Clinic Registered Nurse Jobs in South Dakota
Clinic Registered Nurse jobs in South Dakota are concentrated in Sioux Falls, Rapid City, and Aberdeen, where Sanford Health, Avera Health, and Monument Health anchor the largest clinic and outpatient networks in the state. Demand is strongest for nurses with experience in primary care, chronic disease management, and pediatric clinic settings, with openings at every level from new graduate to senior care coordinator. South Dakota's growing rural health initiative has also created consistent clinic RN roles in smaller communities served by regional health systems. Scan the live roles below and apply to whichever ones fit.
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Day Shift (United States of America)Pay Range:
The pay range for this position is listed below. Actual pay rate dependent upon experience.
$27.75 - $41.25Position Highlights
Primary nurse for Dr. Gupta
May be eligible for a $10,000 sign on bonus
You Belong at Avera
Be part of a multidisciplinary team built with compassion and the goal of Moving Health Forward for you and our patients. Work where you matter.
A Brief Overview
Responsible for providing professional nursing care to patients and families. Communicates with physicians as well as other healthcare team members to provide excellent patient care.
What you will do
- Performs general nursing care to patients. Administers prescribed medications and treatments in accordance with nursing standards. Coordinates the patient care activities for the clinic.
- Prepares equipment and assists provider during procedures, treatments, examinations, and testing of patients.
- Observes, records, and reports patient’s condition and reactions to drugs and treatments to provider.
- Oversees appointment scheduling and ensures preferences are given to patients in emergency situations. Maintains timely flow of patients.
- Greets patients and prepares them for physical examination. Screens patients for appropriate information including obtaining the health history, taking vitals, and conducting a nursing assessment. Documents obtained information in patient chart. Instructs patient in collection of samples and tests.
- Responds to patient phone calls in a timely manner with appropriate input from the physician.
- Educates patients and families about diagnostic process, medications, nutrition, and maintenance of health and wellness.
- Suggests solutions to patient care crisis problems and complaints.
- Maintains exam rooms with necessary supplies and materials. Ensures cleanliness. Prepares list of medical supplies needed.
- Assures appropriate labeling of pathology specimens according to lab protocol as needed. Performs quality control and maintains records on all lab testing.
Essential Qualifications
The individual must be able to work the hours specified. To perform this job successfully, an individual must be able to perform each essential job function satisfactorily including having visual acuity adequate to perform position duties and the ability to communicate effectively with others, hear, understand and distinguish speech and other sounds. These requirements and those listed above are representative of the knowledge, skills, and abilities required to perform the essential job functions. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential job functions, as long as the accommodations do not cause undue hardship to the employer.
Required Education, License/Certification, or Work Experience:
- Registered Nurse (RN) - Board of Nursing An active license in the state of practice Upon Hire
Expectations and Standards
- Commitment to the daily application of Avera’s mission, vision, core values, and social principles to serve patients, their families, and our community.
- Promote Avera’s values of compassion, hospitality, and stewardship.
- Uphold Avera’s standards of Communication, Attitude, Responsiveness, and Engagement (CARE) with enthusiasm and sincerity.
- Maintain confidentiality.
- Work effectively in a team environment, coordinating work flow with other team members and ensuring a productive and efficient environment.
- Comply with safety principles, laws, regulations, and standards associated with, but not limited to, CMS, The Joint Commission, DHHS, and OSHA if applicable.
Benefits You Need & Then Some
Avera is proud to offer a wide range of benefits to qualifying part-time and full-time employees. We support you with opportunities to help live balanced, healthy lives. Benefits are designed to meet needs of today and into the future.
PTO available day 1 for eligible hires.
Up to 5% employer matching contribution for retirement
Career development guided by hands-on training and mentorship
Avera is an Equal Opportunity Employer - Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability, Veteran Status, or other categories protected by law. If you are an individual with a disability and would like to request an accommodation for help with your online application, please call 1-605-504-4444 or send an email to talent@avera.org.
See All 75 Clinic Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse JobsClinic Registered Nurse Jobs by City in South Dakota
Where South Dakota roles are concentrated, by current openings.
Clinic Registered Nurse Job Market in South Dakota
A snapshot from current South Dakota openings, updated as new roles post.
Who's Hiring
- Avera Health38

- Sanford Health21

- Monument Health9

- Avera St. Mary's2A
- Orthopedic Institute1

Top Industries Hiring
- Healthcare & Medical Services
What South Dakota Employers Look For
The qualifications that appear most often in clinic registered nurse jobs across South Dakota.
- Active registered nurse license issued or recognized by the South Dakota Board of Nursing
- Associate or bachelor's degree in nursing from an accredited program
- Current BLS certification required before or at time of hire
- One or more years of clinical or outpatient nursing experience preferred
- Proficiency with electronic health record systems such as Epic or Cerner
- Strong patient communication skills and ability to triage in a clinic environment
Clinic Registered Nurse Jobs in South Dakota: Frequently Asked Questions
How do you become a clinic registered nurse in South Dakota?
You become a clinic registered nurse in South Dakota by earning an associate or bachelor's degree in nursing, passing the NCLEX-RN exam, and obtaining a license through the South Dakota Board of Nursing. South Dakota participates in the Nurse Licensure Compact, so nurses licensed in other compact states can practice without obtaining a separate South Dakota license. Clinic employers typically expect BLS certification and may prefer candidates with ambulatory care or outpatient experience.
How much do clinic registered nurses make in South Dakota?
Clinic registered nurses in South Dakota earn a median of about $78,060 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $54,040 for the lowest 10% to over $98,220 for the top 10%. Pay rises with experience, specialty, and employer.
Which companies hire clinic registered nurses in South Dakota?
Employers hiring clinic registered nurses in South Dakota right now include Avera Health, Sanford Health, and Monument Health, based on current listings on Migrate Mate as of October 2026. Sanford Health and Avera Health together operate the largest network of outpatient clinics across the state, making them consistently among the most active hirers of clinic RNs in South Dakota.
Which South Dakota cities have the most clinic registered nurse jobs?
Sioux Falls, Rapid City, and Yankton have the most clinic registered nurse openings in South Dakota. Sioux Falls drives the largest share of listings as home to the Sanford and Avera flagship campuses and their associated specialty clinics, while Rapid City's growth is anchored by Monument Health's expanding outpatient network, and Aberdeen reflects steady demand from regional Avera and Sanford clinic operations serving the northeast corridor.
How can I get hired as a clinic registered nurse in South Dakota with little or no experience?
The most realistic entry path is applying to new graduate nurse residency programs run by Sanford Health and Avera Health, both of which accept NCLEX-eligible candidates and provide structured outpatient and clinic rotations. Lateral moves from roles such as medical assistant, LPN, or patient care technician at a South Dakota clinic are common stepping stones. Holding a compact Nurse Licensure Compact license and a current BLS certification will give applicants a clear edge over candidates still awaiting state board results.
Where can I find and apply to clinic registered nurse jobs in South Dakota?
You can find and apply to clinic registered nurse jobs in South Dakota on Migrate Mate, which lists current openings across Sioux Falls, Rapid City, Aberdeen, and smaller South Dakota communities. Search the roles available, identify the ones that match your experience and preferred setting, and apply directly to the employers posting them.
See All 75 Clinic Registered Nurse Jobs in South Dakota
Find roles in South Dakota that match your experience and apply in just a few clicks.
Find Clinic Registered Nurse Jobs