Principal Jobs at Genentech with Visa Sponsorship
Principal roles at Genentech sit at the intersection of scientific leadership and cross-functional strategy, covering areas like regulatory affairs, clinical development, and medical devices. Genentech has a established track record of sponsoring work visas for senior contributors in this function, making it a credible target if you're building a long-term U.S. career in biotech.
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Get Access To All JobsThe Position
The Opportunity
The Portfolio Analytics Principal is a strategic finance leader who shapes how Genentech anticipates market evolution, forecasts portfolio performance, and translates complex business signals into clear, actionable insights that drive decision-making at the highest levels.
This role sits at the intersection of strategy, forecasting, business performance, and advanced analytics. The candidate will partner closely with Genentech CFO, CMG finance team, GPS, Group Finance (eCOE), Investor Relations, Digital/Data & Analytics (DDA), and cross-functional teams to build a best-in-class portfolio intelligence capability—enabling Genentech to make faster, smarter, more patient-centered decisions.
This role requires a combination of executive presence, analytical depth, storytelling ability, and a modern digital mindset, including automation and AI-enabled analytics.
Key Responsibilities:
Strategic Business Partnering & Enterprise Influence
- Serve as a trusted thought partner to senior stakeholders (Genentech CFO, CMG finance team, GPS, Group Finance (eCOE), Investor Relations, DDA, etc.), ensuring US insights align with the One Pharma Strategy, CMG priorities, and long-term enterprise commitments.
- Translate business questions into analytical priorities, and ensure insights are decision-relevant, outcome-driven, and timely.
Forward-Looking Scenario Planning, Opportunity Identification, & Risk Anticipation
- Contribute to building and scaling forward looking scenario planning: detecting early signals across market dynamics, competitive landscape, access environment, demand trends, and internal execution performance.
- Integrate multiple data sources (sales, demand, payer, epidemiology, competitive intelligence, macro trends, etc.) to identify growth opportunities, business risks, and emerging portfolio inflection points.
- Strengthen Genentech’s ability to anticipate near- and long-term portfolio direction with scenario thinking and predictive forecasting.
Analytics Systems, Automation & AI Enablement
- Help to build, enhance, and automate the analytical tools and systems supporting portfolio performance and forecasting.
- Partner with Digital/DDA teams to leverage AI and advanced analytics (forecasting automation, anomaly detection, scenario modeling, insight generation) to increase speed, accuracy, and scalability.
- Help to shape analytics products across Finance, translating stakeholder needs into clear business requirements and ensuring continuous improvement of outputs and user experience.
Forecasting & Business Planning Leadership
- Help to strengthen the Monthly Outlook process, with a heavy emphasis on forecasting accuracy, forward-looking insights, and executive-level storytelling.
- Deliver robust portfolio revenue insights that inform Genentech’s P&L commitments to Roche and enable proactive performance management.
- Support the Head of Portfolio Forecasting in shaping the strategic direction and evolution of the overall forecasting and insights service model.
Executive Storytelling & Decision Support
- Develop compelling narratives around business performance and outlook, simplifying complexity into clear strategic implications for senior leaders.
- Provide recommendations on scenarios, supporting leadership in making informed decisions.
- Drive alignment across stakeholders by ensuring a consistent and trusted portfolio story across Finance, Strategy, and Enterprise reporting.
Capability Building & Talent Leadership
- Build and continuously evolve the capabilities required for world-class portfolio analytics: tools, talent, workflows, governance, and operating model.
- Mentor and develop analysts and forecasting professionals, strengthening business judgment, data literacy, and modern technical capability.
- Proactively assess resourcing needs and flex talent toward the highest-value business priorities.
Continuous Improvement & Enterprise Impact
- Lead change efforts to improve portfolio forecasting, simplify analytics workflows, and increase speed and decision usefulness.
- Drive cross-organizational opportunities (Genentech/Roche) to improve speed, simplicity, patient-centricity, and effectiveness through insights.
Compliance & Integrity
- Ensure full compliance with Genentech/Roche policies and all laws and regulations governing business conduct.
Who You Are
- Bachelor’s degree in business, finance, economics, engineering, mathematics, statistics, operations research, health sciences, or related field.
- 10+ years experience in forecasting, insights, strategy, and/or business planning.
- 7+ years experience in pharma, biotech, or related industries.
- Demonstrated experience leading organizational change and driving adoption of new tools/processes.
- Strong executive communication skills with proven ability to influence senior stakeholders.
- Deep expertise in analytics, forecasting, and business storytelling.
- Ability to define and execute long-term capability roadmaps (strategy, goals, KPIs, delivery model).
- Strong negotiation and interpersonal skills, with demonstrated ability to align diverse stakeholders.
The expected salary range for this position based on the primary location of California is $165,800 - $307,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
The Position
The Opportunity
The Portfolio Analytics Principal is a strategic finance leader who shapes how Genentech anticipates market evolution, forecasts portfolio performance, and translates complex business signals into clear, actionable insights that drive decision-making at the highest levels.
This role sits at the intersection of strategy, forecasting, business performance, and advanced analytics. The candidate will partner closely with Genentech CFO, CMG finance team, GPS, Group Finance (eCOE), Investor Relations, Digital/Data & Analytics (DDA), and cross-functional teams to build a best-in-class portfolio intelligence capability—enabling Genentech to make faster, smarter, more patient-centered decisions.
This role requires a combination of executive presence, analytical depth, storytelling ability, and a modern digital mindset, including automation and AI-enabled analytics.
Key Responsibilities:
Strategic Business Partnering & Enterprise Influence
- Serve as a trusted thought partner to senior stakeholders (Genentech CFO, CMG finance team, GPS, Group Finance (eCOE), Investor Relations, DDA, etc.), ensuring US insights align with the One Pharma Strategy, CMG priorities, and long-term enterprise commitments.
- Translate business questions into analytical priorities, and ensure insights are decision-relevant, outcome-driven, and timely.
Forward-Looking Scenario Planning, Opportunity Identification, & Risk Anticipation
- Contribute to building and scaling forward looking scenario planning: detecting early signals across market dynamics, competitive landscape, access environment, demand trends, and internal execution performance.
- Integrate multiple data sources (sales, demand, payer, epidemiology, competitive intelligence, macro trends, etc.) to identify growth opportunities, business risks, and emerging portfolio inflection points.
- Strengthen Genentech’s ability to anticipate near- and long-term portfolio direction with scenario thinking and predictive forecasting.
Analytics Systems, Automation & AI Enablement
- Help to build, enhance, and automate the analytical tools and systems supporting portfolio performance and forecasting.
- Partner with Digital/DDA teams to leverage AI and advanced analytics (forecasting automation, anomaly detection, scenario modeling, insight generation) to increase speed, accuracy, and scalability.
- Help to shape analytics products across Finance, translating stakeholder needs into clear business requirements and ensuring continuous improvement of outputs and user experience.
Forecasting & Business Planning Leadership
- Help to strengthen the Monthly Outlook process, with a heavy emphasis on forecasting accuracy, forward-looking insights, and executive-level storytelling.
- Deliver robust portfolio revenue insights that inform Genentech’s P&L commitments to Roche and enable proactive performance management.
- Support the Head of Portfolio Forecasting in shaping the strategic direction and evolution of the overall forecasting and insights service model.
Executive Storytelling & Decision Support
- Develop compelling narratives around business performance and outlook, simplifying complexity into clear strategic implications for senior leaders.
- Provide recommendations on scenarios, supporting leadership in making informed decisions.
- Drive alignment across stakeholders by ensuring a consistent and trusted portfolio story across Finance, Strategy, and Enterprise reporting.
Capability Building & Talent Leadership
- Build and continuously evolve the capabilities required for world-class portfolio analytics: tools, talent, workflows, governance, and operating model.
- Mentor and develop analysts and forecasting professionals, strengthening business judgment, data literacy, and modern technical capability.
- Proactively assess resourcing needs and flex talent toward the highest-value business priorities.
Continuous Improvement & Enterprise Impact
- Lead change efforts to improve portfolio forecasting, simplify analytics workflows, and increase speed and decision usefulness.
- Drive cross-organizational opportunities (Genentech/Roche) to improve speed, simplicity, patient-centricity, and effectiveness through insights.
Compliance & Integrity
- Ensure full compliance with Genentech/Roche policies and all laws and regulations governing business conduct.
Who You Are
- Bachelor’s degree in business, finance, economics, engineering, mathematics, statistics, operations research, health sciences, or related field.
- 10+ years experience in forecasting, insights, strategy, and/or business planning.
- 7+ years experience in pharma, biotech, or related industries.
- Demonstrated experience leading organizational change and driving adoption of new tools/processes.
- Strong executive communication skills with proven ability to influence senior stakeholders.
- Deep expertise in analytics, forecasting, and business storytelling.
- Ability to define and execute long-term capability roadmaps (strategy, goals, KPIs, delivery model).
- Strong negotiation and interpersonal skills, with demonstrated ability to align diverse stakeholders.
The expected salary range for this position based on the primary location of California is $165,800 - $307,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
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Get Access To All JobsTips for Finding Principal Jobs at Genentech Jobs
Align your credentials to specialty occupation standards
USCIS requires Principal roles to qualify as specialty occupations, meaning your degree must directly relate to the job. For Genentech's medical devices function, a graduate degree in biomedical engineering, regulatory science, or a closely related field strengthens your petition significantly.
Target Genentech's regulatory and clinical Principal tracks
Genentech staffs Principal roles most heavily in regulatory affairs and clinical operations for medical devices. Framing your resume around FDA submission experience, cross-functional trial management, or device commercialization puts you in the strongest candidate pool for sponsored positions.
Browse open Principal roles through Migrate Mate
Genentech lists Principal openings across multiple functions at different times of year. Use Migrate Mate to filter specifically for Principal roles at Genentech that include visa sponsorship, so you're not manually sorting through listings that don't apply to your situation.
Confirm your LCA wage tier before accepting an offer
Before signing, ask your recruiter which DOL prevailing wage level Genentech intends to use on your Labor Condition Application. Principal-level roles in the San Francisco Bay Area typically fall at wage levels III or IV, and a mismatch can create complications during H-1B filing.
Prepare for PERM if a Green Card is part of your plan
For EB-2 or EB-3 sponsorship, Genentech's legal team typically initiates PERM after you've been in role for a defined period. The DOL audit process for Principal-level positions in medical devices can extend timelines, so request an early conversation about your employer's green card process during offer negotiations.
Principal at Genentech jobs are hiring across the US. Find yours.
Find Principal at Genentech JobsFrequently Asked Questions
Does Genentech sponsor H-1B visas for Principals?
Yes, Genentech sponsors H-1B visas for Principal-level roles. The company has a consistent track record of filing H-1B petitions for senior contributors across its medical devices and broader biotech functions. If you're in the H-1B cap lottery or transitioning from F-1 OPT, your recruiter and Genentech's immigration team will coordinate the petition timeline with your start date.
Which visa types are commonly used for Principal roles at Genentech?
H-1B is the most common visa type for Principal roles at Genentech. F-1 OPT and STEM OPT extensions are used as bridge arrangements for recent graduates before H-1B status begins. TN visas are available for Canadian and Mexican nationals in qualifying specialty occupations. For longer-term pathways, Genentech supports EB-2 and EB-3 Green Card sponsorship for Principal-level employees.
What qualifications are expected for a Principal role at Genentech?
Principal roles at Genentech in the medical devices space generally require an advanced degree, most commonly a master's or Ph.D. in biomedical engineering, regulatory affairs, clinical sciences, or a related discipline. Employers at this level also expect demonstrated leadership on cross-functional projects, familiarity with FDA device regulations, and several years of hands-on industry experience in a comparable senior individual contributor capacity.
How do I apply for Principal jobs at Genentech?
You can browse and apply for Principal roles at Genentech directly through Genentech's careers portal. To find openings that explicitly include visa sponsorship, use Migrate Mate to filter for Principal positions at Genentech before applying. When you apply, tailor your materials to highlight regulatory, clinical, or device-specific experience that aligns with the specific Principal track listed in the job description.
How do I manage the timeline between a Genentech offer and my visa filing?
Once you have a signed offer, Genentech's immigration counsel will initiate the relevant petition, whether that's an H-1B, TN, or another category. For H-1B cap cases, the April 1 filing window is fixed, so your offer timing relative to the lottery matters. For TN or H-1B transfers from a current employer, processing can move faster. Clarify expected start dates with your recruiter early so the filing timeline stays on track.
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