Physician Assistant Jobs in South Dakota

Physician Assistant jobs in South Dakota are open across Sioux Falls, Huron, and Rapid City and other South Dakota metros, with employers like Sanford Health, Huron Regional Medical Center, and Sioux Center Health hiring at every experience level. Find a role that fits below and apply directly.

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Overview

Open roles30+
Top employerSanford Health
Top citySioux Falls, SD
Cities hiring9
Work type100% On-site
Top industryHealthcare

Showing 5 of 30+ Physician Assistant jobs

Sanford Health
Nurse Practitioner or Physician Assistant
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Sanford Health
Added 4d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Rapid City, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 5d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Aberdeen, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Other
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 6d ago
Nurse Practitioner or Physician Assistant
Sanford Health
Watertown, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Sanford Health
Nurse Practitioner or Physician Assistant
We won't show you this job again
Sanford Health
Added 1w ago
Nurse Practitioner or Physician Assistant
Sanford Health
Sioux Falls, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
Master's
10,000+

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Huron Regional Medical Center
Physician Assistant or Nurse Practitioner
We won't show you this job again
Huron Regional Medical Center
Added 1w ago
Physician Assistant or Nurse Practitioner
Huron Regional Medical Center
Huron, South Dakota
Nursing
Healthcare Administration
Patient Services & Wellbeing
On-Site
None
201-500

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Physician Assistant Jobs by City in South Dakota

Where South Dakota roles are concentrated, by current openings.

Sioux Falls
7 jobs
Huron
6 jobs
Rapid City
6 jobs
Aberdeen
4 jobs
Pierre
2 jobs
Sd
2 jobs
Brookings
1 jobs
Watertown
1 jobs
Webster
1 jobs

Physician Assistant Job Market in South Dakota

A snapshot from current South Dakota openings, updated as new roles post.

Who's Hiring

  • Sanford Health
    Sanford Health18
  • Huron Regional Medical Center
    Huron Regional Medical Center6
  • Sioux Center Health
    Sioux Center Health4
  • Sanford Bismarck
    Sanford Bismarck2

Top Industries Hiring

  • Healthcare & Medical Services30
  • Non-Profit & Social Services1

What South Dakota Employers Look For

The qualifications that appear most often in physician assistant jobs across South Dakota.

  • Master of Science in Physician Assistant Studies from an ARC-PA-accredited program
  • Current NCCPA certification (PANCE passage or maintenance of certification)
  • Active state PA license or eligibility for licensure in the hiring state
  • Two or more years of clinical experience in a relevant specialty setting
  • Proficiency with electronic health records systems such as Epic or Cerner
  • Current BLS certification and ACLS certification for acute care or hospital roles

Physician Assistant Jobs in South Dakota: Frequently Asked Questions

How many physician assistant jobs are there in South Dakota?

There are 30+ physician assistant openings in South Dakota on Migrate Mate as of June 2026, with the most roles in Sioux Falls, Huron, and Rapid City. New positions post regularly as employers across South Dakota hire.

How much do physician assistants make in South Dakota?

Physician assistants in South Dakota earn a median of about $133,200 a year, based on May 2025 Bureau of Labor Statistics wage data, ranging from around $104,660 for the lowest 10% to over $158,020 for the top 10%. Pay rises with experience, specialty, and employer.

Which South Dakota cities have the most physician assistant jobs?

Sioux Falls, Huron, and Rapid City have the most physician assistant openings in South Dakota right now, with additional roles spread across smaller metros statewide.

Which companies hire physician assistants in South Dakota?

Employers hiring physician assistants in South Dakota include Sanford Health, Huron Regional Medical Center, and Sioux Center Health, based on current listings on Migrate Mate as of June 2026.

Are there remote physician assistant jobs in South Dakota?

Yes. About 0% of physician assistant openings tied to South Dakota are remote or hybrid as of June 2026. The rest are on-site roles based in South Dakota metros.

How do I apply for physician assistant jobs in South Dakota?

You can apply to physician assistant jobs in South Dakota directly on Migrate Mate. Search the listings above, find roles that match your experience and preferred South Dakota location, then apply to each one that fits.

See All 30 Physician Assistant Jobs in South Dakota

Find roles in South Dakota that match your experience and apply in just a few clicks.

Find Physician Assistant Jobs