Practice Assistant Jobs in Missouri
Practice assistant jobs in Missouri are concentrated in healthcare settings, including physician offices, dental practices, and outpatient clinics, with demand at every level from entry-level roles to experienced clinical support positions. Kansas City, St. Louis, and Springfield are the largest hiring markets, with established employers like BJC HealthCare, Saint Luke's Health System, and Mercy Health consistently posting openings across Missouri. The most in-demand specialties include dental assisting, medical office support, and behavioral health practice assistance. See the openings below and apply to the ones that match your experience.
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Company Overview
Shriners Children’s is an organization that respects, supports, and values each other. Named as the 2025 best mid-sized employer by Forbes, we are engaged in providing excellence in patient care, embracing multi-disciplinary education, and research with global impact. We foster a learning environment that values evidenced based practice, experience, innovation, and critical thinking. Our compassion, integrity, accountability, and resilience define us as leaders in pediatric specialty care for our children and their families.
With 20+ hospitals, outpatient clinics, ambulatory care centers and outreach locations across the globe, we provide excellent care to children up to age 18 regardless of their family’s ability to pay or insurance status. Please click here to learn more about our locations.
CURRENT EMPLOYEES: Please log into Workday Click Here to apply internally through the "Jobs Hub"
Job Description
Shriners Children's St. Louis is seeking a PRN Advanced Practice Provider (Nurse Practitioner or Physician Assistant) to provide weekend coverage for our inpatient pediatric orthopedic service. This position plays a vital role in ensuring continuity of care for hospitalized patients and offers an opportunity to work within a highly collaborative multidisciplinary team dedicated to caring for children with orthopedic and rehabilitation needs.
The APP will be responsible for the ongoing management of the inpatient unit during designated weekend coverage periods, including patient assessment, treatment plan implementation, care coordination, discharge planning, and family education. The inpatient population is generally low acuity, with an average daily census of approximately 3 to 5 patients, and consists primarily of pediatric orthopedic and rehabilitation patients, including children in HALO traction and those recovering from orthopedic procedures. The APP will work closely with pediatricians, orthopedic surgeons, nursing staff, therapists, and other members of the care team to support safe, effective, and family-centered care.
Coverage opportunities include Friday daytime, Friday overnight call, Saturday daytime, Saturday overnight call, Sunday daytime, and Sunday overnight call shifts. During Friday daytime coverage, the APP will be onsite managing inpatient needs and coordinating patient care. Friday night coverage is call-based. On Saturdays and Sundays, the provider will round on all assigned inpatients each morning, collaborate with the pediatrician and care team regarding treatment plans, address clinical concerns as they arise, and remain available by phone for patient care needs throughout the remainder of the shift. Coverage periods are structured as 12-hour shifts (7:00am to 7:00pm). While much of the weekend coverage is managed remotely after morning rounds, the APP must be able to respond to urgent patient care needs and report to the hospital within 30 minutes if an in-person evaluation or intervention is required.
Given the autonomous nature of weekend coverage, Shriners Children's St. Louis is seeking an experienced Advanced Practice Provider (Nurse Practitioner or Physician Assistant) who can practice independently while collaborating effectively with the broader care team. Candidates should have several years of advanced practice experience, preferably caring for pediatric patients in an inpatient setting, and be comfortable assessing patients, managing treatment plans, responding to urgent clinical issues, and coordinating care across disciplines.
To support successful onboarding and independent practice, newly hired APPs will complete a structured orientation program consisting of approximately 20 weekday shifts and 10 weekend day shifts alongside an experienced pediatrician. This onboarding period provides comprehensive exposure to the patient population, inpatient workflows, clinical protocols, and weekend coverage expectations specific to Shriners Children's St. Louis.
The position is compensated at a fixed PRN rate of $62.42 per hour.
This PRN opportunity offers scheduling flexibility while providing meaningful involvement in the care of children requiring specialized orthopedic and rehabilitation services in a mission-driven pediatric healthcare environment.
Key Responsibilities
- Conduct comprehensive and age-appropriate health assessments, histories, and physical exams.
- Formulate differential diagnoses and develop care plans in coordination with supervising physicians and the care team.
- Manage care for specialty populations including orthopedic, spinal, craniofacial, and neuromuscular patients.
- Provide pre-operative and post-operative evaluations and ongoing management in both inpatient and ambulatory surgical environments.
- Order and interpret diagnostic imaging, lab work, and other tests as permitted by licensure and protocol.
- Perform routine procedures and assist in specialty surgical cases within the scope of licensure.
- Prescribe medications and therapeutic interventions consistent with the scope of practice and Shriners Children’s policies.
- Participate in multidisciplinary clinics and care conferences to support coordinated, integrated care.
- Educate patients, caregivers, and staff on disease processes, treatment plans, and home care strategies.
- Document clinical findings, treatment plans, and patient responses using the electronic health record (EHR).
- Support quality improvement, patient safety, and research initiatives as appropriate to the role.
- Provide mentorship or precepting to clinical staff or trainees as assigned.
- Maintain compliance with hospital, state, and federal regulations, including infection control and documentation standards.
- Perform additional duties within the scope of licensure as assigned to support patient care and organizational goals. Maintain all professional licensure, certifications, and mandatory training in compliance with state and organizational requirements.
Required Qualifications
If Physician Assistant
- Master of Physician Assistant Studies (or equivalent degree) from an accredited Physician Assistant program
- Current, unrestricted Physician Assistant license in the state of practice
- Certification by the National Commission on Certification of Physician Assistants (NCCPA)
If Nurse Practitioner
- Master of Science in Nursing (MSN) or Doctor of Nursing Practice (DNP) from an accredited Nurse Practitioner program
- American Nurses Credentialing Center (ANCC), American Association of Nurse Practitioners (AANP), or equivalent board certification in applicable specialty area, such as Pediatric Nurse Practitioner (CPNP-AC, CPNP-PC) or Family Nurse Practitioner (FNP)
- Current, unrestricted Registered Nurse (RN) and Advanced Practice Registered Nurse (APRN) license in the state of practice
Both
- Minimum 2 years advanced practice experience required, preferably in an inpatient setting caring for pediatric patients. Experience with pediatric orthopedic, spinal, or craniofacial, or other surgical patient populations preferred
- Must possess eligibility for active DEA
- Must possess Basic Life Support for Healthcare Providers (BLS for HCP). Pediatric Advanced Life Support (PALS) certification may be required based on clinical assignment
- Credentialing and privileging by the medical staff in accordance with hospital bylaws
- Strong pediatric assessment and clinical decision-making skills.
- Familiarity with pediatric specialty protocols and post-surgical care.
- Excellent communication and interpersonal skills to engage effectively with patients, families, and care teams.
- Proficient in EHR systems and clinical documentation.
- Demonstrated commitment to patient safety, family-centered care, and trauma-informed practice.
See All 14 Practice Assistant Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Practice Assistant JobsPractice Assistant Jobs by City in Missouri
Where Missouri roles are concentrated, by current openings.
Practice Assistant Job Market in Missouri
A snapshot from current Missouri openings, updated as new roles post.
Who's Hiring


What Missouri Employers Look For
The qualifications that appear most often in practice assistant jobs across Missouri.
- Active Missouri registration or recognized credential relevant to the practice assistant specialty
- High school diploma or equivalent, with post-secondary certificate preferred for clinical roles
- Experience with electronic health record systems such as Epic or Cerner
- Strong knowledge of medical or dental terminology appropriate to the practice setting
- Ability to manage patient scheduling, insurance verification, and front-office workflows
- Effective written and verbal communication skills for coordinating with clinical staff and patients
Practice Assistant Jobs in Missouri: Frequently Asked Questions
How do you become a practice assistant in Missouri?
The path depends on the practice specialty. For dental assisting, Missouri does not require a state license but most employers expect a Dental Assisting National Board credential or completion of an accredited program. For medical practice assistants, a certificate from a Missouri community college or vocational program is the most common entry point. Those pursuing clinical roles should verify any facility-specific credentialing requirements with the Missouri Division of Professional Registration.
Which companies hire practice assistants in Missouri?
Employers hiring practice assistants in Missouri right now include Children's Mercy Hospitals & Clinics, Golden Valley Memorial Healthcare, and SSM Health, based on current listings on Migrate Mate as of October 2026. Missouri's concentration of large regional health systems means hiring is steady throughout the year, particularly in outpatient and specialty clinic settings.
Which Missouri cities have the most practice assistant jobs?
The cities with the most practice assistant openings in Missouri are Kansas City, St. Louis, and Clinton. Kansas City and St. Louis dominate the market because they anchor Missouri's largest health systems and specialty care networks, while Springfield's significant regional medical infrastructure drives consistent demand in the southwest part of the state.
Are there remote practice assistant jobs in Missouri?
Yes, but they're rare. Practice assistant roles are largely hands-on and tied to clinical or front-office settings, so fully remote positions are limited. About 33% of practice assistant openings tied to Missouri are remote or hybrid as of October 2026, and those opportunities are most common in medical billing, insurance verification, and administrative coordination functions.
How can I get hired as a practice assistant in Missouri with little or no experience?
The most realistic entry path is completing a certificate program at a Missouri community college, such as those offered at Ozarks Technical Community College or St. Louis Community College, and applying directly to clinic support or patient services roles. Large Missouri health systems including BJC HealthCare and Mercy Health run new-graduate and entry-level hiring programs for clinical support staff. Candidates coming from adjacent roles like medical receptionist, pharmacy technician, or patient care technician also have a strong foothold, and earning a Certified Medical Administrative Assistant credential before applying gives a measurable edge.
Where can I find and apply to practice assistant jobs in Missouri?
You can find and apply to practice assistant jobs in Missouri on Migrate Mate, which lists current Missouri openings across practice specialties and hiring locations. Search the listings to find roles that match your background and apply directly to the ones that fit.
See All 14 Practice Assistant Jobs in Missouri
Find roles in Missouri that match your experience and apply in just a few clicks.
Find Practice Assistant Jobs