Principal Jobs at Genentech with Visa Sponsorship
Principal jobs at Genentech sit at the intersection of scientific leadership and cross-functional strategy, covering areas like regulatory affairs, clinical development, and medical devices. Genentech has a established track record of sponsoring work visas for senior contributors in this function, making it a credible target if you're building a long-term U.S. career in biotech.
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Get Access To All JobsTHE POSITION
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
At USM, we play a pivotal role in driving Genentech's mission to expand patient access to life-changing therapies. Our focus is on empowering healthcare stakeholders with the scientific evidence they need to make informed treatment decisions. By fostering deep collaborations across the dynamic healthcare ecosystem, we are committed to delivering better outcomes for patients while ensuring care remains accessible and affordable for all.
The Opportunity
The Field Medical Excellence & Enablement Lead is a pivotal, execution-focused leader within US Medical, responsible for operational pull-through and maintaining capabilities that uphold scientific and business integrity. Reporting to the Head of Field Medical Excellence & Business Enablement, this individual focuses on the practical application of infrastructure, standards, and technology-driven enablement to drive organizational excellence and deliver tangible business results. The primary objective is to position Field Medical as the #1 organization in the industry and the premier scientific and medical partner of choice for healthcare stakeholders by flawlessly translating corporate strategy into field-level execution and operational discipline.
Key Responsibilities
- Evaluate the external landscape and conduct benchmarking to align medical affairs and field medical needs at the portfolio level to support field medical in generating insights, enhancing customer engagement, and driving impact, while informing clinical trial design, evidence planning, and field medical strategies to address unmet needs and emerging practices.
- Partner with R&D, global, and USM networks as the field medical excellence liaison to align product lifecycle and disease-specific requirements with field medical engagement strategies, fostering collaboration across US Medical, Field Medical, Global teams, Business Development, and Diagnostics teams.
- Develop and advance the field medical enablement execution plan in collaboration with USM teams, establishing frameworks, processes, and prioritization to drive alignment, integration, and change management across the portfolio and initiatives.
- Translate scientific and business challenges and needs into field medical requirements for capabilities, emerging technologies, and omnichannel strategies. Focus on adoption, measurement, and delivery of field medical insights and customer engagement for clinical trial design, medical operations, content strategies, and evidence planning.
- Provide thought leadership to R&D, product development, commercial, and cross-functional teams on industry trends as an innovator and connector. Advance evidence generation and bridge scientific, technical, business, and data-driven approaches and perspectives to enhance field engagement and USM's value proposition, serving as a change agent driving cultural and operational transformation.
- Lead and manage multi-disciplinary teams to achieve project objectives, delivering scalable solutions with clear A to B shifts that integrate into field medical workflows and align with US Medical goals. Synthesize stakeholder feedback into actionable learnings, while addressing challenges and ensuring successful execution.
- Collaborate with compliance to ensure Field Medical tools and processes adhere to regulatory compliance and privacy standards, safeguarding the company's interests and preserving customer data integrity.
Who You Are
Qualifications & Experience
- Education: Bachelor’s degree.
- Professional Experience: Minimum of 5 years of work experience, including 3+ years in the pharmaceutical/biotech/healthcare industry or management consulting.
- Advisory Experience: Prior experience within a consulting firm or similarly fast-paced, client-focused environment, with demonstrated ability to manage complex priorities, provide strategic support, and operate with a high degree of professionalism and discretion.
- Execution Leadership: Proven track record in an operational or "pull-through" role, overseeing the maintenance of scalable capabilities or technology platforms.
- Technical Proficiency: 2+ years in Healthcare Business Analytics with experience in AI/Machine Learning applications and data visualization tools (Spotfire®, Tableau, or RShiny).
- Matrix Navigation: Demonstrated ability to coordinate across complex matrixed environments (Legal, DDA, Compliance) and build trust with senior leadership.
Preferred Experience
- MBA or related graduate-level/advanced degree.
- Launch excellence within the pharmaceutical or biotech industry experience, including cross-functional operational support of pre-launch through commercialization activities.
- 3+ years of experience in clinical development with strong skills in clinical trial data analysis and RWD assets.
- Certifications such as Six Sigma, PMP, or similar.
- Experience with Agile methodologies and a proven ability to embed products into existing workflows for impactful outcomes.
Location and Travel Requirements
- The role is based in South San Francisco, with a minimum of 30% of the time expected to be traveling to locations designated by the Business.
The expected salary range for this position based on the primary location of South San Francisco, CA is $156,500.00 - 290,700.00. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
JOB FACTS
Job Sub Category Operations
Schedule Full time
Job Type Regular
Posted Date Jun 8th 2026
Job ID 202605-112714
THE POSITION
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.
At USM, we play a pivotal role in driving Genentech's mission to expand patient access to life-changing therapies. Our focus is on empowering healthcare stakeholders with the scientific evidence they need to make informed treatment decisions. By fostering deep collaborations across the dynamic healthcare ecosystem, we are committed to delivering better outcomes for patients while ensuring care remains accessible and affordable for all.
The Opportunity
The Field Medical Excellence & Enablement Lead is a pivotal, execution-focused leader within US Medical, responsible for operational pull-through and maintaining capabilities that uphold scientific and business integrity. Reporting to the Head of Field Medical Excellence & Business Enablement, this individual focuses on the practical application of infrastructure, standards, and technology-driven enablement to drive organizational excellence and deliver tangible business results. The primary objective is to position Field Medical as the #1 organization in the industry and the premier scientific and medical partner of choice for healthcare stakeholders by flawlessly translating corporate strategy into field-level execution and operational discipline.
Key Responsibilities
- Evaluate the external landscape and conduct benchmarking to align medical affairs and field medical needs at the portfolio level to support field medical in generating insights, enhancing customer engagement, and driving impact, while informing clinical trial design, evidence planning, and field medical strategies to address unmet needs and emerging practices.
- Partner with R&D, global, and USM networks as the field medical excellence liaison to align product lifecycle and disease-specific requirements with field medical engagement strategies, fostering collaboration across US Medical, Field Medical, Global teams, Business Development, and Diagnostics teams.
- Develop and advance the field medical enablement execution plan in collaboration with USM teams, establishing frameworks, processes, and prioritization to drive alignment, integration, and change management across the portfolio and initiatives.
- Translate scientific and business challenges and needs into field medical requirements for capabilities, emerging technologies, and omnichannel strategies. Focus on adoption, measurement, and delivery of field medical insights and customer engagement for clinical trial design, medical operations, content strategies, and evidence planning.
- Provide thought leadership to R&D, product development, commercial, and cross-functional teams on industry trends as an innovator and connector. Advance evidence generation and bridge scientific, technical, business, and data-driven approaches and perspectives to enhance field engagement and USM's value proposition, serving as a change agent driving cultural and operational transformation.
- Lead and manage multi-disciplinary teams to achieve project objectives, delivering scalable solutions with clear A to B shifts that integrate into field medical workflows and align with US Medical goals. Synthesize stakeholder feedback into actionable learnings, while addressing challenges and ensuring successful execution.
- Collaborate with compliance to ensure Field Medical tools and processes adhere to regulatory compliance and privacy standards, safeguarding the company's interests and preserving customer data integrity.
Who You Are
Qualifications & Experience
- Education: Bachelor’s degree.
- Professional Experience: Minimum of 5 years of work experience, including 3+ years in the pharmaceutical/biotech/healthcare industry or management consulting.
- Advisory Experience: Prior experience within a consulting firm or similarly fast-paced, client-focused environment, with demonstrated ability to manage complex priorities, provide strategic support, and operate with a high degree of professionalism and discretion.
- Execution Leadership: Proven track record in an operational or "pull-through" role, overseeing the maintenance of scalable capabilities or technology platforms.
- Technical Proficiency: 2+ years in Healthcare Business Analytics with experience in AI/Machine Learning applications and data visualization tools (Spotfire®, Tableau, or RShiny).
- Matrix Navigation: Demonstrated ability to coordinate across complex matrixed environments (Legal, DDA, Compliance) and build trust with senior leadership.
Preferred Experience
- MBA or related graduate-level/advanced degree.
- Launch excellence within the pharmaceutical or biotech industry experience, including cross-functional operational support of pre-launch through commercialization activities.
- 3+ years of experience in clinical development with strong skills in clinical trial data analysis and RWD assets.
- Certifications such as Six Sigma, PMP, or similar.
- Experience with Agile methodologies and a proven ability to embed products into existing workflows for impactful outcomes.
Location and Travel Requirements
- The role is based in South San Francisco, with a minimum of 30% of the time expected to be traveling to locations designated by the Business.
The expected salary range for this position based on the primary location of South San Francisco, CA is $156,500.00 - 290,700.00. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Relocation benefits are not available for this job posting.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
JOB FACTS
Job Sub Category Operations
Schedule Full time
Job Type Regular
Posted Date Jun 8th 2026
Job ID 202605-112714
See all 52+ Principal Jobs at Genentech
Sign up for free to unlock all listings, filter by visa type, and get alerts for new Principal Jobs at Genentech.
Get Access To All JobsTips for Finding Principal Jobs at Genentech
Align your credentials to specialty occupation standards
USCIS requires Principal roles to qualify as specialty occupations, meaning your degree must directly relate to the job. For Genentech's medical devices function, a graduate degree in biomedical engineering, regulatory science, or a closely related field strengthens your petition significantly.
Target Genentech's regulatory and clinical Principal tracks
Genentech staffs Principal roles most heavily in regulatory affairs and clinical operations for medical devices. Framing your resume around FDA submission experience, cross-functional trial management, or device commercialization puts you in the strongest candidate pool for sponsored positions.
Browse open Principal roles through Migrate Mate
Genentech lists Principal openings across multiple functions at different times of year. Use Migrate Mate to filter specifically for Principal roles at Genentech that include visa sponsorship, so you're not manually sorting through listings that don't apply to your situation.
Confirm your LCA wage tier before accepting an offer
Before signing, ask your recruiter which DOL prevailing wage level Genentech intends to use on your Labor Condition Application. Principal-level roles in the San Francisco Bay Area typically fall at wage levels III or IV, and a mismatch can create complications during H-1B filing.
Plan around H-1B cap timing if you're on OPT
If you're currently on F-1 OPT, your H-1B petition must be filed by April 1 to take effect October 1. Genentech has sponsored both standard cap and STEM OPT bridge scenarios, so clarify with your HR contact which pathway applies to your start date.
Prepare for PERM if a Green Card is part of your plan
For EB-2 or EB-3 sponsorship, Genentech's legal team typically initiates PERM after you've been in role for a defined period. The DOL audit process for Principal-level positions in medical devices can extend timelines, so request an early conversation about your employer's green card process during offer negotiations.
Frequently Asked Questions
Does Genentech sponsor H-1B visas for Principals?
Yes, Genentech sponsors H-1B visas for Principal-level roles. The company has a consistent track record of filing H-1B petitions for senior contributors across its medical devices and broader biotech functions. If you're in the H-1B cap lottery or transitioning from F-1 OPT, your recruiter and Genentech's immigration team will coordinate the petition timeline with your start date.
Which visa types are commonly used for Principal roles at Genentech?
H-1B is the most common visa type for Principal roles at Genentech. F-1 OPT and STEM OPT extensions are used as bridge arrangements for recent graduates before H-1B status begins. TN visas are available for Canadian and Mexican nationals in qualifying specialty occupations. For longer-term pathways, Genentech supports EB-2 and EB-3 Green Card sponsorship for Principal-level employees.
What qualifications are expected for a Principal role at Genentech?
Principal roles at Genentech in the medical devices space generally require an advanced degree, most commonly a master's or Ph.D. in biomedical engineering, regulatory affairs, clinical sciences, or a related discipline. Employers at this level also expect demonstrated leadership on cross-functional projects, familiarity with FDA device regulations, and several years of hands-on industry experience in a comparable senior individual contributor capacity.
How do I apply for Principal jobs at Genentech?
You can browse and apply for Principal roles at Genentech directly through Genentech's careers portal. To find openings that explicitly include visa sponsorship, use Migrate Mate to filter for Principal positions at Genentech before applying. When you apply, tailor your materials to highlight regulatory, clinical, or device-specific experience that aligns with the specific Principal track listed in the job description.
How do I manage the timeline between a Genentech offer and my visa filing?
Once you have a signed offer, Genentech's immigration counsel will initiate the relevant petition, whether that's an H-1B, TN, or another category. For H-1B cap cases, the April 1 filing window is fixed, so your offer timing relative to the lottery matters. For TN or H-1B transfers from a current employer, processing can move faster. Clarify expected start dates with your recruiter early so the filing timeline stays on track.