Information Security Engineer Jobs in Ohio
Information Security Engineer jobs in Ohio are open across Cincinnati and Miamisburg and other Ohio metros, with employers like Medpace and Accelevation hiring at every experience level. Find a role that fits below and apply directly.
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JOB SUMMARY
We are hiring a full-time Cybersecurity Engineer who is technical, dedicated to learning new things, security-minded, has strong initiative, and is able to manage projects autonomously. The Information Security team defends the company’s digital infrastructure by designing, implementing, and improving the company’s cybersecurity architecture. This is a critical role responsible for protecting infrastructure, cloud, edge devices, and data against unauthorized use, modification, exfiltration, or damage. If you’re excited to be part of a fast-growing team, then Medpace is a great place to grow your career.
Responsibilities:
- Design, deploy, and maintain enterprise security solutions with minimal oversight, collaborating with global IT teams to protect Medpace’s systems (e.g., implementing new security tools or architectures).
- Experience with network security across on-prem and cloud environments, including segmentation strategies, next-generation firewalls, Azure networking (Virtual Networks, private endpoints, firewalls), and Conditional Access policies; able to work with network teams to implement solutions.
- Own the administration and reliability of key security platforms (such as privileged access management, EDR, and SIEM), ensuring they are well-configured, up-to-date, and fully operational; coordinate upgrades and fixes proactively.
- Lead cross-functional security projects (e.g., cloud security improvements, EDR, identity security enhancements) from planning through execution, coordinating with stakeholders across departments to deliver results.
- Serve as a technical escalation point for complex security incidents or issues, independently investigating and resolving advanced problems (especially during off-hours for global coverage) and providing guidance to SOC Analysts and IT teams as needed.
- Improve and automate security operations by developing scripts, integrations, or workflows to reduce manual effort, enhance detection capabilities, and streamline incident response (e.g., building security automation in cloud or SIEM).
- Integrate security into enterprise systems and processes, working closely with Network, Cloud, and DevOps teams to embed robust security controls and best practices into infrastructure and software lifecycles.
- Document architectures, procedures, and solutions, ensuring knowledge is captured and shared; mentor and cross-train team members (especially developing Analysts) to strengthen overall team capabilities.
- Stay current with emerging threats and technologies, continuously researching new security trends, tools, and techniques to drive innovative improvements in the organization’s security posture.
QUALIFICATIONS
- Bachelor’s degree in Information Systems, Cybersecurity, or a related field.
- 4+ years of experience in IT/Information Security (with at least 2 years in a security engineering role or similar).
- In-depth knowledge of enterprise IT environments, including Windows Server/Active Directory, networks, and cloud architectures (Azure preferred), and how to secure them.
- Proven hands-on experience with security technologies, including some variety of SIEM, endpoint detection & response, identity/privileged access management, and cloud security tools.
- Excellent communication and documentation skills, with the ability to clearly explain complex security concepts to both technical and non-technical stakeholders and coordinate effectively across teams.
- Strong analytical and problem-solving skills, capable of independently troubleshooting and resolving complex security issues.
- Proficiency in scripting or automation (e.g., PowerShell, Python) to integrate and automate security processes.
- Self-motivated and continuously learning, with the ability to quickly adapt to new technologies and evolving threats.
NICE TO HAVE:
- Experience in one or more specialized security domains is a plus – for example, DevSecOps pipeline security, cloud security architecture (Azure/AWS), network segmentation, AI governance, advanced identity management, red-team/pentesting, or enterprise vulnerability management tools.
- Familiarity with regulated industries (e.g., healthcare, financial, defense) and related compliance frameworks (ISO 27001, NIST, GDPR, etc.) is beneficial.
MEDPACE OVERVIEW:
Medpace is a full-service clinical contract research organization (CRO). We provide Phase I-IV clinical development services to the biotechnology, pharmaceutical and medical device industries. Our mission is to accelerate the global development of safe and effective medical therapeutics through its scientific and disciplined approach. We leverage local regulatory and therapeutic expertise across all major areas including oncology, cardiology, metabolic disease, endocrinology, central nervous system, anti-viral and anti-infective. Headquartered in Cincinnati, Ohio, employing more than 6,000 people across 40+ countries.
WHY MEDPACE?:
People. Purpose. Passion. Make a Difference Tomorrow. Join Us Today.
The work we’ve done over the past 30+ years has positively impacted the lives of countless patients and families who face hundreds of diseases across all key therapeutic areas. The work we do today will improve the lives of people living with illness and disease in the future.
CINCINNATI PERKS:
- Flexible work environment
- Competitive PTO packages, starting at 20+ days
- Competitive compensation and benefits package
- Company-sponsored employee appreciation events
- Employee health and wellness initiatives
- Community involvement with local nonprofit organizations
- Discounts on local sports games, fitness gyms and attractions
- Modern, ecofriendly campus with an on-site fitness center
- Structured career paths with opportunities for professional growth
- Discounted tuition for UC online programs
AWARDS:
- Named a Top Workplace in 2024 by The Cincinnati Enquirer
- Recognized by Forbes as one of America's Most Successful Midsize Companies in 2021, 2022, 2023 and 2024
- Continually recognized with CRO Leadership Awards from Life Science Leader magazine based on expertise, quality, capabilities, reliability, and compatibility
WHAT TO EXPECT NEXT
A Medpace team member will review your qualifications and, if interested, you will be contacted with details for next steps.
See All 5 Information Security Engineer Jobs in Ohio
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Find JobsInformation Security Engineer Jobs by City in Ohio
Where Ohio roles are concentrated, by current openings.
Information Security Engineer Job Market in Ohio
A snapshot from current Ohio openings, updated as new roles post.
Who's Hiring
- Medpace3

- Accelevation2

Top Industries Hiring
- Science & Research3
- Manufacturing2
What Ohio Employers Look For
The qualifications that appear most often in information security engineer jobs across Ohio.
- 3-5 years of experience in information security, network security, or a related discipline
- Proficiency with SIEM platforms such as Splunk, Microsoft Sentinel, or IBM QRadar
- Hands-on experience with vulnerability management tools like Tenable Nessus or Qualys
- Relevant certification such as CISSP, CompTIA Security+, CEH, or equivalent
- Working knowledge of NIST CSF, ISO 27001, or SOC 2 compliance frameworks
- Bachelor's degree in computer science, cybersecurity, information systems, or a related field
Information Security Engineer Jobs in Ohio: Frequently Asked Questions
How many information security engineer jobs are there in Ohio?
There are 5+ information security engineer openings in Ohio on Migrate Mate as of June 2026, with the most roles in Cincinnati and Miamisburg. New positions post regularly as employers across Ohio hire.
How much do information security engineers make in Ohio?
Information security engineers in Ohio earn a median of about $110,480 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $68,070 for the lowest 10% to over $171,450 for the top 10%. Pay rises with experience, specialty, and employer.
Which Ohio cities have the most information security engineer jobs?
Cincinnati and Miamisburg have the most information security engineer openings in Ohio right now, with additional roles spread across smaller metros statewide.
Which companies hire information security engineers in Ohio?
Employers hiring information security engineers in Ohio include Medpace and Accelevation, based on current listings on Migrate Mate as of June 2026.
Are there remote information security engineer jobs in Ohio?
Yes. About 0% of information security engineer openings tied to Ohio are remote or hybrid as of June 2026. The rest are on-site roles based in Ohio metros.
How do I apply for information security engineer jobs in Ohio?
You can apply to information security engineer jobs in Ohio directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred Ohio location, then apply to each one that fits.
See All 5 Information Security Engineer Jobs in Ohio
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