Support Lead Jobs in South Carolina
Support Lead jobs in South Carolina are concentrated in Charleston, Columbia, and Greenville, where employers across healthcare systems, financial services, and manufacturing operations consistently hire for this role at both team lead and senior coordinator levels. Large employers with deep roots in the state, including Prisma Health, Santee Cooper, and BMW Manufacturing, maintain ongoing demand for support leads who can oversee service delivery, coach frontline staff, and manage escalations. The most in-demand specialties are IT support leadership, customer operations management, and technical service coordination. Scan the live roles below and apply to whichever ones fit.
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Explore what happens when ideas Intertwine
At Intertwine Associates, we live by a simple promise: We show up ready to work. We partner with organizations across government, management, strategy, and technology to deliver operational efficiency and measurable impact. Our focus is on practical solutions, tailored frameworks, and innovation that drives meaningful results. Join a team where expertise meets execution, and where your work truly matters. Read more here: www.intertwineassociates.com
Key Role:
Work in a dynamic, fast-paced environment as an Innovative Solutions Opening (ISO) Coordinator using your familiarity with Other Transactions (OTs) supporting the Advanced Research Projects Agency for Health (ARPA-H). Enable the agency to manage and provide oversight of advanced research and development efforts; help shape future R&D concepts, programs, and solutions; integrate and advance our nation’s healthcare ecosystem processes, policies, and enabling technologies; and enable the agency to expand its healthcare and scientific scope into yet unknown areas. Provide direct support to R&D performer teams, Government Program Managers, and stakeholders across the health innovation ecosystem.
Assist with the development and administration of ARPA-H programs and projects across a Mission Office portfolio. Support the development of solicitations and related acquisition documentation; manage ISO proposals from receipt through disposition; track negotiations; and coordinate within the Mission Office and across ARPA-H for cost proposals and technical evaluations. Track metrics accurately and manage multiple parallel projects and tasks simultaneously on short timelines.
Collaborate effectively within a diverse team by building strong working relationships with scientists, engineers, contracting officers, IT professionals, and other advisors involved in the portfolio. Relentlessly own the end-to-end process and collaborate across teams, acting as the center point for effective progress, ensuring continuous momentum and effective data management using tools like Jira and Confluence. Communicate complex processes and concepts clearly and concisely to both technical and non-technical audiences. Evaluate IT systems and processes, identify opportunities for optimization, and recommend functional improvements that enhance efficiency and effectiveness. Conduct independent research, analyze data, and make recommendations. Actively participate in brainstorming sessions and problem-solving exercises to drive the portfolio forward.
Strong client or customer engagement is required in this role. You will interface directly and continuously with the Government Program Manager, Mission Office leadership, contracting and acquisition personnel, performer teams, and external members of the public — and are expected to represent Intertwine Associates and the client with professionalism, responsiveness, and sound judgment at every touchpoint by owning the process, serving as the go-to for any next step required to keep the process moving. This is a remote position with approximately 10-20% CONUS travel.
Basic Qualifications:
- Bachelor’s degree required, with five or more years of professional work experience.
- Demonstrated understanding of contracting and/or procurement, preferably in a government or research environment.
- Demonstrated ability to track metrics effectively and to manage multiple parallel projects and tasks simultaneously.
- Demonstrated ability to evaluate IT systems and processes, identify opportunities for optimization, and recommend functional improvements to enhance efficiency and effectiveness.
- Familiarity with information management systems, including Jira and Confluence.
- Strong client or customer engagement required, proven ability to build and sustain trusted relationships with government stakeholders, performer teams, and cross-functional partners, and to serve as a dependable point of contact in a high-visibility client environment.
- Excellent written and verbal communication skills, both internally and externally with members of the public.
- Demonstrated ability to conduct independent research, analyze data, and make recommendations.
- Demonstrated ability collaborating with cross-functional stakeholder teams.
- Ability to work independently and collaboratively as part of a team, and to prioritize work.
- Highly detail-oriented, organized, and proactive.
- Strong work ethic and a passion for healthcare and scientific discovery.
- U.S. citizenship or lawful permanent residency is required per contract.
- Active federal government Public Trust, or the ability to obtain one.
Additional Qualifications:
- At least one year of experience supporting DARPA or related federal “ARPA” agencies (IARPA, ARPA-E, HSARPA).
- Experience working with Other Transaction Agreements, grants, contracts, and cooperative agreements.
- General knowledge of acquisition documentation requirements (RFI, SN, BAA, J&A), with hands-on experience working with each.
- Experience supporting a federal or commercial health agency or organization.
- Knowledge of the biomedical research landscape.
- Two or more years of experience in federal healthcare and/or scientific consulting.
- Experience supporting complex healthcare programs and programs of a research and development nature.
Intertwine Associates LLC – Equal Employment Opportunity Statement
Intertwine Associates LLC is an Equal Opportunity Employer. We are committed to fostering a diverse and inclusive workplace where all individuals are treated with respect and dignity. Employment decisions at Intertwine Associates LLC are made without regard to race, color, religion, sex (including pregnancy, sexual orientation, and gender identity), national origin, age, disability, genetic information, marital status, veteran status, citizenship status, or any other characteristic protected by applicable federal, state, or local laws.
We comply with all applicable laws governing nondiscrimination in employment and strive to ensure that our workplace reflects the values of fairness, equity, and opportunity. All qualified applicants will receive consideration for employment without regard to any protected status. We also prohibit retaliation against individuals who report discrimination, participate in investigations, or otherwise exercise their rights under equal employment laws.
Intertwine Associates LLC is proud to support the mission of our clients, including U.S. Federal Government agencies, by providing exceptional technical talent and services. As such, certain roles may require U.S. citizenship or specific security clearances in accordance with federal contract requirements.
Compensation, Bonuses, and Other Incentives:
Intertwine Associates LLC offers a competitive compensation package. The anticipated base salary range for this position is $90,000-$220,000 per year. This range is a good-faith estimate at the time of posting and reflects the base salary the company reasonably expects to offer for this role. Actual base salary will be determined based on lawful, job-related factors, including education, experience, specialized expertise, credentials, geographic location, scope of responsibilities, internal equity, client and contract requirements, and funding availability.
This position may be eligible for discretionary bonuses, signing or retention incentives, or other variable compensation, as stated in the applicable written offer or plan documents. Any bonus or incentive is not guaranteed and is subject to applicable plan terms, individual and company performance, client or contract requirements, funding availability, and applicable law. Bonuses and other incentives are separate from base salary and may be modified or discontinued. The salary range does not include potential bonuses, other incentive compensation, or benefits. Nothing in this posting creates an employment contract or guarantees any specific salary, bonus, incentive, benefit, or term of employment.
See All 21 Support Lead Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Support Lead JobsSupport Lead Jobs by City in South Carolina
Where South Carolina roles are concentrated, by current openings.
Support Lead Job Market in South Carolina
A snapshot from current South Carolina openings, updated as new roles post.
Who's Hiring
- Five Below12

- Aramark2

- KBR1

- Rippling1

- Safe Harbor1

Top Industries Hiring
- Education
What South Carolina Employers Look For
The qualifications that appear most often in support lead jobs across South Carolina.
- Experience supervising or mentoring a support team in a professional environment
- Demonstrated ability to manage ticket queues, escalations, and service-level targets
- Proficiency with CRM or helpdesk platforms such as Salesforce, Zendesk, or ServiceNow
- Strong written and verbal communication skills for cross-functional coordination
- Associate or bachelor degree in business, information technology, or a related field
- Familiarity with workforce scheduling, performance reporting, and quality assurance processes
Support Lead Jobs in South Carolina: Frequently Asked Questions
How do you become a support lead in South Carolina?
Most support leads in South Carolina move into the role after building several years of hands-on experience in a support specialist or coordinator position, then demonstrating leadership through mentoring or escalation handling. There is no state-issued license required for this role in South Carolina. Employers across Greenville, Columbia, and Charleston typically look for candidates with a relevant associate or bachelor degree and a record of steady progression within a support function, whether in IT, customer operations, or technical services.
Which companies hire support leads in South Carolina?
Employers hiring support leads in South Carolina right now include Five Below, Aramark, and KBR, based on current listings on Migrate Mate as of August 2026. South Carolina's mix of healthcare systems, utility companies, and advanced manufacturing operations means openings appear across multiple industries rather than clustering in a single sector.
Which South Carolina cities have the most support lead jobs?
Columbia, Charleston, and Aiken lead South Carolina for support lead openings. Charleston's growth in technology, logistics, and healthcare has expanded demand there, while Columbia draws volume from state government agencies and large university-affiliated health systems, and Greenville benefits from the dense concentration of automotive, manufacturing, and financial services employers anchored by companies like BMW and Michelin in the upstate region.
Are there remote support lead jobs in South Carolina?
Yes, and they are more common than in many comparable roles. About 50% of support lead openings tied to South Carolina are remote or hybrid as of August 2026, reflecting the desk-based, coordination-heavy nature of the work. Roles focused on IT helpdesk oversight, customer operations management, and software support tend to offer the most flexibility, while positions requiring on-site team supervision or hands-on technical oversight are more likely to be fully in-office.
How can I get hired as a support lead in South Carolina with little or no experience?
The most realistic entry path is to start as a support specialist or customer service representative at a large South Carolina employer, then volunteer for shift lead or queue management responsibilities. Prisma Health and MUSC Health in the healthcare space, along with technology services firms in the Columbia and Greenville corridors, regularly hire entry-level support staff who can grow into lead roles. Earning a CompTIA or ITIL Foundation certification gives candidates a measurable edge even without prior supervisory experience.
Where can I find and apply to support lead jobs in South Carolina?
You can find and apply to support lead jobs in South Carolina on Migrate Mate, which lists current openings across the state. Search the available roles, identify the ones that match your experience and preferred location, and apply directly through each listing. No account or profile is needed to search and apply.
See All 21 Support Lead Jobs in South Carolina
Find roles in South Carolina that match your experience and apply in just a few clicks.
Find Support Lead Jobs