Site Manager Jobs in North Carolina
Site Manager jobs in North Carolina are concentrated in construction, manufacturing, and industrial development, with demand running from entry-level supervision to senior project leadership across the state's fastest-growing regions. Charlotte, Raleigh, and the Research Triangle drive the largest share of openings, where major employers like Skanska, Holder Construction, and Duke Energy maintain lasting operations. The most in-demand specialties are commercial construction management, industrial facility oversight, and infrastructure project coordination. Find a role that fits below and apply directly.
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Showing 5 of 83+ Site Manager jobs
Updated: Yesterday
Location: Remote, NC, United States
Job ID: 25107574
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Description
Senior Site Contract Specialist / Contract Manager (Sponsor Dedicated/ Remote- US Only)Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
Discover what your 25,000 future colleagues already know:
Why Syneos Health
- We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
- We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
- We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.
Job Responsibilities
May lead multi-country projects including negotiating and preparing contracts, budgets, and related documents for participation in industry-sponsored clinical trials.
Produces site-specific contracts from country clinical trial agreement (CTA) template. Reviews and owns site-specific contracts from country template. Submits proposed CTA and investigator budget for site review.
Negotiates budget and contract with site and via Site Contracts Service Centre and SSUL with Sponsor until resolution of issues.
Performs quality control and arranges execution of CTAs as well as archival of documents into repositories and capture of metadata. Reviews contracts for completeness and accuracy, and ensures that corrections are appropriately made and documented.
Administers all contract management processes, including coordination with relevant protocol, informed consent, institution, investigator, vendor, consultant, and customer agreement documents at a project level.
Generates amended contract and/or budget documents as necessary, preparing contract management documentation for projects, and streamlining the contract/proposal or internal processes; initiates and introduces creative ideas and solutions.
Works closely with Site Contract Service Center and Legal to harmonize site contract to reflect sponsor's master service agreement terms.
Works closely with SSU lead, Clinical Operations and Finance to validate the load of departmental budgets and corresponding backlog.
Identifies possible contract or process operational risk and proactively works within the team to provide solutions. Establishes strong working relationships with SSU lead, customer and internal project teams. Escalates deviations to department leadership and/or Site Contract Service Center and/or Legal Department.
Provides support to business development and represents site contracts/Site Start-Up (SSU) at internal or customer meetings.
Works within the forecasted country/site contracting timelines, ensures they are complied with and tracks milestone progress in agreed upon SSU tracking system in real time.
Collaborates with internal and external legal, finance, and clinical operations departments, including communicating and explaining legal and budgetary issues.
Maintains and actively supports review and development of contract templates, budget templates and site specific files and databases.
Serves as key communication liaison between site contracts staff and internal and external customers. Provides functional guidance and keeps internal and external teams aware of all contract statuses or pending issues. Prepares correspondence as necessary.
Trains and mentors less experienced staff members on departmental Standard Operating Procedures (SOPs), and ensures quality of team work products. Maintains and updates training material for site contract team.
Actively participates in higher level discussions about overall company goals, departmental objectives, and specific project aims.
Facilitates the execution of contracts by company signatories.
Monitors basic financial aspects of the project and the number of hours/tasks available per contract; escalates discrepancies in a timely fashion.
Reviews and complies with Standard Operating Procedures (SOPs) and Work Instructions (WIs) in a timely manner, keeps training records updated accordingly and ensures timesheet compliance.
Qualifications:
Bachelor's degree in a related field or equivalent experience
Moderate contracts management experience that includes experience in a contract research organization or pharmaceutical industry
Practical knowledge of a professional area, typically obtained through education combined with experience
Strong understanding of regulations, SOPs, and project requirements related to site identification
Excellent negotiation and communication skills
Ability to manage and review site performance metrics
Experience in managing site confidentiality agreements (CDAs) and site information forms (SIFs)
Preferred Qualifications
5+ years of site contracts and study start-up (SSU) experience within a global CRO or pharmaceutical sponsor environment, including ownership of multi-country studies.
Demonstrated expertise negotiating site CTAs and investigator budgets, including direct interaction with sites, sponsors, Site Contract Service Centers, and Legal teams.
Strong experience drafting and managing site-specific CTAs from country or global templates and ensuring alignment with sponsor MSAs and country requirements.
Proven ability to manage contract amendments and protocol-driven changes, maintaining compliance with timelines, quality standards, and documentation requirements.
Experience serving as an escalation point for complex contract, budget, or process issues, with a track record of proactive risk identification and resolution.
Hands-on experience with SSU tracking systems and contract repositories, including real-time milestone tracking and metadata management.
Demonstrated leadership in training and mentoring junior staff, including contribution to SOPs, WIs, templates, and internal training materials.
Experience supporting business development activities, such as proposal development, bid defenses, or sponsor-facing meetings.
Salary Range
$56,400 – $95,900
Location
Open to US-Remote candidates.
Certifications:
Relevant certifications in clinical research or site management preferred
Necessary Skills:
Strong organizational and time management skills
Ability to work independently and as part of a team
Proficiency in using relevant software and tools for site management
Detail-oriented with strong analytical skills
Ability to handle multiple tasks and projects simultaneously
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
$56,400.00 - $95,900.00The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos Health
Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
http://www.syneoshealth.com
Additional Information
Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.
Summary
Roles within the Site Start-Up/Site ID job family are responsible for managing and executing the site identification process in accordance with regulations, SOPs, and project requirements. This includes completing and negotiating site confidentiality agreements (CDAs) and site information forms (SIFs) with sites, maintaining, reviewing, and reporting on site performance metrics, serving as the primary point of contact for investigative sites, and tracking the completion of site identification for sites. Impact and Contribution Individual contributors with responsibility in a professional or technical discipline or specialty, but may manage two or fewer employees. May direct the work of lower level professionals or manage processes and programs. The majority of time is spent contributing to the design, implementation or delivery of processes, programs, and policies, using knowledge and skills typically acquired through advanced education. Established and productive individual contributor. May manage defined components of projects or processes within area of responsibility. Requires practical knowledge of a professional area, typically obtained through education combined with experience.Updated: Yesterday
Location: Remote, NC, United States
Job ID: 25107574
Join our Talent Network
Description
Senior Site Contract Specialist / Contract Manager (Sponsor Dedicated/ Remote- US Only)Our Clinical Solutions team members act with a drug development mindset, applying their years of experience and deep expertise to truly understand customer needs and represent those in the solutions we shape.
Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to deliver – for one another, our customers, and, most importantly, for those in need.
Discover what your 25,000 future colleagues already know:
Why Syneos Health
- We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
- We are committed to building an inclusive culture – where you can authentically be yourself. Central to this is our purpose – Driven to Deliver – which captures the passion of our colleagues to show up each day and shape solutions that have the ability to dramatically impact someone’s life.
- We are continuously building the company we all want to work for and our customers want to work with. Why? Because we know that when we bring together smart colleagues from across the world, we can shape the future of healthcare, driving impact for customers and defining the pace of patient progress.
Job Responsibilities
May lead multi-country projects including negotiating and preparing contracts, budgets, and related documents for participation in industry-sponsored clinical trials.
Produces site-specific contracts from country clinical trial agreement (CTA) template. Reviews and owns site-specific contracts from country template. Submits proposed CTA and investigator budget for site review.
Negotiates budget and contract with site and via Site Contracts Service Centre and SSUL with Sponsor until resolution of issues.
Performs quality control and arranges execution of CTAs as well as archival of documents into repositories and capture of metadata. Reviews contracts for completeness and accuracy, and ensures that corrections are appropriately made and documented.
Administers all contract management processes, including coordination with relevant protocol, informed consent, institution, investigator, vendor, consultant, and customer agreement documents at a project level.
Generates amended contract and/or budget documents as necessary, preparing contract management documentation for projects, and streamlining the contract/proposal or internal processes; initiates and introduces creative ideas and solutions.
Works closely with Site Contract Service Center and Legal to harmonize site contract to reflect sponsor's master service agreement terms.
Works closely with SSU lead, Clinical Operations and Finance to validate the load of departmental budgets and corresponding backlog.
Identifies possible contract or process operational risk and proactively works within the team to provide solutions. Establishes strong working relationships with SSU lead, customer and internal project teams. Escalates deviations to department leadership and/or Site Contract Service Center and/or Legal Department.
Provides support to business development and represents site contracts/Site Start-Up (SSU) at internal or customer meetings.
Works within the forecasted country/site contracting timelines, ensures they are complied with and tracks milestone progress in agreed upon SSU tracking system in real time.
Collaborates with internal and external legal, finance, and clinical operations departments, including communicating and explaining legal and budgetary issues.
Maintains and actively supports review and development of contract templates, budget templates and site specific files and databases.
Serves as key communication liaison between site contracts staff and internal and external customers. Provides functional guidance and keeps internal and external teams aware of all contract statuses or pending issues. Prepares correspondence as necessary.
Trains and mentors less experienced staff members on departmental Standard Operating Procedures (SOPs), and ensures quality of team work products. Maintains and updates training material for site contract team.
Actively participates in higher level discussions about overall company goals, departmental objectives, and specific project aims.
Facilitates the execution of contracts by company signatories.
Monitors basic financial aspects of the project and the number of hours/tasks available per contract; escalates discrepancies in a timely fashion.
Reviews and complies with Standard Operating Procedures (SOPs) and Work Instructions (WIs) in a timely manner, keeps training records updated accordingly and ensures timesheet compliance.
Qualifications:
Bachelor's degree in a related field or equivalent experience
Moderate contracts management experience that includes experience in a contract research organization or pharmaceutical industry
Practical knowledge of a professional area, typically obtained through education combined with experience
Strong understanding of regulations, SOPs, and project requirements related to site identification
Excellent negotiation and communication skills
Ability to manage and review site performance metrics
Experience in managing site confidentiality agreements (CDAs) and site information forms (SIFs)
Preferred Qualifications
5+ years of site contracts and study start-up (SSU) experience within a global CRO or pharmaceutical sponsor environment, including ownership of multi-country studies.
Demonstrated expertise negotiating site CTAs and investigator budgets, including direct interaction with sites, sponsors, Site Contract Service Centers, and Legal teams.
Strong experience drafting and managing site-specific CTAs from country or global templates and ensuring alignment with sponsor MSAs and country requirements.
Proven ability to manage contract amendments and protocol-driven changes, maintaining compliance with timelines, quality standards, and documentation requirements.
Experience serving as an escalation point for complex contract, budget, or process issues, with a track record of proactive risk identification and resolution.
Hands-on experience with SSU tracking systems and contract repositories, including real-time milestone tracking and metadata management.
Demonstrated leadership in training and mentoring junior staff, including contribution to SOPs, WIs, templates, and internal training materials.
Experience supporting business development activities, such as proposal development, bid defenses, or sponsor-facing meetings.
Salary Range
$56,400 – $95,900
Location
Open to US-Remote candidates.
Certifications:
Relevant certifications in clinical research or site management preferred
Necessary Skills:
Strong organizational and time management skills
Ability to work independently and as part of a team
Proficiency in using relevant software and tools for site management
Detail-oriented with strong analytical skills
Ability to handle multiple tasks and projects simultaneously
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
$56,400.00 - $95,900.00The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate’s qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos Health
Over the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you’ll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
http://www.syneoshealth.com
Additional Information
Tasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees. The Company is committed to compliance with the Americans with Disabilities Act, including the provision of reasonable accommodations, when appropriate, to assist employees or applicants to perform the essential functions of the job.
Summary
Roles within the Site Start-Up/Site ID job family are responsible for managing and executing the site identification process in accordance with regulations, SOPs, and project requirements. This includes completing and negotiating site confidentiality agreements (CDAs) and site information forms (SIFs) with sites, maintaining, reviewing, and reporting on site performance metrics, serving as the primary point of contact for investigative sites, and tracking the completion of site identification for sites. Impact and Contribution Individual contributors with responsibility in a professional or technical discipline or specialty, but may manage two or fewer employees. May direct the work of lower level professionals or manage processes and programs. The majority of time is spent contributing to the design, implementation or delivery of processes, programs, and policies, using knowledge and skills typically acquired through advanced education. Established and productive individual contributor. May manage defined components of projects or processes within area of responsibility. Requires practical knowledge of a professional area, typically obtained through education combined with experience.See All 83 Site Manager Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
Find Site Manager JobsSite Manager Jobs by City in North Carolina
Where North Carolina roles are concentrated, by current openings.
Site Manager Job Market in North Carolina
A snapshot from current North Carolina openings, updated as new roles post.
Who's Hiring
Top Industries Hiring
- Retail
- Manufacturing
- Construction & Real Estate
- Consulting & Professional Services
- Science & Research
What North Carolina Employers Look For
The qualifications that appear most often in site manager jobs across North Carolina.
- Active North Carolina General Contractor license or work under a licensed contractor as required
- Bachelor's degree in construction management, civil engineering, or a related technical field
- Proven experience managing subcontractors, schedules, and budgets on commercial or industrial projects
- Proficiency with project management software such as Procore, Bluebeam, or Microsoft Project
- Strong knowledge of OSHA safety regulations and ability to maintain a compliant job site
- Ability to read and interpret construction drawings, blueprints, and project specifications
Site Manager Jobs in North Carolina: Frequently Asked Questions
How do you become a site manager in North Carolina?
Most site manager roles in North Carolina require a degree in construction management, civil engineering, or architecture, combined with field experience as a superintendent or project engineer. North Carolina does not issue a state site manager license directly, but general contractors operating in the state must hold a license through the North Carolina Licensing Board for General Contractors. Building experience under a licensed GC and earning credentials such as the OSHA ten-hour or thirty-hour certification strengthens your candidacy considerably.
Which companies hire site managers in North Carolina?
North Carolina site manager roles are posted by Fitch Irick, Syneos Health, and Zips Car Wash and others right now, based on current listings on Migrate Mate as of August 2026. North Carolina's active construction market, anchored by Charlotte's skyline growth and the Research Triangle's expanding life sciences campuses, keeps a broad range of regional and national contractors hiring consistently.
Which North Carolina cities have the most site manager jobs?
Charlotte, Durham, and North Carolina post the most site manager openings in North Carolina. Charlotte leads because of its sustained commercial real estate and infrastructure development, Raleigh and Durham benefit from Research Triangle biotech and tech campus construction, and Greensboro supports a steady pipeline of industrial and logistics facility projects tied to its central location along major freight corridors.
Are there remote site manager jobs in North Carolina?
Yes, but they're rare. Site management is fundamentally an on-site role requiring daily presence to oversee crews, inspect work, and coordinate deliveries, so fully remote positions are uncommon. About 36% of site manager openings tied to North Carolina are remote or hybrid as of August 2026, and those tend to be pre-construction planning or owner's representative roles where document review and coordination happen off-site.
How can I get hired as a site manager in North Carolina with little or no experience?
The most realistic entry path is starting as a field engineer, assistant superintendent, or construction coordinator with a mid-size general contractor active in North Carolina's Charlotte or Raleigh markets. Large firms like Skanska and Holder Construction run structured associate project manager programs that bring in candidates with a construction management degree and no site experience. Earning your OSHA thirty-hour certification and completing an internship through the Associated Builders and Contractors Carolinas chapter signals readiness to employers who might otherwise require prior supervisory experience.
Where can I find and apply to site manager jobs in North Carolina?
You can find and apply to site manager jobs in North Carolina on Migrate Mate, which lists current openings from employers hiring across the state right now. Search the available roles, identify the ones that fit your experience and location, and apply directly to each one.
See All 83 Site Manager Jobs in North Carolina
Find roles in North Carolina that match your experience and apply in just a few clicks.
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