Practical Nurse (LPN) or Medical Assistant | Salem Harrisburg and Tea Clinic Float PRN
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Added 4d ago
Registered Nurse (RN) or Licensed Practical Nurse (LPN) or Medical Assistant | Salem Harrisburg and Tea Clinic Float PRN
Avera Health
Tea, South Dakota
Healthcare Administration
Nursing
Patient Services & Wellbeing
$20 - $41.25/hr
CCMA Certification
10,000+

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Registered Nurse (RN) Supervisor | Clinic and Infusion
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Added 5d ago
Registered Nurse (RN) Supervisor | Clinic and Infusion
Avera Health
Yankton, South Dakota
Business Operations
Human Resources
Project Management
Managed Registered Nurses (RNs)
10,000+

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See All 75 Clinic Registered Nurse Jobs in South Dakota

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Clinic Registered Nurse Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
42 jobs
Rapid City
12 jobs
Yankton
5 jobs
Aberdeen
4 jobs
Tea
2 jobs
Pierre
2 jobs
Canton
1 job
Lemmon
1 job
Sturgis
1 job

Clinic Registered Nurse Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Avera Health38
  • Sanford Health21
  • Monument Health9
  • Avera St. Mary's2
  • Orthopedic Institute1

Top Industries Hiring

  • Healthcare & Medical Services

What South Dakota Employers Look For

The qualifications that appear most often in clinic registered nurse jobs across South Dakota.

  • Active registered nurse license issued or recognized by the South Dakota Board of Nursing
  • Associate or bachelor's degree in nursing from an accredited program
  • Current BLS certification required before or at time of hire
  • One or more years of clinical or outpatient nursing experience preferred
  • Proficiency with electronic health record systems such as Epic or Cerner
  • Strong patient communication skills and ability to triage in a clinic environment

Clinic Registered Nurse Jobs in South Dakota: Frequently Asked Questions

How do you become a clinic registered nurse in South Dakota?

You become a clinic registered nurse in South Dakota by earning an associate or bachelor's degree in nursing, passing the NCLEX-RN exam, and obtaining a license through the South Dakota Board of Nursing. South Dakota participates in the Nurse Licensure Compact, so nurses licensed in other compact states can practice without obtaining a separate South Dakota license. Clinic employers typically expect BLS certification and may prefer candidates with ambulatory care or outpatient experience.

How much do clinic registered nurses make in South Dakota?

Clinic registered nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.

Which companies hire clinic registered nurses in South Dakota?

Employers hiring clinic registered nurses in South Dakota right now include Avera Health, Sanford Health, and Monument Health, based on current listings on Migrate Mate as of October 2026. Sanford Health and Avera Health together operate the largest network of outpatient clinics across the state, making them consistently among the most active hirers of clinic RNs in South Dakota.

Which South Dakota cities have the most clinic registered nurse jobs?

Sioux Falls, Rapid City, and Yankton have the most clinic registered nurse openings in South Dakota. Sioux Falls drives the largest share of listings as home to the Sanford and Avera flagship campuses and their associated specialty clinics, while Rapid City's growth is anchored by Monument Health's expanding outpatient network, and Aberdeen reflects steady demand from regional Avera and Sanford clinic operations serving the northeast corridor.

How can I get hired as a clinic registered nurse in South Dakota with little or no experience?

The most realistic entry path is applying to new graduate nurse residency programs run by Sanford Health and Avera Health, both of which accept NCLEX-eligible candidates and provide structured outpatient and clinic rotations. Lateral moves from roles such as medical assistant, LPN, or patient care technician at a South Dakota clinic are common stepping stones. Holding a compact Nurse Licensure Compact license and a current BLS certification will give applicants a clear edge over candidates still awaiting state board results.

Where can I find and apply to clinic registered nurse jobs in South Dakota?

You can find and apply to clinic registered nurse jobs in South Dakota on Migrate Mate, which lists current openings across Sioux Falls, Rapid City, Aberdeen, and smaller South Dakota communities. Search the roles available, identify the ones that match your experience and preferred setting, and apply directly to the employers posting them.

See All 75 Clinic Registered Nurse Jobs in South Dakota

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